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Speaker 0 lays out a concise hierarchy of health priorities centered on mitochondrial function. The core claim is that mitochondrial health is the foundation of longevity because if mitochondria cannot produce cellular energy efficiently, no supplement or gadget stack will compensate. The speaker asserts that the biggest mitochondrial killer is not aging itself but seed oils residing in cell membranes, which allegedly block the ability to produce cellular energy. This positions dietary fats at the top of the list of factors that influence mitochondrial performance, even above commonly pursued advancements like red light panels, peptide stacks, and continuous glucose monitors. From this perspective, the speaker cautions against spending thousands of dollars on gadgets or devices before addressing fundamental biological levers. The emphasis is on actionable, no-cost steps that directly influence mitochondrial energy production. The three recommended actions are presented as the essential, prior steps to optimize mitochondrial function before considering more advanced interventions. First, eliminate seed oils from the diet. The claim is that seed oils are a primary mitochondrial killer because they disrupt the mitochondria’s ability to generate energy, thereby undermining overall cellular health and longevity. Second, obtain morning sunlight within thirty minutes of waking. This step is framed as an immediate cue to enhance mitochondrial responsiveness to energy production, contributing to improved mitochondrial efficiency without any financial cost. Third, engage in movement for thirty minutes daily. The act of physical movement is described as another signal that mitochondria respond to immediately, reinforcing the link between activity and cellular energy generation. The speaker encapsulates these recommendations as a no-cost biohacking stack, emphasizing simplicity and immediacy. The exact components of this stack are: (1) no seed oils, (2) morning sunlight within thirty minutes of waking, and (3) thirty minutes of movement each day. The overarching message is that, before pursuing higher-cost interventions or devices, one should implement these three foundational practices, as mitochondria respond to them immediately and they establish a baseline for cellular energy production. The wording underscores speed and accessibility, suggesting rapid, tangible benefits from these actions prior to exploring other technologies or supplements.

Reason why we need so much coenzyme Q10 in our heart is because that is the part of the body that generates the most energy out of any part. I mean, it has to generate a lot of energy, and it's constantly beating 20 fourseven. It never really relaxes. And so you need this specialized coenzyme to maintain that energy. And because it produces all the energy, it comes with a lot of exhaust, so we also need to clean that up as well. So that's why coenzyme q 10 is so important.

B vitamins are recommended for low energy, as they deplete during stress. Vitamin B12 is particularly important, and adenosylcobalamin is the preferred form because it directly supports mitochondrial function, which produces energy. Sunlight exposure, grounding, and cold exposure, such as cold showers, can also boost mitochondrial function and energy levels.

Brain fog originates in the mitochondria, the energy factories within brain cells. The brain has more mitochondria than any other organ, utilizing 20% of the body's energy. Mitochondria generate energy from glucose using CoQ10 and from fat using acetylcarnitine. Mitochondrial dysfunction can starve brain cells, and is evident in neurodegenerative diseases before symptoms manifest. The speaker faced threats for using CoQ10 for hospital patients, despite its Nobel Prize recognition. The speaker recommends daily supplementation with CoQ10 1000mg, acetyl L-carnitine 1000mg, and PQQ 20mg to support brain energy.

