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Muscles are where you dispose of glucose, and our ability to metabolize glucose and regulate glucose levels is central to our existence on this planet. When we get it just a little bit wrong, we go to hell in a handbasket. That's what type two diabetes is. The difference between you and someone with type two diabetes is an extra one teaspoon of glucose in the bloodstream. The most important part of blood sugar regulation is having muscles that are big enough to put the glucose into, and that are insulin sensitive enough to respond to the signal of insulin. That's how critical it is that we regulate our blood sugar.

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We are genetically designed for intermittent fasting, just like our ancestors. When the body is in a fasted state, our inner physician recognizes a famine. In response, it keeps the body and brain alert, energized, and focused so we can hunt and find food to survive. To achieve this, the body releases counterregulatory hormones like cortisol, glucagon, and human growth hormone. Additionally, the brain produces brain-derived neurotrophic factor, which acts as a fertilizer for the brain. This process is your innate intelligence providing your system with energy and resources. Use this energy and focus to have an amazing, intentional, and productive day.

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And it turns out that fasted exercise is the most effective way to burn fat. With seven to nine hours of your overnight fast being spent sleeping, fasted exercise is an easy fit into your busy schedule because all you have to do is wake up and start exercising. Plus, you don't have to waste precious time allowing for digestion because it takes place before your first meal of the day. Fasted exercise is a powerful tool that can help you maximize the benefits of your fast and amplify your body's natural preference for fat burning while fasting. If you wanna maximize your fat burning potential, then schedule your fasted exercise near the end of your fast before your fastbreaker. Lastly, be sure to download Xero for more health hacks like this and to gain insight into your personal fat burning mode.

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The only reason to burn glucose is to regulate blood glucose concentration. Muscles burn glucose if they have a lot of it. The only way to stop this is by not eating carbs, which allows muscles to burn fat. A study of a low-carb athlete showed that he could cycle at a very high rate. From the start of a 100km time trial, he burned 1.7 grams of fat per minute. Carb-adapted individuals typically start at 0.4-0.5 grams and take hours to reach similar levels. Muscle glycogen content determines how much fat and carbohydrates are burned.

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When glucose is ingested, it causes a glucose spike in the bloodstream, which insulin lowers. The higher the glucose, the more insulin the pancreas releases. Insulin sequesters glucose to the liver and fat for storage. Insulin's job is to take whatever you're not burning and put it into fat for storage. Insulin is the energy storage hormone. If you're active, glucose will clear into muscle, so blood glucose won't rise as much and the pancreas will put out less insulin. If you didn't exercise, the insulin will take the excess glucose in your blood and store it as fat. This insulin rise is particularly egregious in terms of metabolic disease.

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Exercise snacks are short bursts of intense exercise—'80% max heart rate for, like, one to three minutes'—performed 'thirty minutes or up to an hour either before or after a meal.' This vigorous exercise raises lactate, which 'gets soaked up by the muscle' and causes 'glucose transporters to come up to the muscle and opening the gates,' so when you eat, 'the glucose goes into your muscle.' It's 'more anabolic,' and you want it to go there, not 'a huge rise and then drop in the postprandial glucose response.' 'Exercise snacks' is supported by 'lots of studies'—'especially with people with type two diabetes' who have trouble 'maintaining their blood glucose levels.'

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Cortisol is an energy signaling molecule indicating a need for energy. It liberates free fatty acids into the bloodstream to prepare the body. Problems arise when cortisol remains elevated throughout the day without downregulation. There's a difference between slightly elevated cortisol all day versus a large spike after training that then decreases. Ingesting carbohydrates signals the presence of nutrients and energy, specifically carbohydrates, which can cause cortisol levels to decrease because the body doesn't need to liberate free fatty acids for fuel.

