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What kind of work are you doing now? I work for Eurofins in various clinical trial settings. I don't believe you know how to read and interpret the tests. What tests? Let's discuss PCR validation. How do you validate a PCR? What’s the sensitivity of a test? It’s how well the test can detect low amounts of material. Sensitivity is the percent chance that an infected person tests positive. That’s a good way to put it. Now, specificity? It’s how accurate the test is in detecting what it’s supposed to detect, not something else. What you’re hoping to detect?

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We need to be careful not to have too many false positives due to extensive testing. Tests are not 100% accurate and have a small margin of error. If the overall infection rate decreases and testing is expanded to millions, there will be more false positives than actual positives. These are the challenges we face and the insights we gain. Therefore, it still makes sense to offer more testing, but not just randomly every day, rather with a specific goal in mind.

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This video discusses the PCR test used to diagnose COVID-19 and raises concerns about its accuracy and potential misuse. The test amplifies a small amount of DNA to detect the virus, but when run for too many cycles, it can produce false positives. The inventor of the PCR test, Kary Mullis, stated that it was not meant for diagnostic purposes. The CDC itself acknowledges the limitations of the PCR test and will be changing its method in 2022. The video also explores claims about the test containing sterilizing solutions, storing DNA, and even acting as a vaccine. It urges viewers to question the information presented and seek out alternative sources.

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The PCR test, commonly used for COVID-19, involves a nasal swab. According to Kary Mullis, the Nobel Prize-winning scientist who created the test, it can detect almost anything if amplified enough. However, Mullis himself stated that the PCR test should not be used to diagnose diseases, as it only detects fragments of illness. Many laboratories worldwide run the test at high amplification levels, leading to a high rate of false positives. Even Anthony Fauci acknowledged that results beyond 33 cycles are likely not infectious material. The New York Times reported that 90% of PCR tests were not indicative of active illness. Lowering the amplification cycles resulted in significant reductions in case numbers. In the past, PCR tests have caused false positives, such as in a whooping cough pseudoepidemic. Some criticize Fauci for misleading the public.

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The test for COVID-19 cannot differentiate between live and dead matter, only detecting fragments of viruses, leading to guaranteed false positives. This was used to create cases for a public health emergency, enabling the use of untested vaccines. There are claims that true isolates of viruses, including SARS-CoV-2, do not exist; the viral genomes are only computer-generated. Historical evidence from the 1918 influenza pandemic shows no proof of transmission, as attempts to infect volunteers failed. Current symptoms attributed to COVID-19 may arise from various factors, including environmental toxins and EMF exposure, rather than a specific virus. The idea of a virus causing disease is questioned, and the evidence for SARS-CoV-2 remains unproven.

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A Chinese study published in Nature conducted 10 million PCR tests in Wuhan and found that out of the 300 asymptomatic cases, none produced a live virus in the lab setting. This suggests that high cycling of PCR was generating false positives. PCR detects nucleic acid, not disease, and is typically followed up with confirmatory tests. The study did not confirm the presence of infectious viral particles through culture-based methods. False positives occur when healthy individuals with residual viral DNA are magnified due to high cycling. PCR can detect viral RNA long after the disappearance of the infectious virus.

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The existence of the virus is questioned due to the initial PCR test methodology being based on a computer model virus, not a purified isolate from real patients. China did not have a pure isolate, so they used elements of a genetic code to create a computer model sequence. This sequence became the basis for the PCR test. The WHO document states that the diagnosis of SARS CoV-2 should not rely on isolating the virus. The virus has never been purified, and the disease is based on generic symptoms that could be anything.

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The PCR test, used to determine COVID-19 cases, amplifies RNA fragments to detect the virus. However, the high amplification can also detect traces of dead virus or remnants from other coronaviruses. Scientists recommend not testing over 30 cycle thresholds to avoid false positives. When labs reduced the cycles, case numbers significantly decreased. False positives can occur almost half the time, especially in populations with low COVID-19 prevalence. In the past, PCR tests have caused false epidemics. The test requires skilled technicians and careful handling, but it is currently being conducted on a large scale with hastily trained personnel. Therefore, it is important to question the accuracy of reported case numbers.

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Misusing PCR isn't quite accurate; it's more about how results are interpreted. PCR can detect almost anything in a sample, leading to the belief that everything is present in the body. While PCR amplifies a single molecule for measurement, the implications of finding something like HIV are less straightforward. The measurement for HIV isn't precise, unlike measuring tangible items like apples. Tests for HIV rely on invisible components, making results inferred rather than definitive. PCR itself is a method for amplification and doesn't indicate illness or the potential harm of what is detected.

