reSee.it - Tweets Saved By @ElliotHershberg

Saved - September 2, 2024 at 9:36 AM
reSee.it AI Summary
This week, I came across three fascinating papers. First, one discusses how bacteria can create new repetitive toxic genes to self-destruct in response to infection. Second, I learned about new viroid-like elements, termed Obelisks, which are phylogenetically distinct and found in about 7% of human stool samples. Lastly, there's an in-depth exploration of Fanzors, the smaller eukaryotic RNA-guided endonucleases discovered by the Zhang Lab last year. What a week—biology is truly crazy!

@ElliotHershberg - Elliot Hershberg

Three of my favorite papers published this week: 1. A mechanism for bacteria to create *new* repetitive toxic genes to kill themselves in response to infection (!!)

@ElliotHershberg - Elliot Hershberg

2. Discovery of new viroid-like elements—which the authors call Obelisks—that nobody knew about, but are completely phylogenetically distinct and present in ~7% of human stool samples (!!)

@ElliotHershberg - Elliot Hershberg

3. A deep dive into the mechanisms of eukaryotic gene-editing systems called Fanzors—the smaller, eukaryotic RNA-guided endonucleases that the Zhang Lab discovered last year.

@ElliotHershberg - Elliot Hershberg

What a week. Biology is crazy. Toxic gene creation: https://doi.org/10.1126/science.adq3977 Discovery of Obelisks: https://www.biorxiv.org/content/10.1101/2024.01.20.576352v1 Fanzor mechanisms: https://doi.org/10.1016/j.cell.2024.07.050

Viroid-like colonists of human microbiomes bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution biorxiv.org
Structural insights into the diversity and DNA cleavage mechanism of Fanzor Fanzor (Fz) is an ωRNA-guided endonuclease extensively found throughout the eukaryotic domain with unique gene editing potential. Here, we describe th… sciencedirect.com
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