TruthArchive.ai - Tweets Saved By @breakfast_dogs

Saved - November 2, 2024 at 12:39 PM
reSee.it AI Summary
Chen Zhu's journey from a barefoot doctor to China's Health Minister illustrates the country's evolution. Fluent in English and French, he played a pivotal role during SARS and was instrumental in establishing the Wuhan P4 lab, despite security warnings. His connections with French scientists and institutions aimed at studying coronaviruses raised concerns about transparency. Zhu was involved in discussions about the origins of SARS-CoV-2, and recent proposals hinted at collaborations with various Asian countries. The implications of these partnerships and the origins of the virus remain contentious topics.

@breakfast_dogs - Dog's Breakfast

Barefoot Doctor to B-52 Chen Zhu personifies the narrative of China's rise. Sent to the countryside during the Cultural Revolution he taught himself medicine, becoming a "barefoot doctor". Eventually he rose to become Health Minister. Is Zhu central to the Covid cover-up? 🧵

@breakfast_dogs - Dog's Breakfast

Zhu is fluent in English and French. A Francophile, he did his PhD in France, supervised by a doctor who was a close friend of Jacques Chirac. During SARS he was Vice President of CAS (WIV's parent). When Institut Pasteur sent a scientific team to help, he saw an opportunity.

@breakfast_dogs - Dog's Breakfast

Zhu was the driving force behind the Wuhan P4, and became good friends with businessman Alain Mérieux, who promoted the project in France. The project was signed off by the Chirac government overruling warnings from French security forces about PLA interest in biowarfare.

@breakfast_dogs - Dog's Breakfast

Institut Pasteur Shanghai was set up as a joint venture with CAS. It was intended the P4 would be run as a joint venture, giving French scientists oversight. This didn't eventuate, no French scientists went to Wuhan. IPS staff were mostly Chinese, but linked to Pasteur's network.

@breakfast_dogs - Dog's Breakfast

Chen Zhu was Health Minister between 2007-2013, while WIV were working towards their *fraudulent* claim of a bat origin of SARS. It wasn't solely a WIV initiative. There is clear co-ordination with other State Key Labs, such as AMMS and HKU (incl Tommy Lam).

@breakfast_dogs - Dog's Breakfast

Less well known is a more recent Chen Zhu proposal. This would have involved the outposts of Instituts Pasteur and Mérieux in Cambodia, Laos, Vietnam and Bangladesh, collaborating with China to sample novel pathogens.

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After the infamous Feb 1 teleconference, it was Chen Zhu that Farrar contacted to discuss concerns of artificial origin. Zhu might seem a good choice, a back channel to China's upper echelon. The response was rapid. @Florin_uncovers nailed the link.

@Florin_Uncovers - Florin

The Proximal Origin Puzzle (Part 1) On Feb 1 Farrar learns SARS2 is likely lab made. Same day he alerts powerful Chinese official Zhu Chen! Next days they lock steps with China to coverup the origin: Holmes joins PLA pangolin study, Shi denies a lab leak & Andersen flipflops.🧵

@breakfast_dogs - Dog's Breakfast

The next day, a proposal (directed at Fauci) for a joint venture between Harvard and Zhong Nanshan's institute, lavishly funded with a $118 million donation from Evergrande, would study coronavirus origins - over the longer term.

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And Holmes was contacted by Tommy Lam who wanted to draw attention to the pangolin sequences. Some had already been uploaded as metagenomic data in late January, but hadn't yet been noticed by western scientists.

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As he tells it, the day after the infamous Farrar/Fauci/Fouchier teleconference he got a call from an old colleague Tommy "Tsan Yuk" Lam now at HKU. Tommy Lam had done postdoc in the Oxford Zoology department where Holmes was based before moving to Australia.

Video Transcript AI Summary
We decided to write a summary statement, and the next day, my colleague at the University of Hong Kong, Tommy Lam, sent me a sequence from a pangolin that was closely related to SARS-CoV-2. The receptor binding domain of SARS-CoV-2 appeared unique, but the same sequence was found in the pangolin, suggesting a natural origin. Initially, I believed there was a 60-40 chance of a lab leak, which later shifted to 80-20 for a brief period. However, I quickly changed my mind based on new evidence.
Full Transcript
Speaker 0: Kind of conclusion was we should write something up as a kind of summary statement. And then, literally, in the next day, my colleagues at University of Hong Kong, Tommy Lam, emailed me, said I've got this sequence from a pangolin. It's kinda close. Can you take a look? And what the amazing thing was that when the when the odd things about that SARS CoV-two was the receptor binding domain look kinda look kinda strange, right, look looked unique. Suddenly, in the pangolin, the same sequence more or less is there. Right? So suddenly, suddenly look very unusual, rather alien. There it is in nature. Okay. So then it all kind of, you know, the, there it is. That must be natural. So then, you know, within like, I've I've you know, I'm famously quoted online saying Eddie Holmes thought that, you know, it was 6040 for a lab leak. In fact, it might have been 8020 at some point. That that phase lasted for like 3 days. Right? And then very quickly, very quickly, I changed my mind because of the date

@breakfast_dogs - Dog's Breakfast

Two weeks later Institut Pasteur in Paris received a visit from the Chinese ambassador Lu Shaye. A press release on Pasteur's site proudly lists the many ways their Asian outposts collaborate with China.

