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Cholesterol happens to be one of the most important things in your body. I can assure you, and I can prove it from the scientific literature in cardiology, that everything that you hear in the advertisements for lowering cholesterol is fraudulent. Cholesterol betcha. 25 to 30% of the brain's made out of cholesterol. How many people need brains? Nobody in politics. They talk about the cholesterol in the arteries. Yeah, that's been studied. What does it turn out to be? 1.5% of the plaque is fat, and of that, point 5% is cholesterol. 90% of it's calcium. So where's the problem? Calcium or cholesterol? Calcium. You bet.

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Cholesterol is not linked to heart disease. Ancel Keys, a researcher, committed scientific fraud by falsely claiming a connection between cholesterol and cardiovascular disease. Despite evidence of this fraud, cardiologists and primary care physicians continue to prescribe statins based on outdated guidelines due to malpractice concerns. In the past, cholesterol levels of 300-350 were considered normal, and people were generally healthier without the focus on cholesterol management. The real cause of cardiovascular disease is damage to the glycocalyx, a crucial but often overlooked organ in the body.

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"Fat, saturated fat and cholesterol are all very healthy things." "Your brain is 25% made of cholesterol." "So imagine blocking cholesterol production in your brain." "What do you think that's going to do, gentlemen?" "Ansel Keys himself started by saying if you eat cholesterol, your cholesterol level will go up." "He did experiments on humans and fed them 10 eggs a day or something." "And what he found is it had absolutely no impact on their blood cholesterol level." "None." "For every one millimole fall in your cholesterol level, the rate of heart disease death went up twenty percent." "Cholesterol is a molecule." "It's found in human beings, so it's hugely important substance in our bodies."

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The speaker claims they have elevated cholesterol but do not need a statin because they eat a significant amount of saturated fat from animal meat and avoid seed oils, which raises LDL cholesterol. They believe a classically trained doctor would recommend a statin, but elevated cholesterol does not mean increased cardiovascular disease risk. The speaker claims that eating in this way means they are metabolically healthy, or insulin sensitive. They assert that medical literature shows elevated LDL is not a significant cardiovascular risk factor in healthy individuals with high HDL, low triglycerides, and low fasting insulin. They also claim there is no evidence that statins lower cardiovascular risk in healthy individuals like themselves, but statins will increase the risk of negative side effects.

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Sugar, not fat, causes fat accumulation. When sugar is consumed, insulin levels increase. Insulin's primary role is to inhibit other forms of energy use, including fat metabolism. Consequently, fat accumulates in the blood, leading to elevated blood fat levels. Individuals with high sugar intake tend to have elevated triglycerides due to high insulin levels. High insulin levels are generally associated with diets rich in sugar, especially refined sugars.

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People with high cholesterol levels purportedly don't get Alzheimer's because the brain loves fat. A good cholesterol level is suggested to be 200-250. It's claimed that many people are on cholesterol-lowering medication and fat-free diets, leading to increased carb consumption due to a lack of satiation. The speaker alleges cholesterol levels have been lowered to get more people on medication and that people are eating margarine. Despite these changes, heart disease is purportedly still the number one killer.

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A low carb diet reduces total carbohydrate and sugar while increasing dietary fat, which will generate a higher LDL, but it will be that large, buoyant LDL, which is cardiovascularly neutral. The goal is to get the small, dense LDL down, and statins don't touch those. The question raised is whether lowering LDL (which is not important) at the cost of putting yourself at risk for hyperglycemia (which is important) is a good trade.

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Cholesterol is not dangerous and is needed by the body as an antioxidant and for hormone production, especially LDL cholesterol. There is no bad cholesterol, only what we do to it. 25% of the body's cholesterol is in the brain, which is 60% fat. Lowering cholesterol can increase the risk of heart problems and depression, and numbers under 300 are not dangerous. LDL cholesterol is used to make hormones and is only bad when high carbohydrate intake causes LDL particles to become small and dense. Small dense particles can lodge in arterial walls, while light fluffy particles do not. A healthy diet of moderate protein and higher fat will result in light fluffy LDL particles. When told to lower cholesterol, it's important to know if it's HDL or LDL and whether the LDL is small dense or light fluffy.

