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- We need to stop trusting the experts. - We were told at the beginning of COVID, don't look at any data yourself. Don't do any investigating yourself. Just trust the experts. - And trusting the experts is not a feature of science. It's not a feature of democracy. It's a feature of religion, and it's a feature of totalitarianism. - In democracies, we have the obligation, and it's one of the burdens of citizenship, to do our own research and make our own determination. - And we're gonna give people gold standard science. We're gonna publish our protocols in advance. - We're going to tell people what we're doing, and then we're gonna use data, and we're gonna publish the peer reviews, which is never published by CDC studies. We're going to publish any time that we can the raw data, and then we're going to require replication of every study, which never happens at NIH now. That's something new that we're bringing in, is that every study will be replicated.

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A Stanford scientist, John Iannidis, wrote a convincing paper in 2005 titled, Why Most Published Biomedical Papers Are False. The reasoning is not due to scientific fraud, but because science is difficult. When a statistically significant result is published, such as P equals 0.05, it means that some percentage of the time, the result will be false, even after peer review. Peer review involves colleagues reading the paper and looking for logical flaws, but not rerunning experiments or reanalyzing data. Peer review is not a guarantee of truth. Given the inherent difficulty of science, any published result has a high likelihood of being a false positive.

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Every day, just the 1% of the cells of your DNA that gets replicated stretches from here to the sun four times. If you're to line it up end by end, that's very hard to conceptualize. But it should give you a little bit of humility before you go and start monkeying with it with these vaccines that can actually alter your DNA. And that's what I'm gonna show you. Is that the vaccines had a DNA contamination in them that didn't tell you about that could in fact alter your genome. Alright? These people are vibe coding your genome. And this is a major attack surface to the human gene pool because if this thing starts to alter the lifespan of people, it's going to part you with your Bitcoin. You're gonna end up spending money in a fiat system that has no controls, has no liability, and ends up oftentimes inducing mandates to get what it wants done. Many people had have peer have gone and replicated this work. It happened on Twitter. It did not happen very quickly in the peer review system. The peer review system kinda kicked it out. Some of these papers have now been peer reviewed, but it took years for them to come to this conclusion. Now, the FDA, the EMA and the TGA have all admitted that this mistake has happened. How did it happen? There's a big bait and switch. Pfizer actually ran the trial of 22,000 people on the process on the left and after they got to the trial, they then switched to the process on the right and didn't retrial the drug. And in doing so, they left a tremendous amount of excess DNA behind in the product. So all of the vaccine efficiency numbers you've heard in the news are flawed. They're not real because that's not what actually went into the trial. What went to the public was actually something that came out of this process too. It's published now in the BMJ that this fraud happened and no one has yet been prosecuted for it. So what did they leave in there? What they left in there was something we know from the polio scandal. If you're not familiar with the polio scandal, that polio vaccines were also contaminated with something known as SV40 and it created a massive cancer wave. Now the whole virus isn't in these vaccines, but there is a very curious part of this called the SV40 region that Pfizer intentionally removed from the disclosure that they gave to the FDA. So the FDA has admitted that this SV40 material is in there. They did not spell this out to the regulators. The regulators did not find them and they're actually running cover for them saying this DNA is too little consequence to matter, it's too small, and it's not functional. But we know it's functional because Dean et al has published that this piece of DNA drives DNA straight to the nucleus. It gets used in gene therapy vectors.

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Danish study on aluminum in vaccines should be retracted, scientists say. The article by doctor Hvid, an apologist for aluminum in vaccines from Denmark, was caught. The first appendix published with the journal was not the right one; after press hoopla, the correct statistics were published. Senior scientist Collie Blanowski analyzed and said, 'they lied.' There is a 'statistical correlation between higher doses of aluminum' in their data, showing that people who got more aluminum had higher rates of autism, ADHD, and other neurodevelopmental problems, and it should be retracted. If you remember back in COVID, the surgosphere study was 'completely laced with fraudulent data, and it was retracted.'