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A new collaboration may have been discussed, which would have seen Chinese scientists from IPS join Institut Pasteur du Laos (IPL) in an expedition to sample bats. IPL had sampled hundreds of bats in 2017, funded by US DoD, but - for unknown reasons - *never sequenced them*.

@breakfast_dogs - Dog's Breakfast

Ultimately it seems IPS didn't participate in the field trip, for unknown reasons (perhaps optics). But a few weeks beforehand, a Chinese military delegation visited. In early July samples were collected that contained the new closest relative to SARS-CoV-2 - Banal-20-52.

@breakfast_dogs - Dog's Breakfast

Five SARS-like viruses were discovered - all from the one site (of 4 sampled). While some sequences purport to explain the SARS-CoV-2 and pangolin RBD, others have the RmYn02 RBD and its "proto-FCS", there are also sequences from ZC45, found 3000km away. Chance incroyable!

@breakfast_dogs - Dog's Breakfast

I've wondered if Banal-52 is a reference to B-52, the plane that carpet bombed Laos during the Vietnam war? It is plausible that a similar virus, with an FCS insert, could become SARS-CoV-2. It suggests an origin outside China. And if artificial, it might be a US creation?

@breakfast_dogs - Dog's Breakfast

But I don't believe the Banals are genuine natural viruses - evidence for this in a paper coming very soon. There are uncomfortable diplomatic ramifications. In 2023 Institut Pasteur dissolved its partnership with CAS. Unsurprisingly, Covid origins weren't mentioned.

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Links: https://www.mediapart.fr/en/journal/france/310520/strange-saga-how-france-helped-build-wuhans-top-security-virus-lab https://www.radiofrance.fr/franceinter/enquete-sur-le-p4-de-wuhan-ce-laboratoire-qui-suscite-tant-de-fantasmes-construit-avec-l-aide-de-la-france-3907490 https://www.pasteur.fr/en/home/institut-pasteur/institut-pasteur-throughout-world/news/chinese-ambassador-france-visits-institut-pasteur https://zenodo.org/records/13476370

Enquête sur le P4 de Wuhan, ce laboratoire qui suscite tant de fantasmes, construit avec l’aide de la France Voulu et mis sur pied avec l’aide de la France, le très sensible laboratoire de virologie P4 de Wuhan qui fait aujourd’hui l’objet de beaucoup de spéculations, a peu à peu échappé au contrôle des scientifiques français. Selon la cellule investigation de Radio France, un vaccin contre le Covid-19 y a récemment été testé radiofrance.fr
The Chinese Ambassador to France visits the Institut Pasteur On Friday February 14, 2020, Stewart Cole, President of the Institut Pasteur, played host to His Excellency Mr Lu Shaye, Chinese Ambassador to France, who was visiting the Institut Pasteur to show support both personally and on behalf of his country for the Institut Pasteur’s efforts in response to the novel coronavirus outbreak. pasteur.fr
Scrutinizing the extraordinary mosaic evolution of SARS-like coronaviruses Papers and sequences published by Wuhan Institute of Virology (WIV) are fundamental to our understanding of zoonotic SARS-like bat coronaviruses, the presumed ancestors of both SARS and SARS-CoV-2. The seminal paper that is “Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor” (Ge et al, 2013) and the viral sequences Rs3367, RsSHC014 and WIV1 published to GenBank in November, 2013[i]. This, and subsequent papers from WIV, make explicit and implicit claims in relation to the evolution of SARS which contradict a widely accepted model of recombination in single-stranded RNA viruses. Most startlingly, an imputable recombination between ancestors of Rs3367 and RsSHC014 occurs precisely at a breakpoint previously identified by WIV experimentally as optimal, and chosen by another group in an experiment to create a synthetic chimera. Another implied recombination involves the natural insertion of a novel gene, ORFX, into an otherwise undisturbed backbone sequence. WIV’s work purports to show evidence of natural evolutionary mechanisms that may cause rapid species and/or tissue tropism changes, or gain of function via acquisition of a novel gene as an insert. It is important that these results be independently verified. zenodo.org
Saved - July 2, 2024 at 3:21 PM
reSee.it AI Summary
The posts discuss the challenges of cultivating live zoonotic viruses from fecal samples, the possibility of synthetic chimeras, and the use of intracerebral inoculation to infect lab animals. There is speculation about the origin of certain viruses and the potential involvement of specific institutions. The posts also mention the distribution of pangolin samples and the lack of independent detection of pangolin viruses. The author hints at a forthcoming thread on "Getting away with it" and teases a future post on airborne respiratory viruses.

@breakfast_dogs - Dog's Breakfast

How to Make and Deploy a Bioweapon and Get Away With It. Don't try this at home (unless your home is at least BSL-3) Part 1: Growing a Backbone Cultivating a live zoonotic virus from a sample is much harder than it is to sequence one from RNA fragments. But there are ways. 🧵 https://t.co/OwdEG5nBVs

@breakfast_dogs - Dog's Breakfast

WIV claim to have only ever obtained 3 live bat cov isolates: WIV1, WIV16 & RsSHC014. but I'm not convinced these are from natural samples at all, I suspect they're synthetic chimeras. WIV claim they cultivated these from bat fecal samples, but this is particularly challenging.

