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@MeasslainteIRL - Thomas Anthony III

Lou Gehrig’s Disease – Are We Looking for Solutions!? Amyotrophic Lateral Sclerosis (ALS) – also known as Lou Gehrig’s disease (or Charcot’s disease in Europe) – is characterized by the degeneration of motor neurons and leads to debilitating and potentially fatal symptoms. https://pmc.ncbi.nlm.nih.gov/articles/PMC10886908/ The Spike protein – whether from the virus itself or from COVID-19 injections – can induce or contribute to inflammation in the nervous system, triggering ALS or worsening the condition in people already affected. Specifically, the Spike can affect purinergic receptors, especially P2X4 and P2X7. The P2X7 receptor is particularly concerning, as it plays a central role in neuroinflammation and pain. Interestingly, P2X7 expression increases when TLR4 is stimulated by LPS (lipopolysaccharide) in microglial and astrocyte cells – both of which are part of the central nervous system (CNS). Microglia are the CNS’s resident immune cells, responsible for removing toxic threats — but they can become pro-inflammatory. P2X7 is a hallmark of this pro-inflammatory state in microglia. To note: the Spike protein interacts with LPS, potentially due to leaky gut (intestinal barrier dysfunction), and also with amyloid beta (Aβ42) fibers. These complexes — Spike/LPS or Spike/Aβ42 — can fully activate the TLR4 receptor. https://www.cureus.com/articles/218170-impact-of-the-sars-cov-2-spike-protein-on-the-innate-immune-system-a-review#!/ With a compromised blood-brain barrier, these Spike-related molecular complexes can cross into the CNS, triggering TLR4, and increasing P2X7 expression. P2X7 can also be stimulated by extracellular ATP, which is released during inflammation. When there's reduced ectonucleotidase activity (particularly Ado, short for adenosine), the overexpression of P2X7 becomes dangerous. Adenosine helps break down extracellular ATP — so if Ado is low, ATP accumulates and further stimulates P2X7, ramping up inflammation. Adenosine is also tied to NAD+ https://pmc.ncbi.nlm.nih.gov/articles/PMC9512238/ Another point: P2X7 is a gateway receptor not just for SARS-CoV-2, but also for HIV. That’s yet another similarity between these two viruses. All in all, targeting P2X7 is a promising strategy, and research is ongoing. https://pmc.ncbi.nlm.nih.gov/articles/PMC9877316/ Currently, the main medications approved for ALS treatment include riluzole, edaravone, and tauroursodiol/sodium phenylbutyrate. While they offer some benefits, due to ALS’s severity and the lack of a definitive cure, new pharmaceutical targets must be explored. Purinergic modulation has shown promising results in ALS management, and additional strategies could include: Anti-inflammatory and anti-apoptotic compounds Reducing oxidative stress Modulating neuronal ion channels One promising avenue: boosting NAD+ to provide some immediate support. Oral supplementation with NAD+ precursors like: Nicotinamide (NAM) Nicotinamide riboside (NR) Nicotinamide mononucleotide (NMN) …could help. These are converted into NAD+ via biosynthesis pathways inside cells. However, this is only a short-term aid if the underlying causes of NAD+ depletion aren't addressed. https://pmc.ncbi.nlm.nih.gov/articles/PMC9512238/ Note: NAD+ is linked to SIRT1, which plays a role in maintaining intestinal barrier integrity and supporting the commensal (beneficial) gut flora. Follow Annelises work 👌 #ALS #NAD+ #NMN #SIRT1 #P2X7 #TLR4

Amyotrophic Lateral Sclerosis in Long-COVID Scenario and the Therapeutic Potential of the Purinergic System in Neuromodulation Amyotrophic lateral sclerosis (ALS) involves the degeneration of motor neurons and debilitating and possibly fatal symptoms. The COVID-19 pandemic directly affected the quality of life of this group, and the SARS-CoV-2 infection accelerated the ... pmc.ncbi.nlm.nih.gov

Impact of the SARS-CoV-2 Spike Protein on the Innate Immune System: A Review The Spike protein enables the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by binding to multiple receptors, including the angiotensin-converting enzyme 2 (ACE2). Scientific studies also indicate that Spike is involved in severe forms of coronavirus disease 2019 (COVID-19), "long-haul COVID diseases" - also known as "long COVID syndromes" or "post-acute sequelae of SARS-CoV-2 infection" (PACS) - or, recently, in adverse reactions to lipid nanoparticle-messenger ribonucleic acid (mRNA) vaccines or other anti-COVID19 products. Numerous mutations, notably within the subunit 1 of Spike (S1), prevent neutralization by antibodies, but more generally, the virus has developed numerous strategies to avoid immune system surveillance, especially type-I interferons (IFN-I). Meanwhile, a “hyperinflammatory” state, named “cytokine storm,” sets in. However, what role does the Spike protein play in the immune escape mechanisms? Can its inflammatory activities affect IFN-I? Does Spike block IFN-I or hijack them for the virus benefits? What are the other potential consequences? This article was written to provide an up-to-date and more general overview of the impact of the Spike protein on the innate immune system and its effectors at the molecular level. cureus.com

The Role of NAD+ in Regenerative Medicine The understanding of the molecular and cellular basis of aging has grown exponentially over recent years, and it is now accepted within the scientific community that aging is a malleable process; just as it can be accelerated, it can also be slowed ... pmc.ncbi.nlm.nih.gov

Identification of a novel P2X7 antagonist using structure-based virtual screening P2X4 and P2X7 receptors are ATP-gated ion channels, which play important roles in neuropathic and inflammatory pain, and as such they are important drug targets in diseases of inflammatory origin. While several compounds targeting P2X4 and P2X7 ... pmc.ncbi.nlm.nih.gov

The Role of NAD+ in Regenerative Medicine The understanding of the molecular and cellular basis of aging has grown exponentially over recent years, and it is now accepted within the scientific community that aging is a malleable process; just as it can be accelerated, it can also be slowed ... pmc.ncbi.nlm.nih.gov

@AnneliseBocquet - Bocquet Annelise 🔬🧬📚🚜

Oh, et bien... perturbations de la barrière hémato-encéphalique dans des cas de covid-long... et une approche d'exploration médicale envisagée. Cet article est intéressant ⤵️ https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-025-04133-4 "Notre étude suggère que l'IC PASC/covid long est au moins en partie liée à une

