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The heart requires a high concentration of coenzyme Q10 because it generates more energy than any other part of the body. The heart is constantly working and needs coenzyme Q10 to maintain its energy production. Energy production creates exhaust, and coenzyme Q10 is also needed to clean up this exhaust.

Reason why we need so much coenzyme Q10 in our heart is because that is the part of the body that generates the most energy out of any part. I mean, it has to generate a lot of energy, and it's constantly beating 20 fourseven. It never really relaxes. And so you need this specialized coenzyme to maintain that energy. And because it produces all the energy, it comes with a lot of exhaust, so we also need to clean that up as well. So that's why coenzyme q 10 is so important.

Inhales speed the heart up, exhales slow it down due to respiratory sinus arrhythmia. During inhalation, the diaphragm moves down, creating more space for the heart. Blood flows more slowly through the larger volume, causing the brain to signal the heart to speed up. During exhalation, the diaphragm moves up, reducing space, and blood moves more quickly. The brain then signals the heart to slow down. Increasing the duration or intensity of exhales relative to inhales will induce calm. Conversely, increasing the intensity or duration of inhales relative to exhales will increase alertness.

Air, specifically oxygen, is declared to be good for you.

Vitamin B12 is essential for red blood cell production, which transports oxygen throughout the body. A vitamin B12 deficiency leads to a decrease in red blood cells, reducing oxygen delivery to body tissues. This can result in weakness, fatigue, and exhaustion.

As people age, their lung capacity decreases, with most individuals losing 40% by age 50 and 60% by age 80. This decline is often due to a lack of exercise and shallow breathing. However, there are ways to prevent and regain lung capacity. Regular physical activities like walking, push-ups, and core strengthening exercises can help maintain lung function. Deep breathing is also crucial. If lung capacity has already been lost, exercising the lungs through deep breathing can help regain it. Ensuring adequate oxygen intake is important for overall well-being, as seen when children struggling with schoolwork benefit from physical activities like skipping rope or running.

Vitamin B12 is essential for red blood cell production, which transports oxygen throughout the body. A vitamin B12 deficiency leads to a decrease in red blood cells, reducing oxygen delivery to body tissues. This can result in weakness, fatigue, and exhaustion.

The speaker discusses cortisol as both essential and potentially harmful when chronically elevated. "We also see that it's during that nighttime phase when we drop levels of cortisol, which otherwise, if left in high concentrations, it's it's a stress related chemical." "It's it's an adaptive chemical too." "We all need cortisol." "But if you're just chronically high in cortisol, that is, you know, deathly for your cardiovascular system." "And sleep will actually ratchet down that level." Sleep reduces cortisol levels, and the speaker implies this protects cardiovascular health. Understanding this pattern highlights the importance of sleep in hormonal regulation.

Lactate was once considered bad because it was thought to cause the burning sensation in muscles. However, research from George Brooks at UC Berkeley has revealed that lactate doesn't cause the burn and is actually a "miracle molecule." Lactate, a metabolite, enters circulation and is used for energy by the heart, brain, and liver, similar to beta-hydroxybutyrate. Lactate is transported through the same transporter and used as energy. Lactate also enables muscles to communicate with other organs, like the brain, acting as a signaling molecule. When muscles work hard, lactate signals the body to respond and adapt.

Breath work is presented as a cheap and impactful way to increase health span and lifespan. Every emotional state is a combination of a neurotransmitter and oxygen. The difference between anger and passion is one neurotransmitter and the presence of oxygen. Without enough oxygen in the blood, one cannot experience elevated emotional states like passion, joy, arousal, or elation. No one has ever woken up laughing because the oxidative state to experience laughter isn't present upon waking. Anger, however, requires zero oxygen and can be experienced even when close to death. To achieve an elevated emotional state, one needs to put oxygen into the bloodstream to bind neurotransmitters.

The speaker explains that energy is produced in mitochondria, the subcellular organelles that exist in hundreds to thousands within a single cell. They consume oxygen and food to combust them like an engine, producing energy in the form of ATP. The process is described as an assembly line with many steps, enzymes, and nutrients, and one of the key steps requires coenzyme Q10 (CoQ10) to make energy. The speaker notes that, as people age, CoQ10 production declines. This decline also occurs with other factors such as stress, chronic stress, toxins, and certain medications like statins. When CoQ10 levels are lower, there is a corresponding reduction in energy experienced with aging, and it can also lead to some serious diseases.

"Our bodies would fill up with lactic acid and succinic acid, like if we were to have a heart attack or when somebody has a heart attack." "They don't die instantly." "If they're there for five or seven minutes without oxygen, they may die because the brain dies." "But if you can get the heart to beat again and get oxygen back in the system, you can come alive again." "Highest level of amino acid is the glutamine." "Lactic acid is coming from glucose to sugar and succinic acid is coming from the amino acid glutamine." "And they build up and that tells you you're fermenting." "You're getting energy without oxygen because you're not breathing." "Very simple." "You're not breathing, but I'm not dead yet."

Nitric oxide is naturally made in our bodies. A Nobel Prize was awarded for the discovery that nitric oxide plays a significant role in the cardiovascular system. This discovery revealed nitric oxide as a vasodilator helping to reduce blood pressure and increase oxygen in the blood. Produced by the lining of the blood vessels known as the endothelium, nitric oxide acts as a messenger molecule telling blood vessels to widen or dilate and contract or relax like an elastic band. With enough nitric oxide, blood vessels can relax and widen allowing blood to flow from and to the heart. As we age we produce less nitric oxide. This can cause the cardiovascular system to become less elastic which can reduce the flow of oxygenated blood to vital organs. This is the reason it's important to have an active lifestyle and a diet that's rich in nitrates which bio convert to nitric oxide and may help maintain normal blood pressure levels and a healthy cardiovascular system.

