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Depression is not caused by a deficiency in a serotonin reuptake inhibitor, but rather a general deficiency in serotonin. Serotonin is made in the gut through methylation, and 90% of the body's serotonin resides there. Therefore, if there isn't enough serotonin in the gut, there won't be enough elsewhere in the body. Depression usually begins in the gut, not as an outside cluster of symptoms.

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Speaker 0 argues that the food supply is treated with a chemical called folic acid, which is not a natural vitamin and did not exist until the 1980s. According to the speaker, folic acid is not found anywhere on the surface of the earth, whereas folate does exist in nature. The speaker notes that during pregnancy, women are told to take high doses of folic acid, and questions why a man-made chemical that didn’t exist until the eighties is deemed absolutely necessary for a healthy pregnancy. The comparison is made between folate and methylfolate, implying a distinction between natural forms and synthetic forms. The speaker also states that in the United States, the entire grain supply—flour, rice, bread, pasta, grains of any kind, and cereals—is required to be sprayed with folic acid, although this is not openly labeled as such. Instead, it is described as fortified or enriched foods. The speaker claims that these fortified or enriched nutrients are fed to children, and asserts that half of the population has a gene mutation that prevents them from processing folic acid effectively. The consequence, according to the speaker, is that when a person cannot process a high amount of something introduced into the body, it becomes dysfunctional. The speaker then connects this to a broader societal issue, describing a common scenario: a child goes to school, comes home with a phone call reporting inattention and poor ability to follow directions, and the ensuing medical response is the prescription of stimulants such as Adderall or Ritalin. The speaker characterizes this as a solution that uses amphetamines to accelerate the central nervous system to match the pace of a racing mind, rather than addressing underlying factors. Ultimately, the speaker presents a proposed solution: remove folic acid, fortified, and enriched nutrients from the diet, and observe changes in behavior. The underlying claim is that eliminating these synthetic nutrients would calm behavior and improve function, implying that the current approach relies on artificial chemistry rather than natural nutrition.

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Research has revealed that folate deficiency in a child's brain can lead to autism. We have also identified an exciting therapy that may benefit larger numbers of children who suffer from autism. Peer reviewed literature has documented that up to sixty percent of folate deficient children with ASD can have improved verbal communications if given Leukavorin. I have instructed NIH, FDA, and CMS to help doctors treat children appropriately. Jay will help tell that story, which started with sound science, the kind that restores faith in government.

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A junk food diet leads to printed-out changes in the brain, particularly in areas highly relevant to mental disorders. The discussion centers on the hippocampus, an area crucial for learning and memory, and also implicated in mental disorders. A key factor that helps the hippocampus grow and function is a protein called BDNF. When junk food is fed to animals, the level of BDNF drops, and BDNF is described as “manure for the brain” because it promotes the growth of new nerve cells in the hippocampus. Lisa’s studies claim that junk food can shrink the hippocampus and is associated with telltale signs of depression. The speakers emphasize that the broader evidence generated over the last five years suggests a pattern: people with better quality diets are much less likely to have depression, while those with unhealthy diets rich in processed foods are more likely to have depression. The discussion then highlights a particularly striking study. Researchers took a group of sedentary but otherwise healthy men and put them on a junk food diet for one week. Within that one-week period, they observed the same sorts of deficits in memory and cognition that are seen in animal models and that appear to be linked to the hippocampus. In other words, a short duration of junk food consumption produced measurable declines in cognitive performance in healthy individuals, mirroring hippocampal-linked deficits described in other studies. Throughout the conversation, the emphasis remains on the potential impact of diet quality on brain function and mental health, with a specific focus on the hippocampus, BDNF, and the rapid cognitive effects observed in a brief junk food intervention. The speakers connect dietary patterns to both structural (potentially hippocampal) changes and functional outcomes related to memory, learning, and mood, underscoring the apparent link between nutrition and mental health risk.

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But eating a bowl of pasta and a basket of bread here, and you just feel like you wanna go to sleep and you're in a bad mood. I think folic acid is being targeted here as the root cause of metabolic dysfunction in America. When you look at breads and pastas, the bigger issue that I see, and when you compare it to the foods you eat in Europe, is the ultra processed nature of the foods. The resources, the nutrients are almost largely uninterrupted and the food we're consuming from the grocery store here in The US has been already pre made and pre fabricated in such a way that it stimulates a huge glucose response. Insulin resistance is the key, the root cause of all the weight issues and metabolic dysfunction we see in The US.

