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Fat burning is about hormones, not just cutting calories. Understanding the hormones that burn fat versus those that store fat, and how to trigger or avoid them, can make you successful. Doctors may assess hormones and, if they find low testosterone, they may prescribe testosterone. Among fat-burning hormones, insulin is the key one. Insulin is made by the pancreas and it does a lot of things, including helping you store fat. You cannot burn fat if insulin is too high. Even if you boost other fat-burning hormones, if insulin—the fat-making hormone—is elevated, it nullifies all of the other hormones that help you lose weight.