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Megyn Kelly hosts a discussion on transitioning and de-transitioning, featuring Walt Heyer and Grace Ladinsky-Smith, both of whom regret their transitions. Walt transitioned to Laura Jensen in his forties but de-transitioned after realizing he needed therapy for childhood trauma rather than surgery. He recounts how adverse childhood experiences, including emotional and sexual abuse, influenced his decision to transition. He emphasizes that many individuals who transition may be dealing with unresolved trauma rather than genuine gender dysphoria. Grace, who began questioning her gender in her twenties, underwent a double mastectomy and hormone therapy but later recognized her mistake. She describes her experience as being influenced by social media and a mental health crisis, leading her to believe that transitioning would resolve her issues. Both Walt and Grace face backlash from trans activists for sharing their stories, highlighting the societal pressure to affirm transitions without exploring underlying psychological issues. The conversation shifts to the medical perspective, with Dr. Julia Mason and Dr. Erica Anderson discussing the implications of puberty blockers and cross-sex hormones. They outline significant risks associated with these treatments, including bone density issues, cognitive effects, and irreversible changes to sexual function. They express concern over the lack of thorough evaluations before medical interventions are prescribed, noting that many young people may be seeking transition as a solution to broader psychological problems. The discussion also touches on the increasing number of young girls identifying as trans and the potential societal factors influencing this trend. Both doctors advocate for a more cautious approach, emphasizing the need for individualized assessments and addressing underlying mental health issues rather than rushing into medical treatments. They call for a systematic review of the scientific evidence surrounding these practices, similar to actions taken in countries like Sweden and Finland, which have begun to reassess their approaches to gender-affirming care for minors.

HGH is often viewed as a "Fountain of Youth Elixir," associated with preventing age-related decline in bone strength and fat metabolism. The podcast features Peter Attia and Derek, who shares his journey from a skinny teenager to a knowledgeable figure in bodybuilding and hormone therapy. Derek grew up in Vancouver, Canada, and became interested in weightlifting in high school, driven by peer pressure and the desire to gain muscle. His exploration of bodybuilding led him to delve into anabolic steroids and hormones, which he researched extensively through forums and literature. He experienced significant weight gain and side effects, including sleep apnea, while using high doses of anabolic steroids, which he later learned were far above therapeutic levels. Derek discusses the complexities of hormone therapy, particularly testosterone and its derivatives. He notes that while testosterone is essential for muscle growth, its use can lead to various side effects, including gynecomastia and hormonal imbalances. He emphasizes the importance of understanding the balance between testosterone, estrogen, and DHT (dihydrotestosterone) in maintaining health and performance. The conversation also touches on the use of growth hormone (GH) and its perceived benefits in bodybuilding and anti-aging. Derek mentions that while GH can aid in fat loss and muscle preservation, its effects are often exaggerated, and the long-term consequences of its use are not well understood. He highlights the need for caution when considering GH and the potential risks associated with its use, particularly in the absence of medical supervision. Derek explains the role of HCG (human chorionic gonadotropin) and Clomid in maintaining fertility and testosterone production in men undergoing hormone therapy. He notes that HCG can stimulate the testes to produce testosterone, while Clomid can trick the brain into increasing testosterone production by blocking estrogen receptors. He stresses the importance of maintaining testicular function during testosterone therapy to prevent long-term hormonal issues. The discussion also covers the use of SARMs (selective androgen receptor modulators) and their potential benefits and drawbacks compared to traditional anabolic steroids. Derek points out that while SARMs may offer some advantages in terms of selectivity and reduced side effects, they are not without risks and are often used inappropriately. Throughout the conversation, Derek emphasizes the need for a nuanced understanding of hormone therapy, the importance of individualized treatment plans, and the potential consequences of long-term anabolic steroid use. He advocates for a balanced approach to hormone management, considering both the benefits and risks associated with various compounds. The podcast concludes with a discussion on the importance of education and awareness in navigating the complexities of hormone therapy and bodybuilding.