Dr. Alexis Cohen (Jasmine Cohen) and the host discuss a wide-ranging view of health, science, and society, centered on mitochondria, light biology, and decentralized approaches to knowledge and healing. - On science, health, and authority: - Cohen argues that “we really haven’t been doing science for about seventy years now” and that modern science has become scientism, with people looking to scientists and doctors as authority figures over personal health, even though no one can fully know another’s lived body experience. - She emphasizes that aging is a reflection of mitochondrial heteroplasmy and that there are ways to slow or speed that burden, but contemporary living habits harm mitochondrial health. She asserts there are incentives to promote lifestyle advice that is not monetizable (outdoor activity, barefoot grounding, seasonal eating, movement), which she says slows research and access to information. - The conversation asserts a need to reclaim personal authority over health and to recognize life as magical and miraculous. - Personal entry into Bitcoin and crypto curiosity: - Cohen notes she and her partner became interested in Bitcoin in 2018, with a continued engagement including taking a cryptography course to understand the underlying proofs rather than accepting information at face value. - Background and work: - The host introduces Cohen as a Princeton-trained molecular biologist, a PhD focusing on metabolism, gut health, and circadian biology, who shifted from academic research to helping people rebuild health through nutrition, movement, mitochondrial function, and light exposure. Cohen shares that her own childhood illnesses, weight issues, and colitis prompted a pivot from academia to health coaching, emphasizing ownership of wellbeing through science and practical lifestyle strategies. - Cohen highlights that she values rigorous science but seeks practical lifestyle strategies to empower clients to understand their biology and take ownership of their health. - Dance, embodiment, and biology: - Cohen describes taking up social dancing (salsa, bachata, merengue, fox trot, hustle) and training intensely. She explains dancing challenges the brain in novel ways, requires being guided by a partner, and expands neural connections. - The host shares similar experiences with dance, noting body memory across decades and the importance of movement, rhythm, and social connection for health. - Mitochondria, heteroplasmy, and light: - Cohen explains mitochondria as the battery of the cell, with their own circular DNA and multiple roles in ATP production, biosynthesis, and epigenetic regulation. Heteroplasmy, the mutation burden in mitochondrial DNA, reflects dysfunction that can lead to energy production deficits across tissues. - She notes three key mitochondrial outputs: - ATP production powers cellular processes and metabolism. - Metabolic water production (including deuterium-depleted metabolic water). - Biophotons, photons largely in the UV range, emitted by mitochondria and nucleus during electron transport; older, sicker individuals emit more light due to increased permeability of the system. - Cohen argues aging mirrors mitochondrial heteroplasmy and mutation accumulation, with higher mutation burdens in tissues like immune cells, gut, liver, and brain associated with disease. She also discusses that mitochondria contribute to energy, water, and biophotons, and that modern life elevates heteroplasmy by lifestyle choices. - She argues heteroplasmy can be slowed or sped, and that there are actionable interventions—though the exact list is not exhaustively enumerated in this segment. - Why mitochondrial health isn’t the central target: - Cohen says mitochondrial health research is less profitable because it emphasizes lifestyle and environmental changes rather than drugs, which affects funding and research direction. She describes a system where focusing on broad environmental and lifestyle changes could be financially less lucrative than drug-centered approaches. - She expands on historical dynamics in science, including siloing of scientists and the development of a paywalled academic publishing model, suggesting that the system discourages holistic, integrative approaches that would unify mitochondrial biology with systems biology. - Light, circadian biology, and UVA/UVB: - The discussion shifts to light as a regulator of mitochondria. Cohen divides the sun’s spectrum into ultraviolet (UVB and UVA), visible light, blue light, and near infrared (NIR). She emphasizes that near-infrared light penetrates deeply and stimulates mitochondria, while UVB promotes melanin production via POMC and MSH peptides, affecting energy balance, mood, and metabolism. - UVB light triggers alpha-MSH and beta-endorphin production, the latter contributing to mood and dopamine support, and helps regulate energy expenditure and appetite via POMC-derived pathways; UVB exposure supports melanin synthesis, redox balance, and photoreception across tissues. - UVA light activates Neuropsin receptors on eyes and skin, aiding circadian entrainment and nitric oxide production, which improves vasodilation and nutrient delivery. Neuropsin is present in skin and testes; its stimulation is linked to testosterone and fertility enhancements. UVA also helps anchor local circadian rhythms in tissues. - Cohen discusses the misperception that UV light is universally harmful and argues that melanin is not only protective but can facilitate energy capture from high-energy photons to support energy metabolism in humans. Melanin’s roles extend beyond protection to potential energy transduction, with POMC, MSH, and alpha-MSH linking light exposure to metabolic regulation. - The My Circadian app is recommended as a tool to track