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"Cholesterol has nothing to do with heart disease. Zero." "Here's the thing. Ansel Keyes was a researcher. He committed scientific fraud." "He lied on the papers that determined them saying, oh, look, cholesterol is highly implicated in cardiovascular disease." "Turns out he lied. They've proven there was fraud, but yet all the cardiologists and all the PCPs, because the standard of care guideline is still if the cholesterol is this number two zero one, you better prescribe a statin." "And if you don't, we will not defend you in the court of law if you get sued." "My grandmother was alive, the normal cholesterol at my age was 350." "So everybody used to walk around with 300, 350, and it was very normal." "They have not educated you on what really is causing it." "What's causing cardiovascular disease is damage to what's called the glycocalyx." "The glycocalyx is probably the largest organ in your body, and none of you have even heard of it."

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People with high cholesterol levels don't get Alzheimer's because the brain loves fat. A good cholesterol level is probably around 200-250. However, many people are now on cholesterol-lowering medication and fat-free diets, which leads to overconsumption of carbs. This is done to lower cholesterol levels and increase the number of people on medication. Additionally, people are eating margarine instead of fats. Unfortunately, these measures have not reduced heart disease, which remains the number one killer.

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Cholesterol has nothing to do with heart disease, zero. Ansel Keyes was a researcher who committed scientific fraud, lying on the papers that determined them, saying cholesterol is highly implicated in cardiovascular disease. They know he lied; we’ve proven there was fraud. But yet all the cardiologists and all the PCPs, because the standard of care guideline is still if the cholesterol is this number “two zero one,” you better prescribe a statin, and if you don't, we will not defend you in the court of law if you get sued. That’s why they all do it, because of their malpractice. I’ve had physicians tell me this. They’re like, of course we know they’re bullshit. When my grandmother was alive, the normal cholesterol at my age was 350. So everybody used to walk around with three hundred three hundred fifty and it was very normal and they were all skinny and nobody worked out. Nobody was fat in 1950, 60, 70, they were thin. Three twenty, three fifty, that was normal. In the labs, two physicians, that’s normal. Nobody was treated. Three fifty is not high. I’m sorry they have not educated you on what really is causing it. What’s causing cardiovascular disease is damage to what’s called the glycocalyx. The glycocalyx is probably the largest organ in your body and none of you have even heard of it.

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The most dangerous idea in history is the claim that cholesterol causes heart attacks, which is false and unproven. Cholesterol is essential to animal life and present in every cell membrane; without enough cholesterol, cells die. Humans have historically consumed animal fats, but were told to stop, assuming experts knew best, which was a mistake.

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Eating a diet high in cholesterol is not linked to heart disease, contrary to common belief. Cholesterol is vital for the body, and the idea of good and bad cholesterol is a myth. Statin drugs lower cholesterol by causing liver inflammation, potentially leading to brain issues. The rise in Alzheimer's disease cases correlates with the increase in statin drug prescriptions. It is crucial to prioritize brain health by avoiding statin drugs.

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For years, they've blamed fat and red meat for heart disease, but that all started with one flawed study. Back in the nineteen fifties, a researcher by the name of Hansel Keyes launched the seven country study. Ansel Keyes cherry picked the countries he included in his study, leaving out countries like France who have a high intake of saturated fat but had no increased risk of heart disease. Even worse, he left out other key health factors, things like sugar intake, a sedentary lifestyle, and even smoking. And by ignoring these, he was able to point the finger at fat and red meat as the overall villain. It's time to address the real enemies, unstable blood sugar, high intake of processed foods, and overall metabolic dysfunction. Now is the time to question the narrative and get back to what truly makes us healthy.

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There is no high-level evidence showing even a correlation between cholesterol and heart disease. The Journal of American Medical Association published a report in 2015 detailing internal documentation from the Sugar Research Foundation. This documentation showed evidence suggesting sugar caused heart disease, and detailed how they paid off three Harvard professors to falsify data and publish fraudulent studies. These studies were designed to make it appear as if cholesterol was correlated with heart disease and exonerate sugar. One of these professors, Professor Mark, became head of the USDA and helped author the 1977 USDA dietary recommendations to significantly reduce saturated fats and cholesterol because it caused heart disease.

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In the 1970s, it was learned that dietary fat raised LDL, which predicted heart disease. While both are true to an extent, only small dense LDL predicts heart disease. Dietary fat raises large buoyant LDL, while carbohydrates, especially sugar, raise small dense LDL. Therefore, high LDL levels don't automatically necessitate statins. If LDL is high, the cause should be investigated, but statins aren't always the answer. It is claimed that four out of five people on statins are prescribed them unnecessarily.