@breakfast_dogs - Dog's Breakfast

Viruses can't survive for long without host cells to infect and replicate, so feces must be very fresh (or quickly frozen). Even then, bat feces contain many microorganisms (yeasts/fungi, bacteria, phages), and cytotoxic substances that can kill cells before they can be infected. https://t.co/B7WSKMmdaT

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WIV, and CSIRO "batman" Linfa Wang unsuccessfully tried to rescue viruses from feces several times. AMMS also tried and failed. No-one had successfully recovered any live RNA virus from feces before WIV1was announced in 2013. https://t.co/pgQWEByRGi

@breakfast_dogs - Dog's Breakfast

To achieve this, WIV did little differently than on previous attempts. Apparently they got lucky. Doubly so because they managed to find the precursor to SARS. But they had also been quietly trying to engineer this hypothesized "missing link" virus in the lab. So, I wonder...? https://t.co/aavUoBJgF6

@breakfast_dogs - Dog's Breakfast

A Baric led UNC/Vanderbilt team had previously rescued an artificial chimeric bat virus with the RBD from human SARS substituted. A synthetic virus avoids the problems of toxic contaminants and keeping the virus alive. But Baric was still unable to cultivate a purely bat virus. https://t.co/WVndXxKYBm

@breakfast_dogs - Dog's Breakfast

WIV also failed at this apparently (at least initially). https://t.co/2rAAIq8fuZ

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But if obtaining live virus from feces and cell culture is hard (or impossible), there is a simpler way if you don't care so much about maintaining fidelity with the original strain. And it also has other advantages for those interested in infecting different host species... https://t.co/GvHKSCKY3R

@breakfast_dogs - Dog's Breakfast

Intracerebral inoculation is the technique the PLA used in 2017 to infect suckling immune deficient mice with their bat virus discovery ZC45. It involves directly injecting fluid from ground infected tissue of freshly killed animals directly into the brains of live lab animals. https://t.co/oFj7z27OqA

@breakfast_dogs - Dog's Breakfast

This technique isn't new. It was used as far back as 1930 to infect mice with yellow fever. Normally the brain is protected from infection by the blood-brain barrier. The technique circumvents that defense, and the immune response in the central nervous system is far less robust. https://t.co/0lWlTH8xPU

@breakfast_dogs - Dog's Breakfast

Immune deficient mice aren't the only option for applying this technique. In the 1990's Baric was developing theories of coronavirus spillover. On several occasions he refers to an experiment involving the intracerebral inoculation of primates with mouse coronavirus MHV. https://t.co/ui5RLWMYcu

@breakfast_dogs - Dog's Breakfast

Another Baric insight was that persistent infection (up to 210 days) produced MHV variants which could infect cells from other species. Using immune-suppressed baby mice or cell culture allows infection to persist, rather than be cleared by the immune system in days, as normal. https://t.co/6n0qmbxKvz

@breakfast_dogs - Dog's Breakfast

We know the PLA used this technique with the ZC45 virus and BALB/C mice, might they have also used it on other species? An October 2016 paper made some interesting observations about the pangolin immune system (h/t @Engineer2The) suggesting a new immune deficient animal model. https://t.co/og4zVtcEvc

@breakfast_dogs - Dog's Breakfast

By the next year Yigang Tong of AMMS was working (in secret) on purported pangolin viruses. Coincidence? https://t.co/0E5X7SsrWe

@breakfast_dogs - Dog's Breakfast

The pangolin samples from AMMS have been distributed far and wide. I know of five separate groups (WIV, HKU, GIABR, SCAU, NUS) that published papers about them, though none acknowledge the PLA source. They were instructed to say they came from 某些特定机构 "certain institutions".

@breakfast_dogs - Dog's Breakfast

Curiously, others have been unable to independently detect pangolin viruses. Some unusually useful work from EcoHealth produced this null result👇 https://t.co/Hlr6uYPBRv

@breakfast_dogs - Dog's Breakfast

But it's also possible the pangolin was only a convenient scapegoat, never infected in nature or a lab, but samples of pangolin tissue deliberately contaminated to give that impression. I'll weigh the evidence for this in a forthcoming thread on "Getting away with it".

@breakfast_dogs - Dog's Breakfast

Some handy hints for the DIY-er if you really insist on trying this out at home. At least make sure an exhaust fan is running and wear some rubber gloves. This is the level (BSL-2) that Yigang Tong worked on pangolin viruses. https://t.co/RfCcGKZxgi

@breakfast_dogs - Dog's Breakfast

Thanks to @drlimengyan1 @Engineer2The @NLink247 @daoyu15 for ideas and discussions on this topic. Coming soon... Part 2: "Give your pathogen wings: what makes an airborne respiratory virus?"

Saved - March 12, 2024 at 12:33 AM
reSee.it AI Summary
The SARS-CoV-2 furin cleavage site (FCS) has several unusual features, including a leading proline, a non-canonical sequence, and potential O-glycosylation sites nearby. These features resemble those found in the FCS of MERS, a distantly related virus. The lengthened FCS creates an extended flexible loop, which is important for pathogenesis. The presence of potential O-glycosylation sites near a proline is also seen in MERS. The similarities between the FCS of SARS-CoV-2 and MERS raise questions about their origins and potential implications. Researchers, including Yusen Zhou and Lanying Du, have been studying MERS and working on vaccines for both MERS and SARS. Peter Hotez, who worked closely with Du, has been involved in projects related to pan-coronavirus vaccines. The cross-reactivity between SARS-CoV-2 and other coronaviruses, including MERS, has implications for immunity and the potential for antibody-dependent enhancement (ADE). The presence of non-neutralizing epitopes in SARS-CoV-2, catalogued by Zhou and Du, could contribute to ADE. The connection between the AMMS (PLA), the WIV, and various researchers involved in studying coronaviruses raises further questions. The discovery of a 2018 PhD thesis supervised by Yusen Zhou, which focused on creating Chinese dominant HLA mice and evaluating epitopes of MERS, adds to the concerns surrounding the origins and potential manipulation of SARS-CoV-2.

