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Our genes have stayed the same, but the environment has changed dramatically, with 50,000 new chemicals of unknown toxicology introduced. Increased stress patterns, time urgency with social media, and climate changes are factors. The biosphere has changed, with a loss of diversity and simplification of our diet. We get 90% of our calories from less than eight foods. Our genes never knew they were gonna be exposed to these things over a short period. Genes can't mutate fast enough to keep up.

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Chicken consumption may be linked to worsening bladder infections due to antibiotic-resistant superbugs found in poultry. Research suggests that bacteria from chicken, particularly e coli, may be transmitted to humans through meat consumption, contributing to persistent and costly urinary infections. Antibiotic use in agriculture, including in healthy chickens, is a concern as it may lead to antibiotic resistance in bacteria. Treatment for these infections is becoming more challenging and expensive, with multiple courses of antibiotics often necessary.

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We isolated coronaviruses from animals in the past to understand their threat to other species by culturing them on different cell types. This process, known as gain of function, involves enriching mutants that can infect new species. The speaker emphasizes that mass vaccination in humans is a significant gain of function experiment, leading to virus evolution. This real-world experiment involves constant virus changes due to human-to-human transmission under vaccine pressure.

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Infections are not caused by bacteria, but rather by the body's natural process of eliminating toxins and dead cells. The presence of bacteria in the body is normal and essential for health. Antibiotics kill beneficial bacteria, disrupting the body's ability to detoxify properly and leading to recurring infections. Addressing the root cause of toxemia is crucial for preventing infections.

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" I'm a big believer of vitamin c. " "This doesn't mean it's going to work for everyone and we're not making any claims. " "There is definitely something about vitamin C through the years that have said to people, wait, vitamin C is pretty safe. " "But then we looked at the in vitro studies and that's how they grow the bitter bacteria. " "In vitro studies of vitamin C effect on the microbiome, you actually see increased Bifidobacteria with in vitro. " "So we just proved on a human clinical model what the in vitro model did. " "I'm on this big push of increasing the betrobacteria. " "That's my science... my vision. " "Are antibiotics good? Are they good long term? " "Now we're in the world of biologics. What are biologics doing to the microbiome? " "Maybe all disease starts with lots of bifidobacteria. " "As I'm improving the benefit of bacteria, I see improvement in the disease clinically as a physician."

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The speakers discuss the expected mutation of the virus and the impact of vaccination. They acknowledge that as people become immunized, the virus will try to find ways to evade the vaccine. The more people are vaccinated, the more pressure is put on the virus to mutate. Some virologists warn that vaccinating the entire world with narrow immunity could lead to the emergence of superbugs. They urge for the use of the right vaccine in the right place and caution against mass vaccination during a pandemic. They argue that current interventions and mass vaccination may be causing more harm than good, driving the emergence of more infectious and potentially lethal variants.

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Key data points highlight UK antibiotic use and global resistance. "In 2020, about 13,000,000 antibiotic prescriptions were given out in The UK." "Children aged zero to 14 made up three point six million of those." "And in 2023, the World Health Organization declared antibiotic resistance one of the top global health threats and estimated that it is responsible for one point two seven million global deaths in 2019 and contributed to almost five million deaths." "That was 2019." "I can tell you that the figures have risen dramatically since then." The statements indicate a marked increase in both UK prescriptions and global deaths related to antibiotic resistance since 2019.

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"The public is tired. They're tired of the old science. They're tired you know, antibiotics were great." "I trained in the world of antibiotics where we were giving antibiotics for everything." "then came the biologics, and then it became biologics for everything." "And now we're in the pill poop level, and it's gonna be pill poop for everything, you know." "So science is only good as science is during the moment in time where the research is not advanced." "What me and doctor Barodi do is we're the innovators." "We're the ones that are basically on the frontline challenging the status quo and saying, why not look for this?" "Why isn't Crohn's mycobacterial paratuberculosis? And why shouldn't I look for it?"

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I've often been asked if this is the end of all the parasitic issues we're facing. I urge people not to be complacent. While Donald Trump may act as a barrier to the chaos, we must remain vigilant. I like to compare this situation to the evolution of superbugs caused by improper antibiotic use. When people stop taking antibiotics early, weaker bacteria die off, leaving stronger ones to thrive. This misapplication leads to the development of superbugs. Similarly, the "woke mind virus" can evolve if we don't address it properly. We must be proactive to prevent further issues.