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Speaker 0: Asked about the system of retractions and whether retracting a paper discredits a hypothesis, and on what basis retractions occur. Speaker 1: Responded that quoting papers that are later retracted does not negate a hypothesis; there is no rule requiring a hypothesis to be retracted if a cited paper is retracted after publication. They note that the practice involves harassing journals rather than logically disproving a hypothesis. For example, they may present a dozen questions to the journal, answer all of them, and then continue harassing the journal to the point that the journal ignores the answers and retracts the paper to avoid further harassment.

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Ideas are just concepts to explore and discuss, and you shouldn't be attached to them. The issue arises when people become possessive, wanting their ideas to prevail, often leading to dishonesty. Individuals may manipulate information or dismiss opposing views unethically to advance their careers. Academia and media often reward this behavior, especially when it results in high-profile publications. Ultimately, there's a tendency to prioritize personal success over truthfulness.

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Science is often misunderstood. Many people with advanced degrees only trust peer-reviewed papers and ignore observation, thinking, and discussion. This narrow view is pathetic. Academia values peer-reviewed papers, but this blocks new scientific insights and advancements. Breakthroughs in science usually come from the fringe, not the center of the profession. The finest candlemakers couldn't have imagined electric lights. Our ignorance and stupidity may lead to our downfall.

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The speaker discusses the finding of plasmids in Pfizer vaccines, referencing a widely read paper that initiated inquiry into the consequences of this residual contaminant. David Speaker replicated this work in Canada, finding it in every one of over 30 vials. Philip Buchholz replicated this in South Carolina, and Dr. Sid Lee replicated the work using different primers and Sanger sequencing. Bridget Koning has replicated this in Germany, and several federal agencies have admitted the presence of DNA, though disagreeing on clinical implications. Ulrich Kammerer's lab replicated the work, transfecting plasmids from the vaccines into cell lines, where they persisted for several cycles of cell division. High schoolers interning at the FDA White Oak facility also measured it and found it to be significantly over the limit. Numerous studies have replicated these findings, with most finding levels over the limit. One individual with ties to Moderna claims it is not over the limit. Kaiser et al. claimed to have found it slightly over the limit but deemed it inconsequential; however, their DNA isolation method has been refuted by Kommer and Konig.

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The gold standard in scientific research requires replication, which is currently lacking at the NIH. At least 20% of NIH budgets should be allocated to replication studies, and all science should be published with raw data and peer reviews. A notable example is a 20-year-old NIH study on amyloid and Alzheimer's, which incorrectly claimed amyloid plaques were the cause. This led to the cessation of alternative hypotheses and resulted in 800 studies based on a fraudulent premise, wasting two decades in the search for a cure. It's crucial to eliminate outdated practices and ensure transparency and replicability in scientific research.

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Kendall asks for an explanation of the process by which the MMR vaccine causes autism, referencing the movie Vaxxed. Speaker 2 responds that they are currently researching those questions, as parents and physicians have reported children developing autism immediately after the MMR vaccine. The speaker claims studies that should have been done long ago were not. Instead, the speaker alleges that captured researchers at the CDC, mainly people who work for the pharmaceutical industry, produced bad epidemiological studies. The speaker asserts that these studies deliberately avoided comparing health outcomes in vaccinated versus unvaccinated groups. Speaker 0 states that this is one of the things they are studying now with gold standard science. Speaker 2 confirms they are doing gold standard science, which includes replication. They are allocating about 20% of their budget to replicating studies. Speaker 0 explains replication as an independent group repeating a study with the same parameters and data sets to achieve the same result. Speaker 2 agrees.

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A PDF crowdsourced document that I believe CNN put out was sent to me by a New York Times reporter researching me, citing 200 different studies on vaccines that supposedly used placebo. I spoke with Dr. Joel Worsch, a pediatrician with an MS in epidemiology who wrote a book and is credible, neutral, and honest, and he says we don't know. There's not enough data to know. He breaks it down: the vast majority of these studies are not on the CDC schedule; many used active comparables, not inert placebo. After filtering, 25% of these studies pertain to vaccines on the schedule. Of those, inert placebo is used in about 5% of items. Longitudinal safety studies are zero; perhaps one or two were prelicensing. Journalists do their job: I spoke to doctor Joe; here's what I found. Cognitive dissidence is described as insecurity about flaws in the party.