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First you eat. When you eat, we're going to see how you build up energy in the body. You take glucose because glucose it's important for the body. When you eat, 80% of that glucose goes to the cells so you can have energy. Then 20% of that, it's going to go to your liver and it's going to go to your muscles. When it goes to your muscles, you're going to store that as glucose or glycogen, which is the form where you store that. As you keep eating and glycogen storage in the muscles increases, you're going to start to export that glucose in the form of fat. That fat is called triglycerides because the liver and the muscle cannot store more glycogen than it can.

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When you fast, your metabolic rate increases, as shown in numerous studies. This is due to basic physiology. When you don't eat, insulin levels fall, allowing your body to use stored calories. Simultaneously, other hormones rise. Your sympathetic tone, or fight-or-flight response, increases, as do cortisol and growth hormone levels. These hormones signal your body to start using calories. Consider a hungry wolf in the wild: it's activated and more dangerous than a well-fed lion. After eating, you become lethargic and want to digest your food, lacking energy. The idea that fasting slows your metabolism is false. In reality, it speeds up.

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Muscle is a significant glucose consumer, and more muscle mass helps lower blood sugar levels more efficiently. If two people with identical bodies consume the same amount of glucose, the person with more muscle will see a quicker return to baseline blood sugar levels. When muscle exercises, it clears blood sugar even faster, sometimes without needing insulin. Normally, insulin is required to allow glucose into muscle cells, but during exercise, muscle can bypass the need for insulin and directly absorb glucose. This internal mechanism allows the muscle to pull in energy quickly, reducing the need for insulin and lowering overall insulin levels during exercise.

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When we eat things that are sweet, that taste sweet, like orange juice, granola, breakfast cereal, honey, we feel that dopamine rush. And that dopamine rush is not energy. Again, it is pleasure, but it's often confused for energy. What you wanna do if you really wanna get proper energy sustainably is you wanna eat in the morning a savory breakfast instead of a sweet one. That means a breakfast that is based around protein with some fat. You can put some starch in there, and you can put some sweet taste in the form of whole fruit if you want.

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Salt. For years, salt has been vilified. Salt was never the enemy. It was sugar. The reason why they convince you about salt and sugar, they can make stuff with sugar in it and send it to you because sugar is sweet, very addictive. Sodium is important for muscle contractions. Get a cup of water and put salt in it. That would do give you the electrolytes that you need to do the workout. Guys, if you're trying to build muscle, make sure you have enough salt in your diet because it's important. Sodium is important for muscle contraction. Don't let them lie to you.

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Well, exercise lowers blood sugar. And it also lowers glutamine. But my late good friend George Cahill published some papers on showing how exercise could actually lower glutamine availability. When you exercise, you're burning and you're not eating a lot of carbs. Your mitochondria burning ketones and the oxygenation from all the exercise is keeping those mitochondria super healthy at their highest level of energy efficiency. Oxygen is coming in and you're burning ketones, which I already told you is a super fuel. So your body is super healthy. These bodies from the Paleolithic period, these men were jacked. Was no obesity in these people. They had tremendous energy. They're not dying from the things that are killing us. They're dying from injuries and infections.

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And I'm going to go out on a limb and say that even better than regular exercise might be some fasted exercise. You cannot deny the improvement in blood lipids that happen with people that are exercising in a fasted state. What I would recommend for liver health is maybe doing fifteen or twenty minutes of easy fasted cardio in the morning just simply before you eat. It's that simple. You don't have to do anything crazy.

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To burn fat, it's important to understand how the body burns energy. The body first uses sugar in the blood as an energy source, and insulin blocks other forms of energy utilization. After sugar, the body taps into glycogen stored in the liver and muscles. When glycogen runs out, the body can get energy from lean muscle or fat. Many people make the mistake of exercising without enough sugar in their bloodstream, leading to the body breaking down lean muscle for energy. To effectively lose fat, try the 30-30-30 method: consume 30 grams of protein within 30 minutes of waking up, followed by 30 minutes of steady-state cardio exercise. Additionally, check hormone levels as high estrogen can cause water retention.

