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In this episode of the Sean Ryan Show, host Shawn Ryan interviews Dr. Michael Bagnell, a functional neurologist, about brain health, functional medicine, and various neurological conditions. Ryan discusses the frustrations many people face when seeking help from traditional doctors, emphasizing that functional medicine practitioners are more invested in patient health and education. Dr. Bagnell explains the importance of brain health and shares insights on preventing conditions like Alzheimer's and dementia. He discusses the significance of movement for maintaining cognitive sharpness and addresses short-term memory loss, which can be linked to various brain regions and conditions, including traumatic brain injuries (TBIs) and ADHD. He highlights the need for comprehensive assessments to understand individual brain health and the potential therapies available. The conversation shifts to the effects of psychedelics on brain function, with Dr. Bagnell noting their potential to alter the default mode network, which may help with memory retrieval and emotional recovery. He acknowledges that while psychedelics can be beneficial for some, they are not suitable for everyone and should be approached with caution. Ryan and Dr. Bagnell also discuss the impact of marijuana on anxiety and mood, with Dr. Bagnell emphasizing the need for careful consideration of its effects, especially regarding long-term use. He mentions the importance of understanding individual brain chemistry and the potential for addiction to substances, including social media, which can drive dopamine release and influence behavior. The discussion includes the long-term effects of COVID-19, particularly "long COVID," which can manifest as brain fog and other cognitive issues. Dr. Bagnell explains that the brain stem is often affected by the virus, leading to various symptoms that may require rehabilitation similar to physical injuries. They also touch on addiction, particularly in military personnel, and how the pursuit of dopamine can lead to addictive behaviors. Dr. Bagnell emphasizes the need for a holistic approach to treatment, considering the body, mind, and spirit in recovery processes. Finally, Dr. Bagnell introduces an innovative dolphin-assisted therapy program designed to help individuals with neurological conditions. He describes the therapeutic benefits of interacting with dolphins, which can provide emotional and cognitive support, enhancing overall well-being. Overall, the episode highlights the complexities of brain health, the potential of functional medicine, and the importance of personalized approaches to treatment and rehabilitation.

Theo Von chats with TJ Miller about his career, creative approach, health, and philosophy. Miller calls himself a film man and comedian and explains why he often interviews through characters, citing Gore Burger, a giant blue alien puppet created with two puppeteers in control of the eyes and mouth. He notes Gore Burger has done Snoop Dogg’s GGN Network and describes the device he uses to animate the mouth while others handle the eyes. He says he enjoys interviewing through a character who doesn’t know humans, so the questions come from that angle. He describes his podcast Cashing In With TJ Miller, with Cash Levy, where Levy can never get another guest, so Miller is his only guest for six years, and the interviews lean toward absurdist questions such as whether attaching a handle to anything makes it a ladle, debate about mittens versus gloves, etc. Miller then talks about his acting work and how he negotiates character and appearance. He recalls the Ready Player One experience, where he asked Spielberg if his Boba Fett vibe would work; Spielberg encouraged him, and he explains how he prepared by drawing on Boba Fett imagery. He also shares memories of Yogi Bear 3D auditions, including renting a bear, bringing a Ranger hat, and sending a self-made audition video to Allison Jones and Warner Brothers executives, which helped land the part. A major thread is his health. He reveals an arteriovenous malformation (AVM) in his frontal lobe that hemorrhaged and was surgically removed, leaving golf-ball sized brain tissue gone. He explains the condition contributes to mania, and that he is treated with medication to prevent seizures and manage mania. He describes manic episodes, times when he mistook drones for birds or believed cameras watched him, and recalls a moment when he smashed a computer during a mania episode. He emphasizes that he is not bipolar, but prone to manic episodes, and that medication helps manage it. The conversation moves to the realities of Hollywood and the independence of stand-up. Miller argues that stand-up offers control and integrity that film and TV sometimes strip away. He discusses moving to New York to pursue more stand-up work, valuing the city’s pace and live energy over Los Angeles. He notes Kate, his partner, as an installation artist, and explains how their relationship influences touring and life choices, including renewals of vows in Big Sur and living in New York. Towards the end, Miller reflects on fame, media, and the temptations of press. He says stand-up offers control and independence, and he remains grateful for live, international touring.

In this episode of "Conversations with Tyler," host Tyler Cowen interviews Theodore Schwartz, a neurosurgeon and author of "Gray Matters." Schwartz discusses the extensive training required to become a neurosurgeon, which typically involves 16 years of education and training. He suggests that undergraduate and medical education could be condensed, but emphasizes the importance of experience and maturity in surgical practice. The conversation shifts to the role of AI in neurosurgery, where Schwartz believes AI could excel in interpreting MRI scans but not in making complex surgical decisions, which require a surgeon's unique skill set. He also highlights the lack of standardized data collection on surgical outcomes, which could improve patient care. Schwartz addresses the challenges of selecting a neurosurgeon, recommending that patients seek referrals from healthcare professionals and consider the surgeon's experience. He notes the demanding nature of neurosurgery, which can impact personal lives, leading to high divorce rates among surgeons. The discussion touches on the future of brain surgery, including advancements in deep brain stimulation and brain-computer interfaces, with Schwartz optimistic about their potential to treat various conditions. He reflects on the philosophical implications of consciousness and identity, suggesting that much of what defines us is rooted in brain circuitry. Finally, Schwartz shares his plans to develop a medical device aimed at benefiting a larger population, indicating his commitment to advancing neurosurgery and patient care.

