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Suleika Jaouad, an artist and Emmy award-winning columnist, shares her journey with cancer, beginning with her leukemia diagnosis at 22. After going into remission, her cancer returned a decade later, coinciding with her husband John Batiste's rise in the music industry. Suleika describes feeling stuck while the world moved on, emphasizing the emotional challenges of living with an indefinite diagnosis. She recounts how her experience in the hospital led her to adopt the role of a war correspondent, documenting her journey through journaling, which later became her New York Times column, "Life Interrupted." Suleika reflects on the pressure to be productive during her illness, initially wanting to use her time in the hospital to read and achieve lofty goals. However, she found herself stripped of ambition and instead turned to creative expression through journaling and painting. Her parents' creative projects during her illness inspired her to engage in her own artistic endeavors, leading to a sense of agency amidst her limitations. The conversation touches on the societal narratives surrounding illness, particularly the expectation to emerge transformed. Suleika challenges these narratives, advocating for the importance of sharing the messy, uncertain aspects of illness. She emphasizes the need for rituals to mark transitions in life, particularly for those who have experienced trauma. Suleika's writing and creative work became a means of processing her experiences and connecting with others. She embarked on a road trip to meet individuals who had reached out to her, exploring their stories of resilience and healing. The discussion also highlights her relationship with John, who supported her throughout her illness and continued to pursue his music career. As she navigates her current health challenges, Suleika has shifted her perspective to live each day as if it's her first, focusing on curiosity and small joys rather than urgency. She acknowledges the ongoing uncertainty of her health but finds solace in creative expression and connection with others. The conversation concludes with reflections on the importance of embracing change and the power of choice in response to life's challenges.

Emily Levine shares her experience with Stage Four lung cancer, emphasizing her acceptance and gratitude for life despite its challenges. She discusses her past struggles with reality, ultimately finding joy in embracing it. Levine critiques the mindset of those who seek to defeat death, arguing it disrespects nature and life. She celebrates the cyclical nature of existence, viewing death as a part of the gift economy. Her perspective highlights the importance of connection and interaction in creating a meaningful reality.

Dax Shepard reflects on his father's passing ten years ago, sharing memories of their journey through cancer. His father, David Robert Shepard, died at 62 from small cell carcinoma. Dax recalls their partnership in navigating treatment decisions and the emotional moments they shared, including therapeutic car rides and visits to favorite restaurants. Despite the challenges, Dax's father's vibrant personality shone through, especially in his interactions with friends and nurses. The bond they formed during this time was profound, culminating in a final connection with Dax's pregnant wife. Ultimately, his father's passing was peaceful and filled with gratitude.

In this episode of Armchair Anonymous, hosts Dax Shepard and Monica Lily Patman discuss intense 911 call stories, starting with Abby from Indiana, who recounts a terrifying incident where she and her fiancé were shot at just days before their wedding. Abby describes waking up to gunfire, her husband urging her to crawl to safety, and the police discovering 43 bullet holes in their home. The attack was a case of mistaken identity linked to a previous resident's criminal activity. Despite the trauma, Abby found solace in her wedding, which occurred shortly after the incident. The conversation shifts to Michael, who shares a harrowing experience as a teacher when a student collapsed during class. He called 911, and despite attempts to revive her, she died from a heart attack. The sister of the deceased remained unfazed, attributing her sister's death to poor health choices. The episode highlights the unpredictability of life-threatening situations and the emotional aftermath of such experiences.

Ashley Kane shares his profound journey of grief after his daughter, Alia, was diagnosed with AML leukemia shortly after her birth. He describes the emotional turmoil of learning about her aggressive illness, the challenges of hospital life during COVID, and the determination to create a positive environment for her. Despite initial hope through chemotherapy, Alia relapsed, leading to a desperate search for alternative treatments, including a stem cell transplant. Kane organized a massive donor campaign, resulting in hundreds of thousands of people registering to help. As Alia's health deteriorated, Kane faced the heartbreaking reality of bringing her home to die. He emphasizes the pain of losing a child and the darkness that enveloped him during that time. Yet, he also highlights the beautiful moments shared with Alia, cherishing every second they had together. After her passing, Kane struggled with grief and contemplated suicide but found a renewed purpose through his daughter's legacy. He now channels his pain into raising awareness for childhood cancer, founding the Aelia Foundation, and engaging in extreme physical challenges to honor Alia. Kane stresses the importance of embracing grief, talking about lost loved ones, and appreciating life. He encourages others to show up daily, find strength in their struggles, and understand that grief can coexist with love and beautiful memories. His mission is to ensure that Alia's spirit lives on while helping others facing similar battles. For updates, he invites people to follow him on Instagram and through the Aelia Foundation.

