TruthArchive.ai - Tweets Saved By @APazyryk

Posted - April 14, 2024 at 8:32 PM

Saved - November 28, 2024 at 11:36 AM

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The discussion centers on the implications of IgG3 class switching induced by Novavax and its potential link to autoimmune disorders. Concerns arise about IgG4 antibodies specific to viral spikes and their ability to trigger immune reactions. Roland clarifies that IgG4 antibodies do not cause autoimmune diseases but can cross-react with self-tissues. He emphasizes that afucosylated antibodies pose a greater risk. Akruschke notes that IgG4-related illnesses are rare but acknowledges increasing cases, referencing specific conditions studied in relation to vaccines.

@APazyryk - Altai Pazyryk

@mrmickme @RolandBakerIII Is there any benefit to IgG3 class switch induced by Novavax?

@notquitegonzo - notquitegonzo עם ישראל חי

@mrmickme @APazyryk @RolandBakerIII Forgive me for my lack of clarity and therefore question Does this indicate a risk for developing auto-immune disorders from nvx booster?

@RolandBakerIII - Roland Baker

@notquitegonzo @mrmickme @APazyryk Antibodies against IL-4, IL-13 receptors& tumor necrosis factor circumvent the class switch to IgG4 with mRNA vaccines. Clearly this is specific to mRNA vax and not ad vector and protein sub-unit vax. https://www.medrxiv.org/content/10.1101/2023.09.29.23296354v1

Suppressed IgG4 class switching in dupilumab- and TNF inhibitor-treated patients after repeated SARS-CoV-2 mRNA vaccination medRxiv - The Preprint Server for Health Sciences medrxiv.org

@RolandBakerIII - Roland Baker

@notquitegonzo @mrmickme @APazyryk No these IgG4 antibodies are specific to the viral spike and don't cause autoimmune disease. The causal connection to IgG4-RD is that you first get an autoimmune disease and the class switch to IgG4 that binds "self" is to prevent damage caused by autoimmune disease.

@a_kruschke - A.Kruschke

@RolandBakerIII @notquitegonzo @mrmickme @APazyryk Could these anti spike IgG4 trigger an immune reaction to the tissues where the spikeproteins are incorporated?

@RolandBakerIII - Roland Baker

@a_kruschke @notquitegonzo @mrmickme @APazyryk Do you mean like where SARS2 spikes are budding from mRNA vaccine or adenovirus vector vaccine transfected cells? Yes, you could see cross reactions to "self" on the cell. But in general IgG4 have less off a tool kit to cause immune reactions than IgG3.

@RolandBakerIII - Roland Baker

@a_kruschke @notquitegonzo @mrmickme @APazyryk If there is an antibody type we should all be worried about it's afucosylated antibodies. They can cause very severe disease.

@a_kruschke - A.Kruschke

@RolandBakerIII @notquitegonzo @mrmickme @APazyryk Yes I meant the reaction to the "Spikeprotein presenting cells". The question was just scientific interest. The other antibodies you mentioned are certainly much more concerning in clinical practice.

@a_kruschke - A.Kruschke

@RolandBakerIII @notquitegonzo @mrmickme @APazyryk Those IgG4 related illnesses are extremely rare. It became a bit less rare meanwhile. M. Ormond/retroperitoneal fibrosis, ... https://pubmed.ncbi.nlm.nih.gov/36814401/ ... mesenterial panniculitis. Pfizer even made a study about. https://www.ehealthme.com/vs/pfizer-biontech-covid-vaccine/mesenteric-panniculitis/

New-onset retroperitoneal fibrosis following COVID-19 mRNA vaccination: Coincidental or vaccine-induced phenomenon? - PubMed The Pfizer-BioNTech mRNA vaccine is a US Food and Drug Administration-approved coronavirus disease 2019 (COVID-19) vaccine. Although it is reported to be safe and effective, immune dysregulation leading to autoimmunity has become an area of concern. Retroperitoneal fibrosis (RPF) is an immune-mediat … pubmed.ncbi.nlm.nih.gov

Pfizer BioNTech Covid Vaccine and Mesenteric panniculitis, a phase IV clinical study of CDC and FDA data - eHealthMe Mesenteric panniculitis is found among people who get Pfizer BioNTech Covid Vaccine, especially for people who are male, 60+ old, have been taking the drug for ehealthme.com