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Here's what alcohol abuse can do to your gut and liver health, and these are problems that I'm seeing all the time. Here's what a normal liver should look like, and years of alcohol abuse makes it look like this. It's shrunken. It has a lot of fat deposition. It's scarred. Eventually, it stops working, and that can be irreversible. Alcohol can cause pancreatitis, which is inflammation of the pancreas and hospitalizes people every year. Alcohol can cause gas ritis and ulcers that can cause life threatening bleeding. Alcohol use puts you at risk for the development of cancers in the colon, stomach and esophagus. It's on the rise here in America so always be cognizant about how much alcohol you're intaking. As we go into 2025 make taking care of your gut and liver health one of your resolutions.

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One of the main health harms from alcohol, especially heavy alcohol use, is liver damage. The first thing that happens is inflammation of the liver. And when your liver gets inflamed, you start getting fat deposit in the liver. That actually can totally reverse if you stop drinking or you make changes. The amazing thing with the liver. It's a really regenerative organ. But there is a point where you cross the threshold where you can no longer repair the damage, and that's when you get to a stage called cirrhosis. From fat deposition, then you start getting scarring. Your body lays down all the scar tissue because of the chronic inflammation in your liver and when your liver becomes so scarred that it's really stiff and and starts not functioning well that's cirrhosis. I'm seeing people in their early 30s with cirrhosis in the hospital. What? Yes.

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Main offender is alcohol. I know that's not the offender in you. But the main offender for liver inflammation is alcohol because it's not the alcohol itself. It's what the alcohol becomes. Alcohol is converted into something called acetaldehyde, which makes your blood pH very low, very acidic, and this irritates the the liver. But don't forget the liver's filtering out everything. The liver is like if you want any organ on team Ryan, you want the liver. Right? It can take over the function of other organs. Main offender is alcohol. I know that's not the offender in you.

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And one of the bad things that happens is that the liver suffers. The liver is involved in all sorts of things, production of important hormones and other factors related to metabolism, and when mice can eat around the clock, their livers got very sick. Fatty deposits in the liver, other factors in the liver, essentially taking down the pathway of liver disease. The time restricted feeding essentially reversed that or led, in many cases, to even healthier liver conditions, and that's based on this study, but also additional studies also now in humans.

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One of the best things you can do to support and promote a healthy liver is to drink fresh squeezed beet juice over an extended period of time. One ounce of beet juice every week increasing by one ounce until you are at four ounces a day. week one, one ounce, week two, two ounces a day, week three, three ounces a day, week four, four ounces a day and then you stop after week four and you can add other things to make it taste better, right, like carrot and apple and beet juice is a great tasty combination. Beet juice stimulates the genesis of new liver cells called hepatomeogenesis. You can surgically remove a seventy something percent of your liver. It will grow back, right? It's the only organ that can

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liver and organ meats are really good and healthy for us. They're nutrient dense and they have tons of micro and macronutrients. The trick is to make liver taste good. It's a super simple approach: get some grass fed liver, slice it into little pieces, either raw or sear the outside. Once you've got that liver where you want it to be, sprinkle some salt on top of it. A little teeny tiny bit of maple syrup on top of that liver and salt will make it go from tasting like a poop crap in Santa Claus' tissue. Turn it into something that tastes really delicious. Add some salt, add some honey or maple syrup, and you are good to go. Good to go.

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Your liver is one of the hardest working organs in your body. It's also one of the largest, located on the right side of your belly, just below your diaphragm. To help digest fats, your liver produces 1,000 milliliters of bile per day. It also plays a key role in keeping your blood sugar level constant. If it gets too high, your liver removes some sugar from your blood and stores it as glycogen. Too low, and it breaks down that glycogen to put some sugar back in. Your liver also makes special proteins so your blood can clot, and it stockpiles vitamins and minerals for whenever your body needs a boost. On top of all that, it detoxifies your system by removing harmful substances from your body like alcohol and medication by products.

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Transcript emphasizes that the liver, not the digestive tract, should be the first check for digestive issues: 'The number one place is not to look to your digestive tract' and 'The very first place that we need to look is actually your liver.' It explains that 'Your gallbladder, if you still have one, is attached to your liver' and that 'Your liver makes something called bile and then that bile gets excreted or pumped out into your small intestine' after food leaves the stomach. It notes the liver's central role, citing 'I have called the liver the most overworked, underpaid organ in the entire body for many many years.' It lists indicators to look at: 'ALT, AST, bilirubin, alkaline phosphatase, albumin' and mentions liver-active hours 'between two and 4AM.' It ends with 'For more info, click the link below.'