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Science hinges on replication, yet NIH stopped enforcing it, creating incentives to publish even when hypotheses fail. Null results often go unpublished, and journals resist publishing critiques of vaccines due to pharmaceutical funding. Editors like Marcia Engel and Richard Horton have lamented that journals have become propaganda vessels for pharmaceutical companies. Pharma pays to publish, hires mercenary scientists to validate products, and preprints spread favorable findings. Pharma reps visit doctors to influence prescribing. It is claimed that 50% of revenues to most pediatricians come from vaccines, and insurers offer bonuses for high vaccination rates, pressuring doctors to follow schedules. Corporate ownership now surrounds practice, with many doctors employed by corporations and facing revenue pressure. The system is described as incentivized to keep people sick, and the conclusion is we’re the sickest nation in the world.

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Big Pharma, they own everything. There's a number of past chief editors of journals, and we're not talking just, you know, like some throwaway journals. We're talking New England Journal of Medicine, Lancet, British Medical Journal. Okay. Some of the biggest journals in the world. Those are top three out of the top four that I just named. Journal of American Medical Association is the other one. But chief editors in the last twenty years, at least six of them have come out and said that at least 50% of the science that's published is fake. Come on. Read their quotes. Marcia Angel is one of them that I can remember her name. There's a guy by the name of Richard something or other from the British Medical Journal who said the same thing. I just read an article about it the other day. I'll I'll send it to you because it's I'm not surprised. I mean, depth of corruption is is stunning and and the fact that pretty much nothing's been done about it makes you wonder how long this can all last.

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People leaving universities with advanced degrees only trust peer-reviewed papers, stifling new scientific insights. Breakthroughs often come from outside the mainstream, not the center of a profession. This narrow view of science is blocking progress and may lead to self-destruction.

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I mean, it's become a joke. These papers that are winning awards at the American College of Gastro, and they're not getting published. So and what I do is I do what I do best, which is basically stir up shit, and I call all my friends. And I go, by the way, my paper has been retracted. That paper of the finding COVID in the stools Yeah. Was considered to be retracted. So, I called Trial Site News, and I said, by the way, you may wanna investigate. That's how they found out about the publishing house, private publishing house that is retracting these papers. So somebody must be paying them. And then I called all my colleagues, Mayo Clinic, Harvard, Yale, and I go, by the way, remember that paper that I found COVID? Well, it got retracted. And they're like, what? But it it passed peer review. Well, your peer review means nothing. And here's the thing. So guess what? You're not getting paid to do these peer reviews. Maybe you should start charging the journals now because clearly, they're going about wasting your time reviewing a paper, and they're going behind your back to retract the paper because it doesn't fit the narrative. So, that's what I do. So, and then the other thing that I did is I called the National Institute of Standards, Scott Jackson. And I basically said, remember my paper that we found COVID in the stools, and you also found COVID in the septic tanks? Well, my paper was retracted. And, you know, they couldn't believe it. They could this is at the government level. People are waking up to see we have a problem. Yeah. This is like the burning of the books.

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176 drugs that were considered safe and effective, but now are off the market because they found they were quite dangerous. Accutane, they took it off the market because they found it creates liver damage after twenty seven years. Hey, these things were backed by science. But I think the worst of the worst is that industry is allowed to cherry pick their data and not have to publish the studies that don't align with what they want. So the main question is who is funding the study, which many times gives grants to universities. And then you have industry, which then also funds the universities. And then we allow industry to pay certain individuals who sit on boards and committees that regulate a lot of the guidelines in our health care. Unfortunately, what we're missing in science is this thing called ethics.

