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@anabology - anabology
The 'Alt-Right Cancer Cure' Fenbendazole, Mebendazole, and Ivermectin. But how do they actually work? 🤔 Thread🧵
@anabology - anabology
These drugs are all known as "dewormers." But are they killing parasites in cancer patients? Do parasites cause cancer? Let's dig into the mechanism to find out:
@anabology - anabology
Fenbendazole and mebendazole both disrupt microtubules, a mechanism shared by FDA-approved cancer drugs like taxol (which came from the Pacific yew tree). By disrupting the skeleton of the cell, these drugs stop cell division. But they may do more than just halt cancer growth.
@anabology - anabology
Disrupting microtubules could change the structure of water in the cell. Malignant cancer cells, notably, lose this structured water state, which contributes to their unchecked growth.
@anabology - anabology
This water structure-cancer link was first measured by Raymond Damadian, the inventor of MRI. Damadian knew that cancer cells had less of an electrical charge. He also knew that water structure changes always went in hand with bioelectric changes.
@anabology - anabology
Cancer cells were known to be electrically depolarized, so the water structure was expected to be different as well. This insight led to the MRI as a way to detect cancer through water structure differences. (The MRI measures water structure, roughly)
@anabology - anabology
So briefly: Fenbendazole and mebendazole may fix the water structure in cancer cells.
@anabology - anabology
Then there’s Ivermectin. The standard explanation is that it paralyzes parasites by hyperpolarizing their cells (making them more electrically charged; a 'resting' state). But humans don’t experience paralysis from Ivermectin -- its action appears selective to parasites.
@anabology - anabology
Here’s where it gets interesting: Simpler organisms like parasites tend to have less morphological complexity and *less structured water within their cells.* In higher organisms, structured water exists more in differentiated and specialized cell types.
@anabology - anabology
So, if Ivermectin’s effects are tuned to target machinery in cells that have lost water structure,* it might be selectively hyperpolarizing cells with less water structure. Like parasites, or cancer cells. *(Gilbert Ling's principle of the preferred counter-ion)
@anabology - anabology
Since bioelectricity and water structure go hand in hand, fixing the cell's voltage often fixes the water structure.
@anabology - anabology
This selectivity suggests that Ivermectin could specifically targeting unstructured states in cancer while sparing healthy cells from any big effect. This makes it a natural fit for selectively affecting unhealthy cells.
@anabology - anabology
So: these drugs may work by halting cell division.. AND By fixing water structure / bioelectricity in cancer cells.
@anabology - anabology
Notably, this cocktail is derived from natural molecules, as were FDA-approved drugs that share the mechanism (i.e. taxol). Nature seems to do a better job than humans at making drugs that can kill a parasite rather than the host.
@anabology - anabology
The synthetic small molecules that humans have made have generally been toxic to both host and cancer. You just have to hope that the cancer is weaker than the host.
@anabology - anabology
In conclusion: these drugs likely don't work through simple 'deworming,' and likely work directly on the cancer cells in a really clever way. These therapies need to be available for those who want them. #MAHA
@anabology - anabology
Credit for @MakisMD for publishing the protocol
@anabology - anabology
@anabology - anabology
I feel like there must be an “underground truth” in every science. Things have stagnated universally and this must be why. For bio/biochem: - “evolution comes from random mutations” - “membrane pumps create ion gradients” - “molecules interact in lock-and-key fashion with proteins” - “proteins fold into a defined configuration” All ridiculous presumptions that dominate the field and prevent progress. For finance, the ergodic assumption seems to be an equivalent. The fact that people like Mark Spitznagel at Universa can make so much profit by paying attention to non-ergodicity means finance assumes markets are more ergodic than they are. This is arbitrage at its finest. In math, the axiom of infinity seems ridiculous. The fact that you can add two infinite sets together and get any finite answer just by rearranging the terms seems to make it so addition is not commutative in ZFC. I think this should make us question the axiom of infinity. Also, infinity breaks math’s connection to physics, as the physical world is quantized. For physics, maybe loop quantum gravity is misleading everyone? Not briefed in that field. Wolfram’s ideas around computational irreducibility seem like a more sensible approach. Are there similar things in engineering? Are rockets blowing up because of the mainstream narrative? Psychology? Computer science?