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Drinking fresh beet juice over time supports a healthy liver. Start with 1 ounce a week, increasing by 1 ounce each week up to 4 ounces daily. Beet juice, combined with carrot and apple, tastes great and promotes the growth of new liver cells. The liver can regenerate even after 70% removal, making it unique. Beet juice stimulates this process, making it a gentle way to support liver health. Welcome to the health empire.

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In the UK, there are 24 million registered organ donors, but waiting times for organs like lungs can exceed two years, leading some to lose hope. In the US, liver transplants may take up to five years. In contrast, in China, emergency organ transplants can occur in as little as four hours. This rapid availability raises concerns, particularly regarding the Uyghur population in Xinjiang, where individuals were reportedly forced to give blood in 2016 under the guise of health checks. There are suspicions that this blood collection is part of a system to create an organ database. When someone needs an organ, their sample is matched with a person in Xinjiang, who may then go missing, resulting in the organ being provided to the requester.

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Brain death is a lie invented to harvest organs and avoid the expense of treating non-productive individuals. Organs for transplant must come from living persons, not cadavers. This information is suppressed because it would upset people. Those aged 16 to 30, especially if unconscious and on a ventilator, are at risk of organ harvesting. Individuals declared brain dead have a beating heart, circulation, and respiration; otherwise, they would simply be considered dead.

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Drinking fresh squeezed beet juice over an extended period of time is highly beneficial for supporting a healthy liver. Start with 1 ounce of beet juice per week and gradually increase it by 1 ounce each week until reaching 4 ounces a day. Adding other ingredients like carrot and apple can enhance the taste. Beet juice stimulates the growth of new liver cells, known as Genesis. Interestingly, the liver is the only organ capable of regenerating itself, even if 70% of it is surgically removed.

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Do you realize how many people have a fatty liver? But here's the cool thing. There's a recent study, I did an entire video on this. Within fourteen days in the ketogenic diet, you can reduce up to 50% of the fat off of your liver by keeping your carbs under 30 grams a day. Now what was fascinating about the study was this, they didn't see any change in their waist, so they still had a gut, but 50% of their fat was removed from their liver. So if you start the ketogenic diet and you get a little frustrated because you're not seeing initial weight loss, that's because the body's going to go after the liver fat first before these other areas.

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Alcohol can damage the liver, but whether the liver can repair itself after stopping drinking depends on the stage of damage. The early stage, steatosis (fatty deposits), is typically reversible within four to six weeks of abstaining from alcohol. However, heavy alcohol use can lead to fibrosis (scarring) and eventually cirrhosis. Cirrhosis can result in end-stage liver disease, which is not reversible.

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Die Leber ist reich an Cholin, Vitamin A (Retinol), Biotin, Folsäure, Riboflavin, Selen, Mangan, Magnesium, Zink und Kupfer. Es wird vermutet, dass Organe Wachstumsfaktoren und Peptide enthalten, die das entsprechende Organ im menschlichen Körper unterstützen können. Es gibt Hinweise darauf, dass der Verzehr eines Organs einzigartige Wachstumsfaktoren liefert, die in Muskeln nicht vorkommen und das entsprechende Organ unterstützen könnten. **English Translation:** The liver is rich in choline, Vitamin A (retinol), biotin, folic acid, riboflavin, selenium, manganese, magnesium, zinc, and copper. It is believed that organs contain growth factors and peptides that can support the corresponding organ in the human body. There is evidence that consuming an organ provides unique growth factors not found in muscle that may support the corresponding organ.

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Organs cannot be taken from cadavers because brain cells die within minutes of oxygen deprivation. A person is not dead if their heart is beating, they are metabolizing fluids, or having bowel movements. Brain death is a lie manufactured for eugenics, to facilitate organ harvesting. The best organ donors are 30 years old, with a beating heart, circulation, and on a ventilator. The decision to take organs is made early, as treatment to preserve organs differs from life-saving treatment. In the UK, everyone is an organ donor unless they opt out. When a 999 call is made, the system assesses the caller's medical history, tax contributions, and worth to determine if they receive life-saving treatment or are considered an organ donor. This system is eugenics.

