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Vitamin D3 is the only vitamin humans can make, and every cell has a receptor for it. As we age, vitamin D3 levels decrease, and when they remain in single digits, rheumatoid arthritis-like symptoms can occur. A doctor might diagnose rheumatoid arthritis based on symptoms alone and prescribe corticosteroids. The speaker claims that corticosteroids lead to joint replacements in about six years. The speaker alleges that this cascade begins with a vitamin D3 deficiency, leading to an incorrect diagnosis, unnecessary medication, and ultimately, an unneeded joint replacement. After the joint replacement, reduced mobility allegedly brings on diseases exacerbated by reduced movement, and mortality risk increases.

Researchers in Austria studied the correlation between testosterone and vitamin D levels in two groups over one year. One group received over 3,000 IU of vitamin D daily, while the other received a placebo. The vitamin D group's vitamin D levels increased from 32 to 86. Their total testosterone increased by approximately 25%, and their free testosterone increased by 20%. The speaker suggests that individuals with lower testosterone levels should check their vitamin D levels and sleep quality before considering HRT or TRT. Low vitamin D levels can impact sleep, energy, and testosterone.

Many people are vitamin D deficient, leading to increased risks of depression, Parkinson's, Alzheimer's, and cancer. Supplementing vitamin D alone won't help if you're eating poorly, not exercising, smoking, or drinking excessively. However, in an otherwise healthy lifestyle, correcting low vitamin D can make a big difference. It's important to consider context, as magnesium is crucial for converting vitamin D into its active form. About 50% of people don't get enough magnesium from sources like dark leafy greens, pumpkin seeds, dark chocolate, and almonds. Stress, coffee, alcohol, and sugar deplete magnesium levels. Magnesium is an anti-aging macro-mineral involved in DNA repair enzymes.

Taking too much vitamin B6, especially from high-dose supplements, can damage nerves, sometimes permanently, causing sensory neuropathy with symptoms like numbness, tingling, burning pain, and difficulty walking. Neurologists should ask patients with neuropathy about vitamin use, particularly B6. The daily recommended amount of B6 is between 1.3 and 2 milligrams, with an upper limit of 100 milligrams, though some experts recommend lower limits, such as 12 milligrams per day. Studies show that doses above 50 milligrams daily, or even lower doses taken for over a year, can be toxic. Over-the-counter supplements often contain much more than this. Individual reactions vary; some tolerate 500 milligrams daily, while others develop neuropathy from just 6 milligrams. High-dose B6 is necessary for some medical conditions, but for the average person, a balanced diet provides enough B6, and megadoses are unnecessary and potentially harmful.

A new study suggests that a common vitamin used to strengthen bones may also slow aging. The discussion centers on vitamin D and its potential anti-aging benefits. In a large randomized, placebo-controlled study, researchers found that individuals who took vitamin D compared to those who did not actually had a shorter telomeres, a DNA marker associated with aging. The implication discussed is that, while vitamin D is already known to be beneficial for older adults in reducing risks of cancers, autoimmune conditions, and other metabolic diseases, it may provide an additional aging-related advantage by affecting telomere dynamics. Specifically, the group taking vitamin D showed less shrinkage of telomeres over time, suggesting a potential slowing of cellular aging relative to the control group. The conversation also touches on the broader interest in staying youthful and the relevance of vitamin D to cancer care. One speaker notes that their oncologist advised taking vitamin D after a cancer-related diagnosis, highlighting its perceived importance in cancer management and overall health. However, there is an important caveat about dosing. There is concern about the possibility of overdosing on vitamin D. It is noted that extremely high doses can be dangerous and may actually counteract benefits by accelerating aging or negating protective effects. Therefore, dosing should be carefully managed. For most people, a common recommendation is around two thousand to three thousand international units (IU) per day, with the understanding that many individuals should be taking vitamin D. Nevertheless, if a person has a vitamin D deficiency, a physician may prescribe a higher dose, underscoring the need for medical supervision rather than self-prescribing. The dialogue closes with an emphasis on consulting a physician to determine appropriate vitamin D intake and to avoid overdose, acknowledging the potential risks associated with excessive supplementation. The speakers express appreciation for the medical guidance and the reminder to adhere to professional recommendations regarding vitamin D use.

