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Clinics may use standardized TRT protocols for ease, but individual success varies. For example, NHS guidelines prescribe one injection of 250mg Sustenone every three weeks or 1000mg testosterone decanoate every 12-14 weeks. US insurance models may require patients to halt treatment for retesting, contributing to the rise of TRT clinics. Initial injectable treatment, or even topical creams, can cause a dopamine upswing, leading to men feeling great initially. As the body normalizes to the new testosterone level, this feeling diminishes. Chasing this initial feeling can create misaligned expectations and set one up for failure. Testosterone also impacts neurotransmitters like serotonin and may mildly inhibit the MAOI enzyme.

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We're starting the process with Ting, who wants a vagina. The network of moms is supportive. Nicole is a junior in high school, planning surgery between junior and senior year. She's doing great.

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- "Puberty blockers are a group of medications or hormones that we use in the transgender population to stop puberty from progressing." - "We call them in endocrinology gonadotropin releasing hormone analogs or agonists." - "Their job is to really interfere with the signaling from the brain to either the ovaries or the testicles that produce the hormones." - "When somebody starts puberty, we can use them to stop the puberty from progressing, thereby allowing somebody to really explore their gender without the pressure of having secondary sex characteristics that are often permanent." - "And the really nice thing about puberty blockers is that they are reversible, so it's a really nice way for an adolescent to be able to explore their gender." - "We like to use them in birth assigned males who have already even gone through a full male puberty because they are able to then use a lower dose of estrogen."

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Speaker 1 had gynecomastia surgery because he was tired of worrying about what clothes to wear. During a follow-up appointment, he tells Dr. Duffer that one nipple seems to get more erect than the other and sticks out a little more. Dr. Duffer says that Speaker 1 looks really good and natural and that one side of his chest is firmer, possibly due to more scar tissue. Speaker 1 says he noticed tissue when he was 13 and it never went away with working out or dieting. He researched plastic surgeons and was nervous at first due to swelling, but the results were priceless. He doesn't have to obsess over what to wear anymore. Later, Speaker 1, who is Officer Sewell, offers the doctor and another person a ride to a gay bar. He then invites a cop to hang out with them later at the gay bar.

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I'm a trans guy. I've never been to the gynecologist. Today's the fucking day. I asked that they put a note on it: this is a trans guy; he's gonna present male. I called today to make sure the note's on my chart. She said, "The notes on your chart that you're, a trans man and blah blah blah." Okay. Cool. Have a good day, miss Allen. She works at a women's health clinic, and my name is fucking Sasha. Jesus Christ, guys. Full transparency, I'm tweaking out. My anxiety for my fucking audition for The Voice was, like, here. My gyno visit is here. If anything weird occurs, like, people with good intention can just say things uncomfortable and awkward. I don't have the mental capacity; but all I know is afterwards, I'm getting a sweet treat and I'll tell you how it goes. So fucking pray for me.

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Dr. Olsen decides to start Josie on blockers and promises to give her estrogen in two years. Josie receives the blockers as an arm implant and holds on tight as she prepares for the next chapter of her life. The speaker reflects on how just 20 years ago, they wouldn't have been able to provide blockers, and Josie would have had to go through male puberty, which terrifies them. They express uncertainty about whether Josie would have survived male puberty.

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Max, who identifies as a boy, is visiting the doctor to discuss hormone blockers to prevent puberty. He has started experiencing some breast growth and feels uncomfortable. His parent expresses concern about medical interventions and their effects on bone health and psychosocial development. The doctor explains that hormone blockers can halt puberty progression and reassures that if Max changes his mind, he can still go through female puberty later. The procedure involves inserting a small implant in Max's arm, which will last about 14 to 18 months. The entire process is quick, taking only about 10 to 15 minutes.

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We've been experimenting with a new technique. The idea is to castrate a boy before puberty so his voice doesn't change. You know how a boy's voice can be beautiful before puberty, but then it changes? We're really proud of Antonio's singing. Does he like what we've done? Well, it's hard to say. Antonio seems indifferent. When asked about the castration, he didn't give much of a response. He might just prefer singing over talking. It seems like he might be a bit lost in thought, possibly due to the procedure.

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Today is National Coming Out Day, and I'm excited to announce that I'm going back on testosterone. I loved being on it before, but needed to connect with my emotional body. I had to unwind trauma from being read as a man and sacrificing parts of myself. I now embrace my femininity and look forward to exploring it on a testosterone-dominant body. I feel a new wave of expression and excitement for this journey ahead. Cheers to new beginnings!