Asymmetrical glymphatic dysfunction in patients with long Covid associated neurocognitive impairment- correlation with BBB disruption - BMC Neurology The glymphatic system, a waste clearance pathway, has been implicated in several neurological conditions associated with neuroinflammation. COVID-19 associated neurocognitive impairment, part of the post-acute sequelae of SARS-CoV-2 infection (PASC), is strongly associated with neuroinflammation and disrupted blood-brain barrier (BBB). Several studies have implicated a synergistic interaction between the glymphatic system dysfunction and BBB disruption. In this proof-of-concept study, we investigated the role of the MRI metric diffusion along the perivascular spaces DTI (DTI-ALPS) in patients with PASC and correlated this with the BBB capillary permeability metric- K trans derived from Dynamic contrast enhanced (DCE) perfusion. 14 subjects with PASC who had persisting symptoms of anosmia, ageusia, fatigue, and cognitive impairment (CI) and ten healthy age and sex matched controls were recruited. All PASC subjects underwent routine and advanced MR brain imaging at two time points, (3 months +/- 2 weeks) after initial infection - referred as Time Point 1 (TP-1) - and 10 repeated the MRI scan 12 months (+/- 2 weeks) later - referred as Time Point 2 (TP-2), while the controls had MR imaging done only at TP-1. All had mild neurocognitive impairment. In the final analysis we included those who had DTI study at both time points (n-10). MR imaging included DCE perfusion and DTI in addition to anatomical imaging. Given the small size of the sample and nonnormality of data in the descriptive analyses, nonparametric analyses were used for group comparisons. A two-sample Wilcoxon rank sum test was used to show the differences in DTI-ALPS between the patients and controls in the predefined regions of interest. Spearman’s correlation coefficient (rho) was used to assess the correlation between DTI-ALPS index with K trans. There was significant reduction in the DTI-ALPS index between the patients and controls in the left hemisphere (z = 2.04, p < 0.04). However, there was no significant change over time in the index. There was a strong inverse correlation between the central white matter K trans and DTI-ALPS index (rho = 0.66, p < 0.03). Our study indicates that disordered para vascular drainage, a marker for glymphatic system and BBB damage may contribute to neurocognitive impairment (NCI) among patients with PASC. The DTI-ALPS index, which does not require contrast injection, has the potential to serve as a non-invasive biomarker. bmcneurol.biomedcentral.com

@AnneliseBocquet - Bocquet Annelise 🔬🧬📚🚜

Maladie de Charcot, on cherche des solutions !? La sclérose latérale amyotrophique (SLA) - ou maladie de Charcot - se caractérise par une dégénérescence des motoneurones et des symptômes invalidants, potentiellement mortels. https://pmc.ncbi.nlm.nih.gov/articles/PMC10886908/ La Spike, celle du virus ET des injections anti-covid, peut induire ou contribuer au développement d'une inflammation dans le système nerveux, déclenchant la SLA, ou aggravant l'état des personnes atteintes de cette maladie. De fait, la Spike peut impacter les récepteurs purinergiques, notamment P2X4 et P2X7. Ce dernier, le récepteur P2X7, est particulièrement sensible car il joue un rôle important dans la neuroinflammation et... dans la douleur. De façon intéressante, l'expression de ce récepteur, P2X7, est accrue suite à une stimulation du TLR4 par le LPS, au niveau des cellules microgliales ou des astrocytes. Ces cellules sont constitutives du système nerveux central, la microglie (ou cellules microgliales) représentant les cellules immunitaires innées résidentes dans le système nerveux. Elles sont en charge d'éliminer les éléments potentiellement toxiques pour le système nerveux... et elles peuvent prendre un phénotype pro-inflammatoires. P2X7 appartient au phénotype pro-inflammatoire de la microglie. Pour mémoire, la Spike interagit avec le LPS, provenant potentiellement d'une perturbation de la barrière intestinale. La Spike interagit aussi avec les fibres Aβ42. Les complexes moléculaires "Spike/LPS" ou "Spike/Aβ42" peuvent activer le TLR4 complètement. Avec la perturbation de la barrière hémato-encéphalique, ces complexes moléculaires "Spike/LPS" ou "Spike/Aβ42" peuvent alors activer le TLR4 et accroître l'expression du P2X7. Le P2X7 est aussi stimulé par l'ATP extracellulaire, libéré lors d'une inflammation. Corrélé à une diminution d'ectonucleotidase, Ado notamment, la surexpression de P2X7 est une bombe explosive. En effet, Ado dégrade l'ATP extracellulaire... si Ado est diminué, alors on aura une accumulation d'ATP extracellulaire qui vont activer d'autant plus P2X7 et entraîner une inflammation importante. Ado est lié au NAD+ ... https://pmc.ncbi.nlm.nih.gov/articles/PMC7887318/ Autre point : le récepteur P2X7 est une clé pour le VIH... et le SARS-COV-2. Oui, encore un point commun entre ces deux virus. Quoiqu'il en soit, cibler P2X7 est une piste intéressante. C'est en cours de recherche... https://pmc.ncbi.nlm.nih.gov/articles/PMC9877316/ Actuellement, les principaux médicaments approuvés dans différentes régions du monde pour le traitement de la SLA sont le riluzole, l'édaravone et le tauroursodiol/phénylbutyrate de sodium. Malgré les effets positifs de ces médicaments, compte tenu de la gravité de la SLA et de l'absence d'un traitement final efficace pour cette maladie neurodégénérative, davantage de cibles pharmaceutiques doivent être explorées... la modulation purinergique a présenté des résultats très intéressants dans le contrôle de la SLA mais il est aussi possible de rechercher des anti-inflammatoires et anti-apoptotiques, de réduire le stress oxydatif et moduler les activités des canaux ioniques neuronaux. Favoriser le NAD+ est une piste potentielle pour tenter de soulager en immédiat. https://pmc.ncbi.nlm.nih.gov/articles/PMC9512238/ La supplémentation orale en composés précurseurs du NAD+ peut être envisagée  : nicotinamide (NAM), nicotinamide riboside (NR) et nicotinamide mononucléotide (NMN). Ces précurseurs sont utilisés par les voies de biosynthèse du NAD+ et convertis en NAD+ dans la cellule. Mais ce sera à court terme si on ne traite pas les causes profondes de cette déprivation en NAD+. Nota bene : NAD+ lié à SIRT1. Cela peut aider au maintien de la barrière intestinale et de la flore commensale. Bonne journée !

Amyotrophic Lateral Sclerosis in Long-COVID Scenario and the Therapeutic Potential of the Purinergic System in Neuromodulation Amyotrophic lateral sclerosis (ALS) involves the degeneration of motor neurons and debilitating and possibly fatal symptoms. The COVID-19 pandemic directly affected the quality of life of this group, and the SARS-CoV-2 infection accelerated the ... pmc.ncbi.nlm.nih.gov

Ectonucleotidases in Acute and Chronic Inflammation Ectonucleotidases are extracellular enzymes with a pivotal role in inflammation that hydrolyse extracellular purine and pyrimidine nucleotides, e.g., ATP, UTP, ADP, UDP, AMP and NAD+. Ectonucleotidases, expressed by virtually all cell types, immune ... pmc.ncbi.nlm.nih.gov

Identification of a novel P2X7 antagonist using structure-based virtual screening P2X4 and P2X7 receptors are ATP-gated ion channels, which play important roles in neuropathic and inflammatory pain, and as such they are important drug targets in diseases of inflammatory origin. While several compounds targeting P2X4 and P2X7 ... pmc.ncbi.nlm.nih.gov

