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Concerning research from China was published last week. Researchers took a virus from pangolins and cultured it in a lab. They then infected mice with this virus, which killed all of them through brain infection. These mice were transgenic, meaning they had human ACE receptor genes. The virus, a coronavirus from pangolins, killed all the infected mice. This kind of experimentation is dangerous and should be banned immediately.

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The transcript discusses the legal and practical prospects of cloning a human being, focusing on the near-term feasibility and the institutions involved. It asserts that strictly speaking it would be legal to clone “me” tomorrow at a leading IVF clinic outside of New York, where people with the technology, the ability, and the desire exist to genetically engineer human embryos to become the first in the world to clone a human being. The speaker notes that there is “no doubt that human beings will be cloned,” and attributes this potential to Doctor Jacques Cohen, described as a leader in the field, who would need only the approval of his clinic’s ethics committee to make history. The conversation then shifts to the idea that, given the money and permission, cloning could occur within a year or two. The responder says, “We could clone you probably in within two years,” indicating a timeline for making a clone a reality. The transcript also presents a concrete example from a research facility in Scotland that pioneered the technique, showing that an actual cloning process is taking place there. Although the example shown is of an animal, the speaker explains that the same method could be applied to humans. The described procedure is laid out simply: take a cell from a human, such as a scraping of skin, obtain an egg from a female, remove the nucleus from the egg, fuse the skin cell and the enucleated egg with a spark of electricity, and you have an embryo. If this embryo is implanted in a woman, nine months later you would have a carbon copy of the person from whom the skin cell was taken. The speaker emphasizes the steps that lead from a skin cell to an implanted embryo and ultimately to a clone, portraying the process as technically straightforward and within reach given the appropriate approvals and resources. Overall, the transcript frames cloning as an imminent and legally permissible capability in elite IVF and research settings, driven by prominent figures like Dr. Cohen, with a plausible two-year horizon and a shown proof-of-concept in Scotland, while outlining the key molecular steps involved in producing a cloned embryo.

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A study funded by grants from the NIAID office, run by Dr. Anthony Fauci, involved grafting scalps from 5-month-old aborted babies onto lab rats. The study aimed to see how long the scalps could keep growing. The photographs in the published study show baby scalps with growing hairs on the backs of lab rats. Planned Parenthood abortion providers claimed to have supplied the aborted baby body parts for these experiments at the University of Pittsburgh. Dr. Fauci has not been held accountable for this study, despite being responsible for overseeing the grants. It is important for him to answer questions about the ethical and legal compliance of these experiments in front of the United States Congress.

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Humanized mice are used in labs to test new drugs, showing chimeras already exist. A US Supreme Court ruling states that synthetic DNA can be patented, creating intellectual property rights. mRNA vaccines like Pfizer and Moderna create new genomes within people, according to the court case. The vaccines genetically modify cells throughout the body, raising questions about intellectual property rights.

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Humanized mice are used in labs to test new drugs, showing that chimeras already exist. The US Supreme Court decision allows the patenting of synthetic DNA, creating intellectual property rights. mRNA vaccines like Pfizer and Moderna create a new genome within people, as stated in the case. The shots genetically modify cells throughout the body, raising questions about separating synthetic DNA from the new genome. Translation: The video discusses the existence of chimeras, a US Supreme Court decision allowing patenting of synthetic DNA, and how mRNA vaccines create a new genome within individuals. It raises concerns about separating synthetic DNA from the new genome.