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When we eat things that are sweet, that taste sweet, like orange juice, granola, breakfast cereal, honey, we feel that dopamine rush. And that dopamine rush is not energy. Again, it is pleasure, but it's often confused for energy. What you wanna do if you really wanna get proper energy sustainably is you wanna eat in the morning a savory breakfast instead of a sweet one. That means a breakfast that is based around protein with some fat. You can put some starch in there, and you can put some sweet taste in the form of whole fruit if you want.

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Whenever we eat anything, it will turn to glucose in our blood. This glucose in our blood gives us energy. In order for our body to access the energy from this glucose, our body releases insulin. This insulin is the key to our cells. It allows the glucose to enter our muscles and our organs to be used for energy and help them work. The more we eat, the more glucose is released and the more insulin is required to get that into our muscles and our organs, which allows our body to function. If we run out of room in our organs and our muscles, but we still have all this glucose in our bloodstream, where does it go? It goes into our liver to be stored for later. All of this extra glucose gets stored as fat.

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And the reason that a fat cell can grow and shrink is fat cells absorb what are called triglycerides. Triglycerides are formed from a multitude of different things, but generally speaking, let's just say it's just food in general. It's usually carbohydrates, but we'll just say it's food in general. When you consume food, and you're consuming food every two or three hours like a lot of the fitness industry wants us to do, or like we've heard is healthy, what happens is insulin allows these fat cells to get larger. It allows triglycerides to be absorbed by the fat cell, allowing them to expand. So basically what we have to remember is fat cells don't fully burn, they shrink and they expand, and they swell up when they have triglycerides that get absorbed in

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Checklist for summary approach: - Identify the core narrative: reassessment of a long-term ketogenic diet after experienced symptoms. - Capture key personal health details: cramps, heart palpitations at night, sleep issues, testosterone level mentioned. - Highlight the evolving view on ketosis: its benefits, its role as “powerful medicine,” and its relation to fasting. - Note the acknowledgement of overuse: ketosis and insulin. - Preserve specific claims about insulin’s role and its relationship to carbohydrates and electrolytes. - Include the explicit question about insulin returning after reintroducing carbohydrates. - Exclude evaluative judgments or external context; present claims as stated. - Translate if needed; maintain exact phrasing where it mirrors the original claims. - Keep the final summary within 372-465 words. After a year and a half of a ketogenic diet with no carbohydrates, I had to sort of look at the way I was feeling and say I don’t feel as good as I want to feel. I get cramps in the morning, I’m having heart palpitations while I’m sleeping, I’m not sleeping really well, and the last time I checked my testosterone it was lower than I wanted to be, like four or 500. So I had to kind of look at this and say you know what I need to reevaluate this perspective on a ketogenic diet. I’ve really since come to believe that though ketosis is super helpful for humans and turns on a lot of important genes that are involved in cellular housecleaning, autophagy, and affects genes in a positive way, it’s powerful medicine. Kind of like fasting, you can overuse it. I realized, oh, I’ve overused ketosis and insulin, this peptide hormone that is released when you eat primarily carbohydrates, but some protein induces insulin release. We think of insulin as a bad hormone, but it’s such an important hormone for the human body. You don’t have at least phasic, meaning spikes of insulin throughout the day or throughout the week. You’re really not going to be able to hold on to electrolytes at the level of the kidney as much as you want to. Can insulin come back once you’ve reintroduced carbohydrates?

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Burning calories in general and burning fat calories. Isn't the goal to burn fat calories? When you actually go out and exercise it's very rare that you're going to burn any fat calories at all. Go ahead and try this experiment: work out three hours, weigh yourself just before and right after, and see how much weight you lost—It'll be zero. The calories you burn when you exercise are mainly sugar, stored sugar calories in the form of glycogen. Glycogen is a bunch of sugar molecules attached together, glucose molecules attached together as one unit and that's called glycogen, stored in the muscle and in the liver.