The Role of NAD+ in Regenerative Medicine The understanding of the molecular and cellular basis of aging has grown exponentially over recent years, and it is now accepted within the scientific community that aging is a malleable process; just as it can be accelerated, it can also be slowed ... pmc.ncbi.nlm.nih.gov

@AnneliseBocquet - Bocquet Annelise 🔬🧬📚🚜

Voici la première partie des explications concernant l'article 'impacts de la protéine Spike du SARS-CoV-2 sur l'immunité innée : une revue'. Ci-joint le lien vers l'article. https://www.cureus.com/articles/218170-impact-of-the-sars-cov-2-spike-protein-on-the-innate-immune-system-a-review#!/

Video Transcript AI Summary

**French Summary:** Anaïs Bloqué explique l'impact de la protéine Spike du SARS-CoV-2 sur le système immunitaire inné, en se concentrant sur le TLR 4. La Spike seule n'active pas complètement le TLR 4 pour induire une réponse antivirale complète (interférons de type 1). L'association Spike-LPS (lipopolysaccharide bactérien) est nécessaire. L'activation des interférons 1 augmente l'expression d'ACE2, récepteur du virus, via les ISG, sensibilisant l'organisme à l'infection. Les ARN messagers des vaccins peuvent aussi activer les interférons 1 via MDA5. La Spike, protéine amyloïde, peut induire la production de fibres A bêta 42, aggravant l'inflammation. L'augmentation de NF-κB par les ISG peut bloquer p53 (suppresseur de tumeur) et induire le micro-ARN MIR-200c, diminuant l'expression d'ACE2. Chez les personnes avec comorbidités (diabète, obésité), une boucle d'amplification inflammatoire Spike-LPS-TLR4 réduit l'ACE2 disponible, menant à une suractivation de l'angiotensine 2. La Spike persistante pourrait causer des pathologies dégénératives à long terme. **English Translation:** Anaïs Bloqué explains the impact of the SARS-CoV-2 Spike protein on the innate immune system, focusing on TLR 4. Spike alone does not fully activate TLR 4 to induce a complete antiviral response (type 1 interferons). The Spike-LPS (bacterial lipopolysaccharide) association is necessary. Activation of interferon 1 increases ACE2 expression, the virus receptor, via ISGs, sensitizing the body to infection. Vaccine mRNAs can also activate interferon 1 via MDA5. Spike, an amyloid protein, can induce the production of A beta 42 fibers, worsening inflammation. Increased NF-κB by ISGs can block p53 (tumor suppressor) and induce microRNA MIR-200c, decreasing ACE2 expression. In people with comorbidities (diabetes, obesity), a Spike-LPS-TLR4 inflammatory amplification loop reduces available ACE2, leading to overactivation of angiotensin 2. Persistent Spike could cause long-term degenerative pathologies.