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Think about what we've done with autism. Right? There's a whole big push of finding answers for autism. The problem with autism. It's not a one answer. No, it's a myriad of answers. It's really risk factors. What are the risk factors that puts my kid at risk for autism? And the risk factors could be you gave your kid antibiotics, could be mom was drinking a lot of alcohol during pregnancy, could be mom was stressed during pregnancy, could be maybe something in the vaccine. Right? But you can't talk about that because that kills, that starts hesitancy, that creates a narrative change, but we have to talk about that. We have to look at all the risk factors so we could say, okay, antibiotics on their own is not going to create autism because you have seen kids that took antibiotics and didn't get autism. Vaccines on their own are not going to create autism because we've seen kids that were vaccinated and are fine and never got autism. However, what are the cumulative risk factors?

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Chuck Benbrook states that American farmers are as reliant on pesticides as they were 30-40 years ago. Pesticides seem like a simple solution for farmers dealing with weeds, insects, or plant diseases and have created a profitable industry. Farmers have become overly reliant on them, and the adverse effects of pesticides on the pests themselves has become a huge problem.

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"My job, I know my job, my job is to wake up humanity to the microbiome and the fact that humanity is going extinct." "look in 1970, the rate of autism was one in ten thousand." "Now it's one in thirty in some areas of the country. California, one in twelve point five boys have autism." "twenty five percent of newborns are born with adequate levels of good bacteria." "out of 4,000 stool samples, less than five percent have bifidobacteria, which is an important microbe that helps us break down sugars." "So, you know, what happens when one in one kid has autism? What happens when there's no more bifidobacteria on the planet because we've destroyed it all? We stop living. That's it."

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Americans are prescribed around £7.7 million worth of antibiotics annually, which is equivalent to over 800 prescriptions for every 1,000 people. Surprisingly, approximately 80% of the population receives antibiotics in a given year.

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I have been healthy for 27 years without colds or flu because our bodies are full of bacteria and viruses that help us stay well. Our immune system can create its own viruses and bacteria to fight off illness. Babies can be born with cancer due to lack of proper nutrition and exposure to stress in the womb. Giving newborns unnecessary vaccinations can be harmful. The debate between Pasteur and Beauchamp about the importance of germs versus the immune system still impacts modern medicine. Beauchamp's belief in the immune system's strength is overshadowed by Pasteur's germ theory, which led to the pharmaceutical industry's dominance.

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Robert F. Kennedy Jr.: Hi, it's Robert F. Kennedy Jr. here, your HHS secretary. At HHS, we have a division called the Biomedical Advanced Research and Development Authority, or BARDA. BARDA drives some of our most advanced scientific research. It funds developments of vaccines, drugs, diagnostics, and other tools to fight emerging diseases and national health threats. Over the past few weeks, BARDA reviewed 22 mRNA vaccine development investments and began canceling them. Let me explain why. Most of these shots are for flu or COVID, but as the pandemic showed us, mRNA vaccines don't perform well against viruses that infect the upper respiratory tract. Here's the problem: mRNA only codes for a small part of the viral proteins, usually a single antigen. One mutation and the vaccine becomes ineffective. This dynamic drives a phenomena called antigenic shift, meaning that the vaccine paradoxically encourages new mutations and can actually prolong pandemics as the virus constantly mutates to escape the protective effects of the vaccine. Millions of people, maybe even you or someone you know, caught the omicron variant despite being vaccinated. That's because a single mutation can make mRNA vaccines ineffective. The same risk applies to flu. After reviewing the science and consulting top experts at NIH and FDA, HHS has determined that mRNA technology poses more risk than benefits for these respiratory viruses. That's why after extensive review, BARDA has begun the process of terminating these 22 contracts totaling just under $500,000,000 To replace the troubled mRNA programs, we're prioritizing the development of the safer, broader vaccine strategies, like whole virus vaccines and novel platforms that don't collapse when viruses mutate. Let me be absolutely clear: HHS supports safe, effective vaccines for every American who wants them. That's why we're moving beyond the limitations of mRNA for respiratory viruses and investing in better solutions. Thank you. Produced by the U. S. Department of Health and Human Services.