Many Australians report vitamin B6 toxicity from supplements, leading to symptoms like numbness, heart rhythm issues, muscle loss, and hospitalization. Cases arose after an Australian broadcast highlighted the issue of inadvertent poisoning from excessive synthetic vitamin B6. Vitamin B6 is often included in supplements like zinc and magnesium. While the recommended daily intake is 1.3 to 1.7 milligrams, some supplements contain 100 milligrams. High doses are sometimes used to treat deficiencies, but regular supplementation differs. The TGA regulates products exceeding 10mg as medicines, emphasizing the need for consumers to understand supplement ingredients and ensure they align with their healthcare needs.

The most crucial nutrient for the human body is vitamin D3, often deficient but easily fixed. Take at least 5,000 IUs of vitamin D3 with 120-140 micrograms of K2, preferably MK-7 for better absorption. This combination helps calcium go to the bones instead of the arteries, reducing risks of high blood pressure, heart disease, congestive heart failure, peripheral artery disease, stroke, and heart attack.

Osteomalacia involves bones becoming very soft, possibly occurring on a massive scale subclinically. The speaker believes they had it in high school due to poor diet and vitamin D deficiency, leading to fractures. In osteomalacia, certain proteins don't develop well. Vitamin D controls calcium absorption by 20 times in the small intestine. There are two vitamin D systems: one controlling calcium and another that is non-calcium related. A vitamin D blood test will likely show a level of 30 or less, indicating the need to take vitamin D3.

Vitamin D is important; take at least 10,000 IUs, but for chronic problems, take 20,000-40,000 IUs. When taking vitamin D3, take K2 simultaneously to prevent calcium buildup in the arteries. K2 drives calcium from the blood and joints back into the bone, protecting against hypercalcemia. The ratio is 10,000 IUs of vitamin D3 to 100 micrograms of K2. If increasing D3 to 20,000 IUs, then take 200 micrograms of K2.

Vitamin D3, a neurosteroid produced in the brain from sunlight, may protect against neurodegeneration. Every major brain area has vitamin D receptors, including those for memory and mood. Harvard studies are using high-dose vitamin D for depression. These receptors control over 900 genes related to brain health. Low vitamin D levels may increase cognitive decline risk by 290%. Research indicates optimal D3 levels protect against depression, dementia, and brain aging. The brain will take vitamin D from other tissues if levels are low. Have vitamin D levels tested, aiming for 75-100 ng/mL. Take 5,000-7,000 IU of D3 daily with vitamin K2 for optimal absorption and brain benefits.

The body may be deficient in vitamin D if experiencing low back pain, high blood pressure, depression, inflammation, or sleep issues like sleep apnea and snoring. Skin problems such as acne and dermatitis can also indicate a deficiency. Surprisingly, autoimmune diseases may also signal a need for more vitamin D. It is claimed that sufficient vitamin D3 intake can induce remission in autoimmune conditions.

About 80% of people are deficient in vitamin D, which can lead to various health issues like depression, Parkinson's, Alzheimer's, and cancer. However, simply taking vitamin D supplements won't help if you have an unhealthy lifestyle. If you clean up your lifestyle and still have low vitamin D levels, it can make a big difference. It's important to note that even if you spend a lot of time in the sun or take vitamin D supplements, without adequate magnesium in your diet, the enzymes that convert vitamin D into its active form won't function properly. Unfortunately, 50% of the population doesn't consume enough magnesium, which can be found in dark leafy greens, pumpkin, dark chocolate, and almonds. Magnesium is crucial for DNA repair enzymes and has anti-aging properties.

"The secret to antiaging? It shouldn't cost a billion dollars. It's the cheapest form of vitamin d." "Harvard backed randomized control trial, the gold standard when evaluating if something works, where over a thousand adults were followed for four years." "And what they showed is vitamin d three slowed telomere shortening, aka biological aging, by nearly three years." "We take two thousand to max four thousand IUs of vitamin d three a day." "But it's important that we marry this to vitamin k two so that that calcium ends up in our bones and not our arteries." "Last, magnesium, because your body cannot activate vitamin d three without it." "And the best part of this study, the authors had zero conflicts of interest. Nada, Zip, Zilch. Just pure science." "Let me know if you guys have any questions below."