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Dolly the sheep was the first mammal cloned from an adult somatic cell. A guest on the Joe Rogan podcast, biotech entrepreneur Ben Lam, warned that gene editing is out of control. Lam claimed China has already created genetically modified children, referencing a 2018 case where a Chinese scientist edited embryos to resist HIV. He also said there's debate over whether those embryos were edited for enhanced intelligence. Lam identified BGI (Beijing Genomics Institute) as a key player, alleging they harvest DNA at scale under the guise of free COVID testing. A Reuters investigation revealed BGI collected genetic data for the Chinese military without consent via prenatal tests. Lam claimed BGI openly seeks to sequence the global population to find genes tied to intelligence. He suggests this isn't new and other countries are using CRISPR. He warns of clinics offering gene editing, similar to IVF, to select a child's traits. He believes mankind is trying to play God through transhumanism, which he calls a dark manipulation. He also claims the population is being dumbed down and that transhumanism will come for the children, potentially through childhood vaccines. The speaker then pivots to tariffs and encourages listeners to call Kirk Elliott Precious Metals to protect their assets with low-cost bullion.

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I can clone you by using your skin cells and an egg, but it's illegal. However, we can create mini organs from your cells to test drugs. In our lab, we grow mini brains from people with or without a predisposition to Alzheimer's. We can age these brains to 80 years old in just a few months, causing them to lose their electrical activity and develop dementia. By activating three embryonic genes, we can reverse the aging process, restoring electrical activity and eliminating Alzheimer's. We have successfully done this in mice, improving their memory and learning abilities.

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The speaker announces the birth of the first baby clone, named Eve. The location is not disclosed. The speaker expected to have a press conference with the baby, parents, and scientists, but is alone due to the difficulty of the announcement. The speaker mentions working with human eggs since January and it took three months to finalize the process. They had success quickly and refined the technique until spring when they started implantations. Out of 10 implantations, five were terminated within the first three weeks. The parents have not yet appeared but the speaker hopes they will in the future.

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It's a groundbreaking achievement that took 2 years and over 10,000 egg injections. Deleting a specific gene resulted in a significant decrease in glomeruli in the brain, which is crucial for processing sensory information and generating behavior.

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A billion genetically modified mosquitoes are being released in the Florida Keys to combat diseases like dengue, yellow fever, and Zika. This is the first time such mosquitoes are being released in the US. The British biotech company, Oxitec, obtained permission from the EPA to release them across 6,000 acres in Florida and Texas. However, a 2019 Yale University study warned that this plan could have unintended consequences. It suggested that the release of these mosquitoes could lead to the creation of hybrid mosquito babies that are more resistant to insecticides, potentially worsening the spread of diseases. The potential risks raise concerns about the success of this initiative.

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Scientists plan to introduce a hundred mammoth-like creatures into a Siberian park to study the impact of megafauna on Arctic tundra carbon emissions. They are creating these animals by combining elephant and mammoth DNA using CRISPR technology. The process involves taking Indian elephant DNA and filling in the missing fragments of mammoth DNA to create an embryo. This embryo is then implanted into an Indian elephant, which will give birth to an animal physically identical to a mammoth after a twenty-two-month gestation period. The resulting animal is not a hybrid, but rather a mammoth created using the closest living relative's DNA to complete the genome.

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Chinese researchers have created a super virus by combining a protein from bats with the SARS virus found in mice. This virus could potentially infect humans, although it is currently only being studied in laboratories. The debate over the risks of this research is not new, with some scientists arguing that the benefits outweigh the potential dangers. However, others are concerned about the possibility of the virus directly infecting humans without an intermediate species. The US government had previously suspended funding for research aiming to make viruses more contagious, but this did not stop the Chinese research on SARS. Some experts believe the chances of the virus spreading to humans are minimal compared to the potential benefits, while others disagree.

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Ethical concerns are raised by U.S. and Chinese scientists implanting human cells into monkey embryos. There is uncertainty about the nature of the resulting organism, whether it is human, monkey, or something in between, which raises ethical questions about their use in experiments and potential destruction. Chinese scientists have reportedly cloned monkeys with genetic disease symptoms using CRISPR Cas9 on in vitro fertilized monkey embryos. Monkeys exhibited a disrupted circadian rhythm due to the absence of BMA L1. Somatic cell nuclear transfer was used, implanting 325 embryos into 65 surrogate monkeys, resulting in five cloned monkeys carrying the altered gene. Scientists have also attempted to create human-monkey chimeras by integrating human cells into macaque monkey embryos, grown in a lab for 20 days. The drawbacks or benefits of creating such a hybrid are not yet fully known.