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Speaker 0: Bonjour à tous et à toutes, je suis Anaïs Bloqué, docteur en biologie santé et enseignante d'hématologie immunologie auprès de BTS analyse biomédicale. Avant d'entrer dans le vif du sujet, je précise que je n'ai aucun conflit d'intérêt que ce soit d'ordre professionnel, financier ou privé. Récemment j'ai publié un article traitant des impacts de la protéine Spike du SARS-CoV 2 sur le système immunitaire inné et vous êtes nombreux à me demander des explications quant au contenu de ce papier. Vu le nombre de mécanismes et la complexité de ces mécanismes, j'ai décidé de morceler mes explications en 3 grandes parties, il y en aura peut-être une quatrième, ça dépendra du déroulé de mes petites interventions. Je vais commencer par vous raconter la petite histoire du TLR 4 et du et de la Spike du SARS-CoV 2. Il faut savoir que dans notre organisme, nous avons ce que l'on appelle des PRR ou Patogène Recopnishion Resator qui sont capables de détecter la présence d'éléments pathogènes et en détectant donc ces pathogènes, ces PRR s'activent pour lancer une réponse immunitaire afin de contrer bien entendu les éléments infectieux. L'un de ces PRR est le TLR 4 et il est présent donc à la surface des cellules de notre organisme. Alors la protéine Spike du SARS-CoV-deux ici représentée en rouge dans un cercle toute seule ne peut enclencher l'activation du TLR 4 dans sa totalité. Il y aura induction de cytokines pro-inflammatoires, mais pas l'induction des interférons de type un. Il faut savoir que les interférons de type un sont fondamentaux dans la réponse immunitaire antivirale. Cela va du déclenchement d'un état antiviral, c'est-à-dire la mise en place de mécanismes qui vont entraver la propagation et la réplication du virus dans l'organisme jusqu'à l'orchestration d'une réponse immunitaire innée et adaptative efficace. Alors le fait que la Spike seule ne puisse enclencher la production des interférons un est plutôt de mauvais augure car seule elle ne permet pas à l'organisme de lutter contre le virus. Pour que la Spike active le TLR 4 dans sa totalité, il faut qu'elle s'associe avec le LPS pour l'hypopolisaccharide, un composant que l'on retrouve sur les bactéries gram négatifs le combo Spike LPS va permettre l'activation du TLR 4 avec l'induction de cytokines pro-inflammatoires et l'induction d'une réponse par les interférons de type 1 le problème c'est qu'après l'initiation d'une réponse par les interférons 1 il y a l'expression de petites molécules que l'on appelle ISG pour interférons stimulated jeans certaines publications scientifiques montrent qu'il existe un lien probable entre ACE2 et les interférons de type un via les ISG dont l'ISG quatre-vingt-quinze les résultats expérimentaux suggèrent que ACE2 se comporte comme un iégé par la stimulation de certains PRRS dont MDA V on en reparlera juste après. Le hic c'est que la réponse aux interférons 1 en augmentant l'expression d'ACE2 va sensibiliser l'organisme aux infections par le SARS-CoV-2 car ACE2 est l'un des récepteurs permettant au virus d'infecter l'organisme via l'interaction Spike ACE2. Je vous vois venir vous allez me dire super donc avec un traitement antibiotique permettant de limiter le LPS il n'y aura pas induction des interférons de type 1 et donc pas d'augmentation de l'expression d'ACE2 et la spyde vaccinale ou la spydep pour de proline ne va pas indreve ne va pas induire seul les interférons 1 et donc une augmentation de ce2 bah non c'est faux car les interférons de type 1 peuvent être lancés comme je l'ai dit par les RLR dont MDA5 et ce récepteur détecte quoi Les ARN 0 et l'ARN messager modifié des produits anti covid comme Pfizer ou Moderna. De plus en dehors de cette induction des interférons 1 par mda 5 de plus il est fort probable que la Spike accompagnée de fibres amyloïdes comme les fibres a bêta quarante-deux déclenche le télaire 4. Cette protéine spike est hautement amyloïde et elle peut entraîner directement la production des fibres a bêta quarante-deux par l'organisme auquel elle peut se lier. En effet l'interaction spike a bêta quarante-deux semble accroître la production de cytokines pro-inflammatoires et n'empêche pas l'interaction entre la sous unité s un de la Spike avec son récepteur c'est-à-dire ACE 2. C'est ce que j'appelle le double effet amyloïde. En effet non seulement la spi qui est amyloïde en elle-même c'est-à-dire que si elle est clivée par des protéases elle va former des fibrilles insolubles et dégénératives, mais en plus elle induit la production de ces fibrilles amyloïdes par l'organisme lui-même comme on peut en trouver dans la maladie d'Alzheimer pouvant contribuer à quoi Ben à l'infection virale. Pour en revenir à notre TALR 4 et aux interférons de type un, les ISG comme l'ISG quatre-vingt-quinze ici figuré présentent une autre particularité cela va augmenter les niveaux de NFK pa b pour vous expliquer simplement NFK pa b est un facteur qui permet la synthèse de cytokines pro-inflammatoires comme le IL6. Il existe une autre activité du NFK ab celle de contrebalancer la p cinquante-trois le gardien de notre génome via le MDM 2 ou murine double minute 2 d'ailleurs on sait que une suractivation de NFK ab est potentiellement cancérigène par blocage de la p cinquante-trois. De plus la protéine spike et plus précisément la sous unité s 2 de la protéine spike peut interagir avec la p cinquante-trois et on ignore encore quelles en sont les conséquences. Cela peut d'ailleurs pencher en faveur d'une activité pro-inflammatoire via NFK ab. Il reste à savoir si la sous-unité s 2 de la protéine spyde dite vaccinale ou s 2 p avec ces 2 modifications proline se lie à la p cinquante-trois. Mais il existe quelques éléments de réponse qui font craindre une réponse par l'affirmative. Il existe une autre conséquence par rapport à l'augmentation de NFK pa b. Ce facteur induit l'expression de micro-éréna, donc ce sont des petites molécules qui vont agir sur le transcryptome cellulaire. Et il y a un micro-éréna qui nous intéresse particulièrement dans ce cadre dans ce cas de figure, c'est le MIR de sens C. Le MIR de sens C va bloquer, va empêcher la surexpression de la CE 2. Cela crée une sorte de balance entre la surex surexpression et la sous expression d'ACE2 cependant les études montrent que dans certains pathopathologiques notamment des pathopathologiques avec des comorbidités comme le diabète ou l'obésité les patients présentaient déjà des taux d'expression du MIR de sens C important autrement dit la quantité initiale d'ACE2 présente dans leur organisme était déjà plus faible que chez les individus sans comorbidité dans ce contexte l'interaction Spike LPS avec le TLR 4 ce qui induit les interférons de type un les I g et l'augmentation du NFK pa b avec l'expression du minière de sens c devient vraiment problématique et dangereux car hyper inflammatoire. En effet chez ces individus le peu d'ACE 2 qu'ils ont va se retrouver bloqué par la Spike par l'interaction Spike ACE 2. On sait que ACE 2 est l'un des récepteurs du virus pour infecter l'organisme via la spike. ACE 2 devient donc indisponible pour la dégradation de l'angiotensine 2 ce qui aboutit à la suractivation de la TAR et à la tempéticoatynique que l'on connaît. De façon intéressante l'angiotensine 2 va également augmenter l'expression du TLR 4 ce qui va relancer dessous dans la machine. En effet on se retrouve devant une boucle d'amplification inflammatoire avec une Spike LPS TLR 4 qui induit les interférons de type 1 qui induit les ISG qui induit d'un côté une surexpression d'ACE2 de l'autre côté une augmentation de du NF kapab avec l'expression du MIR de son C une diminution globale d'ACCE2 avec une augmentation des concentrations d'angiotensine 2 c'est enjotensine 2 augmentant l'expression du TLR 4. Donc ça, c'est une véritable boucle d'amplification. Alors ce n'est pas mortel chez tous les individus, juste ceux présentant des hauts niveaux de MIR de sens C et pourquoi parce que certaines publications relatent une diminution en fait des niveaux de MIR de millet chez des patients ayant recouvrés du SARS-CoV-2 ces chercheurs ont certainement étudié les conséquences de l'infection par le SARS-CoV-2 en dehors de toute co-infection c'est-à-dire sans LPS et en dehors de toute comorbidité mais si il y a de faibles taux du MIR de sang C en général alors plus rien n'arrête la surexpression des CE2. A partir de là l'angiotensine 2 est dégradé et il y a une activation de l'axe AT de R masse R avec la production d'iL 10. Cette iL 10 est quant à elle une cytokine anti-inflammatoire qui va aussi accroître l'expression d'ACE2 et il s'agit là d'une boucle tolrogène. Cela va expliquer pourquoi la protéine spike peut persister des mois dans l'organisme après une infection par le virus ou après les injections à ARN messager modifié en codant cette fameuse protéine car oui cette spyte persiste longtemps et avec ses propriétés amyloïdes on peut craindre des pathologies dégénératives sur le long terme avec un effet cumulatif par exposition répétée à la protéine spike alors le SARS-CoV 2 ne tue pas dans l'immédiat ce qui explique on va dire le faible nombre de décès lors des premières vagues épidémiques mais mais cela va s'inscrire dans le temps. La prochaine fois je vous raconterai l'histoire du TLR 2 puis ensuite l'histoire de l'i l 6 du MIR cent-quarante-huit a et ensuite après je verrai si je le développe sur les propriétés amyloïdes ou pas. Je vous remercie de votre attention et je vous souhaite une excellente journée.

Impact of the SARS-CoV-2 Spike Protein on the Innate Immune System: A Review The Spike protein enables the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by binding to multiple receptors, including the angiotensin-converting enzyme 2 (ACE2). Scientific studies also indicate that Spike is involved in severe forms of coronavirus disease 2019 (COVID-19), "long-haul COVID diseases" - also known as "long COVID syndromes" or "post-acute sequelae of SARS-CoV-2 infection" (PACS) - or, recently, in adverse reactions to lipid nanoparticle-messenger ribonucleic acid (mRNA) vaccines or other anti-COVID19 products. Numerous mutations, notably within the subunit 1 of Spike (S1), prevent neutralization by antibodies, but more generally, the virus has developed numerous strategies to avoid immune system surveillance, especially type-I interferons (IFN-I). Meanwhile, a “hyperinflammatory” state, named “cytokine storm,” sets in. However, what role does the Spike protein play in the immune escape mechanisms? Can its inflammatory activities affect IFN-I? Does Spike block IFN-I or hijack them for the virus benefits? What are the other potential consequences? This article was written to provide an up-to-date and more general overview of the impact of the Spike protein on the innate immune system and its effectors at the molecular level. cureus.com

@AnneliseBocquet - Bocquet Annelise 🔬🧬📚🚜

Oh, et bien... perturbations de la barrière hémato-encéphalique dans des cas de covid-long... et une approche d'exploration médicale envisagée. Cet article est intéressant ⤵️ https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-025-04133-4 "Notre étude suggère que l'IC PASC/covid long est au moins en partie liée à une