sunrise, UVA/UVB rise, and lux (brightness) to optimize exposure. Cohen notes indoor environments rarely exceed 1000 lux, while outdoor brightness can reach 60,000–60,200 lux, significantly impacting serotonin production, mood, and cognition. She emphasizes the importance of bright daytime light for circadian alignment and melatonin suppression at night. - Infrared, LEDs, and indoor lighting: - The conversation covers lighting technologies, noting fluorescent tubes and LEDs minimize near-infrared and maximize blue light, which disrupts circadian rhythms and flicker, stressing the eyes and sympathetic nervous system. Cohen argues that modern lighting deprives people of infrared and UV radiation, both critical for mitochondrial function and circadian health. - She criticizes the push for energy efficiency that reduces thermal and infrared energy, arguing it contributes to systemic health issues. She emphasizes the importance of incandescent and near-infrared-rich lighting for indoor environments and sun exposure to sustain metabolic health. - Grounding, EMF, and environmental exposure: - Grounding (direct contact with the earth) is presented as a way to discharge excess positive charge in tissues, reducing inflammatory burden and supporting mitochondrial function. Cohen shares practical grounding instructions—grounding directly to the earth when possible, wearing natural fibers, and using grounding footwear. - Non-native electromagnetic fields (EMFs) from Wi-Fi, Bluetooth, 5G, and other sources are discussed as contributors to mitochondrial dysfunction and inflammation. Cohen cites Robert Becker’s historical work on non-thermal EMF effects and Havana syndrome as context for potential biological risks. She suggests practical mitigation, including reducing EMF exposure, using Ethernet where possible, and using tinfoil to shield exposure in certain situations. Plant life can absorb EMF, and grounding, sunlight, and strategic use of red and infrared light are recommended to compensate where exposure is high. - The discussion includes practical home strategies, EMF-blocking window panels, EMF-blocking paint, and even temporary shielding (e.g., tinfoil) as a do-it-yourself mitigation approach. - Travel, circadian disruption, and protocols: - Cohen outlines travel challenges: high altitude cosmic radiation exposure (non-AVMF exposure), cabin EMFs, circadian misalignment, and sedentary behavior. She suggests pre- and post-travel strategies such as grounding, sun exposure, hydration, lymphatic support, and blue-light management to ease time-zone transitions. - She promotes an ebook protocol focused on lymphatic support and circadian realignment, available for purchase, with a holiday discount code holydays. Blue-light blocking strategies and red-light strategies are included to facilitate adaptation to new time zones. - Health, mental health, and pediatric considerations: - The hosts discuss mental health concerns, including PTSD, anxiety, and depression, emphasizing circadian regulation, light exposure, sleep hygiene, and reducing screen exposure. Cohen notes the importance of bright daytime light and a dark, cool sleeping environment for sleep quality and mood. She mentions a study showing even small nighttime light exposure can influence daytime metabolic markers, emphasizing the importance of darkness at night. - Birth, medications, and vaccines: - They touch on birth experiences, epidurals, and how early life interventions can influence long-term health and microbiome development. Cohen discusses pain as a portal to healing and critiques reliance on certain pharmaceutical approaches. - On vaccines, Cohen describes observed adverse effects post COVID-19 vaccination, including histamine issues, barrier permeability, and rapid cancer reports linked to vaccine exposure, while underscoring the lack of widespread funding to investigate these relationships. She mentions turbo cancers and batch variation as topics already discussed by researchers like Kevin McKernan and a need for independent inquiry. - Decentralization, science, and Bitcoin again: - Cohen envisions a decentralized health system in which multiple modalities (acupuncture, Chinese medicine, Ayurveda, allopathic medicine) can be tested for proof of work, with outcomes guiding what works best for individuals. She believes decentralization is necessary for genuine innovation, with a future vision of a decentralized, funded light research lab and a retreat model to study circadian biology, mitochondrial function, and nature-based health in diverse environments (North America and equatorial regions). - She sees Bitcoin as a tool that enables financial sovereignty and autonomy, providing an opportunity to fund decentralized science and publish findings on blockchain to protect against censorship. She highlights the potential for Bitcoin to support a lab through deflationary funding and to empower researchers and patients alike. - Closing: - The conversation closes with practical resources: Thinkific-hosted classes, an online book club, and a QuantumU course that reframes science education around decentralized, nature-based principles. Cohen emphasizes accessible contact options (Instagram and email) and a holiday discount for courses and ebooks. The participants express enthusiasm for ongoing collaboration, travel and events, and continued education in Bitcoin, science, and holistic health. Overall, the episode centers on mitochondria as a foundational health driver, the essential role of light and circadian biology in energy, mood, metabolism, and aging, and a call for decentralized, nature-aligned science, with Bitcoin framed as a funding and governance tool to empower individuals and researchers to pursue health innovation beyond centralized institutions.