@breakfast_dogs - Dog's Breakfast

Lord have MERSy - it's the Fu@in Cleavage Site Again! There are odd features of SARS-CoV-2 furin cleavage site that some claim no-one would have engineered that way. They speak for themselves, its designers must have their reasons. First we must know: what was their intent?

@breakfast_dogs - Dog's Breakfast

The unusual features are: 1) A leading Proline. 2) A non-canonical sequence. Furin is not cleaved with maximum efficiency. 3) The site has been created by an out-of-frame insertion, not substitution. 4) Presence of potential O-glycosylation sites nearby.

@breakfast_dogs - Dog's Breakfast

1) A leading Proline, the "P" in "PRRAR". The reason for the Proline isn't obvious, though proline has unique structural attributes. It also enhances the chances of O-glycosylation nearby. But in some variants the P has mutated to something else, suggesting it isn't optimal.

@breakfast_dogs - Dog's Breakfast

There is also a leading P in the FCS of MERS. So what, you ask? MERS is only distantly related, right?

@breakfast_dogs - Dog's Breakfast

2) It's a non-canonical sequence. Missing an R (or K) in P2. SARS-CoV-2 has a minimal RXXR sequence but doesn't have the "canonical" RXRR pattern and so furin doesn't cleave it with maximum efficiency.

@breakfast_dogs - Dog's Breakfast

@wanderer_jasnah clearly hadn't heard of MERS (and there are many others with non-canonical sequences too Jas!). MERS FCS also lacks an Arginine in P2, and so isn't cleaved with maximum efficiency. In fact SARS-CoV-2 is more efficiently cleaved by furin than MERS.

@breakfast_dogs - Dog's Breakfast

Sequence lengthened by insertion. Compared to other related viruses, the loop on which the FCS is located is longer. The FCS is created by inserting four additional amino acids. *Most* previous experiments created an FCS by changing another residue to R, not adding new ones.

@breakfast_dogs - Dog's Breakfast

The extra length of the insert creates an extended flexible loop off the surface of the spike. This length in itself is known to be important to pathogenesis. Is there another example of this? Yes - MERS.

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4) O-Glycosylation sites The Proximal Origin authors first noticed the presence of potential O-glycosylation sites leading to the FCS. These are simply Serine or Threonine residues. They don't always attach to glycans, but one thing that increases the odds is a nearby Proline.

@breakfast_dogs - Dog's Breakfast

In what other virus can we find a similar pattern of potential O-glycosylation sites, near a Proline? You guessed it...MERS.

@breakfast_dogs - Dog's Breakfast

So the FCS resembles that of MERS in several structural and functional ways, and the sequence looks quite similar. Why could this be? Maybe as a fallback? I'm not sure?

@breakfast_dogs - Dog's Breakfast

Like SARS, MERS was of great interest to the biodefense industry. Both are far more virulent than other human covs. One objective of research was a vaccine that would work against both. But understanding the pathogenicity of MERS could also be useful for nefarious purposes.

@breakfast_dogs - Dog's Breakfast

One group that was working towards such a vaccine was centered around husband and wife, Yusen Zhou and Lanying Du. Zhou is the PLA officer who died in mysterious circumstances in May 2020. https://www.dailymail.co.uk/news/article-12205705/Chinese-military-expert-filed-patent-Covid-vaccine-died-mysterious-circumstances.html

Chinese scientist who filed patent for Covid vaccine died mysteriously Zhou Yusen died in mysterious circumstances in May 2020, aged 54. US investigators are said to have been told 'Zhou fell from the roof of the Institute', although this has not been confirmed. dailymail.co.uk

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Du is less well known, but perhaps the more accomplished coronavirologist. She met and married Zhou in Beijing, then did her PhD with Bojian Zhang at HKU. BJ Zhang was also a guest professor at AMMS and instrumental in SARS origin tracing. https://covorigin.org/2023/05/17/the-furin-cleavage-site-part-1-nexus/

The Furin Cleavage Site Part 1: Nexus The interface between S1 | S2 • US | China • Military | Civilian • SARS | MERS The FCS has been the standout feature of the SARS-CoV-2 both in its awkward protrusion from a previously conserved part of the spike sequence, and in the controversy and discussion it has raised. Several theories have been… covorigin.org

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Du then moved to the US and was based at the Lindsley F. Kimball Research Institute at New York Blood Center with Shibo Jiang. Other PLA scientists such as Wenbo Tai, also trained and worked there.

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Du studied and is a leading expert in MERS and its FCS, its role in conformational dynamics and pathogenicity. Although some are now claiming that no FCS was ever *inserted* experimentally - Du and Jiang were involved in an experiment that did exactly that.