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The liver is a recoverable organ and can be revived with the right conditions. There are herbs like milk thistle, dandelion, and gentian that can cleanse and tone the liver. These herbs are very bitter, so it's best to take them in a glycerin tincture or tablet form. Lemon also acts as a tonic for the liver. Wearing a castor or compress over the liver area for 4 or 5 hours a day can also help. By implementing these measures, the liver can gradually recover.

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The speaker claims a benefit of something is the ability for the liver to detoxify better. They also state it will cause a release of bile, which will help in digesting fats. The speaker says this will help the liver work and help the digestive juices work through that area.

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Your body has the ability to repair itself, even from serious conditions. By maintaining a surplus of energy and a hydrated alkaline environment, your body can heal any issue. This means that there are no incurable diseases, only a point of no return where permanent damage has occurred. To illustrate this, we compare two cadavers, one healthy and one unhealthy. The unhealthy specimen shows a dirty liver, blackened stomach, pancreas, and spleen, and a buildup in the bowel known as mucoid plaque. By understanding the importance of energy and hydration, we can support our body's natural healing abilities.

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The liver can create a specific enzyme within seconds of encountering a new compound to detoxify it. Half of the liver can regenerate within thirty-six hours. Milk thistle is a natural product that can rev up liver metabolism. Most doctors don't learn about milk thistle.

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The human liver can grow back up to 70% of its size in just a few weeks. That means that even if a pretty significant portion of your liver is lost, it can literally regenerate and become goddamn near as good as new. Unfortunately, your liver is the only part of the body that has that kind of superpowers, so don't go trying it on your finger. That also means that it's the only organ in the body that you can donate half of to somebody else, and both halves will literally grow back into their own functioning livers. After all, it's literally the only thing that will stop it from magically healing itself. So don't destroy your liver just in case you need it to regenerate later or you wanna donate part of it to someone else. Stay healthy, my friends. You're welcome.

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Pharmaceuticals cause a lot of liver damage. A great example is paracetamol or acetaminophen or Tylenol. It doesn't that actually dissolves liver tissue. So, I was with the Poisons Control, group in Colorado. They said during the holiday season their largest cases tend to be people that have overdosed on Tylenol or teenagers tried to take too much and maybe, like, attempted suicide or anything. But Tylenol and we have we have liver transplants and sometimes to people that have taken way too much Tylenol because Tylenol dissolves liver tissue. Tylenol dissolves liver tissue. During the holiday season, their largest cases tend to be people that have overdosed on Tylenol.

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Doctor Holland and Fasano at Harvard published a study that shows when humans eat wheat, every human that eats wheat, not just the celiacs, but every human that eats wheat gets tears in the inside lining of the gut every time they're going to disease. There’s a barrier between your bloodstream and your intestines called your gut lining, and your gut lining has microscopic holes in it. Over time, if somebody has intestinal inflammation, large holes open up in your gut lining. Some cells turn over very quickly; the inside lining of the gut has a new lining every three to seven days. So you had toast for breakfast, it heals; you have a sandwich for lunch, it heals; pasta for dinner, it heals; croutons on your salad, it heals; a cookie, but it heals day after week, after month, after year, after year, after year, until one day you don’t heal anymore. When you don’t heal, that’s pathogenic intestinal permeability, and these tears can occur and stay torn when you lose tolerance. You don’t heal anymore, whether you’re two years old, 22, or 72, it just depends on when you cross that threshold as to when this happens, but it happens. What can happen now is undigested food particles such as gluten, casein, toxins, bad bacteria, candida can leak from the intestines into the bloodstream. Your body says those shouldn’t be here. It starts this immune response, and if that isn’t corrected over time, it can start autoimmune disease, and systemic inflammation can affect the joints causing rheumatoid arthritis; it can affect the thyroid causing Hashimoto’s thyroiditis; it can affect the colon causing things like Crohn’s disease or the muscles causing fibromyalgia. So really all autoimmune disease is first caused by leaky gut. It starts in the gut lining. The biggest factors causing this gut reaction are: certain foods, refined grain products; sugar is a big one because sugar feeds candida and yeast in your body, which causes this issue. Genetically modified organisms are wired with pesticides and viruses, which kill off beneficial microbes in the gut, causing leaky gut and autoimmune disease. Also looking at hydrogenated oils; artificial sweeteners are a big one—all of these things contribute to leaky gut. So if you have any inflammatory condition or really any chronic condition, gluten should be at the top of your list in thinking about why, whether it’s an autoimmune disease, digestive disorders, depression, neurologic issues; many of these things are driven through gluten, and by doing an elimination diet you can often see the impact. We’ve seen athletes like Djokovic, who’s actually selling his career by removing inflammatory foods like gluten and dairy and sugar, and seeing him go from near the bottom of the pile of professional tennis players to number one and unbeatable.