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A stem cell technology called STMT is being discussed. It involves taking the egg of a young woman and replacing its nucleus with our DNA. The speaker mentions that this technology has been tested on mice, resulting in fat mice with six backs that were very active. However, the speaker expresses ethical concerns about using this technology to create curvy, sexy black women from Africa.

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This precision tool introduces a protein RNA complex into cells or tissues to correct mutations. The complex can be injected into fertilized eggs, such as those of a mouse. In an experiment targeting the gene for black coat color, edited eggs implanted in a female mouse resulted in mostly white pups. These mice have a single genetic change in every cell, giving rise to the white coat color, but are otherwise normal. This type of experiment used to take at least a year; now it can be done in a few weeks. The technology has seen exponential growth in publications and is being used for targeted genetic changes in plants, fungi, and animals important agriculturally or as pets. It's also being used to make changes in stem cells and in animal models of human disease, with the possibility of making changes in humans in the future.

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Human clones, indistinguishable from us, may already be among us, according to whistleblowers and researchers. The concept of cloning gained traction after the 1997 cloning of Dolly the sheep and the 2018 cloning of rhesus monkeys, suggesting advancements could be decades ahead in classified projects. Some believe celebrities might be cloned to maintain their marketability, while others speculate that historical figures could be revived through cloning. Allegations of secret cloning projects, including a disturbing discovery of human fetuses in Russia, raise ethical concerns. Cloning could potentially provide organs for transplants, but the implications are vast. The idea of cloning has permeated popular culture, with references in media and celebrity tweets. As pet cloning becomes a reality, the possibility of human cloning looms closer, prompting questions about its ethical ramifications and the identities of those who may have been replaced.

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Human cloning is a controversial topic that some researchers claim has already been developed by classified military projects. The cloning of animals, such as Dolly the sheep, has been successfully achieved, and there are claims that human cloning is also possible. Cloning could have various applications, including creating replacement organs for medical purposes. There are theories that celebrities and even historical figures have been cloned. The idea of cloning is being subtly introduced to the public through movies, TV shows, and news stories. The possibility of human cloning raises ethical concerns and questions about the authenticity of certain individuals.

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CRISPR and genome engineering tools are accessible, leading to international use. Colossal has stated they will not apply these technologies to humans, but will evaluate others' applications. A scientist in China edited babies' embryos to resist HIV, also cloning and genetically modifying them. This violates the moratorium on germline edits, changes passed to future generations. There are claims the scientist also edited the children to increase their intelligence, but this is debated. The Beijing Genomics Institute (BGI), funded by the CCP, offered free COVID testing globally, collecting data. The CEO stated they are sequencing the world population, seeking genes for intelligence, and will act on their findings. There is speculation that the children from the earlier experiment are now excelling due to genetic modifications.

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We are investing in stem cell technology called SCNT, which involves using the egg of a young woman and replacing the nucleus with our DNA. This genetic modification aims to enhance certain traits, particularly those found in curvy, sexy black women from Africa. We believe it is unethical to monopolize this genetic perfection. The practice has been tested in mice, resulting in weight loss and improved physical appearance. However, it is important to ensure the safety of everyone involved.

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Alden and colleagues found that Pfizer's genetic code can be integrated into the human genome within an hour in a cancerous cell line. This suggests that Pfizer and Moderna's genetic material might become a permanent part of human DNA. There is no study confirming or denying this possibility. The concern is that if eggs or sperm incorporate this genetic code, it could be passed on to future generations. This lack of research is seen as reckless and worrisome.