Taking 10,000 to 20,000 IUs of vitamin D3 daily for 14 days is comparable to 20-40 minutes of sun exposure. The RDA of 600 IUs is insufficient because the immune system, muscles, endocrine system, hormone systems, and brain all require higher levels of vitamin D. To maintain these systems, a minimum of 10,000 IUs daily is recommended.

Vitamin D3 is described as the single most important nutrient in the human body, yet 50% of the world's population is clinically deficient. This deficiency is easily fixed with supplementation. It is recommended to supplement with a minimum of 5,000 IUs of vitamin D3 and 120-140 micrograms of K2, specifically the MK4 version, which is believed to be the most bioavailable. Vitamin D3 with K2 helps calcium deposit into the bone rather than the arterial wall. Vitamin D deficiency is claimed to be a risk factor for developing high blood pressure, heart disease, congestive heart failure, peripheral arterial disease, and may increase the incidence of stroke and heart attack.

Vitamin D deficiency increases the risk of cancer, and taking vitamin D can prevent cancer. It is also effective for treating depression and important for the immune system. Big pharma dislikes vitamin D because it reduces the risk of many diseases. Studies on vitamin D are often designed to fail using low doses. Higher doses are recommended for those with chronic inflammation or autoimmune diseases. The sun is beneficial and avoiding it increases the risk of dying. Sunshine also prevents cancer, including melanoma. Spending about 30 minutes in the sun without sunscreen is recommended, as sunscreen may increase the risk of melanoma.

Vitamin D3 is popular, but I advise against it. It's made from rat poison's active ingredient, causing hypercalcemia. Big pharma profits more from vitamins than drugs. Pfizer's investment led to a 90% deficiency rate. D3 is made from radiated sheep's wool and toxic chemicals, then added to GMO soybean oil. The sun is better than a pill. Share natural ways to boost vitamin D for a free guide.

Deficiencies in vitamin D3 have been overlooked for years, but now patients are experiencing symptoms like morning soreness, foot and ankle pain, knee and hip discomfort, and difficulty making a fist. Unfortunately, many family medicine practitioners misdiagnose these symptoms as rheumatoid arthritis and prescribe high-dose prednisone, a corticosteroid. However, research shows that starting corticosteroids leads to joint replacement within 6 years and one day. This misdiagnosis also affects mobility, as reduced movement is linked to increased mortality. In reality, these symptoms are often caused by a simple vitamin D3 deficiency, leading to unnecessary medication and joint replacements.

Sunlight deficiency is claimed to be the biggest cause of disease, with studies suggesting avoiding the sun is as risky as smoking. Insufficient sun exposure is allegedly responsible for almost 400,000 deaths per year and an increased incidence of almost every disease. Vitamin D is described as critical for dopamine synthesis, mood, weight loss, immune function, and glucose metabolism. Vitamin D supplementation is associated with a claimed 40% lower rate of dementia, and 4,000 IU of vitamin D reportedly boosted testosterone 40% in one study. Beyond vitamin D, the sun purportedly shrinks fat cells and improves the gut microbiome. Red and near-infrared light from the sun is said to structure water in mitochondria, boosting energy production and setting the circadian rhythm.

Sunlight is our greatest form of natural energy, and we are like walking solar panels. Covering up our skin is like putting tarps over solar panels on our roofs, preventing us from absorbing energy. Taking oral Vitamin D supplements reduces the body's ability to produce it naturally, down-regulating hormonal production. Doctors often recommend taking Vitamin D without testing blood levels, prescribing arbitrary amounts like 5,000 or 10,000 IU daily for years. This can lead to the body's inability to raise levels or produce Vitamin D from the sun because the normal systems have been down-regulated. Introducing something into the system always has consequences.

Vitamin D is crucial; take at least 10,000 IUs, or more (20,000-40,000 IUs) for chronic issues. When supplementing with Vitamin D3, it's important to take Vitamin K2 simultaneously, especially regularly, to prevent calcium buildup in the arteries. Vitamin K2 directs calcium from the blood and joints back into the bone, counteracting the hypercalcemia risk associated with Vitamin D toxicity. The recommended ratio is 10,000 IUs of Vitamin D3 to 100 micrograms of Vitamin K2.