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- "Your skeletal muscle, that is the muscle that you use to lift things up, the muscles that you use to walk, the muscles that you use to move in general, are the main players in charge in glucose disposal from your body." - "That basically means that the more muscle that you have, the more glucose that you're gonna burn at any given point in time." - "Multiple studies have shown that increased muscle mass increases skeletal muscle glucose uptake." - "So how do you increase muscle mass?" - "You have to apply some form of resistance against those muscles." - "And the resistance that we all have available at our homes is gravity." - "Try doing three sets of 20 squats three to four times a week to build the biggest muscle in your body or your legs." - "Just like this." - "You got this."

Mind Pump Show

Fastest Way To Burn Fat & Build Muscle With One Morning Activity | Mind Pump 2474
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The most anabolic hormone in the body is insulin, which can promote muscle growth but also lead to fat gain. Bodybuilders in the '80s and '90s saw significant muscle increases partly due to insulin use, which helps shuttle glycogen and amino acids into muscles. However, insulin resistance can lead to muscle loss and fat storage, making insulin sensitivity crucial for muscle gain and fat loss. Strength training and physical activity after meals can enhance insulin sensitivity. Bodybuilders often manipulate insulin for muscle gain, but this practice is dangerous and not recommended. Insulin can be anabolic, but maintaining sensitivity is key. Starting the day with a high-protein breakfast improves insulin sensitivity throughout the day, leading to smaller insulin spikes. Continuous monitoring of blood sugar levels with CGMs has shown that certain foods, like Skittles, can cause significant insulin spikes. The discussion also highlights the importance of managing cravings and behaviors related to food. Cheat meals can lead to unhealthy eating patterns, and it's essential to focus on balanced eating rather than restrictive diets. The hosts emphasize that understanding how food affects blood sugar can help individuals make better choices and manage cravings effectively. The conversation shifts to the impact of technology on social interactions and mental health, particularly among younger generations. The hosts discuss how technology can lead to loneliness and social anxiety, making it harder for individuals to connect in person. They reflect on how social skills have changed with the rise of social media and digital communication. The hosts also touch on the importance of maintaining relationships and the negative effects of loneliness on health. They discuss the need for balance in life, including social connections, physical health, and mental well-being. In a segment about holiday fitness strategies, they suggest focusing on strength building during the holiday season rather than strict dieting. This approach allows individuals to enjoy holiday meals while still making progress in their fitness goals. The episode concludes with discussions about the importance of coaching and support in fitness journeys, emphasizing that recovery and mental health are just as crucial as physical training. The hosts encourage listeners to seek guidance and be patient with their progress, especially after significant lifestyle changes.

Mind Pump Show

Carbs Explained: Build Muscle Without Getting Fat | Mind Pump 2678
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Carbs aren't the enemy. They're energy for work and growth, and when used correctly they can help you build muscle and burn fat. Excess calories—not carbohydrates—drive fat gain, and protein has a higher thermic effect than fats or carbs. The hosts trace the low-carbohydrate backlash to the Atkins era, noting how the wave of diet myths can cycle from vegan to carnivore and back, fueled by social media and sensational books. Carbs, they explain, are essential for energy during intense training and for sustained performance, especially in power, strength, and sprint work. They discuss which carbs are easy to digest to maximize performance: white rice, sweet potatoes, and fruit, while gluten-containing or highly processed breads and pastas can cause issues for many people. They advise avoiding gluten-containing carbohydrates when calories and macros are equal, as gluten can be hard to digest and processed options slow you down. For workouts, a couple hours before a hard effort is typically beneficial, though some athletes perform well in fasted states depending on prior meals. They also note that endurance-type activities may be less carb-dependent than high-intensity power efforts. Post-workout carbohydrates support recovery and glycogen replenishment, and a window after training is discussed with nuance. The GLUT4 mechanism and insulin help shuttle amino acids and fluids into muscle, but the practical takeaway is to use carbs strategically—before for energy, after for recovery, and in accordance with daily activity. They emphasize a few practical habits: eat carbohydrates after a hard session if you plan another workout soon; eat protein and fats first in meals to stabilize blood sugar and limit cravings; avoid drinking carbs habitually because it’s easy to overconsume. Carbohydrate timing also touches sleep: some people sleep better with carbs at dinner because serotonin and melatonin can be supported by carbohydrate intake, while others experience sleep disruption from blood-sugar spikes. The speakers stress that carbohydrates are not essential, so dieters can adjust intake to activity level and goals. They discuss carb cycling and daily undulations, noting that varying grams across days can help manage calories without sacrificing essential protein and fats. The broader point is that carbs are a flexible tool, best used with attention to digestion, timing, and personal response.