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Speaker 0: The most dangerous idea in human history is this idea that cholesterol causes heart attacks. It was not true. It was never true. It was never proven. Yet, it was accepted as fact. It's ridiculous when you think about it because cholesterol is something nature puts in every single one of our cells. It is essential to life, to animal life. All animals, not just humans, every form of animal must have cholesterol in our cell membrane. And if the cell doesn't have enough, it die. Speaker 1: Humans have survived an awful long time eating animal fats. So all of a sudden, the powers that be tell us they're literally off the table, and we followed suit thinking that these people know what they're talking about, and we were really off base.

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People with high cholesterol levels purportedly don't get Alzheimer's because the brain loves fat. A good cholesterol level is suggested to be 200-250. It is claimed that many people are on cholesterol-lowering medication and fat-free diets, leading to increased carbohydrate consumption due to a lack of satiation. The claim is made that cholesterol levels have been lowered to get more people on cholesterol medication, and people are eating margarine. Despite these changes, heart disease is allegedly still the number one killer.

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A flawed study from the 1950s, the "seven country study" by Hansel Keyes, is the origin of blaming fat and red meat for heart disease. Keyes' data showed a link between saturated fat and heart disease, which shaped nutritional policy for decades. However, Keyes cherry-picked countries for his study, omitting countries like France with high saturated fat intake and no increased heart disease risk. Keyes also left out key health factors like sugar intake, sedentary lifestyle, and smoking, which have huge effects on heart health. By ignoring these, he blamed fat and red meat as the villain. Despite cutting out eggs, red meat, and butter for decades, heart disease rates continue to skyrocket. The real enemies are unstable blood sugar, high intake of processed foods, and overall metabolic dysfunction. It's time to question the narrative and focus on what truly makes us healthy.

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Cholesterol is a nutrient, not a disease, and is essential for sex hormones, steroid hormones like cortisol, vitamin D synthesis, and bile. It is also needed for every cell membrane. In 2015, the American Heart Association said cholesterol is no longer a nutrient of concern and removed the saturated fat cap of 10%. If we don't eat enough cholesterol, our bodies will make it. The true problem in blood work is triglycerides, which can be reduced by dropping carbs, not with drugs. Lowering carbs and triglycerides will improve heart health.

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Speaker 0 argues that the American Heart Association used money to spend decades fabricating a huge pile of evidence to support the idea that cholesterol causes heart attacks, and that this pile of evidence is nonsense. He notes that some very smart scientists who have sifted through it have come to the same conclusion, that there is nothing here and no evidence. He adds that when you cut out vegetable oils and eat healthier foods, very likely your total cholesterol levels will go up, and your doctor will tell you to stop following this diet that’s improving your health and transforming your life. He warns it may scare you into taking a statin drug, which he calls one of the most dangerous drugs out there. He mentions that there is a whole chapter in Dark Calories about this so you can fortify your knowledge, and that you have to know more than your doctor because doctors are miseducated.

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When someone has a heart problem, they are told to stop eating fats because of cholesterol. However, the truth about cholesterol is that the liver produces it according to the body's needs. 80% of the cholesterol made by the liver comes from glucose, while 20% comes from fat. The problem lies in the misconception that it is the butter on the bread that is the issue, when in fact it is the bread itself. There are two main types of cholesterol: HDL, which is considered good because it carries excess cholesterol back to the liver, and LDL, which is considered bad but actually plays a role in repairing and rebuilding. LDL also delivers cholesterol to the brain, which the brain needs. Interestingly, breast milk in the first month of life contains the highest levels of cholesterol.

The Peter Attia Drive Podcast

229 ‒ Understanding cardiovascular disease risk, cholesterol, and apoB
Guests: Allan Sniderman, Tom Dayspring
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In this episode of The Drive podcast, Peter Attia discusses atherosclerotic cardiovascular disease (ASCVD), cholesterol, and the importance of tracking APOB levels with guests Allan Sniderman and Tom Dayspring. They emphasize that ASCVD is a prevalent and inevitable disease affecting human longevity, with significant implications for health span and lifespan. The discussion highlights that while many believe ASCVD primarily affects older individuals, a substantial number of heart attacks occur before age 65, underscoring the need for early awareness and prevention. Attia explains that ASCVD is characterized by cholesterol buildup in artery walls, leading to reduced blood flow and potential heart attacks. Cholesterol, essential for cell membranes and hormone production, is often misunderstood in terms of its "good" and "bad" classifications. The podcast argues against labeling cholesterol as good or bad, emphasizing that the focus should be on the behavior of lipoproteins, particularly APOB, which is a better predictor of cardiovascular risk than traditional cholesterol metrics. The conversation also critiques the reliance on 10-year risk calculations for prevention, noting that many heart events occur before the age thresholds used in these assessments. Instead, they advocate for a more proactive approach to monitoring and reducing APOB levels, suggesting that optimal levels should be targeted early in life to prevent ASCVD. The episode concludes with a call for better understanding and communication around cholesterol and cardiovascular health, encouraging listeners to consider the implications of their lipid profiles and overall cardiovascular risk.