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The first speaker expresses interest in whether bioengineering students have opinions about rights related to organs grown inside pigs, noting a massive organ shortage and horror stories about organs being harvested from people not yet pronounced dead. They point out that there are massive companies in China and in the United States growing organs by the thousands inside pigs. The second speaker adds that some of those companies have just received permission to genetically hybridize pigs or other animals with human DNA to humanize the organs. They explain that the area of research—using pigs to grow organs for humans—has been under investigation for a long time. The second speaker shares their background: they were a professor at Northwestern University for ten years before coming to Stanford, starting in 1997, and moved to Stanford in 2007. They note that the people in their department are good-hearted and want to help people, and they have been treated well at Stanford and love their colleagues. The second speaker mentions a colleague, Mark Skyler Scott, who is attempting to 3D print a whole human heart from human cells. They say Scott is working on cutting-edge stuff and that, given time—five to seven years—Scott could succeed, highlighting that he received a huge ARPA-H award. They remark that if it saves a child’s life, people may not care whether a technology is 3D-printed. The discussion touches on the moral terrain of these advancements, acknowledging that difficult questions arise when considering life-saving technologies. In closing, the second speaker reiterates that there is a gray area surrounding these developments and emphasizes that it is a big deal.

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Researchers at the Bill Gates Foundation-backed Leiden University Medical Center are developing genetically modified mosquitoes to deliver malaria vaccines. A recent study showed that 8 out of 9 participants who received bites from one type of modified mosquito were protected against malaria, while those in the placebo group received no protection. Despite safety concerns and ethical issues regarding informed consent, the research continues, with plans for larger trials and potential applications for other diseases. Meanwhile, an Australian regulatory body is reviewing an application to release genetically modified mosquitoes to combat dengue fever. The implications of using insects as vaccine carriers raise significant ethical questions, and there are ongoing calls for accountability regarding these experiments.

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Lab-grown meat, shaped like a steak, is gaining attention. However, concerns arise due to insufficient testing on its long-term effects. The meat is produced from replicated animal stem cells.

Lex Fridman Podcast

Daphne Koller: Biomedicine and Machine Learning | Lex Fridman Podcast #93
Guests: Daphne Koller
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In a conversation with Lex Fridman, Daphne Koller, a Stanford professor and co-founder of Coursera, discusses her transition to using machine learning for drug discovery at her company, insitro. She emphasizes the potential of data-driven methods to revolutionize biomedicine, particularly in understanding diseases like Alzheimer's and schizophrenia, which she rates as closer to zero in understanding their mechanisms. Koller believes that while curing all diseases is a long-term challenge, improving health spans is a more attainable goal. She highlights the importance of creating high-quality datasets for machine learning to develop predictive models that can aid in drug discovery. Koller also reflects on her personal motivation stemming from her father's illness and the limitations of traditional animal models in research. She advocates for innovative approaches like "disease in a dish" models using induced pluripotent stem cells to better understand diseases at the cellular level. The discussion touches on the broader implications of AI, the importance of ethical considerations, and the need for societal norms that promote altruism.

a16z Podcast

a16z Podcast | What's in the Water at the George Church Lab?
Guests: George Church, Jorge Conde
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In this a16z podcast episode, renowned scientist George Church discusses his groundbreaking work in genome sequencing and editing, particularly CRISPR technology. Joined by Jorge Conde, Church reflects on the implications of recent CRISPR developments, including the controversial creation of CRISPR babies in China, which aimed to provide resistance to HIV by knocking out the CCR5 gene. He emphasizes the ethical considerations surrounding germline editing and the need for regulatory oversight. Church also highlights the potential of whole genome sequencing for preventive medicine, advocating for lower costs and better privacy protections to encourage wider adoption. He shares insights from the Personal Genome Project, which aimed to educate participants about the risks and benefits of sharing genomic data. Looking ahead, Church envisions advancements in three-dimensional molecular mapping and increased genome editing capabilities, while pondering the future of de-extinction efforts, such as creating mammoth hybrids. The conversation underscores the intersection of science, ethics, and societal impact in genetic research.
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