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there's sort of three things that I've I've been able to ascertain as risks of misuse or overuse or inappropriate use of antibiotics, which is the impact on the gut microbiome, the you're contributing to the rise in antibiotic resistance, and Those are the main things. I guess even with the diseases you get, you'll be slower to heal because you're less if you've got that resistance. That is one of the things that we do see, particularly those who are long term ill. We know that they lose some of the healing capacity. So much of the work I do is to aim to put some of that right. And there's links to colorectal cancers?

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The other part of it is the reason people drink raw milk is so their immune systems are adaptive to threats. The studies in Europe are very clear about that. The kids that drink raw milk don't get the flu and don't get the cold. Those are viruses. Every year they don't get that for ten years of the study. They're not taking a vaccination that changes every year. They're taking raw milk that changes every year because the cows adapt to that year's environment and that year's virus and creates antibodies for the new strain every year. So Mother Nature's blueprint has got this going on, and she's right. We just have to appreciate that and be farmers over pharmacies here. And America is such a bad way with our gut microbiome and immune compromise that fear is an easy thing to manipulate. So we have to not go there with the fear. It's just sad.

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Speaker 0 discusses the idea that a new consensus about serious side effects from COVID vaccines is causing people, including medical experts, to reexamine other vaccines given in childhood. He references an anonymous Substack author under the name the Midwestern doctor, who provides a thoughtful assessment of widely accepted childhood vaccines. According to the Midwestern doctor, many vaccines have negligible or nonexistent benefits but have documented side effects. He cites MMR, DPT, flu, and tetanus vaccines as examples. The author argues that after bacterial childhood vaccinations were introduced, this approach led to the infection and other bacterial infections becoming more common and mutating into more dangerous strains that affected many people who were not previously susceptible, and created a variety of new side effects from the infections not seen before. He contends that the response to these infections worsening has been to develop new vaccines for them, which, in his view, has further accelerated this downward spiral and also generated big pharma profits. In conclusion, regarding COVID vaccines, the Midwestern doctor writes that “these recent publications and the data sets that Dowd's estimate Ed Dowd's estimate is based upon show clearly and unambiguously that the risk of the COVID vaccines greatly outweigh any possible benefit they might have.” Doctor Pierre Corre, who has gained prominence as a COVID vaccine critic, posted on X that the article calls him to rethink his acceptance of the manufacturer consensus about the childhood vaccine schedule. Corre is quoted as saying, “before COVID, I didn't think there were serious issues with the childhood vaccines, but now, like many, I've come to question that assumption.”

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Here's the thing I learned about the microbiome, which is very important. You can live with a sterile gut. And this is why the whole naturopath world sees improvement in what you do with everything you do. You could live in a sterile world, right, where you kill off all the microbes. But here's the problem. You go from that sterile world to India where you're walking barefoot and you're catching a parasite going to your foot to your brain or to your pancreas, and then next thing you know, you wake up one morning and you're like cancer. You can live in the sterile environment and you're perfectly fine in that sterile environment, but then once you go to the streets, you're gonna get sick because you're not exposed to all these microbes. And you can live in a diverse environment where you're protected with the environment.

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According to the speaker, Albert Einstein said humanity would only have four years to live if all the bees were destroyed. The speaker believes humanity will only have four years to live if bifidobacteria are destroyed, and claims we are close to that point. The speaker states that after analyzing a thousand stool samples with deep genetic sequencing, bifidobacteria are present in less than five percent of people. The speaker further claims that out of those thousand samples, only about twenty had bifidobacteria present above ten percent, which the speaker finds alarming.

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The speaker emphasizes caution with antibiotic use, noting that while not advising against antibiotics, they can cause harmful effects. They point out that the microbiome will never revert to its exact previous state after an antibiotic course, and that a person will not regain the prior pattern of microbes. The speaker adds that they themselves used to take antibiotics frequently at the first sign of sickness. The core idea is that antibiotics target bacterial infections and do not affect viral infections. They do not kill every microorganism; some microbes survive treatment. Those survivors can become highly resistant, evolving into “super bugs,” and they can pass this resistance information to other microbes. As a result, antibiotics that once worked may no longer be effective in the future. The speaker warns that this scenario represents a slippery slope: once antibiotic resistance develops, the effectiveness of these drugs can diminish over time. To mitigate potential disruption to the microbial community, the speaker advises that whenever an antibiotic is taken, it is also important to take a probiotic at the same time to restore the microbial population.