First thing that happens in your body when you experience a glucose spike is that your mitochondria, the little factories inside of each of your cells, they get stressed out. But if your mitochondria are hurt, stressed out, overwhelmed, then it's a completely different story. That is a symptom of your mitochondria being overwhelmed. So even though your mitochondria love transforming glucose into energy and that's their job, if you give them a big glucose spike, if they see this mountain of glucose arriving too quickly, they get stressed out, they shut down and they can't make energy as efficiently anymore. Cue chronic fatigue. That's the first thing that happens in your body when you spike.

We all know that getting older is inevitable, but how we age is something we have a lot of control over. And, of course, we talk about food and sleep, no doubt, but we also have to spend some time talking about supplements. And today, we're talking about a formula that helps increase levels of NAD plus NAD plus is a game changer. It's an anti aging game changer because it's a coenzyme, which means it's a helper molecule found in every single cell in your body, and it's critical for energy. Because as we age, our NAD levels go down, which affects how we produce energy. Less NAD means your cells aren't functioning at their peak. So we need to give ourselves the resources that they need to function optimally.

Mitochondria generate energy via ATP, but new research suggests they are more than just energy factories; mitochondrial dysfunction is linked to diseases like diabetes, autism, and cancer. To support mitochondria, one must stress them through hormesis, where "what doesn't kill you makes you stronger." Five ways to stress mitochondria include: intermittent fasting (practiced differently by men and women), cold exposure (cold showers or cryotherapy), sauna (heat exposure activates heat shock proteins), exercise, and gratitude. Research indicates happier people are healthier, and being in a grateful state activates the parasympathetic nervous system, balancing the autonomic nervous system. Gratitude, or "vitamin G," may contribute to healthier mitochondria.

Mitochondria, you know, the energy producers, the powerhouses within every cell. Brain cells may have as many as a thousand mitochondria in each neuron. Mitochondria are seen diffusely throughout the body in virtually all of our cells, interestingly, not in our red blood cells, but certainly in our white blood cells. And having good mitochondrial function and numbers within our white blood cells, is an important player as it relates to a proper effective immune function and keeping, inflammation in balance. They recognize the importance of dysfunction or problems with the mitochondria, as being a major risk factor in things like obesity, diabetes and hypertension.

Speaker 0: The discussion centers on mitochondria as the energy factory of the cell and how a shortened lifespan can stem from problems with this organelle. There are a few factors and variables involved: the quality of the fuel entering the mitochondria, and the biochemical reactions that take that food and extract different things to turn it into energy, specifically in the form of ATP, at the end of this entire assembly line. Every single biochemical reaction that occurs inside this system requires vitamins, minerals, and trace minerals. Nutrition is essential for proper mitochondrial function, with specific nutrients highlighted as critical: B1, B2, B3, B5, Coenzyme Q10, and the trace minerals manganese, zinc, iodine, copper, and magnesium. The speaker emphasizes that these elements are vitally important for the mitochondria to function. The implication is that without these nutrients, the mitochondria will not operate well. In contrast, consuming too much junk food is suggested to impair mitochondrial function, contributing to dysfunction. The overall message is that there can be a couple of reasons why the mitochondria do not function correctly, including inadequate or imbalanced nutrition and excessive junk food intake, which can disrupt the energy production process that mitochondria are responsible for.

