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Fenbendazole is described as more than just a dog dewormer, comparing that description to saying water is only for lawns. It works on various animals, impacting cestodes, nematodes, flukes, and protozoa like giardia.
Fenbendazole isn't approved for human use because research is done on animals, while its cousins, mebendazole and albendazole, are researched on humans. Joe Tippins, diagnosed with small cell lung cancer, was sent home with hospice after chemotherapy led to metastasis. Following a vet's advice, he took fenbendazole, and within three months, his scans were clear.
Fenbendazole binds to microtubules, preventing mitosis and causing apoptosis, similar to taxanes and vinca alkaloids. It arrests cells, upregulates tumor suppressor genes like p53 and p21, and is similar to metformin in glucose control. It inhibits hexokinase two, which is upregulated in cancers to increase glucose uptake. It also helps the immune system recognize tumors and reverses tumor-associated macrophages.