The Peter Attia Drive Podcast

283 ‒ Gut health & the microbiome: improving and maintaining the microbiome, probiotics, & more
Guests: Colleen Cutcliffe
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The microbiome is a mutable ecosystem of microbes, including bacteria, viruses, fungi, and yeasts, residing in and on the human body. Colleen Cutcliffe, with a background in biochemistry and molecular biology, discusses her journey from academia to founding Pendulum, a company focused on microbiome-based products. She emphasizes the potential of microbiome interventions, particularly through fecal microbiome transplants, to improve health outcomes. Cutcliffe explains that the gut microbiome is established at birth, primarily influenced by the mode of delivery and early exposure to maternal microbes. The diversity of the microbiome peaks in early adulthood and declines with age. While the idea that microbes outnumber human cells is debated, the functional importance of these microbes is clear, as they contribute significantly to bodily processes. The conversation shifts to the differences between prokaryotic bacterial cells and eukaryotic human cells, highlighting that bacteria can replicate independently and evolve rapidly, which is a factor in antibiotic resistance. The relationship between humans and their microbiota is generally symbiotic, although some bacteria can become pathogenic under certain conditions, such as *Clostridium difficile*, which can proliferate when antibiotics disrupt the balance of the microbiome. Cutcliffe discusses the Human Microbiome Project, which revealed significant variability in microbiomes across individuals, influenced by factors like genetics, diet, and environment. The complexity of the microbiome makes it challenging to draw definitive conclusions about specific strains and their functions. The conversation also touches on the role of different microbes, including the potential benefits of *Akkermansia muciniphila*, which is associated with metabolic health and glucose regulation. Cutcliffe describes how *Akkermansia* can stimulate GLP-1 secretion, a hormone that helps regulate blood sugar levels and appetite. Pendulum's product, Glucose Control, was developed based on clinical trials showing its efficacy in lowering A1C and blood glucose spikes in individuals with type 2 diabetes. The formulation includes multiple strains to enhance metabolic function. Cutcliffe notes the importance of rigorous scientific validation in the supplement industry, which is often plagued by unsubstantiated claims. The discussion highlights the challenges of studying the microbiome, including the need for longitudinal data and the difficulty of controlling for dietary factors. Cutcliffe emphasizes the importance of understanding individual microbiome responses to interventions, as well as the potential for future research to uncover more about the gut-brain connection and the impact of diet on microbiome health. Overall, the conversation underscores the evolving understanding of the microbiome's role in health and disease, the potential for targeted microbiome therapies, and the importance of scientific rigor in developing effective products.

The Diary of a CEO

No.1 Herbal Medicine Expert: This Over The Counter Drug Is Quietly Killing You!
Guests: Simon Mills
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Simon Mills, a pioneering herbal practitioner with more than fifty years in natural medicine, argues that conventional medicines have saved lives but carry long‑term risks and that we overuse antibiotics, fueling resistance. He emphasizes that many people could benefit from plant‑based medicines that act quickly and diversely, sometimes alongside standard care. Mills frames his mission as helping people become stronger by using plants within a scientific framework that complements conventional healthcare. He notes that traditional plant knowledge was displaced by modern pharmaceuticals as urban living reduced practical knowledge of herbs, and he describes how different cultures still rely on plants as medicine, including in Europe, China, and parts of Asia. Mills stresses that the body’s biology is accessible through the gut. He explains that digestion, the microbiome, and the liver connect to virtually all health outcomes, including brain health, immune function, and inflammation. He cautions that inflammation is a natural defense, not the enemy, and that chronic inflammation often has upstream causes in the gut and microbiome. Antibiotics not only wipe out pathogens but also disrupt gut diversity, contributing to resistance and longer healing times. He cites WHO figures and recent prescribing stats to underscore urgency. In practice, Mills sees thousands of patients with chronic conditions, including cancer, autoimmune disease, gut disorders, and hormonal problems. His approach is to fine-tune health by addressing root function—digestion, liver and kidney function, and circulation—rather than merely treating symptoms. He shares case examples: Heather, a 65-year-old with a severe skin condition linked to infections and gut-lung interplay, who improved rapidly after gut and lung support; and Karen, 37, with panic and anxiety whose liver function and sugar cravings were targeted, yielding cycle stabilization and mood benefits. Both illustrate that plant remedies often work through the gut-liver-brain axis. Mills demonstrates practical remedies: ginger and cinnamon teas warm and clear airway congestion; cayenne plasters and mustard baths can relieve joint pain by increasing local blood flow; garlic as a prebiotic with potent antiseptic properties; echinacea for upper respiratory infections; resins like frankincense and myrrh for mucous membranes. He discusses turmeric’s curcumin, its microbiome-mediated effects, and its potential in arthritis and brain health; green tea and rosemary as neurovascular protectors; cacao and dark chocolate as brain and heart supporters. He promotes dietary richness—eating the rainbow, prioritizing color-rich polyphenols, root vegetables, greens, and diverse plant foods—to nourish the microbiome and health. He cautions about long-term uses of acid-suppressants like omeprazole, proposing the raft method with slippery elm or seaweed-based products to protect the gut while wean off acid suppression. He also notes that lifestyle changes and intermittent fasting have context-dependent value. The discussion closes with practical advice on cost-effective, plant-forward eating, and the need for more reliable, evidence-based herbal resources. He also touches on the tastiness and versatility of foods and spices, including ginger, cinnamon, garlic, echinacea, rosemary, green tea, cacao, and matcha, highlighting how these can support heart, brain, gut, and immune health through polyphenols, prebiotics, and microbiome interactions. He emphasizes that there is no one-size-fits-all diet and that plants function as medicines best when personalized to the individual.