B vitamins, especially B12, are recommended for low energy, as they are depleted during stress. It is claimed that not all B12s are equal, and adenosylcobalamin is the preferred type. This form of B12 is said to directly benefit the mitochondria in cells, which produce energy. Sunlight exposure, grounding, and cold exposure, such as cold showers, are also presented as ways to boost mitochondrial function and energy levels.

Today I want to talk about the newest addition to the longevity formula PQQ, also known as the longevity vitamin. What makes PQQ so unique is it works at the cellular level to increase the amount of mitochondria. We call that mitochondrial biogenesis. As we age, we naturally start to lose mitochondria, which gives us less cellular energy. The less cellular energy, the less energy you will feel, but also your body won't function as well. We can short circuit that process by utilizing PQQ. If we can increase mitochondrial biogenesis in our brains, it will help our cognition, it's going to help our memory, it's going to help you verbalize things better. But it doesn't just work in our brain, it works all over your body, including in your white fat cells. By increasing mitochondria, we can convert them into their more metabolically active brown fat cell version.

So NAD is what might those mitochondria, little micronite, little energy producing things use to make energy. So you you need there are two molecules in the body that are really great. You need both for life. And without them, as I said, you're dead. ATP is the energy, and NAD makes that. And as we get older, the levels of NAD go down. Our body makes less and actually also degrades it more. Yep. So I if you take my skin or in the study that they took people's skin, when you're 50, you've got half the levels of this NAD that you did than you did when you're 20, which is scary because this is this molecule is required for

Testosterone production requires healthy mitochondria because the steroid precursors to testosterone are synthesized by the is road And other of the best things you can do to stimulate mito biogenesis. That is the production of new healthy mitochondria. Mitochondria. This thing is fucking awesome. The speaker ties testosterone synthesis to mitochondrial health, implying that steroid precursors are produced in mitochondria and that promoting mito biogenesis—the production of new healthy mitochondria—is beneficial. They express strong enthusiasm for mitochondria, calling them 'awesome.' Because the claim links hormone production to mitochondrial function, the discussion frames mitochondrial biogenesis as a potential mechanism to enhance testosterone synthesis, emphasizing new healthy mitochondria as the key outcome.

Mitochondria are cells that function as battery-making machines, producing ATP, the body's energy currency. The body makes its weight in ATP daily, but ATP is not stored; it's made on demand. To increase energy levels, it's important to support mitochondria with cofactors like B vitamins, magnesium, zinc, and coenzyme Q10, as well as specific foods. For more information on increasing energy, the speaker recommends watching their YouTube video on fatigue.

PQQ, or paralloquinolone quinone, is the newest addition to the longevity formula and is known as the longevity vitamin. PQQ works at the cellular level to increase the amount of mitochondria through mitochondrial biogenesis. As we age, we lose mitochondria, resulting in less cellular energy and decreased bodily function. PQQ can short circuit this process. Increasing mitochondrial biogenesis in our brains can improve cognition, memory, and verbalization. PQQ also works throughout the body, including in white fat cells. By increasing mitochondria, white fat cells can be converted into metabolically active brown fat cells.

We have ATP, but it's really electromagnetism, not an energy currency. Without ATP, proteins won't unfold, gel won't form, and there will be no electromagnetism, energy, or life. Gilbert Ling showed ATP doesn't have more energy than other chemicals.

Mitochondria generate energy, but also possess intelligence and DNA. Mitochondrial dysfunction is linked to diseases like diabetes, autism, and cancer. To support mitochondria, you must stress them through hormesis, where "what doesn't kill you makes you stronger." Five ways to stress mitochondria include: intermittent fasting, which men and women practice differently; cold exposure via cold showers or cryotherapy; sauna use to activate heat shock proteins; exercise to create energy demand; and gratitude, which activates the parasympathetic nervous system. Research suggests happier people are healthier, and being in a grateful state balances the autonomic nervous system. Gratitude is "vitamin G."