Theo Von opens with a broad tour update, listing new dates in Oklahoma City, North Little Rock, Springfield Missouri, Kansas City Missouri, Sioux Falls, Lacrosse, Green Bay, Moline, Illinois, Colorado Springs, Casper, Billings, Missoula, Bloomington, Columbus, Champagne, Grand Rapids, Lafayette, and Beaumont. He encourages fans to buy directly through theo.com to get properly priced tickets and avoid secondhand sites. Today’s guest is Kevin Smith, the filmmaker, writer, and podcaster known for Clerks, Mallrats, Jay and Silent Bob, Dogma, and Tusk, whose new film The 4:30 Movie is loosely based on his childhood in New Jersey. Kevin Smith riffs about his own career and the culture of modern broadcasting, joking about monochrome printing and Clerks’ black-and-white look tying back to his work. The conversation wanders through the nature of starting a podcast in the late 2000s, SModcast’s early formal openings, and how today’s pods tend to begin without a formal cue. They discuss the reality of being online—critics and fans—and Kevin shares experiences with negative commentary, as well as influences from Joe Rogan, whom he recently spoke with about avoiding constant online reading of good and bad feedback. They touch on Rogan’s move to Austin and Kevin’s own Tennessee residence, near Nashville, with frequent stops in Kentucky and Knoxville during tours. A running thread is the evolution of podcasting from a purely audio enterprise to a multimedia enterprise with live shows and video, including discussions of the immersive, image-heavy modern format. Kevin notes Fleshlight’s early sponsorship of his podcasts as a landmark moment in monetizing the medium, recounting how Fleshlight initially reached out after Zack and Miri Make a Porno and later sponsored Joe Rogan’s show, expanding their market reach. They joke about Celsius energy drinks and a massive Celsius fridge on set, with Kevin detailing how his cast and crew enjoy the brand, and Theo laughing about the abundance of Celsius in their world. The conversation turns personal as Kevin recounts his heart attack story, describing his Widowmaker heart attack, the emergency catheter route through the femoral artery, and the life-saving interventions of the responding medics and doctors. He describes the moment he faced possible death with a sense of peace, then details the hospital sequence and the crucial intervention by Dr. Lenheim. Later, a hormone of memory flickers back to life when he visits a doctor months afterward and learns that the Widowmaker statistic is often misremembered, receiving a correction from Dr. Paula: 83% of patients do not survive, which reframes his gratitude for surviving. He reflects on the potency of the experience and how it has shaped his storytelling and openness about mental health and self-worth. The talk broadens into reflections on being vegan after his heart attack and how his daughter’s influence helped him stay the course on plant-based eating, including practicalities about vegan options while traveling. They joke about the ethics of veganism and the idea of plant-based nutrition, even as Kevin jokes about the occasional tongue-in-cheek questions about erections while on a vegan diet and on blood thinners. They discuss his family life, his daughter Harley Quinn’s acting work, and his ongoing love of cinema, with Kevin describing how personal revelations, including experiences with father figures and Stan Lee, have fed his work. He shares his admiration for Stan Lee’s role in bringing comics to the mainstream and his own memories of meeting Stan, including Stan’s influence on the Marvel universe’s mythology. A major theme is the future of independent filmmaking in a streaming-dominated era. Kevin argues that indie storytelling is primed for a new rise as streaming and theatrical markets shift, noting that the 4:30 Movie cost about three million dollars and was financed by Saban, after his experiences with low-budget filmmaking and the desire to keep the overhead manageable. He asserts that selling direct to consumers—either through a series of screenings with live Q&A, a direct-to-consumer release, or events run by filmmakers themselves—can be financially viable and creatively liberating. He explains that the theatrical release still holds a panache and a capability to connect with audiences in ways streaming alone cannot, even as streaming becomes the default home for many projects. Kevin stresses that “your voice is your currency” and encourages aspiring filmmakers to embrace independent paths, to keep budgets lean, and to deliver good-enough work that is emotionally resonant. He recounts a story about a fan who credits Mall Rats with saving his life by providing a haven during a difficult home life, and he offers a moving reminder that moments in a film can buoy someone for years. The conversation closes with mutual appreciation, playful banter about potential collaborations (including a hypothetical Jay’s brother role for Theo in a future Jay and Silent Bob project) and practical advice about pursuing cinematic work with authenticity and joy, while continually adapting to a rapidly changing media landscape.