In this episode of The Drive podcast, Peter Attia and Derek discuss hormone replacement therapy, particularly focusing on testosterone and its implications for both men and women. They explore the increasing attention on testosterone replacement, the historical stigma surrounding it, and the differences in regulation compared to estrogen and progesterone. Derek explains that testosterone is produced in both genders, with men producing significantly more. It plays a crucial role in muscle protein synthesis and other anabolic processes. They also touch on the role of dihydrotestosterone (DHT) and its effects on sexual differentiation and characteristics. The conversation highlights the complexities of hormone replacement therapy, especially for women, where testosterone is not FDA-approved, and the potential side effects of masculinization. They discuss the lack of clarity around who should consider hormone replacement therapy and the importance of understanding individual hormone levels before starting treatment. Peter shares a personal anecdote about a female patient who experienced significant side effects from an incorrect dosage of testosterone, emphasizing the need for careful monitoring. The discussion shifts to the use of DHEA, an over-the-counter supplement that some women are turning to for boosting testosterone levels. Derek notes that while DHEA can be effective in some cases, its use should be approached cautiously, especially in women with normal hormone levels. The hosts also delve into the role of progesterone in both men and women, discussing its importance beyond reproduction and its potential effects on mood and anxiety. They highlight the need for individualized dosing and monitoring when using progesterone, especially in women who may experience side effects. As the conversation progresses, they touch on the increasing interest in testosterone replacement therapy among younger men and the various avenues through which individuals obtain it, including underground markets and telemedicine clinics. They caution against the risks associated with unregulated sources and the importance of seeking professional guidance. Derek and Peter also discuss the pharmacological landscape surrounding fat loss, including the use of substances like L-carnitine and caffeine. They emphasize that while these compounds may have some benefits, the foundation of effective fat loss remains a well-structured diet and exercise regimen. The episode concludes with a discussion about the influence of social media and the proliferation of misinformation regarding health and fitness. They highlight the importance of critical thinking and skepticism when evaluating claims made by influencers in the health space, particularly those promoting quick fixes or unproven supplements. Overall, the conversation provides valuable insights into hormone replacement therapy, the complexities of managing hormonal health, and the importance of a balanced approach to diet and exercise for optimal health outcomes.

The episode features a wide‑ranging conversation with Jay Campbell about the world of performance biology, biohacking, and the evolving landscape of peptides and hormone therapies. The guest traces his early influences in bodybuilding and the pivotal role of Dan Duchaine, noting how ideas on fat loss, low‑carb eating, and early ephedra–caffeine–aspirin formulations shaped modern training and supplement culture. A core portion explores cyclical ketogenic approaches and the understood, controversial balance between carbohydrate availability, insulin sensitivity, and muscle growth. Campbell emphasizes metabolic flexibility as essential for body composition, arguing that carbs are necessary for brain function and performance, while warning that extreme long‑term ketosis can impair insulin metabolism and thyroid health. The dialogue then shifts to the broader pharmacology of bodybuilding, including the use of aromatase inhibitors and the debate over estrogen’s role in fat loss, muscle fullness, and overall health, with cautions about long‑term cardiovascular and hormonal risks. The bulk of the discussion moves to cutting‑edge biotechnologies: follistatin, myostatin inhibition, and the promise of improved muscle growth through innovative delivery systems, such as albumin‑bound follistatin that extends half‑life and enables less frequent dosing. The speakers address practical aspects of using peptides and small molecules, delivery challenges, local versus systemic effects, and the potential for better joint health and tissue repair when combined with specific regimens. A significant portion focuses on the regulatory and market dynamics around GLP therapies, including patent dominance by large pharma, the potential reclassification of peptides from class two to class one, and the implications for compounding and accessibility in the clinical space. Throughout, the hosts and guest emphasize that these are research tools rather than magic pills, advocating for training, nutrition, and microdosed protocols to optimize outcomes while acknowledging the legitimate risks and regulatory pressures facing the industry. The conversation also touches personal journeys, resilience, and forgiveness, underscoring how individual experiences intersect with science and entrepreneurship in shaping the future of longevity and performance.

Puberty blockers or HRT, hormone therapy, temporarily change physiology, because you're on this stuff forever. If you stop, you will androgenize again, growing hair and deepening your voice. The other option is physical surgery—tens of thousands of dollars—that may not satisfy everyone, creating a murky gray zone about effectiveness. Desensitization, trauma, and brain changes from pornography are cited as links to gender dysphoria and transitioning. Gooning—extended masturbation—creates a path toward novel fetishes, with a goonarchy and a claim that transgenderism is disproportionately represented in that group by 20-25x. Dr. AZ Hakee's DTrans taxonomy outlines four types: transvestites, true trans, rapid onset, autogyophiles; group versus individual therapy is discussed. Emails and anecdotes claim porn addiction can lead to sex with transgender partners; a pattern described across confessions and stories. The speaker notes that less than 2% of patients pursue physical, hormonal, or surgical changes after therapy, and observes autism-linked theory of mind difficulties influencing misgendering and dysphoria. Group therapy is described as superior to one-to-one settings, with long-term engagement sometimes lasting years.