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OBGYNs advise pregnant women to take high doses of folic acid, a man-made chemical not found in nature, to prevent neural tube defects. However, folic acid doesn't prevent anything. The prescription of folic acid began due to a pandemic of neural tube defects in newborns, which research linked to methylfolate deficiency. Instead of prescribing methylfolate, a cheap, man-made version called folic acid was used. Folic acid is the most prevalent nutrient in the U.S. diet, sprayed on grains, cereals, pasta, flour, and rice, labeled as "fortified" or "enriched."

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Most people with idiopathic or generalized anxiety due to low serotonin also have gut issues. Depression often correlates with severe gut problems like gas, bloating, diarrhea, constipation, cramping, or irritability, because neurotransmitters affecting emotional states also control gut motility. Many people attribute gut issues to allergies, listing multiple foods. However, true allergies are consistent, not transient. Gut problems are often blamed on the last food eaten, but reactions can vary even with the same food. This is because the issue is gut motility. Identifying the gene mutation causing a deficiency is key. Supplementing based on this knowledge can restore normal gut motility.

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In one study, they found a folate deficiency in between fifty six and seventy five percent of autistic brains. In another trial, that synthetic folate boosted the IQ 20 to 50% compared to placebo.

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Is red dye 40 causing ADHD in kids? Maybe. There's been a few studies now that I've come across that are pretty strong that show a connection between this dye that is very controversial, red dye 40, it's in a variety of products and foods, and ADHD and different disorders in kids. It's already been known that allergies and headaches and things like that, that's pretty well established. But now they're even thinking that the ADHD, the attention deficit hyperactivity disorder, is connected with red dye 40. So I wouldn't let my kids have it if I were you.

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Speaker 0 explains that you can lose weight eating pasta and bread in Europe, but in the United States a bowl of pasta and a basket of bread can leave you sleepy and in a bad mood; in Italy, a fat bowl of pasta makes you feel amazing. The reason given is that in 1993 the chemical industry allegedly convinced the federal government that grain supplies needed to be sprayed with folic acid, so all flour, bread, pasta, and cereal became enriched. Enriched foods are described as being sprayed with folic acid. Folic acid is labeled as a man-made chemical produced in a laboratory and not found naturally anywhere on Earth. The speaker emphasizes that folic acid is the most prevalent nutrient in the human diet. The message is not to avoid grains, rice, pasta, cereals, or bread, but to eat non-enriched versions of those foods—the organic versions.

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"If you look at kids if you look at patients with anxiety, okay, and you because ADHD, anxiety, similar, pattern in the microbiome anyways. So if you look at patients with anxiety, and now I'm taking my anxious patient, and I see a signature microbiome. Some microbes are overgrown, some microbes are low, and what I'm gonna do is I'm basically gonna give that patient a drug. That drug is blunting here the anxiety. Right?" "But it doesn't fix the microbiome." "You have a signature microbiome for anxiety." "Well, the drugs are great because they're working up here." "They're not working at the gut level. So this the anxiety problem is still there." "Do you think people who have ADHD don't have ADHD and they actually just have anxiety?" "I think people with ADHD are lacking microbes. That's what I think." "And the medication doesn't help at all?" "I I think it probably cuts down the symptoms, but I don't think it fix The root." "which is the the business model of most drugs, by the way."

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Folic acid, a man-made chemical created in a laboratory, is not a natural vitamin B9 and does not exist in nature, unlike folate. Pregnant women are advised to take high doses of folic acid. In the United States, the entire grain supply, including flour, rice, bread, pasta, and cereals, is sprayed with folic acid through fortification or enrichment. According to the speaker, half the population has a gene mutation preventing them from processing folic acid, leading to dysfunction. The speaker suggests that this may cause behavioral issues in children, such as difficulty paying attention and following directions, which are often treated with drugs like Adderall or Ritalin. The speaker proposes removing folic acid from children's diets to improve their behavior, rather than medicating them.

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A doctor stated that many children on behavioral medications may only be reacting to artificial food dyes, which are ironically present in many of those medications. A two-week dye-free period can reveal a food dye intolerance in emotionally disrupted children. Food dyes are found in obvious and hidden processed foods, restaurant food, theater popcorn, prescription and over-the-counter medications, mouthwash, toothpaste, fluoride treatments, shampoo, conditioner, and lotion. Identifying them requires reading the ingredients list. Any child with emotional disruption should be checked for an artificial food dye intolerance.

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15 million pounds of artificial food dye are added to food annually, much of it marketed to children. These dyes are linked to behavior problems in kids, including ADHD and autism. One speaker has observed links between dyes and diseases in their kids and patients, such as allergies, inflammatory diseases, and behavior problems. Data suggests food coloring may cause behavioral disorders. The FDA acknowledges red number three as a known carcinogen, yet it is still approved for use. Red number 40, yellow number five, and yellow number six are also important to note.