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Dr. Kary Mullis, the inventor of the PCR test, explained that the test can find almost anything in anyone if done well. However, using it to claim meaning or diagnose a virus is a misuse. The official protocol for COVID-19 PCR testing has led to false positives, labeling asymptomatic individuals as infected. 30 years ago, Dr. Anthony Fauci pushed for higher doses of the drug AZT for AIDS patients, despite lacking evidence. Mullis discovered there was no proof of HIV causing AIDS. He questioned the CDC's profit motives and the involvement of high-level officials. Mullis wanted to expose Fauci and Gallo but faced little attention. He passed away in 2019, just before the emergence of COVID-19, leaving many questioning the timing.

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The speaker discusses the issue of cycle thresholds in PCR testing. They explain that the original protocol used a cycle threshold of 45, which amplifies the results by 10. This means that even unlikely findings, such as particles from Mars, could be detected. The speaker suggests that by using a high cycle threshold, it is possible to create a pandemic by testing healthy individuals and spreading the myth of asymptomatic spread. This is how cases are created, according to the speaker.

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There have been reports of patients shedding viral RNA for weeks, but it doesn't seem to be infectious. The question is whether they are still a threat for transmission. The idea is to use a cutoff of viral loads determined by PCR to determine if a patient is no longer infectious and can go home or to a nursing facility. A cycle threshold of 35 or more is considered to have miniscule chances of being replication competent. It is frustrating for both patients and physicians when the PCR test shows a high cycle threshold, as it is unlikely to culture virus from it. Reporting the threshold cycle is becoming a standard practice in diagnosis.

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It is important to prioritize PCR tests, but our capacity is not sufficient. Vienna can conduct more PCR tests in a day than all the labs in Germany combined. We lack equipment and personnel, and the German healthcare policy prioritizes the number of tests per person less than Vienna. Currently, rapid tests are essential, but their quality varies, especially regarding the Omicron variant. Authorities, including politicians, should ensure that high-quality rapid tests are used in testing centers, schools, and care homes. We pay a lot for these tests, and we rely on them. However, even the best rapid test is useless if not administered properly. Some test centers have questionable methods, and authorities need to increase supervision.

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Do you have an open mind? Consider that we live in a toxic world, where our cells respond to poisons by packaging and releasing damaged genetic material, called exosomes. This contrasts with the established theory of viruses, which are seen as non-living entities that can cause illness. The coronavirus emerged when a respiratory illness was linked to a new RNA fragment found in patients. Testing methods, like PCR, amplify genetic material, but their arbitrary cutoff points can lead to misleading results. Cases like the Diamond Princess cruise ship show conflicting test results among close contacts, challenging the infectious virus theory. Many who test positive remain asymptomatic, and some fluctuate between positive and negative results. This raises questions about the reliability of PCR tests and whether exosomes could be misidentified as viruses. Ultimately, how confident are you in these tests? Would you choose to be tested?

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There have been reports of patients shedding viral RNA for weeks, but it doesn't seem to be infectious. The question is whether we can use a cutoff of viral load determined by PCR to determine if a patient is no longer infectious. If the cycle threshold is 35 or more, the chances of it being replication competent are very low. It's frustrating for both patients and physicians when the PCR results show a high cycle threshold, like 37, because it's unlikely to culture virus from that. So if someone has a cycle threshold of 37, 38, or even 36, it's just dead nucleotides.

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The speaker asks if a PCR test can be used to determine if a patient is no longer infectious. The other speaker explains that if the cycle threshold is 35 or higher, the chances of the virus being able to replicate are very low. They mention that it is frustrating for both patients and physicians when the cycle threshold is high, but it is unlikely to culture the virus. They conclude that if the cycle threshold is 37, 38, or even 36, it is just dead nucleotides.

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We should be testing every cow weekly using pool PCR to detect asymptomatic infections. America's innovation allows for breakthroughs like pool testing dairy workers. Undetected cases in humans exist because we only track symptomatic individuals, leading to the spread of the virus. Switching to definitive laboratory testing is crucial to identify asymptomatic or mild cases that go unnoticed.

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The speakers discuss the misuse of PCR in estimating viral RNA. They explain that PCR can detect almost anything in the body, making it easy to find even rare viruses like HIV. However, they argue that testing for HIV specifically is unnecessary because individuals with HIV are likely to have other viruses as well. They emphasize that PCR is a quantitative tool that provides measurable information, but it does not determine sickness or the potential harm of a virus. The speakers also mention that PCR cannot differentiate between virus particles and active live viruses. Overall, they highlight the limitations and misinterpretations of PCR testing.