@anabology - anabology
I've just written the 'Milk Manifesto'. https://anabology.notion.site/Milk-Manifesto-e328ddc4812c4d959243f5f44f9768e5?pvs=4 In the manifesto, I outline with >40 references: 1. The health-promoting components that are only found in milk. 2. The fact that drinking pasture-raised milk is more vegan than eating vegetables. Quick list of the unique components: 1. Odd-Chain Saturated Fats: Uniquely found in milk, associated with lower risk of cardiometabolic and metabolic diseases. 2. Milk-Fat Globule Membrane (MFGM): Vital for infant health, neurodevelopment, and beneficial in adults for reducing post-prandial inflammation and other muscle strength. 3. Conjugated Linoleic Acid (CLA): Known for its anticarcinogenic, antiobese, antidiabetic, and antihypertensive properties. 4. Alkylglycerols: The main protector of PUFAs, found in milk, associated with anti-cancer and anti-aging properties. 5. Lactoferrin: An iron-binding protein with antimicrobial, anti-inflammatory, and anticancer activities. 6. Bioactive Peptides: Derived from stomach and gut digestion of milk proteins, known for antihypertensive, antimicrobial, antioxidative, and other beneficial effects. 7. Milk Oligosaccharides: Complex sugars that provide prebiotic a bioactive effects that alleviate metabolic abnormalities. 8. Lactoperoxidase: An antimicrobial protein ensuring sterility of biological fluids. 9. Extracellular Vesicles: Natural lipid nanoparticles in milk that facilitate positive metabolic programming and promote good health. As for the vegan argument, milk produces 0.25 animal deaths per year of calories conservatively, while the least deadly vegetable produces 6.6x this figure.
@turtard - Turtar
@anabology Thoughts on cheap store brand milk? And what’s the best fat % In your opinion
@anabology - anabology
@turtard Raw > Vat pasteurized > Pasteurized > UHT pasteurized Non-homogenized > homogenized Depends on your goals for fat percentage. Milk fat is healthy, but the more you process it, the less information in the milkfat you retain.
@anabology - anabology
Throughout history, governments have used fear as a tool for control. Thyroid function is deeply related to fear. COVID-19 vaccines induce thyroid dysfunction.¹ Mice lacking the main receptor for the active thyroid hormone, T3, show significant increases in fear compared to mice with normal thyroid function.² Over 60% of individuals with hypothyroidism exhibit clinically significant symptoms of anxiety.³ Stalin leveraged Soviet citizens' fears about external threats to restrict their economic freedom, notably eradicating their remaining agricultural autonomy.⁴ The manipulation of the food supply has often been employed as a means of exerting control. Many scholars interpret the great famine of 1931-33 under Stalin as a means by which the regime exerted control over the populace.⁵ One of the main ways that starvation exerts stress on the organism is through the suppression of thyroid hormone⁶, increasing cortisol and other stress hormones.⁷ If I were a government trying to create a fearful population, I would encourage restriction of calories and create a food supply that disrupts thyroid function. Thyroid function would ruin the effects of starvation, after all: T3 prevents starvation-induced cell death⁸, and proper thyroid function reduces cortisol through proper glycemic control.¹⁰ As an evil government, my anti-thyroid food of choice would be polyunsaturated fat. Seed oils and fish oils disrupt thyroid function¹¹, and I could easily make them ubiquitous by calling them 'healthy'. All modern dietary recommendations create a fearful populace, enabling those in power to restrict freedom, as compliance is guaranteed. Contribute to a stronger, more free society by taking charge over your thyroid health.
@anabology - anabology
Sources: 1) https://link.springer.com/article/10.1007/s40618-022-01786-7 2) https://nature.com/articles/4001196 3) https://ncbi.nlm.nih.gov/pmc/articles/PMC4911835/ 4) https://proquest.com/docview/2301886350?pq-origsite=gscholar&fromopenview=true… 5) https://degruyter.com/document/doi/10.4159/9780674042902-intro/html 6) https://sciencedirect.com/science/article/abs/pii/0026049576901621 7) https://doi.org/10.1016/S0889-8529(01)00023-8… 8) https://doi.org/10.1016/j.yjmcc.2005.07.019 9) https://ncbi.nlm.nih.gov/pmc/articles/PMC3968713/ 10) https://ncbi.nlm.nih.gov/pmc/articles/PMC3968713/ 11) https://academic.oup.com/endo/article-abstract/72/1/45/2703001