The Peter Attia Drive Podcast

#155 - Chris Sonnenday, M.D.: The history, challenges, and gift of organ transplantation
Guests: Chris Sonnenday
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Peter Attia welcomes Chris Sonnenday to the Drive Podcast, highlighting their long-standing friendship and Chris's significant role in his development during their time at Johns Hopkins. Chris shares his journey into medicine, influenced by his upbringing and a desire to serve others. He describes his late interest in surgery, drawn to the unique opportunity it provides to help patients during their most challenging moments. Chris explains his choice of Johns Hopkins for residency, motivated by its reputation for clinical excellence and mentorship. He emphasizes the importance of high expectations from mentors, which pushed him to achieve more than he thought possible. Peter reflects on the challenges of residency, noting how it can lead to a loss of empathy and humanity, contrasting his experience with Chris's ability to maintain compassion. They discuss the Morbidity and Mortality (M&M) conference at Hopkins, where surgical outcomes are reviewed, emphasizing accountability and learning from mistakes. Chris recalls a specific incident where he caught a missed diagnosis before a patient was discharged, showcasing his commitment to patient care and the importance of humility in medicine. Chris's decision to specialize in transplant surgery stems from his interest in hepatobiliary diseases and the rapid advancements in the field. He explains the significance of the "bench to bedside" concept in transplantation, highlighting the evolution of kidney transplantation from high mortality rates to successful outcomes due to improved immunosuppression. The conversation shifts to the challenges of kidney transplantation, including the importance of living donors and the complexities of matching donors and recipients. Chris discusses the ethical considerations surrounding organ donation and the ongoing debate about compensating living donors. They also touch on the disparities in organ availability based on geographic location and the impact of brain death on organ procurement. Chris shares a tragic story about a plane crash involving members of the transplant team, emphasizing the importance of teamwork and the risks involved in organ retrieval. The discussion concludes with a focus on liver transplantation, detailing the technical challenges and the historical context of the field. Chris highlights the shift from hepatitis C as a leading cause of liver transplants to the rising prevalence of non-alcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD), emphasizing the need for a comprehensive approach to address these public health issues. Throughout the conversation, Chris reflects on the profound impact of organ donation and the importance of advocating for patients in need, while Peter expresses gratitude for their shared experiences and the lessons learned in their medical journeys.

The Peter Attia Drive Podcast

302 - Confronting a metabolic epidemic: how to prevent, diagnose, & manage liver disease
Guests: Julia Wattacheril
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In this podcast, Peter Attia and Julia Wattacheril discuss the complexities of liver health, focusing on metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD). Julia, a transplant hepatologist, emphasizes the importance of understanding liver disease not just in terms of mortality but also quality of life. She explains that liver disease can stem from various factors, including metabolic issues, and highlights the role of lifestyle changes in managing risks. Julia describes the liver's essential functions, including metabolism, detoxification, and immune response, and notes that it is the only vital organ without extracorporeal support. She shares insights on the lack of effective temporary solutions for acute liver failure, mentioning historical attempts to use animal livers for detoxification. The conversation touches on the evolution of liver disease causes, from infectious agents to alcohol and metabolic disorders, with a significant rise in cases linked to obesity and diabetes. The hosts discuss the liver's resilience and the potential for reversing early-stage liver damage through lifestyle modifications. Julia emphasizes the importance of empowering patients with knowledge about their health risks, particularly regarding diabetes and cardiovascular issues. They explore the relationship between liver health and cancer risk, noting that individuals with liver disease are at increased risk for hepatocellular carcinoma, especially as fibrosis progresses. Julia highlights the role of GLP-1 agonists and other medications in treating metabolic dysfunction and improving liver health. She discusses the importance of non-invasive tests, such as elastography, for assessing liver fat and fibrosis, which can help guide treatment decisions. The conversation also addresses the need for a more nuanced understanding of dietary factors, particularly the impact of fructose and the benefits of coffee on liver health. Overall, the podcast underscores the interconnectedness of liver health with metabolic and cardiovascular health, advocating for a comprehensive approach to patient care that includes lifestyle interventions, early detection, and appropriate medical management.
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