In 2011, Suleika Jaouad was diagnosed with leukemia at 22, facing a 35% chance of survival. Over four years of treatment, she adapted to her new reality, eventually writing a column for the New York Times. After surviving, she struggled with the myth of the heroic journey, realizing recovery's challenges were often overlooked. Jaouad embarked on a 15,000-mile road trip to connect with others who understood her experience. She learned that the divide between the sick and well is porous and that true wellness involves accepting life's complexities and finding meaning in the messiness of existence.

Kate Bowler shares her journey after being diagnosed with stage four cancer at 35, just as she was embracing motherhood and her dream job. She reflects on the Prosperity Gospel, which promises rewards for good behavior, and how her diagnosis challenged her beliefs. Bowler emphasizes the lack of correlation between hard work and life outcomes, revealing that suffering can foster deep connections and love. Despite the chaos, she finds beauty and love in her experiences, learning to live without needing reasons or assurances, embracing both the hardships and joys of life.

A man faces a terminal illness with a radical idea: medicines we already have can cure what we lack. David Fajgenbaum’s journey begins with his mother’s brain cancer, a losing battle that fuels his vow to change medicine. As a medical student, he nearly dies from idiopathic multicentric Castleman disease, enduring dialysis, brief blindness, and last rites. He survives after intensive chemotherapy and vows to find treatments for others, while starting a grief support group named AMF, later Actively Moving Forward. Before long, chemotherapy isn’t enough. He discovers the drugs saving his life were not designed for Castleman’s, and asks: could there be an eighth drug repurposed from another disease? He researches globally, stores blood and tissue, and asks doctors to try drugs used elsewhere. In this crucible, he identifies a key insight: a drug to prevent organ rejection can suppress a harmful immune signal driving Castleman’s. He begins sirolimus and, after relapses, reaches durable remission, marrying Caitlyn in 2014 as his hair regrows. AI becomes his partner. He and Grant Mitchell co-found Every Cure to scan all 4,000 FDA-approved drugs against 18,000 diseases using a biomedical knowledge graph. The goal is to reveal which medicines might treat which conditions. In the first phase, 75 million matches are scored; the team of about 50 has reviewed the top 6,000, deep-dived into roughly 60–70, and advanced about 15 toward plans. Nine programs are active, including lidocaine for recurrence and a Jack inhibitor for Castleman’s. Nonprofit funding plus ARPA-H supports scale. The human side continues. They share successes: Michael with metastatic angiosarcoma responded to pembrolizumab; Kyla, a Castleman’s patient, improved after a JAK inhibitor; Joey, a child at CHOP, showed rapid lab improvements. Caitlyn’s unwavering support culminates in their wedding day. They discuss dissemination: UpToDate is imperfect, and knowledge must reach doctors worldwide, not just scholars. They envision a future where AI-guided matches are tested in labs and moved into trials, expanding access and reducing suffering for thousands. The mission: unlock hidden cures in existing drugs and spread them widely.

