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Low insulin levels allow the body to oxidize more fat. Several factors impact insulin and glucagon, shifting the body toward fat burning. Berberine, derived from a plant, and metformin are increasingly used to lower blood glucose. These compounds effectively reduce blood glucose, which in turn lowers insulin, potentially increasing fat oxidation. Insulin inhibits fat oxidation, the process of converting fatty acids into ATP in the mitochondria. Therefore, maintaining low insulin levels enhances fat oxidation.