@breakfast_dogs - Dog's Breakfast

Du was working for NIH on projects managed by Peter Hotez which included pan-coronavirus vaccines designed by combining epitopes from different human coronaviruses with MERS and SARS. https://grantome.com/grant/NIH/R01-AI139092-03

404 error: Page not found grantome.com

@breakfast_dogs - Dog's Breakfast

Hotez has admitted he worked closely with Du for many years, but he LIED that he didn't know her deceased husband, even though Yusen Zhou was also on his payroll. He even permitted animal testing work to be done in the AMMS Beijing lab. https://t.co/FIWOSXp7yI

@breakfast_dogs - Dog's Breakfast

The Du group weren't the only ones pursuing a SARS/MERS vaccine. Their close collaborators - Fang Li's group from UMN and Wuhan University, and Wuhan Insitute of Virology were also interested. @billybostickson investigated a separate US project. https://t.co/E60lYDPcFi

@BillyBostickson - Billy Bostickson 🏴👁&👁 🆓

17. Random Beta-Coronaviruses? "The question was whether we could develop a single antiviral for both MERS and SARS, and by extension, for whatever random beta-coronavirus would emerge next." https://t.co/9ot8S7rKGO

@breakfast_dogs - Dog's Breakfast

@biophysicsfl observed that SARS-CoV-2 FCS is even more similar to the MERS S2 site in sequence than its S1/S2 having an A in same position. There is some nucleotide homology too. The S2 site in MERS is more efficiently cleaved by furin than the S1/S2. https://t.co/u2DuC2IoAo

@breakfast_dogs - Dog's Breakfast

I also noticed a sequence flanking the FCS (QTNSP) is found in another human coronavirus (HKU1) with nearly identical (14/15) nucleotides. This may be intended to introduce some "pan-coronavirus" immune interaction. https://t.co/PUeL5BXfY2

@breakfast_dogs - Dog's Breakfast

There is sequence and structural homology to MERS elsewhere in the spike (particularly the NTD) and also to other human coronaviruses (e.g NL63) More about that in an earlier thread: https://t.co/FQLNv8RuCu https://t.co/A6CyB4xZw5

@breakfast_dogs - Dog's Breakfast

Evidence of Genetic Engineering of SARS-CoV-2 Part 12(?): Conformational Contortions Recently @florian_krammer et al reported SARS-CoV-2 antibodies cross-reactive to barely related human coronaviruses including MERS. Surprising? Not to me. https://t.co/BsdXccWx03

@breakfast_dogs - Dog's Breakfast

I can speculate about why someone would insert epitopes from unrelated hCoVs. It could be benevolent (e.g. pan-coronavirus vaccine). But it could also be malicious. Zhou and Du catalogued and characterized non-neutralizing epitopes that cause ADE. https://t.co/6FpngCMcZQ

@breakfast_dogs - Dog's Breakfast

SARS-CoV-2 is now known to be cross-reactive with other CoVs including MERS. This could be beneficial (confer immunity broadly across coronaviruses) but if antibodies aren't neutralizing potentially provides a mechanism for ADE, which increases severity of subsequent infections.

@breakfast_dogs - Dog's Breakfast

Such a mechanism is described in this paper. The date of publication and author list are especially interesting, bringing together the AMMS (PLA), the WIV, Lanying Du and Shibo Jiang, and Fang Li and his postdocs (from the State Key Lab of Virology at Wuhan University) https://t.co/42KyrYyi1P

@breakfast_dogs - Dog's Breakfast

Possibly more disconcerting, this thesis uncovered by @florin_uncovers. Humanized mouse models were developed targeting the dominant HLA for Chinese/East Asians. The thesis supervisor is Yusen Zhou and one of the epitopes evaluated is the MERS FCS: https://t.co/KaqA4YXr8U https://t.co/KlQSWnE0ho

@Florin_Uncovers - Florin

I found a 2018 PhD thesis supervised by controversial PLA scientist Yusen Zhou. It's about creating Chinese dominant HLA mice and finding Chinese HLA restricted epitopes for Ebola & the MERS spike. Specialists could discuss how ethical or DURC this is. 1/4 https://web.archive.org/web/20230205232139/https://theses.hal.science/tel-01900581/document https://t.co/P2ygl3bYtO

Saved - January 26, 2024 at 8:54 AM
reSee.it AI Summary
The origin of the 2013-16 Ebola outbreak in West Africa is still a mystery. Some believe in the possibility of a lab leak, although evidence supporting a natural origin is fragile. The lab under suspicion is located at Kenema General Hospital and was run by the Viral Hemorrhagic Fever Consortium (VHFC). There are connections between the VHFC and individuals involved in Covid origins research. Chinese involvement in Sierra Leone and their potential leverage over the US to push a natural origin theory is also discussed. The series of events surrounding the outbreak and subsequent investigations raise questions about the true origin of Ebola.

@breakfast_dogs - Dog's Breakfast

The Proximal Origin of Ebola Part 1 Like Covid-19, there is mystery shrouding the origin of the 2013-16 Ebola outbreak in West Africa (Sierra Leone, Guinea and Liberia). Very different diseases but the outbreaks have much in common, including many of the same people involved.

@breakfast_dogs - Dog's Breakfast

@samhusseini and @bioSRP recently revived interest in the possibility of a lab leak origin. Though they don't claim dispositive proof, they point out that evidence supporting a natural origin is fragile, and a plausible case for a lab leak can be made. https://x.com/BioSRP/status/1584914301214662656

@BioSRP - Bioscience Resource Project

Who framed Guinea? We joined with journalist @samhusseini to investigate the #Ebola2014 outbreak and its cover up. https://www.independentsciencenews.org/health/did-west-africas-ebola-outbreak-of-2014-have-a-lab-origin/

Did West Africa's Ebola Outbreak of 2014 Have a Lab Origin? - Independent Science News | Food, Health and Agriculture Bioscience News Were virologists covering up the role of a US funded pathogen lab in Sierra Leone when they blamed the 2014 West African Ebola outbreak on a Guinean boy? independentsciencenews.org

@breakfast_dogs - Dog's Breakfast

They weren't the first to suspect a lab leak. International law expert Francis Boyle (who had helped implement the Bioweapons Convention in the US) was at the time the leading proponent of a theory that a lab in Kenema, Sierra Leone, with ties to USAMRIID, was responsible.