Asymmetrical glymphatic dysfunction in patients with long Covid associated neurocognitive impairment- correlation with BBB disruption - BMC Neurology The glymphatic system, a waste clearance pathway, has been implicated in several neurological conditions associated with neuroinflammation. COVID-19 associated neurocognitive impairment, part of the post-acute sequelae of SARS-CoV-2 infection (PASC), is strongly associated with neuroinflammation and disrupted blood-brain barrier (BBB). Several studies have implicated a synergistic interaction between the glymphatic system dysfunction and BBB disruption. In this proof-of-concept study, we investigated the role of the MRI metric diffusion along the perivascular spaces DTI (DTI-ALPS) in patients with PASC and correlated this with the BBB capillary permeability metric- K trans derived from Dynamic contrast enhanced (DCE) perfusion. 14 subjects with PASC who had persisting symptoms of anosmia, ageusia, fatigue, and cognitive impairment (CI) and ten healthy age and sex matched controls were recruited. All PASC subjects underwent routine and advanced MR brain imaging at two time points, (3 months +/- 2 weeks) after initial infection - referred as Time Point 1 (TP-1) - and 10 repeated the MRI scan 12 months (+/- 2 weeks) later - referred as Time Point 2 (TP-2), while the controls had MR imaging done only at TP-1. All had mild neurocognitive impairment. In the final analysis we included those who had DTI study at both time points (n-10). MR imaging included DCE perfusion and DTI in addition to anatomical imaging. Given the small size of the sample and nonnormality of data in the descriptive analyses, nonparametric analyses were used for group comparisons. A two-sample Wilcoxon rank sum test was used to show the differences in DTI-ALPS between the patients and controls in the predefined regions of interest. Spearman’s correlation coefficient (rho) was used to assess the correlation between DTI-ALPS index with K trans. There was significant reduction in the DTI-ALPS index between the patients and controls in the left hemisphere (z = 2.04, p < 0.04). However, there was no significant change over time in the index. There was a strong inverse correlation between the central white matter K trans and DTI-ALPS index (rho = 0.66, p < 0.03). Our study indicates that disordered para vascular drainage, a marker for glymphatic system and BBB damage may contribute to neurocognitive impairment (NCI) among patients with PASC. The DTI-ALPS index, which does not require contrast injection, has the potential to serve as a non-invasive biomarker. bmcneurol.biomedcentral.com

@AnneliseBocquet - Bocquet Annelise 🔬🧬📚🚜

Non seulement il stipule qu'il y a surexpression du TLR2/ TLR4 mais il ajoute qu'il y a une augmentation de l'expression du P2X7... c'est une bombe à retardement. Il y a une reprogrammation du SI, sur le long-terme, particulièrement au niveau des macrophages. 24/n

@AnneliseBocquet - Bocquet Annelise 🔬🧬📚🚜

Bien, résumé de la partie 1 : SIRT1 inhibe p53 pour éviter l'apoptose cellulaire. Et p53 inhibe SIRT1 via miR-34a pour exercer son activité, créant une boucle d'amplification apoptotique. Bizarrement, on retrouve une stimulation de p53 après les injections anti-covid dans les

@RHandiSolidaire - Reconquête Handi-Solidaire 🌿🇫🇷

https://www.laselectiondujour.com/charcot-maladie-enferme-vivant Du nom de celui qui l’a découverte en 1869, la Maladie de Charcot est une Sclérose Latérale Amyotrophique touchant 500.000 personnes à travers le monde, dont 8.000 en France. C’est une maladie neurologique dégénérative sans espoir de guérison et une

Charcot, la maladie qui enferme vivant Surnommée « la maladie la plus cruelle du monde », la sclérose latérale amyotrophique (SLA) touche près de 8 000 personnes en France. Derrière cette maladie rare et toujours incurable : patients, proches et chercheurs, se mobilisent pour alerter, sensibiliser, et surtout, faire avancer une recherche encore trop négligée. Car demain, la SLA pourrait frapper bien plus de vies qu'on ne l'imagine. laselectiondujour.com

@Thefish751855 - Thefish

@MeasslainteIRL I've been working on this today (FYI @AnneliseBocquet), but related to the SIRT-1 pathway. All these are related. In short, elevated miR-34a is linked to neurotoxicity, and dysregulated miRNAs are the hallmark of ALS, but it's complicated. https://pmc.ncbi.nlm.nih.gov/articles/PMC8921154/

Insights into the identification of a molecular signature for amyotrophic lateral sclerosis exploiting integrated microRNA profiling of iPSC-derived motor neurons and exosomes Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disorder characterized by progressive degeneration of motor neurons (MNs). Most cases are sporadic, whereas 10% are familial. The pathological mechanisms underlying the disease are ... pmc.ncbi.nlm.nih.gov

@Thefish751855 - Thefish

@MeasslainteIRL @AnneliseBocquet Linking our studies: https://pubmed.ncbi.nlm.nih.gov/24780820/ The Influence of Myeloid-Derived Suppressor Cell Expansion in Neuroinflammation and Neurodegenerative Diseases https://pubmed.ncbi.nlm.nih.gov/38607083/

miR-34a expands myeloid-derived suppressor cells via apoptosis inhibition - PubMed Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population and show significant expansion under pathological conditions. microRNA plays important roles in many biological processes, whether microRNAs have a function in the expansion of MDSCs is still not very clear. In this study, miR-3 … pubmed.ncbi.nlm.nih.gov

The Influence of Myeloid-Derived Suppressor Cell Expansion in Neuroinflammation and Neurodegenerative Diseases - PubMed The neuro-immune axis has a crucial function both during physiological and pathological conditions. Among the immune cells, myeloid-derived suppressor cells (MDSCs) exert a pivotal role in regulating the immune response in many pathological conditions, influencing neuroinflammation and neurodegenera … pubmed.ncbi.nlm.nih.gov

@AnneliseBocquet - Bocquet Annelise 🔬🧬📚🚜

https://pubmed.ncbi.nlm.nih.gov/28652929/ "TNF-α binding to TNF-R1 can activate the transcription factor NFκB. Our laboratory has recently observed an NFκB binding site on the promotor region of microRNA-34a (miR-34a). " Linked directly to the SARS-COV-2 and anti-covid injections... https://pubmed.ncbi.nlm.nih.gov/35588734/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10145134/

TNF-α and Beyond: Rapid Mitochondrial Dysfunction Mediates TNF-α-Induced Neurotoxicity - PubMed This short communication describes our research which demonstrates that TNF-α causes a rapid decline in mitochondrial function, leading to neuronal cell death. As such, this neurotoxic proinflammatory cytokine may play a role in brain damage from stroke and neurodegeneration in chronic conditions su … pubmed.ncbi.nlm.nih.gov

TNF-α+ CD4+ T cells dominate the SARS-CoV-2 specific T cell response in COVID-19 outpatients and are associated with durable antibodies - PubMed Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific CD4⁺ T cells are likely important in immunity against coronavirus 2019 (COVID-19), but our understanding of CD4⁺ longitudinal dynamics following infection and of specific features that correlate with the main … pubmed.ncbi.nlm.nih.gov

COVID-19 mRNA Vaccines: The Molecular Basis of Some Adverse Events Each injection of any known vaccine results in a strong expression of pro-inflammatory cytokines. This is the result of the innate immune system activation, without which no adaptive response to the injection of vaccines is possible. Unfortunately, ... pmc.ncbi.nlm.nih.gov

@AnneliseBocquet - Bocquet Annelise 🔬🧬📚🚜

@Thefish751855 @MeasslainteIRL This is really interesting @Thefish751855!!! MDSCs are bound to IL-10, which increases ACE2 expression. If miR-34a is also bound to MDSCs, we have a direct connection to RAGE!