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An emerging body of science links the microbiome to mental health via the gut-brain connection. Studies in prisons and juvenile detention facilities show extraordinary results when diets are changed. One juvenile detention facility saw suicide rates decrease by 100% and the use of restraints decrease by 75% simply by changing the diet. A Harvard professor is reportedly curing schizophrenia with dietary changes. Violence in prisons went down by 47%. Governors are being urged to change diets in schools and remove food dyes that affect behavior. There are opportunities to improve children's physical and mental health.

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The majority of people with idiopathic or generalized anxiety due to low serotonin also have gut issues. Those with depression often suffer from gas, bloating, diarrhea, constipation, irritability, or cramping because neurotransmitters affecting emotional states also control gut motility. Many people attribute gut issues to allergies, listing wheat, soy, corn, dairy, blueberries, bananas, or gluten as triggers. However, true allergies are consistent, not transient. If someone can sometimes eat a food without reaction, it's likely not an allergy. Gut issues are often correlated to the last food eaten, but the real issue is gut motility. Identifying the gene mutation causing a deficiency is key to knowing what to supplement with to restore normal gut motility.

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Best brain foods to start your day are protein and healthy fat. Keith Conner, when he was at Duke, did a study on children who had ADD and found their medicine worked longer if they had protein to start their day. It is also noted that healthy fat helps you absorb vitamins better. The goal is to have stable blood sugar. The transcript ends with, “the worst foods to start your day next.”

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Speaker 0 states that attractive women seem to have stomach problems because “every woman that has stomach problems suffers from anxiety. They come from the same place.” He then asserts that “Forty four percent of women have a gene mutation called MTHFR,” describing this mutation as an inability to convert folic acid. He notes that this mutation is “this gene mutation, which half of the population has,” and links it to the gut and anxiety issues. He adds that “these women suffer from consistent gut issues, and they also have anxiety.” He emphasizes the prevalence by saying, “It is so prevalent that I have never know, we had more than a hundred and fifty thousand patients come through our functional clinic.” He concludes with, “I have never seen a woman that suffers from anxiety who did not also have gut issues.”

The Ultimate Human

The MTHFR Gene: Why Your Vitamins Might Be Useless (And What to Do) | TUH #096
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Methylation is a crucial process occurring 300 billion times daily, converting nutrients into usable forms. Deficiencies in this process can lead to common ailments. Many people operate at only 55-60% of their potential health due to nutrient deficiencies. The MTHFR gene mutation affects 44-60% of the population, impacting the conversion of folate into its active form, five methyl folate. This mutation can lead to various health issues, including neural tube defects and mood disorders. A 2020 study published in 2024 highlights the importance of five methyl folate for cellular health, showing that supplementation can reverse deficiencies and improve health outcomes. In individuals with the MTHFR mutation, folic acid supplementation does not increase five methyl folate levels, while five methyl folate supplementation results in a tenfold increase. This suggests that those with the mutation should avoid folic acid and opt for five methyl folate. The study also links folate deficiency to hypertension and mood disorders, emphasizing the need for individualized supplementation. The FDA's 1998 mandate to fortify foods with folic acid has had mixed results, particularly for those with the MTHFR mutation. Eliminating fortified foods may significantly improve symptoms in affected individuals. Overall, addressing nutrient deficiencies through proper supplementation can enhance health and well-being.