@breakfast_dogs - Dog's Breakfast

Naturally this idea was mocked and "debunked" by mainstream media (and more recently in a Bob Garry paper) as a "conspiracy theory". https://web.archive.org/web/20231113225114/https://www.telegraph.co.uk/culture/books/11216881/Ebola-is-man-made-and-other-crazy-conspiracy-theories.html

'Ebola is man-made', and other crazy conspiracy theories Is Obama behind the Ebola outbreak? Are planes poisoning us? Is Lady Gaga part of an evil Illuminati plot? The five conspiracy theories you won't believe people believe web.archive.org

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The official line- that a child of 18-months was the index case after contact with infected bats, is questionable. Early suspected cases weren't tested for Ebola, and symptoms are common to many diseases. Bats and animals tested later were all negative. https://www.who.int/news-room/spotlight/one-year-into-the-ebola-epidemic/origins-of-the-2014-ebola-epidemic

Origins of the Ebola epidemic who.int

@breakfast_dogs - Dog's Breakfast

It is now established fact that many early cases went undetected in Sierra Leone. Journalist @sherifink found cases had gone unreported as early as March. By the time testing began in June 2014, the virus had spread widely and was genetically diverse. https://x.com/CD57227/status/1721544552060715486

@CD57227 - CD8

She found out that two cases that got sick in Guinea in March 2014 actually were from Sierra Leone. But the authorities in Sierra Leone claimed they never got the memo. And they didn't find any cases on their side of the border until 2 months later. youtube.com/watch?v=LKLJPl…

@breakfast_dogs - Dog's Breakfast

The lab under suspicion is situated at Kenema General Hospital (KGH). The lab was run by the Viral Hemorrhagic Fever Consortium (VHFC) whose members include Harvard and Tulane, Scripps and UTMB. Some of the leadership will be familiar to those following Covid origins.

@breakfast_dogs - Dog's Breakfast

At the time Kristian Andersen was at Harvard, where he did postdoc with Pardis Sabeti. Bob Garry is also a founding partner in Zalgen Labs, which is based near Fort Detrick and developed an Ebola therapeutic. Doug Simpson is former CEO of Corgenix, which developed an Ebola test.

@breakfast_dogs - Dog's Breakfast

Separate to VHFC but at the same KGH site is Metabiota. This adds an extra layer of intrigue. The VC firm in which Hunter Biden was partner - Rosemont Seneca - was a seed investor in Metabiota, and was actively promoting the company to potential clients and new investors.

@breakfast_dogs - Dog's Breakfast

Emails from the Hunter Biden laptop leak show some at Rosemont Seneca even saw Ebola as a marketing opportunity. Hunter Biden's value to RS was his then Vice-President father. They could market a unique advantage in finding "public policy opportunities" and "avoiding missteps".

@breakfast_dogs - Dog's Breakfast

China also sent a team to Sierra Leone basing themselves on the other side of the country. Though ostensibly there to provide medical support, many were research scientists. Some will also be familiar names - senior among them George Gao of China CDC, and Wuchun Cao of AMMS.

@breakfast_dogs - Dog's Breakfast

On the ground in Sierra Leone the Chinese team was led by AMMS's Yigang Tong and Shandong Uni's Weifeng Shi. In Covid origins work they were responsible for pangolin coronaviruses and RmYN02 respectively. They have worked together often in the past, as have their teams.

@breakfast_dogs - Dog's Breakfast

Tong is closely associated with the discovery (or invention) of the pangolin coronaviruses, some of which have near identical RBD to SARS-CoV-2. In a paper he revealed they had them since 2017. At that time he was involved in a secret military project. https://x.com/breakfast_dogs/status/1744029206860980239?s=20

@breakfast_dogs - Dog's Breakfast

Between 2016-2019 when AMMS isolated the pangolin coronavirus, Tong was working on a major secret research project with a USD 5 million budget.

@breakfast_dogs - Dog's Breakfast

Some have speculated that Andersen and Garry feared if SARS-CoV-2 were the result of a lab leak, it could lead to an investigation of their Sierra Leone activities. Perhaps Ron Fouchier alluded to this in an email following the Feb 1st teleconference? https://x.com/Rebecca21951651/status/1734197785182765421?s=20

@Rebecca21951651 - Rebecca

You have to read this and see the video to see how Fouchier threatened Kristian

@breakfast_dogs - Dog's Breakfast

Chinese involvement may expand this. Perhaps blackmail was used - if you expose our lab leak, we'll expose yours? This might well explain their overnight conversion from a serious concern about artificial origin, to ridiculing it as a "conspiracy theory".