Vitamin D toxicity is described as extremely rare, and is said to involve only one symptom: elevated calcium in the bloodstream. The speaker references Bruce Hollis, a recognized pioneer in vitamin D research, and asks whether a vitamin D toxicity problem has ever been observed. Hollis allegedly responded that he has never seen such a problem, despite involvement in numerous vitamin D studies. The transcript asserts that developing any toxicity would require consuming hundreds of thousands of international units of vitamin D3 for months. Taken together, the remarks suggest a high safety margin for vitamin D intake under typical conditions, with toxicity appearing only after extraordinary, prolonged consumption.

Megan Kelly opens with topics including Congresswoman Jasmine Crockett’s potential Senate bid and an alleged Republican push to recruit her, plus a clarification about Golden Globes “snub” coverage. She previews longevity expert Gary Breka as a second-hour guest and briefly plugs Andrew Klavan, host of The Andrew Klavan Show, inviting listeners to subscribe and highlighting Peak wellness products and a Sun Goddess Matcha offer. Andrew Klavan joins Megan to discuss Hollywood’s value system and the Golden Globes’ new category for best audible podcast. Megan explains that some voters must be courted by Golden Globes organizers to qualify for nomination and recalls that her team withdrew their name to avoid the dog-and-pony show. She notes she never sought the award and that, despite top podcast rankings, they refused nomination. Klavan agrees, adding that he never expected nomination and recounts his experience after writing Empire of Lies, describing a moment in which he realized he would likely not win further awards. He describes his own left-leaning critics and reviews and discusses the broader challenge conservatives face in achieving recognition within the arts. Klavan reflects on the broader impact of awards and the arts, comparing the entertainment world to sex in terms of long-term spiritual influence. He argues that the right has not built the same cultural infrastructure to celebrate and study the arts as the left dominates it, citing examples of left-leaning award outcomes and left-wing content that receives recognition. He contends that Hollywood’s “fake god” status and the way awards are used can influence careers, and he contrasts this with conservatives’ willingness to engage with the system. He recounts his own Hollywood career decline due to political positions and stresses the importance of integrity and fearlessness in speaking one’s mind, even at personal cost. Megan agrees, noting her stance of not seeking acceptance from Hollywood and the corrosive nature of blurring lines between journalists and entertainment elites. The discussion turns to contemporary industry examples, including Met Gala chair selections and celebrity appearances, with Megan criticizing the relevance of chair choices and highlighting celebrities’ perceived decline in cultural prominence. Klavan remarks on Sidney Sweeney’s recent messaging shifts, the pressures from agents and industry gatekeepers, and the broader risk for young conservatives in Hollywood. They discuss actors who have faced career consequences for their beliefs, referencing Zachary Levi’s claims of being gray-listed and the broader risk to conservative artists in the industry. The conversation touches on high-profile figures like Tom Stoppard and Cormac McCarthy as examples of conservatives in the arts, and they reflect on whether the industry’s power and influence are being wielded to push a left-leaning agenda. Megan shifts to a segment about Jasmine Crockett’s Senate bid, noting NOTUS’s report alleging an astroturf recruitment process by the National Republican Senatorial Committee to push Crockett into the race, and that Crockett’s announcement caused Colin Allred to drop out. They discuss Beto O’Rourke and Joaquin Castro vs. Crockett, and the idea that Republicans might have orchestrated Crockett’s bid to defeat a stronger Democrat opponent. They consider the potential consequences and the political dynamics in Texas, with the panelists acknowledging strategic risk but generally viewing the tactic as a savvy play. They critique media and political dynamics, including public reactions to Crockett’s campaign launch, the use of a rapper at her rally, and various congressional personalities described as “crazy women” by some. They debate the complexity of party strategies and how media coverage shapes voter perception, with the conversation highlighting perceived inconsistencies in how media treats different political actors. As the program moves into a commercial break, Megan announces a segment by Gary Breka, a longevity expert and founder of The Ultimate Human, who has worked with Dana White, whom Breka credits with significant health transformation after a personal blood test projected a longer lifespan. The program teases the guest appearance and announces Breka’s discussion topics. The interview with Gary Breka begins, with Megan asking for a synthesis of Breka’s eight tips and the special elements that helped Dana White move from a CPAP-dependent, drug-reliant regimen to feeling like he’s in his twenties. Breka explains the core principles: sleep mastery, a whole foods diet, and non-negotiable mobility, arguing these three are foundational and that no other strategies matter if these aren’t in place. He emphasizes that long-lived populations (Blue Zone studies) achieve health through no processed foods and consistent physical activity, not adherence to any single diet. Breka argues that supplements are appropriate when used to address specific deficiencies uncovered by testing rather than as universal cures. He underscores the importance of nutrient refinement over generic supplementation and explains that genetic methylation testing can identify which nutrients the body can convert into usable forms, guiding targeted supplementation. He uses Dana White as a case study to illustrate how specific gene mutations (including MTHFR) can affect nutrient metabolism and disease risk, such as hypertension linked to homocysteine elevation when conversion of folic acid is impaired. The discussion covers vitamin D3 (cholecalciferol) as a crucial nutrient, noting widespread clinical deficiency and recommending 5,000 IUs daily, paired with vitamin K2 to aid calcium deposition in bones rather than arteries. Breka explains how vitamin D3 interacts with immune function and cites COVID data linking deficiency to morbidity. He advocates for outdoor sunlight exposure while acknowledging practical considerations in colder climates, recommending supplementation when sun exposure is limited. Breka also addresses gut health, tryptophan-to-serotonin conversion, and the interplay between gut function and anxiety, explaining how methylfolate deficiency can manifest as gut motility problems and mood disorders. He discourages relying on broad online supplement searches, urging consultation with a physician or trusted sources, and points listeners to his website, theultimatehuman.com, for more resources and a VIP group offering private Q&A and even an AI assistant for dietary and supplement planning. Megan and Andrew discuss sleep timing, vitamin D3 dosing, and the challenges of obtaining sunlight in northern climates, with Breka advising a combination of sun exposure and supplementation. They touch on circulation and the role of vasomotor activity in overall health, and emphasize the importance of minerals and trace elements for bone health, arguing that calcium alone is insufficient and that regular loading and mineral intake are necessary for bone strength. The program closes with Breka summarizing the three core priorities (whole foods, sleep mastery, mobility), the value of genetic methylation testing, and resources available at TheUltimateHuman.com. Megan thanks Breka and teases returning guests and future topics. She hints at further exploration of health fundamentals, reflecting on the day’s discussions about aging, nutrition, and elite performance. She invites listeners to visit the website and teases the next show with Real Clear Politics and a special appearance by Doug Brunt.