@AnneliseBocquet - Bocquet Annelise 🔬🧬📚🚜

Oui... une fois n'est pas coutume... https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-023-01647-1 Augmentation de l'expression d'ACE2 dans la maladie d’Alzheimer. Je répète : Augmentation de l'expression d'ACE2 dans la maladie d’Alzheimer. Me rappelle d'un grand scientifique qui m'a dit que je me trompais. 😐

Higher angiotensin-converting enzyme 2 (ACE2) levels in the brain of individuals with Alzheimer’s disease - Acta Neuropathologica Communications Cognitive decline due to Alzheimer’s disease (AD) is frequent in the geriatric population, which has been disproportionately affected by the COVID-19 pandemic. In this study, we investigated the levels of angiotensin-converting enzyme 2 (ACE2), a regulator of the renin-angiotensin system and the main entry receptor of SARS-CoV-2 in host cells, in postmortem parietal cortex samples from two independent AD cohorts, totalling 142 persons. Higher concentrations of ACE2 protein (p < 0.01) and mRNA (p < 0.01) were found in individuals with a neuropathological diagnosis of AD compared to age-matched healthy control subjects. Brain levels of soluble ACE2 were inversely associated with cognitive scores (p = 0.02) and markers of pericytes (PDGFRβ, p = 0.02 and ANPEP, p = 0.007), but positively correlated with concentrations of soluble amyloid-β peptides (Aβ) (p = 0.01) and insoluble phospho-tau (S396/404, p = 0.002). However, no significant differences in ACE2 were observed in the 3xTg-AD mouse model of tau and Aβ neuropathology. Results from immunofluorescence and Western blots showed that ACE2 protein is predominantly localized in microvessels in the mouse brain whereas it is more frequently found in neurons in the human brain. The present data suggest that higher levels of soluble ACE2 in the human brain may contribute to AD, but their role in CNS infection by SARS-CoV-2 remains unclear. actaneurocomms.biomedcentral.com

@AnneliseBocquet - Bocquet Annelise 🔬🧬📚🚜

Oh... les astrocytes sont des targets du SARS-CoV-2... waouh, quelle surprise (en fait, non, pas du tout). https://t.co/ZcXucnbHz1 https://t.co/2w5BwmkG5S Les astrocytes, c'est quoi ? Ce sont des cellules gliales constituant notre cerveau... Le cerveau n'est pas constitué que https://t.co/sghCnOHJ9r

@P_McCulloughMD - Peter A. McCullough, MD, MPH®

SARS-CoV-2 Spike Protein Accelerates Alzheimer’s Disease Via Increased ACE2-Mediated Cerebrovascular Inflammation Pandemic Could Lead to Expanded Dementia Population Needing Care These data are worrisome given the ubiquity of Spike protein we assume is retained after SARS-CoV-2

@MeasslainteIRL - Thomas Anthony III

@AnneliseBocquet @Thefish751855 @53v3n0fn1n3 @Fynnderella1 @kacdnp91 @CanningPharm @CheweyLife @dr_morrissey @CShoemakerMD @Kevin_McKernan @KevinMcCairnPhD @LyellJ @MicieliA_MD @dredwild @bertvargas @BertVargas @djnicholl @dr_nickward @caseyalbin @AmmarAlChalabi

@janiesaysyay - Janiesaysyay

@MeasslainteIRL @AnneliseBocquet @Thefish751855 @53v3n0fn1n3 @Fynnderella1 @kacdnp91 @CanningPharm @CheweyLife @dr_morrissey @CShoemakerMD @Kevin_McKernan @KevinMcCairnPhD @LyellJ @MicieliA_MD @dredwild @BertVargas @djnicholl @dr_nickward @caseyalbin @AmmarAlChalabi https://t.co/mtHA79OUWW

@HerbsandDirt - Carole Mac

Another ALS diagnosis for someone who admitted getting the Covid 💉, and also pushed people to get it. How many people is this now? Other than Alzheimer’s Disease, I can’t think of a worse ailment to live with. Heartbreaking. .@unhealthytruth https://t.co/Bmphdlkb47

@CheweyLife - Angela Rhoten

@janiesaysyay @MeasslainteIRL @AnneliseBocquet @Thefish751855 @53v3n0fn1n3 @Fynnderella1 @kacdnp91 @CanningPharm @dr_morrissey @CShoemakerMD @Kevin_McKernan @KevinMcCairnPhD @LyellJ @MicieliA_MD @dredwild @BertVargas @djnicholl @dr_nickward @caseyalbin @AmmarAlChalabi 😞 Read replies.👀👇🏽 https://t.co/huKzS83jx2

@janiesaysyay - Janiesaysyay

👑 Killer Queen ~ Protein Corona 👑 Lipid nanoparticles are the outer coating of the COVID mRNA 💉. LNPs spontaneously acquire a crown of proteins in human blood. This can cause them to aggregate and is a studied aspect of LNP drug design. > https://t.co/qTWDpw6DPo

@janiesaysyay - Janiesaysyay

Hardness of the corona increases durability. "...the hard corona can evolve quite significantly as one passes from protein concentrations appropriate to in vitro cell studies to those present in in vivo studies, which has deep implications for in vitro-in vivo extrapolations." > https://t.co/LfeoYomKU1

@janiesaysyay - Janiesaysyay

Scientists wanted to find out what proteins in the corona allowed the protein corona to be preferentially taken up by cells. Here they are targeting cancer and bone marrow cells for drug delivery. The ApoH protein was a good candidate for cellular uptake. > https://t.co/aWEW5UhqLZ

@janiesaysyay - Janiesaysyay

What is ApoH? It's a plasma protein which binds cardiolipin in the inner mitochondrial membrane. The ❤️ has high metabolic demand and cardiac cells contain a high reservoir of mitochondria 35% of the tissue. Cardiolipin is a major factor in cardiovascular health and disease. > https://t.co/PE7m4JaID1

@janiesaysyay - Janiesaysyay

The ApoH protein allows LNP drugs coated with it to cross cell membranes easily. ApoH would probably enhance the protein corona delivery of the COVID 💉 into cardiac cells. Under certain conditions it can become procoagulative. > https://t.co/JqeXr6izPm

@janiesaysyay - Janiesaysyay

It may be more than one protein and it may depend on each person's phenotype and cell pH. > https://t.co/q4wupa9umv https://t.co/Xy3TYt2Rj5

@janiesaysyay - Janiesaysyay

Depending on the type or mixture of proteins in the corona on the LNP/mRNA 💉, we could see different uptake rates by various cell types. I believe the Pfizer biodistribution study only showed uptake of LNPs with no mRNA? What protein coronas form with full payload? What is🎯? >

@janiesaysyay - Janiesaysyay

*record scraaatch Let's change that tune My darling I 🎵

@janiesaysyay - Janiesaysyay

Can't get enough of your loid babe Spike, I don't know, I don't know why Can't get enough of your loid, babe https://t.co/8iL6FmiQPU

@janiesaysyay - Janiesaysyay

What kind of loid is this that you're givin' me... Is it in your kiss or just because you're sweet?