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The speaker asks if a PCR test can be used to determine if a patient is no longer infectious. They mention that if the cycle threshold is 35 or higher, the chances of the virus being contagious are very low. They also mention that even if a patient has a cycle threshold of 37 or higher, it is unlikely that the virus can be cultured. Therefore, they conclude that a cycle threshold of 37 or higher indicates that the virus is no longer viable.

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PCR is a process that can amplify molecules in the body, making it possible to find almost anything in anyone. However, this doesn't necessarily mean that the presence of a molecule indicates illness or harm. The measurement for HIV, for example, is not exact and is based on invisible factors. PCR itself is just a method to create more of something. It doesn't determine sickness or potential harm.

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In the early pandemic, 2020–2021, eighty six percent of PCR-confirmed COVID cases were not real infections. The speaker asserts that all of the lockdowns, all of the vaccine mandates, and all of those policies that destroyed livelihoods and the economy were based on a completely fraudulent metric. A study is described that compared PCR positive rates by week to the actual antibody testing in the same weeks, noting that the antibody test indicates whether you got antibodies to COVID. The speaker states that only fourteen percent had actual antibodies among those PCR positive cases. It is claimed that it may even be up to ninety percent weren't real infections. The speaker concludes that this fraud is confirmed and calls for accountability for all the people who lost their jobs and were forced to take injections based on this fear campaign, which was based on this false test.

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The PCR test, used to detect the presence of the SARS CoV-2 virus, has come under scrutiny for its reliability and potential for false positives. The test amplifies RNA fragments to identify the virus, but it can also detect traces of dead virus or remnants from other coronaviruses. Testing at high cycle thresholds can result in false positives, especially in populations with low COVID-19 prevalence. Scientists recommend not testing over 30 cycle thresholds to reduce false positives. Lowering the cycle thresholds has led to significant reductions in reported cases. The misuse and misinterpretation of the PCR test has contributed to inflated case numbers and unnecessary panic.

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If a PCR test has a cycle threshold (CT) of 35 or higher, the chances of it being replication competent are very low. So, if someone's PCR test has a CT of 37 or higher, it's unlikely that the virus can be cultured from it. In fact, even a CT of 36 may indicate that it's just dead nucleotides.

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PCR is not misused, but its interpretation can be. PCR can find almost anything in anybody by amplifying a single molecule. Testing for HIV and claiming it has special meaning is the problem, because someone with HIV likely has other viruses. PCR is quantitative and makes minuscule amounts measurable, but this can lead to misinterpretations. HIV measurements are not exact. HIV tests are based on invisible things and inferred results. PCR makes a lot of something out of something, but it doesn't indicate sickness or harm. Even if you believe in HIV, PCR can't differentiate between virus particles or active live virus.

Lex Fridman Podcast

Michael Mina: Rapid Testing, Viruses, and the Engineering Mindset | Lex Fridman Podcast #146
Guests: Michael Mina
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In this conversation, Michael Mina, a Harvard professor specializing in infectious disease and immunology, discusses his first principles approach to science and the importance of rapid at-home testing for COVID-19. Mina emphasizes that such testing is a powerful, feasible solution that should have been implemented earlier. He highlights the high accuracy of these tests in detecting contagiousness and their potential for mass production. Mina reflects on the fascinating interactions between viruses, particularly how measles can devastate immune memory in children, and the evolutionary advantages of such mechanisms. He expresses fascination rather than fear about the complexities of viral behavior and the potential for future pandemics, noting that the current COVID-19 virus could have been much worse. The discussion shifts to the role of rapid testing in controlling the spread of COVID-19. Mina argues that empowering individuals with information about their infectious status can significantly reduce transmission rates. He criticizes the slow adoption of rapid testing in the U.S., attributing it to bureaucratic hurdles and a paternalistic healthcare system that prioritizes perfection over practical solutions. Mina believes that widespread testing could have a transformative impact on public health and the economy. Mina also discusses the challenges of vaccine distribution and the uncertainty surrounding vaccine efficacy and transmission prevention. He stresses the need for rapid testing alongside vaccination efforts to effectively manage the pandemic. The conversation touches on the potential for future pandemics, particularly from influenza viruses, which can mutate rapidly and pose significant threats. Mina warns that the tools for creating engineered viruses exist, raising ethical concerns about gain-of-function research and the potential for bioterrorism. Mina shares his journey of becoming a Buddhist monk and how that experience shaped his perspective on life and suffering. He emphasizes the importance of seeing solutions rather than problems and encourages young people to think broadly and creatively about tackling global challenges. Overall, the discussion underscores the urgency of implementing rapid testing as a public health tool and the need for innovative thinking in addressing future health crises. Mina's insights reflect a blend of scientific rigor, philosophical reflection, and a commitment to improving public health outcomes.
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