The Ultimate Human

Rose Ferguson: Live Q&A on MTHFR Gene Mutation, Autoimmune Disease and Cognitive Decline | TUH #213
Guests: Rose Ferguson
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Gary Brecka and Rose Ferguson host a Q&A, offering insights into nutrition, biohacking, and health. They stress a holistic approach, often connecting health issues to gut function and genetics. For teenagers, they recommend whole foods over addictive processed options, suggesting genetic methylation tests for personalized supplementation with methylated multivitamins and multiminerals. Protein intake is crucial, with Gary promoting "Perfect Amino" for its high bioavailability and lack of caloric impact, especially for those struggling to meet protein goals. Rose advocates for diverse protein sources, including fiber-rich plant proteins. Both caution against peanuts due to mold, mycotoxins, and lectins, which can cause leaky gut. Gut health is a core focus, identified as a root cause for 85% of autoimmune diseases, IBS, and skin conditions like rosacea, eczema, and psoriasis. Factors like stress, alcohol, poor sleep, antibiotics, and mycotoxins disrupt the gut's single-cell lining, leading to inflammation and systemic issues. Hydration, minerals, and therapies like red light and contrast baths are suggested for skin health. Regarding vegan diets, they advise careful preparation, emphasizing protein from sources like hemp seeds, and avoiding processed plant-based foods and heavily sprayed, genetically modified grains. The hosts clarify that widespread gluten sensitivity often stems from modern food processing, particularly fortification with synthetic folic acid, rather than gluten itself. They link the MTHFR gene mutation, affecting nearly half the population's ability to process folic acid, to ADHD and postpartum depression, recommending methylated folate and avoiding fortified foods. They also strongly advise against cyanocobalamin (synthetic B12) due to its cyanide content. Hair loss, including alopecia, is discussed, with Gary suggesting exosomes or topical finasteride and linking it to maternal genetics, DHT, thyroid issues, and stress. The conversation shifts to longevity versus sports performance, where extreme performance often "borrows from the future." Longevity protocols prioritize whole foods, sleep, strong relationships, and appropriate exercise. For Alzheimer's and dementia, termed "Type 3 diabetes" (insulin resistance in the brain), prevention involves maintaining a low glycemic profile, insulin sensitivity, intermittent fasting, and adequate sleep. Gary controversially highlights a strong correlation between statin use and cognitive decline. Finally, heavy metal detoxification protocols are mentioned, emphasizing specific testing methods.

The Ultimate Human

MTHFR Gene Mutation Explained: How to Know If You Have It and What To Do About It | TUH #024
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In this episode of the Ultimate Human podcast, Gary Brecka discusses the MTHFR gene mutation, which affects the body's ability to convert folic acid into methylfolate. This mutation is prevalent, affecting an estimated 44% of the population. Symptoms include anxiety, impaired gut motility, and inconsistent digestive issues like bloating and cramping. Brecka suggests that individuals with MTHFR may benefit from testing and supplementation with methylfolate and B vitamins. He also highlights the mutation's impact on children, linking dietary folic acid to behavioral issues. Removing fortified foods from children's diets may lead to significant behavioral improvements.

Dhru Purohit Show

Doctor Reveals: Simple Ways To Lower Autism Risk Before Pregnancy | Dr. Jeff Zadeh
Guests: Dr. Jeff Zadeh
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The episode centers on a candid, medically grounded discussion about factors that may influence autism risk and what parents can do before and around pregnancy. Dr. Jeff Zadeh, sharing his personal motivation after his son Luke’s autism diagnosis, explains that the medical literature supports an evidence-based approach to reducing autism risk through preconception and early pregnancy interventions. He highlights a flagship idea from his book: starting a prenatal vitamin with methylfolate (not folic acid) five days a week from before conception, arguing that the Boston Birth Cohort study found a 70% reduction in autism risk when mothers took prenatal vitamins at that intensity from the start of pregnancy. The conversation emphasizes that timing matters; benefits appear strongest when vitamin intake begins before conception and continues through the earliest weeks of gestation. The discussion also covers why not all prenatal vitamins are equal, noting that methylfolate is absorbed more reliably than folic acid and that some vitamins with iron types like ferrous bisglycinate can improve tolerance and absorption. Iron status is identified as another critical factor, with recommendations to screen ferritin levels preconception and during pregnancy, since iron deficiency has been linked to higher rates of neurodevelopmental issues including autism. The guests discuss thyroid health, noting that untreated hypothyroidism can be associated with higher autism risk, though evidence for treatment reducing risk remains preliminary. Celiac disease and gluten-free diets before pregnancy are explored as potential modifiers of nutrient absorption, with testing via TTGA blood tests mentioned. The conversation extends to environmental factors, like lead exposure and air pollution, and how adequate folate may mitigate some toxins’ impact on neurodevelopment, a concept labeled as Bertrand’s rule. Vitamin D and omega-3 intake receive particular attention as promising avenues, with recent studies suggesting that improving maternal vitamin D status can reduce adverse pregnancy outcomes and possibly autism risk via reduced preterm birth. The hosts stress that these recommendations are not medical advice but evidence-based proposals and advocate for thoughtful consultation with clinicians. The episode closes with personal reflections on navigating the autism landscape, balancing risk reduction with acceptance, and the hope that broader awareness and education could lessen the burden on families while preserving the value of each individual on the spectrum.