@janiesaysyay - Janiesaysyay

Spike, all I know Is every time you're near I fell a change Something moves I scream #ProteinCorona https://t.co/QrZOYk74VK

@janiesaysyay - Janiesaysyay

Spike if I can only make you see And make you understand Spike you're loid for me is all I need And more than I can stand

@janiesaysyay - Janiesaysyay

I get the same old feelin' every time you're here https://youtu.be/x0I6mhZ5wMw

@janiesaysyay - Janiesaysyay

I feel a change Something moves https://t.co/lmGoNKXJc2

@janiesaysyay - Janiesaysyay

https://t.co/syP9XIsY0P

@janiesaysyay - Janiesaysyay

I scream your name https://t.co/Kfe4kWnClx

@janiesaysyay - Janiesaysyay

🩺 Meet Michel 🩺 Yes doctors are asking this. Scripps Health now asks it on their pre-mammogram questionnaire. A very special doctor asked this 2 years ago. Dr Michel Goldman, a leading expert in immunology and 💉 He championed the COVID 💉 Then something happened >

@janiesaysyay - Janiesaysyay

to make him curious. >

@janiesaysyay - Janiesaysyay

> He got aggressive lymphoma in the lymph nodes along the SAME SIDE as his COVID 💉 >

@janiesaysyay - Janiesaysyay

his left side. >

@janiesaysyay - Janiesaysyay

>

@janiesaysyay - Janiesaysyay

When it came time for his booster, Dr Goldman was 💉d again, this time in his right arm. Soon the lymph nodes on his right side showed aggressive lymphoma too. He was so alarmed by this phenomenon, that he wrote a research paper on it. >

@janiesaysyay - Janiesaysyay

Here is Dr. Goldman's PET scan, showing the rapid increase of lymphoma on his right side after his booster. >

@janiesaysyay - Janiesaysyay

>

@janiesaysyay - Janiesaysyay

In his paper Dr. Goldman uses the terms "dramatic speed" and "rapid evolution" to describe his accelerated or "turbo" cancer. The next time someone tells you there is no such thing as COVID 💉-induced #TurboCancer, introduce them to Dr. Michel Goldman. #Hero

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

🩸 Bad Blood 2 🩸 In 2018, scientists at Memorial Sloan Kettering Cancer Center found that mistranslated mRNA led to truncated proteins. These proteins are inactivated tumor suppressing proteins, causing leukemia and lymphoma cancers. > https://www.mskcc.org/news/scientists-find-cancer-drivers-hiding-new-place

Scientists Find Cancer Drivers Hiding in a New Place New findings from researchers at the Sloan Kettering Institute suggest that cancer causes may be lurking in the molecule that bridges DNA and protein. mskcc.org

@janiesaysyay - Janiesaysyay

We now have data showing #TurboCancer in the COVID vaxxed is not a rare occurrence, as Dr. Michel Goldman hoped his cancer was. Keep hitting "show replies" to see all. >

@janiesaysyay - Janiesaysyay

Hank Green is another science expert who publicly promoted mRNA 💉s. He now has blood cancer, as do some of his followers. #CorrelationNotCausation Keep hitting "show replies" to see all. >

@janiesaysyay - Janiesaysyay

💉💉💉 Vaxxine Dreams 💉💉💉

@janiesaysyay - Janiesaysyay

> #TurboCancer #FlyMeToTheMoon #Rocketman

@EthicalSkeptic - Ethical Skeptic ☀

When growth in Ages 0-54 Excess Cancer Mortality UCoD is faster (24.1%) than MCoD EM growth (18.8%) - that means that these new Excess Cancers are killing more quickly than past cancers have, in this age bracket. There's a name for that... but we are forbidden to say it...

@janiesaysyay - Janiesaysyay

>

@Jikkyleaks - Jikkyleaks 🐭

Well, it used to be rare. This is the same rare lymphoma that Michel Goldman wrote about developing after a COVID mRNA "vaccine". (see next tweet). https://www.news.com.au/entertainment/celebrity-life/sam-neill-shares-sad-cancer-update-after-chemotherapy-treatment-fails/news-story/232e7ec993a516b7f28edd302368835f

@janiesaysyay - Janiesaysyay

>

@janiesaysyay - Janiesaysyay

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@Yash25571056 - Hiroshi Yasuda (保田浩志)

FYI, "..lymphadenopathy caused by COVID-19 vaccination was reported for BioNTech/Pfizer in 44.1%, Moderna in 25%, and Oxford-AstraZeneca in 1.5%, respectively.. suggesting that vaccine-induced axillary lymphadenopathy may mimic metastasis in oncologic patients.. There are also recent reports supporting systematic inflammatory response due to COVID-19 vaccination.. We observed changes in lymph node activity and time interval after vaccination with three different vaccines.. lymph node activity after BioNTech/Pfizer and its relation to reference organs is at the highest at the 10th day with a gradual decrease over time. Almost 70 days after vaccination, the metabolism in the lymph node is not different from background activity. However, in the other two groups, we observed the highest peak of activity in the 4th week for Moderna and at the 10th day for AstraZeneca." 'The systemic impact of different COVID-19 vaccines in 2-[18F] FDG-PET/CT' https://www.nature.com/articles/s41598-023-49376-8