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The speaker expresses concern about the potential negative effects of injections on hormones, attachment, desire, family life, and normal growth. They also mention the potential damage to reproductive organs. The speaker then briefly mentions how to contact them and asks for support. They mention having 14,000 copies of a book available on Amazon. The transcript ends with a mention of Naomi Wolf being in the capital and a mention of a short commercial.

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I will be hanging out with the daughters of my mom's friend while they have a meeting. Jazz is an inspiration as a transgender role model. She shared her surgery experience honestly. Charlie plans to have surgery after high school due to bullying. I recently had surgery with complications, but now I feel great. Stitches came apart a week after surgery, causing pain and distress.

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Here's my transgender daughter, Bella. She was assigned male at birth but now uses she/her pronouns. We're working on getting her medication to block male hormones. Bella is 14 and doing well in her transition. Being trapped in the wrong body affected her mental health, but with medication, we'll get through it together. We also received a grant to cover her transition costs, which is a huge relief. She can finally be who she truly is, which is all she's wanted for years, and we're so happy for her.

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The speaker discusses the standards applied to children and the potential benefits of going on blockers. They mention that blockers can prevent the development of a deep voice, Adam's apple, and facial hair. The speaker shares their personal experience of spending $5,000 on facial hair removal and $25,000 on facial feminization surgery. They believe that blockers can prevent the need for such procedures and alleviate stress.

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"Puberty blockers work at the level of the pituitary gland and they actually suppress the release of the LH and the FSH so that the sex organs are no longer stimulated." "The main benefit is that they prevent the unwanted permanent effects of puberty, and thus future surgeries can be avoided as an adult." "They are also reversible, and thus if the patient decides to stop using pubertal blockers, their endogenous puberty will resume as previous." "Using pubertal blockers can alleviate the depression or worsening gender dysphoria that is often associated with progressing pubertal changes." "Lastly, the use of puberty suppression is recommended by the Pediatric Endocrine Society in their clinical guidelines for the treatment of transgender and gender diverse youth." "The practice of using puberty suppressors in transgender youth is new." "Since the first clinical guidelines were only published in 02/2009."

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I administer my weekly estrogen shot using two needles and half a milliliter of estradiol. I carefully clean the area with an alcohol wipe and then inject the medication into my thigh. I always make sure there is no blood and then apply a band-aid for cleanliness and to ease my anxiety. I keep all my supplies organized, including different needles, medication, and a prescription, especially when I travel. This self-care routine is crucial for my mental health and gender affirmation.

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Abigail's physical changes due to hormone treatments were primarily seen in her voice. However, these treatments caused her to suffer greatly. The chemicals introduced into her body caused pain in her bones, affected her concentration, and disrupted her sleep. To alleviate these issues, she was advised to use CBD oil. Unfortunately, the hormone treatments had a negative impact on Abigail's life, leading her to take her own life. Her mother questions why these changes were allowed if they didn't bring her happiness.

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Beauty blockers have been used by doctors for kids experiencing precocious puberty. The conversation then shifts to transgender children, with one speaker arguing that gender affirming care is life-saving and reduces suicide rates. The other speaker questions the lack of studies on suicide rates among transgender children and argues against medical interventions like hormone therapy and surgeries. The conversation becomes heated, with one speaker claiming that transgender children don't exist and that they should be accepted as they are, while the other argues that they need medical interventions. The debate centers around the belief that transgender children are either born in the wrong body or that they should be accepted without medical interventions.

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Speaker 0 confirms that the person is currently taking 6 milligrams of estrogen per day. Speaker 1 clarifies that they take it twice a day. Speaker 0 reviews the person's history and asks about the surgery they are seeking. They discuss the irreversible effects of estrogen therapy, such as breast development and shrinkage of the testicles. Speaker 0 mentions that hair growth and redistribution may be affected by estrogen. Speaker 1 mentions that they are not complaining about taking daily pills, but rather wondering if it accelerates the process. The conversation ends.

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Here's my transgender daughter, Bella. She was assigned male at birth but now uses she/her pronouns. We're working on getting her medication to block male hormones. Bella is 14 and doing great in her true body. Being trapped in the wrong body really affected her mental health, but with the right medication, we'll get through this together. We even received a grant to cover all the transition costs, which is a huge relief. All she's wanted for years is to finally be herself, and we're so happy for her.

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If you're transgender or nonbinary and feel uncomfortable with your puberty experiences, you're not alone. Puberty blockers can temporarily halt the changes caused by hormones like testosterone and estrogen, giving you more time to figure out your gender identity. It's okay to not have all the answers right now, as understanding yourself takes time. Talking to a trusted adult, nurse, or doctor can be helpful. To learn more, visit plannedparenthood.org/teens.

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I am a transgender man and I want to discuss the role of testosterone in defining masculinity. I have struggled with my identity and felt unhappy as a woman. However, I have come to accept myself as a valid man, despite having female anatomy.

