TruthArchive.ai - Tweets Saved By @gadboit

Posted - April 21, 2024 at 7:48 AM

Saved - November 29, 2024 at 11:21 AM

reSee.it AI Summary

The discussion centers on the challenges of developing broadly neutralizing antibodies for viral infections, particularly COVID-19. One participant highlights the difficulty of finding a neutralization site that the virus cannot mutate. They propose using mRNA technology to produce antibodies, noting potential safety concerns and the complexity of immune responses. Another participant questions the efficacy of antibodies in treating COVID and raises concerns about mRNA's long-term effects, including issues with blood-brain barrier penetration and the risk of antibody-dependent enhancement.

@gadboit - Guy Gadboit

in the wild. At low prevalence, but wide use of this antibody could soon change that... The "holy grail" for a broadly neutralizing antibody is: can you find a place to neutralize the virus that it *can't* mutate with destroying itself? The answer is still no. If it was that...

@gadboit - Guy Gadboit

easy the virus probably wouldn't have made it this far through evolution. Perhaps more interesting than news of yet another antibody therapy that won't work for long is the delivery mechanism. According to the reference for the new tech, antibody treatments are great because...

@gadboit - Guy Gadboit

they are safe and work at once. So why not deliver the abs instead via mRNA LNPs? This way the body's own cells make the antibodies, after a short delay, using far more complex biological pathways, with much greater potential for interesting side-effects? Although I think...

@gadboit - Guy Gadboit

mRNA vaccines have a lot to recommend them, including that they are a better emulation of a live infection than some other vaccine designs, resulting in the right immune response, using mRNA to create *antibodies* is completely different. Now we have other cells, mostly...

@gadboit - Guy Gadboit

monocytes producing antibodies, something they never usually do. LNPs have a strong adjuvant effect, so will we end up with the body making anti-idiotypic antibodies? We still have very limited knowledge of why mRNA vaccines have the side-effects that they do, but some may...

@gadboit - Guy Gadboit

be related to the LNPs, and therefore shared with this new therapy. The reason traditional antibody therapies are safe is because they are just antibodies. Obviously you can't assume this will still be the case if you completely change basically everything about the treatment...

@gadboit - Guy Gadboit

So what is the reason to use mRNA to create antibodies? My cynicism notwithstanding of course it isn't really to reduce safety. According to the reference, it's much cheaper. I trust those savings will be passed on to the consumer. END. h/t @a_kruschke

@a_kruschke - A.Kruschke

@gadboit Finding the "holy grail" by anticipating the future? That sounds more like Harry Potter to me than anything else. ..

@a_kruschke - A.Kruschke

@gadboit .. To be honest, antibodies are a very difficult therapeutic tool for COVID. Perhaps helping in very short time. But I also see it as very critical for the patient himself. Nobody can prevent reinfections. https://www.biorxiv.org/content/10.1101/2023.11.21.567575v1.full ..

SARS-CoV-2 monoclonal antibody treatment followed by vaccination shifts human memory B cell epitope recognition suggesting antibody feedback bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution biorxiv.org

@a_kruschke - A.Kruschke

@gadboit ... Pack this then as mRNA into LNP, which has now shown difficult in terms of BBB passing and myocarditis discussion? mRNA with or without frameshift potential by pseudouridine?

@a_kruschke - A.Kruschke

@gadboit .. mRNA technology still has no stop codons. Using this for a virus with known ADE (look at SARS-1 and MERS, too...)? Ongoing long-term production of an mRNA-coded antibody that will meet a mutated variant in some months? Any other ideas to kill patients more quickly 🙊🙊🙊?