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Megyn Kelly hosts a discussion on transitioning and de-transitioning, featuring Walt Heyer and Grace Ladinsky-Smith, both of whom regret their transitions. Walt transitioned to Laura Jensen in his forties but de-transitioned after realizing he needed therapy for childhood trauma rather than surgery. He recounts how adverse childhood experiences, including emotional and sexual abuse, influenced his decision to transition. He emphasizes that many individuals who transition may be dealing with unresolved trauma rather than genuine gender dysphoria. Grace, who began questioning her gender in her twenties, underwent a double mastectomy and hormone therapy but later recognized her mistake. She describes her experience as being influenced by social media and a mental health crisis, leading her to believe that transitioning would resolve her issues. Both Walt and Grace face backlash from trans activists for sharing their stories, highlighting the societal pressure to affirm transitions without exploring underlying psychological issues. The conversation shifts to the medical perspective, with Dr. Julia Mason and Dr. Erica Anderson discussing the implications of puberty blockers and cross-sex hormones. They outline significant risks associated with these treatments, including bone density issues, cognitive effects, and irreversible changes to sexual function. They express concern over the lack of thorough evaluations before medical interventions are prescribed, noting that many young people may be seeking transition as a solution to broader psychological problems. The discussion also touches on the increasing number of young girls identifying as trans and the potential societal factors influencing this trend. Both doctors advocate for a more cautious approach, emphasizing the need for individualized assessments and addressing underlying mental health issues rather than rushing into medical treatments. They call for a systematic review of the scientific evidence surrounding these practices, similar to actions taken in countries like Sweden and Finland, which have begun to reassess their approaches to gender-affirming care for minors.

On Origins Podcast, Lauren Schwarz and Arthur Rousseau discuss their chapter in The War on Science, focusing on gender-affirming care (GAC) and medical standards. They argue that the World Professional Association for Transgender Health (WPATH) wields influence, with U.S. medical bodies deferring to it, while the UK’s Cass report and countries have begun to curtail such care. They describe WPATH’s standards of care (SOC 8) as presenting itself as evidence-based, lifesaving care, yet note published reviews finding the strength of the evidence often low or indirect, and that guidelines are not always consistent with the underlying literature. They recount that Johns Hopkins underwent political pressure to withdraw systematic reviews and that WPATH later imposed an approval mechanism over future publications. The speakers condemn the reliance on “lived experience” over rigorous evidence, and highlight concerns about age restrictions being removed and consent for minors to hormonal or surgical interventions. They cite a lack of long-term outcome data, no conclusive evidence that gender-affirming care reduces suicide, and cases illustrating the risks of messaging to afraid families. They call for better education, transparency, and a return to science-based medicine, while referencing the Tennessee minors’ care case and urging global alignment.

Megyn Kelly discusses the nomination of Pete Hegseth for Secretary of Defense, highlighting the uncertainty surrounding his confirmation due to media scrutiny and potential opposition from Republican senators. Michael Knowles joins the conversation, expressing support for Hegseth and criticizing the media's attempts to undermine him with unsubstantiated allegations. They discuss the implications of Hegseth's past, including his marital history and accusations of alcohol use, arguing that these issues should not disqualify him from the position. The conversation shifts to the broader political landscape, with Knowles emphasizing the risks for Trump if Hegseth's nomination fails and the potential for other candidates like Ron DeSantis to face similar scrutiny. They note that the media's focus on personal histories could hinder the nomination process for various candidates, including Bobby Kennedy and Tulsi Gabbard. Kelly and Knowles also address the media's portrayal of Hegseth and the motivations behind the attacks, suggesting that personal biases and political agendas are at play. They argue that the standards being applied to Hegseth may not be consistent across the political spectrum, particularly when comparing him to other public figures with checkered pasts. The discussion then turns to the Supreme Court case regarding Tennessee's law banning puberty blockers and hormone treatments for minors. Kelly and Knowles express optimism about the outcome, citing the lack of evidence supporting the efficacy of such treatments and the potential risks involved. They highlight the importance of protecting children from irreversible medical decisions and criticize the ideological motivations behind the push for gender-affirming care. Attorney General Jonathan Sketti of Tennessee joins the conversation, discussing the implications of the Supreme Court's deliberations and the need for evidence-based medical practices. He emphasizes the risks associated with puberty blockers and hormone treatments, arguing that children are not equipped to make such significant decisions about their bodies. Sketti expresses hope that the court will uphold Tennessee's law, allowing states to regulate medical treatments for minors. The conversation concludes with a call to action, urging listeners to support efforts to protect children from harmful medical practices and to hold accountable those who promote ideologically driven policies without sufficient evidence.