The Peter Attia Drive Podcast

317 ‒ Reforming medicine: uncovering blind spots, challenging the norm, and embracing innovation
Guests: Marty Makary
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Dr. Claude Bernard emphasized the importance of objectivity in science, warning against biases that can distort understanding. Marty Makary discusses his new book, "Blind Spots," which explores how shaky ideas in medicine can gain traction due to groupthink and cognitive dissonance. He highlights the dangers of accepting health recommendations presented with absolute certainty, advocating for a culture of questioning in medicine. Makary shares insights on appendicitis treatment, revealing that recent studies show antibiotics can effectively treat non-ruptured appendicitis, challenging the traditional surgical approach. He recounts a case where a patient chose antibiotics over surgery to attend a wedding, illustrating the shift in treatment options and the need for doctors to remain open to new evidence. The conversation shifts to peanut allergies, which have surged since the American Academy of Pediatrics recommended avoiding peanuts in early childhood. Makary argues that this recommendation contributed to the epidemic, as exposure is crucial for developing tolerance. He cites a study that later reversed this guidance, showing that early introduction of peanuts significantly reduces allergy rates. Makary also discusses the overuse of antibiotics and their link to chronic health issues, referencing a Mayo Clinic study that found a correlation between early antibiotic use and increased rates of obesity and learning disabilities in children. He stresses the need for a nuanced approach to antibiotic prescriptions, highlighting the importance of understanding their impact on the microbiome. The discussion touches on ovarian cancer, revealing that it often originates from the fallopian tubes rather than the ovaries. This new understanding could change surgical practices, as removing fallopian tubes may significantly reduce cancer risk. Makary emphasizes the importance of challenging established beliefs in medicine and adapting practices based on emerging evidence. Both hosts express concern about the current state of medical education, criticizing the rote memorization approach that stifles creativity and critical thinking. They advocate for a curriculum that emphasizes understanding uncertainty and the importance of questioning established norms. Makary reflects on the need for humility in medicine, encouraging doctors to acknowledge when they might be wrong and to foster a culture of open dialogue. He highlights the importance of addressing systemic issues in healthcare, such as predatory billing practices and the need for transparency in medical recommendations. The conversation concludes with a call for a more holistic approach to healthcare, integrating lifestyle factors like nutrition and exercise into medical practice. Both hosts remain optimistic about the future of medicine, emphasizing the dedication of healthcare professionals to improve patient outcomes while recognizing the challenges posed by entrenched beliefs and practices.

TED

How a long-forgotten virus could help us solve the antibiotics crisis | Alexander Belcredi
Guests: Alexander Belcredi
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Viruses can cure diseases, particularly through phages, which are viruses that target bacteria. A personal story illustrates their potential when a woman’s chronic bacterial infection healed after phage treatment, leading to a fascination with their medical applications. Phages are abundant and selectively hunt specific bacteria, making them promising alternatives to antibiotics, especially against drug-resistant strains. Despite historical neglect due to the rise of antibiotics, phage therapy is experiencing a renaissance, with numerous biotech companies developing phage-based treatments.
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