Mind Pump Show

You Can't Fully Trust Scientific Studies! This Is Why Can Anecdote Trump Data | Mind Pump 1869
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The discussion emphasizes the importance of balancing scientific findings with conventional wisdom in health and nutrition. The hosts caution against being overly reliant on studies without considering biases and the broader context. They highlight issues with studies on sodium intake, cholesterol, and coffee, pointing out that many conclusions are drawn from poorly controlled research or fail to account for lifestyle factors. The conversation also touches on the historical misguidance in dietary recommendations, such as the preference for margarine over butter and the demonization of egg yolks. The hosts advocate for a critical approach to interpreting studies, suggesting that observational studies are often flawed due to reliance on self-reported data. They stress the need for controlled studies with larger sample sizes to draw valid conclusions. The hosts share anecdotes about the evolving understanding of health, including the recent analysis questioning the serotonin model of depression, which has been foundational for prescribing SSRIs. They discuss the placebo effect and the complexities of cause and effect in health studies, using examples like marijuana use and its correlation with depression. The conversation shifts to the importance of understanding the nuances of health claims and the potential for misinformation. They discuss the financial incentives behind many studies and the challenges of replicating results, especially in psychology and behavior research. The hosts encourage listeners to focus on what is known—such as the benefits of strength training and whole foods—rather than getting lost in the latest studies. The hosts also share personal experiences and insights about parenting, emphasizing the value of involving children in daily activities to foster responsibility and engagement. They discuss the importance of patience and the learning process in both parenting and training, highlighting the need to create positive experiences for children. Finally, they address the challenges of working with older populations in fitness, emphasizing the need for trainers to adapt their approaches to meet the unique needs of seniors. They suggest incorporating mindfulness and social interaction into training programs to enhance the quality of life for older adults, recognizing the profound impact of companionship and engagement on health outcomes.

Armchair Expert

Jud Brewer | Armchair Expert with Dax Shepard
Guests: Jud Brewer
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In this episode of Armchair Expert, Dax Shepard and Monica Padman welcome Jud Brewer, an MD and PhD, who is a psychiatrist, neuroscientist, and author. Brewer is the director of research and innovation at Brown University's Mindfulness Center and has developed an app-based program for treating anxiety, overeating, and smoking. He discusses his book, *The Craving Mind*, which explores the nature of cravings and how to break bad habits. Brewer shares insights about the brain's functioning, particularly how it processes information and forms habits. He explains the "two-body problem" in academia, where couples struggle to find jobs in the same location. Brewer reflects on his upbringing in Indiana, emphasizing the influence of his mother, a single parent who became a successful patent attorney. This experience shaped his feminist views and his interest in neuroscience and psychiatry. The conversation delves into the replication crisis in psychology, where many studies fail to be replicated, leading to questions about their validity. Brewer highlights the importance of understanding that correlation does not imply causation, using examples like the misconception linking vaccines to autism. He discusses how fear can cloud judgment and lead to irrational beliefs. Brewer emphasizes the significance of mindfulness in understanding and changing habits. He explains that cravings are often tied to context and that awareness can help individuals recognize the true reward value of their behaviors. He introduces his app, Eat Right Now, which encourages users to pay attention to their eating habits, helping them realize that unhealthy foods may not provide the satisfaction they expect. The discussion also touches on the difference between excitement and contentment, with Brewer arguing that modern society often equates excitement with happiness, leading to a cycle of craving and dissatisfaction. He advocates for finding joy in the journey rather than focusing solely on outcomes. Brewer shares his research on mindfulness and addiction, revealing that mindfulness training can significantly help individuals quit smoking and manage cravings. He explains how meditation can quiet the brain's self-referential networks, allowing for a more expansive experience of life. The episode concludes with a discussion on the impact of technology and food engineering on human behavior, emphasizing the need for awareness and mindfulness to navigate these challenges. Brewer encourages listeners to explore their own habits and find intrinsic rewards in their lives, ultimately fostering a sense of contentment and connection.

Mark Changizi

Why science itself is not scientific and cannot be centralized. Moment 100
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Science is messy and not purely scientific; it involves chaotic idea generation and a selection process akin to evolution, relying on networks rather than centralized authority to discern truth.