The Peter Attia Drive Podcast

334 - Cardiovascular disease, the number one killer: development, biomarkers, apoB, and more
Guests: Tom Dayspring
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In this podcast episode, Peter Attia and Tom Dayspring discuss atherosclerotic cardiovascular disease (ASCVD), the leading cause of death globally. They begin by outlining key risk factors, including age, smoking, lipid disorders, and high blood pressure. Dayspring emphasizes the importance of measuring ApoB and triglycerides in assessing cardiovascular risk, stating that ApoB is crucial for understanding lipid-related diseases. The conversation delves into the pathophysiology of atherosclerosis, explaining how cholesterol deposits in artery walls lead to plaque formation, which can cause heart attacks or strokes. They highlight that atherosclerosis is a slow process that can begin in childhood, with fatty streaks found in young children. Dayspring notes that most heart attacks occur in individuals over 40, but significant risk factors can develop much earlier. Dayspring explains the difference between causal risk factors (like smoking and high blood pressure) and risk markers (like coronary calcium scores and inflammatory markers). He stresses that while age and genetics are non-modifiable risk factors, lifestyle changes can significantly impact lipid levels and overall cardiovascular health. The discussion shifts to the role of ApoB, which is a marker for the number of atherogenic particles in the bloodstream. Dayspring explains that each ApoB particle corresponds to a lipoprotein that can enter the artery wall and contribute to atherosclerosis. They also discuss the implications of high triglycerides, which can lead to increased ApoB levels and a higher risk of cardiovascular events. Attia and Dayspring touch on the importance of HDL cholesterol, noting that its protective effects are not solely determined by its levels in the blood. They emphasize that HDL functionality is crucial and that high HDL levels do not guarantee cardiovascular protection. The podcast also explores the relationship between cholesterol and brain health. Dayspring explains that cholesterol is vital for brain function, with the brain synthesizing its own cholesterol rather than relying on peripheral sources. They discuss the role of ApoE in transporting cholesterol within the brain and its implications for Alzheimer's disease risk, particularly in individuals with the ApoE4 genotype. Finally, they highlight the advancements in lipid-lowering therapies, including statins and newer medications, and the importance of personalized treatment approaches. Dayspring expresses optimism about future developments in cardiovascular medicine, particularly regarding the understanding of ApoB and the potential for improved diagnostic tools. Overall, the episode provides a comprehensive overview of ASCVD, the role of lipids in cardiovascular and brain health, and the importance of personalized approaches to prevention and treatment.

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Sugar's Sneaky Impact on Your Blood
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Hyperglycemia is the focus: high sugar in the blood. Hyper means super, gly means sugar. The speaker notes we’re not worried about one meal but chronic high blood sugar. The one mechanism highlighted links excess sugar to cardiovascular disease via atherosclerosis. Ox LDL is identified as the villain; normal LDL becomes Ox LDL through interaction with free radicals. LDL is a taxi for fat, delivering fat through the watery blood. Ox LDL triggers immune activation and inflammation, causing platelets to become sticky and the vessel wall to lose integrity, promoting atherosclerosis. When LDL is oxidized, macrophages engulf it, become foam cells, and accumulate around damaged vessels. The trigger is a receptor on many cells called Rage; it is unlocked by glucose, generating inflammation and free radicals. Advanced glycation end products (AGEs) form when glucose attaches to proteins; AGEs are irreversible, and Rage is the receptor for AGEs. Dietary sugar fuels this pathway. Juice provides liquid sugar with little fiber, while whole fruits slow glucose rise due to fiber. Snacks with added sugar increase intake; bread is a starch that eventually becomes sugar. The speaker promotes Whole Foods to control sugar intake, noting that fiber and less processing help manage blood sugar levels. Sugar-heavy foods and liquid sugars are major culprits in hyperglycemia and endothelial damage.
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