@breakfast_dogs - Dog's Breakfast

At the pre-pandemic preparedness "Event 201", George Gao, seated next to now ODNI Director Avril Haines, dropped a reference to rumors of a lab leak in Sierra Leone during a session on controlling "misinformation and disinformation". (From 1:00) https://x.com/KanekoaTheGreat/status/1635437727117352960?s=20

@KanekoaTheGreat - KanekoaTheGreat

Former CIA Director Avril Haines and China's CDC Director George Gao discuss censoring a lab leak at Event 201 in Oct. 2019: "My staff told me that there is misinformation. Some people believe that this is man-made or a pharmaceutical company made the virus." https://www.youtube.com/watch?v=LBuP40H4Tko

Video Transcript AI Summary
There have been more cases and deaths reported in China. Misinformation about the virus being man-made by a pharmaceutical company has caused violations and even deaths. It is important to train healthcare workers to ensure they have accurate information and can provide proper care. Telecommunication companies should be involved in providing access to communication for everyone. Trusted sources, including community leaders and health workers, should amplify the correct message. Constant communication is necessary to address misinformation and respond to concerns. There are foreign disinformation campaigns that need to be countered quickly to effectively combat the pandemic.
Full Transcript
Speaker 0: More cases in China and also death cases reported. And also, my staff told me, that before there's misinformation and, there are some belief. People believe this is a man made, some pharmaceutical company made the virus. So there are some violations and even death is because of this misinformation. As from, like, the citizen, and I don't know if Steve agree with me, when you are doing the field work and you like to do some so called TOT, training of trainers. So we only need to train the health workers. We try to have care workers, they are access to the places, to the public. So make sure they they got the right information. So not necessary, you know, sometimes the health Care workers, they know something, but they if they are not well trained, they might give the wrong information, but also they might say something, oh, I don't know. Even I don't know, that could hurt. So when I remember that such a situation remind me, When I was in early on, when I was interviewed by radio, the national radio, I was asked by one of the audience to say, Okay. We believe Ebola was man made. It's transported from, you know, somewhere. So this is I think this is very important. We do the TOT. So make sure the healthcare workers have the right information. Okay. Thank you. Herveo? I very Speaker 1: much agree with that. So I I mean, I think I agree with a lot of what's been said. I'd just add to it maybe by saying that I think one of the things we want to do is work with telecommunication companies to actually ensure that everybody has access to the kind of communications that we're interested in providing because that's going to be critical for dealing with, obviously, The explosion of the disease. And then another issue, I suppose, is just through that, if you have a trusted source, I believe in the idea that we shouldn't be trying to control communication, but rather flood the zone in a sense with a trusted source That then is influential community leaders as well as health workers, as Brad noted and others on these issues in order to try to amplify the message that's coming through and I think Tim is absolutely right. I certainly seen the value of communicating constantly on these issues so as to continue to deal with sort of the vacuum that can be created in the circumstance. But then also with the comments made about The fact that for all of the disinformation that will be put out, it's going to be important to actually have a response to those questions and to those concerns, as Steven said, and, and I understand from staff that actually there are also, intelligence sources identifying multiple foreign disinformation campaigns And so on. But it's all a part of a larger piece, which is to say that every time there is something that comes out that is in fact false information that is starting to actually hamper our ability To address the pandemic, then we need to be able to respond quickly to it.

@breakfast_dogs - Dog's Breakfast

The day after the infamous Feb 1st teleconference there were other events that appear to be a coordinated Chinese influence operation to derail the case for an artificial origin. The Chinese had clearly been informed of the nature of discussions.

@breakfast_dogs - Dog's Breakfast

On Feb 2nd Edward Holmes was contacted by former colleague Tommy Lam regarding the "discovery" of pangolin coronaviruses. Many of these had already been sequenced and uploaded, and a paper was published in October 2019. But western scientists hadn't given it any attention.

@breakfast_dogs - Dog's Breakfast

Neither Tommy Lam, nor the Guangdong scientists were the source of the pangolin samples and isolates. These came from AMMS, who had had them since 2017. PLA officers Yigang Tong and Wuchun Cao are credited on the final published paper, but oddly, not on the preceding pre-prints.

@breakfast_dogs - Dog's Breakfast

In 2014 Lam had authored, with Holmes and HKU's Yi Guan (also known for work linking civets to SARS-1), a paper on a separate Ebola outbreak happening simultaneously in the DRC. They hinted that, but for its remote location, this outbreak may have looked like a lab leak.

@breakfast_dogs - Dog's Breakfast

Also on Feb 2, 2020, Fauci was contacted by Harvard Medical School about a proposed US$128 million donation from Evergrande. This was to fund a joint Sino-US group to study Covid origins (among other things), presumably to influence the direction investigations might take.

@breakfast_dogs - Dog's Breakfast

The donor's representative, who claimed to be CEO of Evergrande Health, insisted on direct discussion between Fauci and Zhong Nanshan. Zhong had been integral in the attempt to link the SARS-1 outbreak to civets (which many scientists now find dubious). https://x.com/AshleyRindsberg/status/1570357155357679616?s=20

@AshleyRindsberg - Ashley Rindsberg

One day after the teleconference, Harvard Medical School dean George Daley serendipitously reached out to Fauci. As I reported for @TheSpectator, Daley told Fauci he was writing on behalf of Chinese real estate giant, Evergrande (of all organizations). https://spectatorworld.com/topic/fauci-harvard-and-the-ccp/

The Harvard connection Daley and Fauci would have understood the distinction between working with a Chinese vaccine program and taking enormous sums from Evergrande thespectator.com

@breakfast_dogs - Dog's Breakfast

Was it significant that Harvard was the beneficiary, given they were a partner in VHFC? In any case the deal didn't proceed as planned. Only one payment of $12m was ever received. Journalist @AshleyRindsberg failed to track down the intermediary. https://x.com/AshleyRindsberg/status/1678694977596006402

@AshleyRindsberg - Ashley Rindsberg

@mattwridley The CEO of Evergrande Health, who served the bridge between Harvard and the real estate company, subsequently disappeared. I called former employers (per his LinkedIn) – they not only had never heard of him, but didn't operate practices/departments he'd listed on the CV.