Modern Wisdom

Why Is Behavioural Genetics A Hated Science? - Dr Stuart Ritchie
Guests: Dr Stuart Ritchie
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Candidate gene research aimed to link specific genes to traits like intelligence and depression, leading to significant funding and careers. However, this research was largely flawed, with most findings being unreplicable. Behavioral genetics faces distrust due to misconceptions about genetic determinism, particularly regarding traits like intelligence, which some believe implies immutability and justifies social inequalities. Research shows that genetic contributions to traits can vary significantly across different environments, as demonstrated by studies in Estonia. While genetics influences traits like intelligence, environmental factors also play a crucial role. The double standard in accepting genetic influences on non-controversial traits versus contentious ones like intelligence highlights societal biases. Critics argue that educational outcomes are primarily influenced by socioeconomic factors, but studies indicate that schools have limited impacts once other variables are accounted for. The replication crisis has shifted focus from candidate gene studies to genome-wide association studies, revealing that complex traits are influenced by many genes with small effects. Despite improvements, concerns remain about sample diversity and the potential biases in genetic research. The conversation around intelligence and genetics is complex, with historical figures advocating for equitable resource allocation based on genetic understanding. Overall, the field continues to evolve, emphasizing the need for rigorous standards and open scientific discourse.

a16z Podcast

America's Autism Crisis and How AI Can Fix Science with NIH Director Jay Bhattacharya
Guests: Jay Bhattacharya, Erik Torenberg, Vineeta Agarwala, Jorge Conde
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A bold mission to fix science from the inside out unfolds as NIH director Bhattacharya lays out a Silicon Valley–inspired portfolio. Six months in, he launches a $50 million autism data-science initiative, with 250 teams applying and 13 receiving grants to pursue data-driven answers for families. He cites the CDC’s estimate of autism at 1 in 31 and argues for therapies that actually work and clearer causes to guide prevention. One funded effort centers on folinic acid treatment delivering brain folate, improving outcomes for some children with deficient folate processing, including speech in a subset. Not all benefit, but wider access could help. A second thread urges caution with prenatal acetaminophen use, noting evidence of autism risk and signaling guideline changes. He also highlights a cross-agency push on pre-term birth to narrow the US–Europe gap in prenatal care. The dialogue then shifts to the replication crisis in science, born from volume and conservative peer review. Bhattacharya, a longtime grant-panelist, argues that ideas stall because reviewers cling to familiar methods and fear novelty. He describes NIH reforms modeled on venture capital: centralized grant reviews, empowering institute directors to curate portfolios, and rewarding success at the portfolio level rather than individual wins. He emphasizes funding early-career investigators to bring fresh ideas while evaluating mentorship of the next generation. The aim is a sustainable pipeline that balances risk and reward, mirrors scientific opportunity, and aligns with the institutes’ strategic plans. He calls for a broader, transparent conversation with Congress and the public about funding and progress toward healthier lives. He ties trust to gold-standard science—replication and open communication—and notes how HIV/AIDS-era public pressure redirected NIH priorities. The Silicon Valley analogy endures: a portfolio of bets, most fail, a few breakthroughs transform health. AI can accelerate discovery, streamline radiology, and optimize care, but should augment rather than replace scientists; safeguards must protect privacy while expanding open access and academic freedom. The long-term aim is to reduce chronic disease and improve life expectancy. He closes with Max Perutz’s persistence as a blueprint for patient science. He envisions an NIH that protects academic freedom, expands open publishing, and uses AI to augment, curating a diverse portfolio balanced by evidence and bold bets to lift health outcomes for all Americans.

Mark Changizi

Why they believe the interventions work in spite of the evidence. Moment 104
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The illusion of control leads people to believe ineffective interventions, similar to gamblers at a roulette table.

