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Megyn Kelly hosts a discussion on transitioning and de-transitioning, featuring Walt Heyer and Grace Ladinsky-Smith, both of whom regret their transitions. Walt transitioned to Laura Jensen in his forties but de-transitioned after realizing he needed therapy for childhood trauma rather than surgery. He recounts how adverse childhood experiences, including emotional and sexual abuse, influenced his decision to transition. He emphasizes that many individuals who transition may be dealing with unresolved trauma rather than genuine gender dysphoria. Grace, who began questioning her gender in her twenties, underwent a double mastectomy and hormone therapy but later recognized her mistake. She describes her experience as being influenced by social media and a mental health crisis, leading her to believe that transitioning would resolve her issues. Both Walt and Grace face backlash from trans activists for sharing their stories, highlighting the societal pressure to affirm transitions without exploring underlying psychological issues. The conversation shifts to the medical perspective, with Dr. Julia Mason and Dr. Erica Anderson discussing the implications of puberty blockers and cross-sex hormones. They outline significant risks associated with these treatments, including bone density issues, cognitive effects, and irreversible changes to sexual function. They express concern over the lack of thorough evaluations before medical interventions are prescribed, noting that many young people may be seeking transition as a solution to broader psychological problems. The discussion also touches on the increasing number of young girls identifying as trans and the potential societal factors influencing this trend. Both doctors advocate for a more cautious approach, emphasizing the need for individualized assessments and addressing underlying mental health issues rather than rushing into medical treatments. They call for a systematic review of the scientific evidence surrounding these practices, similar to actions taken in countries like Sweden and Finland, which have begun to reassess their approaches to gender-affirming care for minors.

The discussion centers on the rapidly growing movement among millennials identifying as non-binary or a third gender, with about 10% of this demographic embracing such identities. Dr. Debra Soh, a neuroscientist and author of "The End of Gender," expresses concern that many young people may be misdiagnosed as transgender when they are actually just exploring their sexual orientation, particularly in the context of gender dysphoria. Soh argues that transitioning at a young age can lead to negative outcomes, including the potential for regret and mental health issues later in life. She emphasizes the importance of allowing children to explore their identities without rushing into medical interventions. Soh critiques the current academic climate, noting that many researchers avoid discussing controversial topics due to fear of backlash. She highlights the phenomenon of rapid onset gender dysphoria, particularly among young women, suggesting that social pressures may play a significant role. The conversation also touches on the implications of trans women competing in women's sports and the potential dangers of placing individuals in prisons based on gender identity rather than biological sex. Soh advocates for a return to evidence-based discussions about gender and sexuality, warning that the denial of biological realities could have serious societal consequences.

Clementine Breen, a 22-year-old college student and detransitioner, shares her experience with gender transition and the subsequent challenges she faced. At 12, she received puberty blockers, began testosterone at 13, and underwent a double mastectomy at 14, all while feeling disconnected from her female peers and struggling with anxiety stemming from childhood sexual abuse. She did not disclose the abuse to her medical providers, who conducted minimal investigation into her history, leading to a swift diagnosis of gender dysphoria. Clementine highlights the role of Dr. Joanna Olsen Kennedy, a prominent figure in transgender youth healthcare, and Dr. Scott Mosser, her surgeon, in her treatment. She notes that Olsen Kennedy's research on gender-affirming care did not show improvements in mental health, yet the findings were not published to avoid political backlash. Clementine's experience reflects a broader concern about the lack of thorough psychological evaluation and the rush to affirm gender identities without addressing underlying issues like anxiety and depression. Throughout her transition, Clementine felt pressured by her guidance counselor and medical professionals to conform to a male identity, which initially provided her with social acceptance. However, as she continued her transition, she experienced severe mental health issues, including psychosis, which she attributes to both the testosterone and unresolved trauma from her past. After seeking therapy focused on her trauma, Clementine began to understand her identity differently and ultimately decided to detransition. She is now pursuing a lawsuit against the medical professionals involved in her care, aiming to raise awareness about the potential harms of gender-affirming treatments for youth. Clementine emphasizes the importance of addressing mental health issues before making irreversible medical decisions and encourages others to recognize that feelings of discomfort during puberty are common and do not necessarily indicate a need for medical intervention.