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"There's a reason why we have to get two measurements." "a supremely healthy young 17 year old kid coming in with a scary low total testosterone of like 90." "I look at him and, you know, the kid is in fantastic shape." "He's just jacked out of the mind." "And my suspicion is like, I just think this kid is over training." "And then he comes back with a repeat set of labs and he's stone cold normal." "And that's why he was feeling so dadgum drained." "And once we got him set up with something that was a little bit more reasonable, he started to actually progress and feel much better."

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My name is Ethan Dickson, living in Austin's 3rd district. I came out as transgender at 13, facing struggles with hormone blockers, testosterone, and self-harm. After starting cross-sex hormones at 17, I experienced cardiovascular issues, mood swings, and joint pain. At 19, I questioned my distress and realized the harm caused by transitioning. Now 21, I deal with complications like vaginal atrophy and regret permanent changes. I advocate against legislation allowing experimental medicine on children, urging for therapeutic support instead of unnecessary hormone treatments. Reject proposal 64 to protect kids from harm. Translation: My name is Ethan Dickson, and I live in Austin's 3rd district. I came out as transgender at 13 and faced challenges with hormone treatments and self-harm. Starting cross-sex hormones at 17 led to health issues and regret. At 19, I questioned my distress and realized the harm of transitioning. Now 21, I deal with complications and advocate against experimental treatments for children, promoting therapeutic support instead. Reject proposal 64 to protect children from harm.

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The speaker talks about a stage where they noticed changes in their body. They mention that some people might perceive them as a 9 or 10-year-old going through a tomboy phase.

This Past Weekend

Sal Vulcano | This Past Weekend w/ Theo Von #395
Guests: Sal Vulcano
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Theo Von introduces Sal Vulcano, highlighting his upcoming tour dates in Georgia and Florida from June 23rd to 26th, advising fans to purchase tickets only from the official theovonn.com website. Sal Vulcano, known for Impractical Jokers, is also recognized for his podcasts, Hey Babe with Chris Distefano and Taste Buds with Joe DeRosa. Theo and Sal discuss Sal’s sober lifestyle and his recent move to Florida. They contrast Florida’s smaller comedy scene, centered around Zany’s, with larger markets, noting the limited performance opportunities. They reflect on the pandemic's impact on live comedy, the anxiety of maintaining fresh material while touring, and the importance of consistent stage time. Sal explains the complexities of scheduling tours, often prioritizing larger tours over his own, resulting in a constantly evolving schedule. He shares the stress of pre-sale ticketing for shows still in development, including physical symptoms like chest pains, driven by the pressure to deliver quality performances. Sal discusses his experiences with medication, including starting Wellbutrin six months prior for anxiety and depression, reporting gradual improvements. He also addresses his ADHD and OCD diagnoses. He recounts his brief trial with time-release Adderall, which led to two sleepless days, sweating, and dehydration, prompting him to discontinue its use. The conversation shifts to Lexapro, with Theo sharing his own experiences and the understanding that antidepressants aren't a universal solution. Sal outlines his current treatment plan with his doctor, focusing on addressing anxiety before ADHD, with ongoing adjustments to the medication. The conversation humorously digresses into suppositories, their history, and functionality, with jokes about the delivery method and related concepts. This leads to personal experiences with medicine and the balance between medical necessity and humor. The discussion transitions to Sal’s carnival memories, describing rides like the zipper and Himalaya, and the often-unpredictable environments of these attractions. They share anecdotes from the Meadowlands fair and discuss "world’s smallest" performers, debating the definition of "smallest" and the mix of fascination and discomfort these exhibits evoke. Sal recounts his Semester at Sea, a 100-day college voyage with stops in Vancouver, Japan, China, Kenya, Brazil, and Cuba. He describes the blend of classes and port days, and his urban planning major. He remembers a roommate who has since passed away, and reflects on the trip's transformative impact, the scholarship support he received, and the intensity of studying and traveling at sea. They discuss the future of Practical Jokers after Joe Gatto’s departure, emphasizing that the show will feature guest stars like Eric Andre, Method Man, Jillian Bell, Rob Riggle, and David Cross, rather than replacing Joe. Season 10 is set to begin soon, with 18 episodes and 18 guests, with the format allowing for diverse talent. Sal stresses that the show’s core remains friendship and shared humor, with the 40–50 person crew feeling like family. The conversation touches on burnout and the benefits of therapy, including a BetterHelp mention and a Zoom therapy option, highlighting Sal’s commitment to mental health. They conclude with mutual appreciation, promoting Sal’s tour schedule on salvulcanocomedy.com and expressing excitement for future collaborations. (512 words)
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