Losing your breath through exercise three times a week can provide remarkable health benefits. Exercise should be intense enough that carrying a conversation is difficult, indicating hypoxia or low oxygen. This low oxygen state stimulates a beneficial stress response in the body. This response can build muscle, improve blood flow, and cause tissues to release chemicals that slow aging. This practice of intentionally inducing breathlessness for ten minutes, three times a week, can lower disease rates by thirty percent.

Nitric oxide, produced by the endothelium lining blood vessels, functions as a messenger molecule. It signals blood vessels to dilate or widen.

James Nestor’s work suggests we’ve largely lost the ability to breathe correctly. 99% of people are breathing dysfunctionally, harming bodies and brains through how we sit, sleep, and eat. The modern world is conspiring to make us sick—diabetes, asthma, metabolic and autoimmune issues, anxiety, ADHD. Experts said it is 100% related to your breathing at night; bad breathing habits are a recipe for disaster, especially for kids, with a big red flag if you hear them breathing while sleeping. Everyone can become a good breather, and steps are free—we can do this while we’re seated here. The first thing is to Carbon dioxide is seen as this poison. Why? Levels over 800 into a thousand can have serious issues with cognitive and physical functions. I’ve been recording our c o two during this interview; it’s going off. And if we were to continue working for next hours, you will Jesus.

The conversation centers on carbon dioxide (CO2) as a central regulator of physiology, challenging conventional bicarbonate-centric views and highlighting a broad, interconnected view of respiration, hormones, and cellular chemistry. - The speaker traces exposure to and interest in CO2 through diverse lines of thought. Early on, the guest describes encountering Russian and American literature on respiration and notes how pre-1950 Russian scientific works remained accessible in the U.S. He recounts the work of J. C. Woebes, a Hindu-physicist who studied the relation between sensory life properties and physical states, including how metals and rocks can twitch under stimulation and how nerve and muscle-like responses could be amplified and observed in non-biological systems. - A recurring theme is a shift away from membrane-centric cellular models toward the idea that sensitivity and many life-defining properties are intrinsic to complex protein interactions and electronic processes. Gilbert Ling’s perspective, which emphasizes surface effects and the idea that protein complexes govern respiration and cellular behavior without requiring membrane penetration, is highlighted as foundational to the guest’s thinking. Ling’s concept of “cardinal absorbents” (with carbon dioxide, progesterone, potassium, magnesium, and other factors stabilizing protein systems) is presented as a framework that contrasts with traditional bicarbonate-focused acid-base regulation. - The guest connects respiration to electronic control, citing W. F. Coke’s work on respiration as an electronic unit modulated by quinones, donors, and acceptors. He explains that a paired donor-acceptor input in a cell can induce contraction, while individual donors or acceptors alone may not. This electronic viewpoint is linked to Ling’s ideas and to a broader critique of purely bicarbonate-based acid-base explanations, suggesting that bicarbonate bookkeeping fails to capture cellular and tissue-level dynamics. - The discussion expands into CO2’s role in regulating pH and cellular energetics beyond Henderson-Hasselbalch. The guest argues that carbon dioxide is a fundamental regulator that can alkalinize or acidify intracellular environments through carbamino formation and protein interactions, not merely via bicarbonate in plasma. He references Stewart’s approach as an alternative framework to Henderson-Hasselbalch for understanding acid-base balance, especially at the cellular level. - Several clinical and physiological threads are explored: - CO2 as a regulator of oxygen affinity: carbon dioxide acidifies hemoglobin and cells, increasing oxygen uptake while affecting release as part of Bohr-like mechanisms, and CO2 stabilizes proteins through carbamino chemistry. - The idea that CO2 can protect against oxidative damage and support recovery: recent discussions touch on “permissive hypercapnia,” CO2’s antioxidant effects, and clinical observations that elevated CO2 levels are present in some near-death experiences. - The potential for CO2 to influence calcium, cardiac function, and bone metabolism: examples include observations about bones, osteopetrosis, and the effects of CO2-rich environments on bone density and mineral balance. - Nutritional and hormonal interactions: thyroid hormone (T3) augments respiration and cytochrome oxidase activity, increasing CO2 production and oxygen affinity; estrogen and polyunsaturated fats tend to disrupt respiratory balance; progesterone and pregnenolone can support CO2-related cellular responses. The role of endotoxins in lowering CO2 production and their interaction with stress and thyroid activity is also discussed. - The host shares anecdotes and experimental anecdotes illustrating CO2’s practical applications: - Carbonated baths and inhaled CO2 leading to rapid physiological effects. - Household or clinical use of CO2 (for instance, delivering small amounts of CO2 in controlled ways) to influence vascular tone, edema, and tissue perfusion. - Personal experiences with CO2 therapy in acute settings (e.g., stroke-like events) and in chronic conditions (arthritis, vascular issues). - The discussion references a variety of analogies and natural models: - Naked mole rats, bats, and queen bees illustrate how different organisms maintain higher CO2 environments internally, affecting longevity and metabolic regulation. - The Bohr effect, carbamino protein interactions, and the notion that CO2 can act as a context that shapes the behavior of hormones and receptors. - The closing emphasis is on viewing carbon dioxide as a unifying context for physiology across organ systems. The guest argues that understanding CO2’s role provides a framework that can explain respiratory, hormonal, and metabolic phenomena that reductionist medicine often treats in isolation, and he encourages thinking of CO2 as a central context for interpreting physiology rather than as a mere byproduct of metabolism.