Avoiding the sun may be just as dangerous as smoking cigarettes. There's an association between at least 17 different cancers and a vitamin D insufficiency and autoimmune diseases and cardiovascular disease. Vitamin D is intimately involved in over 2,000 different genes. Our immune system absolutely cannot work without vitamin D. 90 to 95% of vitamin D comes from the sun. Even in the early nineteen hundreds, they had sanitariums that you can go to to bathe in the sun as a cure for TB and asthma and many different illnesses. I mean, just think about the mainstream recommendation for sun by the American Dermatology Association. You must stay out of the sun, and if you're out in the sun, use sunblock because the sun is dangerous. I'm talking about a moderate amount of sun so you'd never burn.

- I talk a lot about vitamin D but I wouldn't recommend taking vitamin D by itself. - I would always take vitamin K2 with vitamin D because vitamin D3 increases calcium absorption in your intestines by 20 times and that ends up in the blood so you can have a lot of calcium in the blood which can be a problem for people especially if they're prone to kidney stones or arthritis but vitamin k two comes to the rescue and that takes the calcium from the blood and pushes it into the bone. - One of the really important things that vitamin K2 does is to prevent soft tissue calcium from accumulating. - That could be in your arteries or the joints or any organ. - So to protect you against any potential side effects of vitamin D3, make sure you take vitamin K2 at the same time. - And as far as the ratios go, for every ten thousand IUs of vitamin d three, take a hundred micrograms of vitamin k two.