The Peter Attia Drive Podcast

#143 - John Ioannidis, M.D., D.Sc.: Why most biomedical research is flawed, and how to improve it
Guests: John Ioannidis
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In this episode of The Drive podcast, host Peter Attia interviews John Ioannidis, a prominent physician and scientist known for his work in meta-research and the credibility of medical research. They discuss Ioannidis's journey from Greece to the United States, his extensive background in mathematics and medicine, and his influential papers, particularly one from 2005 titled "Why Most Published Research Findings Are False." This paper presents a mathematical model suggesting that many published biomedical studies are likely incorrect due to biases, small sample sizes, and the competitive nature of scientific research. Ioannidis emphasizes the importance of rigorous scientific methods and quantitative approaches in medicine, arguing that many studies are underpowered, leading to exaggerated results. He highlights the challenges in nutritional epidemiology, where biases and poor methodologies often yield unreliable findings. The conversation touches on the differences between genetics and nutrition research, noting that genetics has adopted more rigorous standards and collaborative approaches, while nutritional studies often rely on flawed observational data. They also discuss the impact of the COVID-19 pandemic on scientific discourse, particularly Ioannidis's involvement in early seroprevalence studies that suggested the virus was more widespread than initially thought. This led to significant backlash from various political and scientific communities, illustrating the tensions between science and politics. Ioannidis expresses concern about the politicization of science and the need for scientists to communicate findings without political bias. Throughout the discussion, Ioannidis reflects on the evolving nature of scientific inquiry, the importance of transparency, and the necessity of improving research practices. He remains optimistic about the future of science, emphasizing the continuous pursuit of knowledge and the potential for meaningful discoveries. The episode concludes with Attia and Ioannidis sharing a personal connection over their appreciation for Mediterranean cuisine and the importance of maintaining a healthy lifestyle.

Modern Wisdom

This is Your Brain on Bullsh*t - David Pinsof
Guests: David Pinsof
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Happiness is not what drives behavior. The host argues that predicting action from a pursuit of happiness is a terrible forecast of behavior, and that this view is both evolutionarily implausible and empirically misleading. Humans are driven by external incentives—food, sex, status, inclusion in groups—shaped by ancestral biology, not by an internal happiness carrot. Happiness, instead, functions as a mechanism that recalibrates expectations after prediction errors: when outcomes exceed expectations (a fine paella, ice cream, or surprising cooking success), the brain updates beliefs and adjusts motivation. Habituation then lowers the impact of repeated rewards, so pursuing particular goods does not require ongoing happiness. The speaker suggests motivation tracks incentives across time and space, and money is a means, not an end in itself. Proximate and ultimate analyses help explain why we want what we want; ends tend to be rooted in biology, while means are molded by environment and culture. The discussion moves to opinions: an opinion is defined as a preference plus social judgments about others who share or do not share that preference, making opinions a battleground over social norms and status. Sharing opinions functions as a loyalty test among allies, and social norms shift as status games invert. The conversation covers the “status game” as a driver of culture, with examples like Shakespearean praise or educational credentials, and explains why brains evolved large for social strategizing—the social brain theory. Arguments are examined: good-faith debate is possible in mundane, practical matters; in politics and discourse, many exchanges are pseudo-arguments that disguise status-seeking as persuasion. A pseudo-argument aims to intimidate or silence rather than persuade. The replication crisis in science is described as a shift in incentives, with status earned by replication and correction rather than hype, and the larger picture presented is that rational inquiry depends on calibrated incentive structures. The dialogue closes with resources: Evolutionary Psychology podcast and blog.

The Origins Podcast

Fifteen Years of DEI in Medicine, No Proof It Works | Roger Cohen, Amy Wax, & Lawrence Krauss
Guests: Roger Cohen, Amy Wax
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Lawrence Krauss hosts a discussion with Roger Cohen and Amy Wax about their chapter in The War on Science, focusing on medical science integrity and the role of diversity, equity, and inclusion DEI. Cohen, Harvard-trained and a cancer drug developer, describes caring for patients with advanced cancer and argues that therapies must rest on rigorous, falsifiable data rather than impressions or consensus. Wax, a Yale biochemist turned Harvard-trained physician who later became a lawyer, emphasizes an evidence-based, quantitative approach and explains how her training informs her critique of policy and DEI initiatives. They contend that the process of developing and approving new cancer treatments provides a gold standard for evaluating interventions, yet health-equity and DEI efforts have been adopted with scant solid evidence of benefit. The Joint Commission and NIH DEI directives are cited as examples of ideology shaping accreditation and funding rather than science. The discussion highlights flawed or non-replicated studies—the Oakland study on racial concordance, the Greenwood neonatal study, and the McKenzie diversity-profitability analysis—and how headlines and citations can outpace critical appraisal. They argue that questioning outcomes, replication, and alternative explanations is often discouraged, with dissent punished as heresy. The conversation closes with calls to sunset weak studies, replace them with rigorous data, and apply standard scientific scrutiny to DEI initiatives, insisting that medicine be guided by evidence and progress rather than ideology.
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