No Lab Coat Required

The 4 things making Americans really, really fat. [pt2]
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Johnny Cole Dickson frames this as part two of what is making America not just fat, but really fat. The discussion centers on multiple factors, not a single cause. The first factor is bread, described as 'bread is the number one most fattening food item in America.' The speaker argues that both how bread is made and the sheer quantity consumed contribute to obesity. The second factor is physical inactivity, a sedentary lifestyle. He notes a BMI conversation and says, 'The Rock is obese,' insisting the Rock is an outlier rather than representative of the typical American. Beyond bread, the host emphasizes that the lifestyle shift toward inactivity is escalating, aided by automation and work-from-home norms that reduce daily movement. He contrasts the idea that you can outrun a bad diet with the reality that a lack of movement compounds calorie imbalance. He reflects on coaching at Fit Code and the experiences with gym members, where the deeper why—family, being around for grandchildren—drives consistency more than vanity. He frames physical activity as integrated into life, not as a separate 'exercise' episode. The discussion then drifts into technology's role: automation, door-to-door services like DoorDash, and remote work diminish the need to be physically active. A provocative chart compares life expectancy gains from vaccines and medical advances with declines in daily movement because of conveniences: 'Since 2001, people meet friends all over the world via the worldwide web without investing a single calorie in locomotion.' The host argues that evolution hasn't kept pace with modern conveniences, creating a mismatch between our biology and our daily activities. He calls this 'the Nuance' of physical activity and movement deposits. On physiology, he explains fat storage as a survival mechanism: fat is 'energy-rich' and stored in adipose tissue as triglycerides for times of starvation. For fat to be used, it must be mobilized into muscle mitochondria, where it is burned for energy, producing water and carbon dioxide as byproducts. The mitochondria are described as the 'powerhouse of the cell,' and the amount of mitochondria in muscle can increase through 'mitochondrial biogenesis' under the right stimulus. He stresses 'use it or lose it' and notes that muscles and mitochondria adapt to the activity level we provide. Finally, he maps practical ways to increase movement deposits: define a modality of motion (walking, dancing, playing with kids, pickleball, yoga), and create micro-workouts that fit into a workday, such as a 33 minutes on / 5 minutes off Pomodoro cycle with short bodyweight sessions. He demonstrates a burpee and its variations to illustrate scalable intensity. The host argues that convenience seduces us toward inactivity, so we must 'inconvenience' ourselves just enough to maintain health, while also appreciating that movement can be joyful and social through classes, clubs, or playing with friends and family. The message is not crash dieting but sustainable, enjoyable movement integrated into daily life.

The Dhru Purohit Show

LATEST SCIENCE On How To Turn Your Body’s FAT STORAGE Switch Off! | Dr. Richard Johnson
Guests: Richard Johnson, Timothy Gower
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Nourishing ourselves through food significantly impacts our hunger and energy levels. The standard American diet contributes to weight gain and obesity, primarily due to high sugar intake. Humans have unique metabolic characteristics that affect energy production and fat storage. Diets rich in protein and specific carbohydrates can enhance energy levels. Additionally, hydration plays a crucial role in maintaining blood concentration and overall health. Understanding these factors is essential for improving dietary habits and health outcomes.
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