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Anti-vaccine activism, which I refer to as anti-science aggression, has emerged as a significant global threat. During the COVID pandemic, 200,000 Americans lost their lives due to vaccine refusal, despite widespread availability. This movement is now spreading to low and middle-income countries and poses a greater risk than gun violence, global terrorism, nuclear threats, or cyber attacks. In the U.S., it has become intertwined with far-right extremism, a trend also seen in Germany. Addressing this issue requires political solutions to combat the rising tide of anti-science sentiment.