In this episode of the Tim Ferriss Show, Tim interviews Suleika Jaouad, author of the New York Times best-selling memoir *Between Two Kingdoms* and creator of *The Isolation Journals*. Suleika shares her journey through a life-altering leukemia diagnosis shortly after graduating college, which led her to explore themes of mortality, resilience, and the human experience. Suleika recounts her experience reporting on a prison hospice in California, where inmates care for fellow prisoners in their final days. This immersive experience challenged her preconceptions and highlighted the compassion and redemption found in unexpected places. She reflects on how her own encounters with mortality during her illness reshaped her understanding of life and identity. After her diagnosis, Suleika faced a long and isolating treatment process that included a bone marrow transplant. She initially resisted the label of a cancer patient and sought to maintain her identity. However, she soon realized that her experience of illness was not just a temporary interruption but a profound transformation. She began journaling as a way to process her feelings, leading to the creation of her *New York Times* column, *Life, Interrupted*, which documented her journey. Suleika emphasizes the importance of vulnerability and connection, sharing how her road trip across the U.S. allowed her to meet individuals who had faced their own struggles. These encounters helped her navigate her own healing process and understand the complexities of trauma and recovery. She advocates for embracing vulnerability as a means to foster intimacy and connection with others. The conversation also touches on the significance of journaling, with Suleika sharing prompts that encourage reflection and self-discovery. She highlights the power of writing to articulate feelings and experiences, especially during challenging times. Ultimately, Suleika's story is one of resilience, creativity, and the ongoing journey of finding one's place between the kingdoms of the well and the sick.

Megyn Kelly welcomes Dr. Roland Griffiths to discuss psilocybin, a naturally occurring compound in magic mushrooms, which is gaining attention for its potential therapeutic benefits in treating depression, anxiety, addiction, and more. Dr. Griffiths, a respected scientist at Johns Hopkins University, emphasizes that his research is grounded in science, not recreational use. He recounts how psychedelics were heavily studied in the 1950s and 60s but faced stigma and regulatory restrictions due to the War on Drugs. Dr. Griffiths explains that his studies involve healthy volunteers who are psychedelic-naive, ensuring unbiased results. Participants report profound, mystical experiences that often become some of the most meaningful events in their lives. Remarkably, many participants describe these experiences as life-changing, leading to lasting positive effects on their worldviews and behaviors. He highlights the importance of trained therapists in guiding these sessions to mitigate risks, such as panic attacks or potential long-term psychotic disorders in vulnerable individuals. Dr. Griffiths also discusses the differences between psilocybin, ketamine, LSD, and MDMA, noting that while psilocybin is a classic psychedelic, ketamine is a dissociative anesthetic with different effects. The conversation shifts to a study on cancer patients, where psilocybin significantly reduced anxiety and depression, helping patients find peace with their mortality. Dr. Griffiths shares his personal journey after being diagnosed with stage four cancer, expressing gratitude for life and emphasizing the importance of mindfulness and compassion. He encourages others to embrace the preciousness of life and remain open to transformative experiences.

Tommy Rivers Puzey, known as Tommy Rivs, is an elite marathoner and ultra runner who faced a life-threatening battle with a rare form of lung cancer in 2020. Despite the odds, he survived and shares his journey of resilience, emphasizing the importance of gratitude, positivity, and community. He reflects on how his experience with endurance sports prepared him for the challenges of illness, highlighting the significance of focusing on what one can control and the emotional energy invested in maintaining a positive attitude. Tommy discusses the support from his wife, Steph, who balanced the harsh realities of his diagnosis with hope for recovery. She shielded him from the dire details of his condition while encouraging him to apply his endurance training mindset to his health journey. He acknowledges the emotional toll of his illness, including the struggle with pain management and the challenges of recovery, such as relearning basic functions after being in a coma. Throughout the conversation, Tommy emphasizes the miracle of life and the importance of recognizing happiness in the present moment rather than waiting for an ideal future. He shares profound insights about the interconnectedness of humanity and the reciprocal relationship with nature, learned during his time in Hawaii. His philosophy centers on service to others, the power of community, and the necessity of cooperation in overcoming life's challenges. Tommy's journey has transformed his perspective on life, urging him to appreciate each moment and the people around him. He expresses gratitude for the support he received during his illness and the kindness of those who rallied around him. His story serves as a reminder of the fragility of life and the importance of living fully in the present, cherishing the connections we have with others. As he continues to recover, Tommy finds joy in simple experiences, such as spending time with his daughters and being in nature. He acknowledges the ongoing challenges of his health but remains optimistic about the future, focusing on the lessons learned from his journey and the beauty of everyday life.