The Ultimate Human

How Your MTHFR Gene Impacts ADHD with Gary Brecka | TUH #043
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Today, we explore the connection between ADHD, the MTHFR gene, and diet. The MTHFR gene is crucial for converting folate into methylfolate, essential for neurotransmitter synthesis, impacting mood and behavior. Variations in this gene can hinder folate metabolism, affecting dopamine and serotonin levels, which are vital for managing ADHD symptoms. A diet rich in natural folate from leafy greens, omega-3 fatty acids, and antioxidants can support brain health. Removing synthetic folic acid from diets may also improve ADHD symptoms. Understanding this link empowers dietary changes to manage ADHD effectively.

The Ultimate Human

Debunking Health Myths with Sage Workinger-Brecka & Gary Brecka | TUH #199
Guests: Sage Workinger-Brecka
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In this episode of the Ultimate Human Podcast, Gary Brecka and his wife, Sage, address frequently asked questions about relationships, health, and business. They emphasize the importance of scheduling quality time together, suggesting activities like hiking in Colorado where they can disconnect from technology and focus on each other. They've shifted their vacation style to prioritize connection over entertainment, finding that the absence of distractions allows them to enjoy each other's company more. They also highlight the significance of laughter and shared activities like sauna sessions and outdoor adventures for both their relationship and health. The discussion covers various health-related topics, including identifying the root causes of fatigue. Gary recommends starting with a basic blood panel and genetic test to identify nutrient deficiencies or hormonal imbalances. He advises testing for mold, mycotoxins, heavy metals, parasites, and viruses, especially if fatigue is a recent onset. Sage shares her experience with mold poisoning from hurricane damage, emphasizing the importance of testing and detoxification. They also discuss daily habits that can negatively impact energy, focus, and mood, such as focusing on the negative and poor sleep habits. Gary stresses the importance of having a consistent morning routine, including sunlight exposure, breath work, and a mineral-rich drink, to align with circadian rhythms. The couple delves into specific health myths and misconceptions, particularly regarding dieting and intermittent fasting. Sage cautions against restrictive diets, especially for young girls, and advocates for eating whole foods in moderation. Gary debunks the myth that women shouldn't weight train and warns against intermittent fasting for women with low blood sugar, as it can disrupt hormone balance. They also discuss tracking biomarkers, with Gary prioritizing sleep, hormones, and nutrient deficiencies, while Sage emphasizes the importance of tracking steps to encourage physical activity. They explore strategies for increasing mitochondrial function naturally, such as high-intensity cardio and red light therapy, and the importance of detoxifying from mold and heavy metals. The podcast also addresses supplements for children, recommending methylated multivitamins and avoiding fortified foods with folic acid. They discuss supporting young boys with ADHD symptoms through methylated vitamins, folic acid avoidance, and structured physical activity. For those looking to transition off caffeine, they suggest alternatives like cacao and matcha tea, along with a morning cocktail of sea salt, amino acids, and hydrogen tablets. They also offer advice on overcoming itchy skin with supplements like resveratrol and magnesium, and warm showers. The episode concludes with a discussion on weight training in a fasted state, with Gary recommending amino acids before workouts, and strategies for fixing low testosterone without TRT, including lifestyle changes and supplements like boron and DHEA.

The Dhru Purohit Show

The Shocking Daily Factors Causing Chronic Disease, Diabetes & An Early Death | Dr. Elisa Song
Guests: Elisa Song
reSee.it Podcast Summary
The health of children is deteriorating, with nearly half diagnosed with chronic health issues. Since 2005, projections indicate kids may have shorter lifespans than their parents. Current statistics show one in five children has eczema, one in ten has asthma, and one in ten has ADHD. Mental health disorders are also rising, with one in two teens expected to be diagnosed by age 18. The pandemic exacerbated these issues, with alarming rates of suicidal thoughts among teenage girls. Autism diagnoses have surged, with one in 36 children now on the spectrum. The gut microbiome plays a crucial role in children's health, developing significantly in the first thousand days of life. Studies indicate that antibiotic and antacid use in infancy increases the risk of allergic diseases and mental health issues. The modern diet, heavily reliant on ultra-processed foods, is damaging children's gut health, contributing to chronic diseases and mental health challenges. Key disruptors of gut health include psychological stress, added sugars, and the over-prescription of antibiotics and other medications. Parents are encouraged to be mindful of their children's diets and to foster resilience through lifestyle changes. Simple swaps in food choices can help mitigate gut dysbiosis. The conversation around children's health must include awareness of environmental toxins and the importance of nurturing the gut microbiome. Parents and caregivers are urged to educate themselves and their children about gut health, emphasizing the importance of resilience and proactive health management. The book "Healthy Kids, Happy Kids" aims to provide practical guidance for fostering microbiome resilience and overall child well-being.
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