@breakfast_dogs - Dog's Breakfast

The Chinese were clearly offering inducements for the Americans to push a natural origin, but did they also have leverage to threaten them - "kompromat"? Perhaps some scientific evidence they had acquired that might show an artificial origin of West African Ebola?

@breakfast_dogs - Dog's Breakfast

To be continued...

Saved - November 23, 2023 at 10:05 AM
reSee.it AI Summary
Sydney University rejected my request for Edward Holmes' emails, citing safety concerns. I appealed to the Information Commissioner, who instructed the university to consider public interest. However, the university refused to disclose any documents, claiming it would take too much time. This is an insult to the public. The estimated cost of assessing the emails is minimal compared to the grant Holmes received. Transparency is crucial to prevent future pandemics, but the university seems compromised by its ties to China. I have reached out to executives with no response. I will continue to pursue transparency, but I'm not optimistic.

@breakfast_dogs - Dog's Breakfast

Update on my own ongoing efforts to get hold of Edward Holmes' emails: Sydney University also initially rejected my application on grounds that it would endanger Holmes' safety (among other things). I refuted this in an appeal to the independent Information Commissioner @IPCNSW.

@garyruskin - Gary Ruskin

@Douglas_Main @EdinburghUni Our request for records of Edward Holmes — also a coauthor of proximal origin— was denied on similar grounds. Universities should side with efforts to uncover the origin of Covid-19, not with efforts to obfuscate it.

@breakfast_dogs - Dog's Breakfast

The @IPCNSW instructed Sydney Uni that they must consider the public interest for and against disclosing each document separately and withhold only those there is a genuine balance of public interest *against* disclosure.

@breakfast_dogs - Dog's Breakfast

If these emails are genuinely about zoonotic viruses it is hard to see what arguments *against* disclosure might be. But the university then came back with a revised offer to disclose NONE of the documents because it would require too much staff time to assess them.

@breakfast_dogs - Dog's Breakfast

Their estimate of this time was 20-25 working days. While I doubt it would take anywhere near this amount of time (these emails are about zoonotic viruses after all) even if it did I find this argument an insult to the public who suffered through the pandemic.

@breakfast_dogs - Dog's Breakfast

To put into context 25 days of uni admin time charged at $50/hour would cost $9375. For comparison, this amounts to 0.2% of the $3.94 million public grant Holmes was recently awarded by @nhmrc for "A metagenomics platform to prevent future pandemics".

@breakfast_dogs - Dog's Breakfast

How can we prevent future pandemics if we can't identify the cause of the recent one? Holmes' origin theories are based on data and samples from the PRC, including the PLA's bioweapons institute (AMMS). His correspondence is the only data that might elucidate their provenance.

@breakfast_dogs - Dog's Breakfast

@Sydney_Uni seem deeply compromised by their dependence on international student fees and research collaborations with China. I've written to @mscott and senior executives several times to plead the case for transparency and accountability and received no response. https://t.co/92t8jofKnG

@breakfast_dogs - Dog's Breakfast

In my view they're not acting in good faith. If costs were genuinely too high they could have negotiated to reduce scope again, or levied a processing fee. I've appealed again to the Information Commissioner and will pursue it as far as possible. But I'm not holding my breath.

@breakfast_dogs - Dog's Breakfast

In Holmes' favour I can see from metadata USYD provided that he hasn't communicated directly with AMMS. That relationship seems to have been mediated by Tommy Lam, so unclear how much he knew of the background (prior to publication of the pangolin paper when it became public). https://t.co/R9StP215EL

@breakfast_dogs - Dog's Breakfast

The previous table relates to documents resulting from my specific search parameters, which (after scope reductions) were restricted to: emails relating to search terms below, dated between December 2019 and July 2020, to/from any names below. This returned 643 discrete items. https://t.co/YnOEXTao8r

Saved - September 22, 2023 at 2:56 PM
reSee.it AI Summary
Australia is expanding its powers to include pandemic prevention and preparedness, not just during a pandemic. A submission can be made within three days regarding concerns about these expanded powers. Visit consultations.health.gov.au for more information.

@breakfast_dogs - Dog's Breakfast

Because the scope of powers is also being expanded to include pandemic "prevention and preparedness", this means "all the time" not just during a pandemic. If in Australia you still have 3 days to make a submission on this bullshit we are signing up to. https://consultations.health.gov.au/health-systems-policy-division/preparing-for-pandemics-and-health-emergencies/

@breakfast_dogs - Dog's Breakfast

Because the scope of powers is also being expanded to include pandemic "prevention and preparedness", this means "all the time" not just during a pandemic. If in Australia you still have 3 days to make a submission on this bullshit we are signing up to. https://consultations.health.gov.au/health-systems-policy-division/preparing-for-pandemics-and-health-emergencies/

Preparing for, and responding to, future pandemics and other international health emergencies - Australian Government Department of Health - Citizen Space The site lists consultations that are run by the Department of Health and Ageing. On this site you can find, share or take part in consultations. consultations.health.gov.au
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