The systemic impact of different COVID-19 vaccines in 2-[18F] FDG-PET/CT - Scientific Reports Austria started its COVID-19-vaccination program in December 2020 with three different vaccines. As the vaccination program continues, we encountered increased 2-[18F] FDG-activity not only in axillary lymph nodes ipsilateral to the injection site but also in other organs. The aim of this retrospective study is to present results of the metabolic activity of ipsilateral axillary lymph nodes, liver, blood pool, spleen, and bone marrow after three different vaccines. To our knowledge, this is the first study to examine systemic response changes in relation to time after COVID-19 vaccination using three different vaccines. The collected data of 220 eligible vaccinated patients (127 with BioNTech/Pfizer BNT162b2, 61 with Moderna, and 32 with AstraZeneca) examined with 2-[18F] FDG-PET/CT were enrolled. The PET/CT examinations were evaluated from day 1 to day 135 (SD: 23.2, median: 26) after different vaccinations. Seventy-one out of these 220 patients underwent a pre-vaccination 2-[18F] FDG -PET/CT. SUVmax of axillary node(s), and blood pool, liver, spleen, and bone marrow as reference organs were calculated. The ratio of SUVmax activity of axillary lymph node to reference organs was also compared in all patients. The tracer activity dynamics were investigated in three different vaccines. After BioNTech/Pfizer vaccination 2-[18F] FDG activity in axillary lymph nodes shows a steady decrease in all patients. Ten days after vaccination the 2-[18F] FDG uptake was at its highest activity. Seventy days after vaccination, tracer activity is not different from the background activity of 2-[18F] FDG in the axillary region. This result also applies to other two vaccines; however, in the 4th week after Moderna vaccination SUVmax in lymph nodes showed the highest peak of tracer activity. With AstraZeneca the highest activity was at the earlier days. There was no significant statistical difference of SUVmax of lymph nodes or its ratios to other reference organs between three groups of vaccines. SUVmax in lymph nodes was statistically significant lower than SUVmax in the liver, spleen, and bone marrow with p-values of < 0.001, 0.044, and 0.001, respectively. In the group of 71 patients with a pre-vaccination PET/CT examination, the median SUVmax of lymph nodes increased significantly after vaccination from 0.82 (IQR 0.59–1.38) to 1.80 (IQR 1.07–3.89)(p < 0.001). In contrast median tracer activity in the liver decreased from 3.37 (IQR 2.83–3.91) to 3.11 (2.56–3.70) (p = 0.032). There was no significant change of tracer activity after vaccination in other reference regions (mediastinum, spleen, and bone marrow). In this group of 71 patients, there was also no significant difference in tracer activity in different types of vaccines. Local site and ipsilateral axillary lymph node activity in 2-[18F] FDG PET/CT after COVID19-vaccination is suggested in many studies. The main challenge is recognizing the changes in lymph nodes during time after vaccination to minimize false interpretation, foremost in patients with oncological diagnoses. Moreover, different vaccines cause different system metabolic changes. The knowledge of vaccine type, the time interval between vaccination and PET/CT scan is essential, especially in therapy evaluation. nature.com

@janiesaysyay - Janiesaysyay

#MeetMichel #CatchUpBoys #CruelSummer

@janiesaysyay - Janiesaysyay

@ichudov - Igor Chudov

Redditor u/_Raspootin_ and his coworker have TUMORS IN THE DELTOID - in the arms used to receive Covid vaccine shots! Doctors are baffled - but this is worrying information! I sincerely hope this is a rare coincidence.🧵👇

@janiesaysyay - Janiesaysyay

#MeetMichel #TurboCancer #VivaLasVegas

@P_McCulloughMD - Peter A. McCullough, MD, MPH®

Here is one of the first published reports of a "Turbo Cancer" in a vaccinated man whose team believed COVID-19 vaccination initiated and accelerated his fatal facial cancer. https://pubmed.ncbi.nlm.nih.gov/37927346/

Bell's palsy or an aggressive infiltrating basaloid carcinoma post-mRNA vaccination for COVID-19? A case report and review of the literature - PubMed We report on an aggressive, infiltrating, metastatic, and ultimately lethal basaloid type of carcinoma arising shortly after an mRNA vaccination for COVID-19. The wife of the patient, since deceased, gave the consent for publishing the case. The malignancy was of cutaneous origin and the case showed … pubmed.ncbi.nlm.nih.gov

@janiesaysyay - Janiesaysyay

Wow, are they behind. This is old news. An expert immunologist in Europe published a paper in 2021 showing his #TurboCancer was from the 💉 #MeetMichel

@Censored4sure - Luther ‘Ćyrus’

“There is no information that suggests that COVID-19 vaccines cause cancer.” To the best of our knowledge, this is the first case reported of a COVID vaccine booster uncovering lymphadenopathy leading to the diagnosis of metastatic prostate cancer. You weren’t looking.. 👀

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

If many patients start to present with tumors on the same side of the body as they were 💉 on, as happened to Michel, they might get suspicious as Michel did, that the 💉 caused their cancer. Switching sides will distribute the oncogenic risk evenly.

@janiesaysyay - Janiesaysyay

Covid 💉 patients are finding tumors on the side of the body they were vaxxed on. >

@janiesaysyay - Janiesaysyay

@mRNAdeaths - They Keep Saying Its Rare

The present case highlights the possible risk of development of malignant lymphoma, including ENKL at the injection site, after the #Pfizer #mRNA vaccine. https://pubmed.ncbi.nlm.nih.gov/37093551/

Newly diagnosed extranodal NK/T-cell lymphoma, nasal type, at the injected left arm after BNT162b2 mRNA COVID-19 vaccination - PubMed Anti-SARS-CoV-2 vaccines were developed in response to the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although the BNT162b2 mRNA vaccine is effective, adverse effects have been reported. Here, we report a case of extranodal NK … pubmed.ncbi.nlm.nih.gov

@janiesaysyay - Janiesaysyay

#TurboCancer #MeetMichel >

@LTCTheresaLong - Theresa M Long, MD, MPH, FS

That was the arm, my dad got 3 COVID shots in…NOTE the “X”marks the spot (radiation therapy) over a massive cancerous tumor…that spread to every bone in his body and killed him within MONTHS…switch arms…how about the author of this trash show proof that they received all 9 recommended boosters!!

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

@JesslovesMJK - Jessica Rose 🤙

VAERS ID: 2584015 "I developed Diffuse large B cell Lymphoma in the armpit of [the] arm right under the vaccination site." 515 days after 1 dose of Moderna. 54-year-old Californian woman. This woman is classified as Unrecovered. A case study photo. https://pubmed.ncbi.nlm.nih.gov/37197431/

B-cell lymphoblastic lymphoma following intravenous BNT162b2 mRNA booster in a BALB/c mouse: A case report - PubMed Unprecedented immunization campaigns have been rolled out worldwide in an attempt to contain the ongoing COVID-19 pandemic. Multiple vaccines were brought to the market, among two utilizing novel messenger ribonucleic acid technology. Despite their undisputed success in decreasing COVID-19-associate … pubmed.ncbi.nlm.nih.gov

@janiesaysyay - Janiesaysyay

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@markharboursha1 - mark harbourshark Smith

getting cancer after covid jabs and booster in the same place and almost dying yesterday from blood loss is just the worst and most scary feeling this is the tumor poking out my arm that had a does of radiotherapy on it on friday sorry about the pic but people need to see

@janiesaysyay - Janiesaysyay

Dr. Goldman had his first COVID 💉💉 in his left deltoid, and within 6 months had tumors along the left side of his body. #TurboCancer with this 💉 is not atypical. Cancer centers have these stats and are not divulging them because they profit from it.

@tulloch1978 - Hello Dave #excessdeaths

"I took 3 Pfizer doses. I had Turbo Cancer. In less than 6 months, the intestine was 75% obstructed and metastasized to the liver. Next week 11th chemotherapy session." #Brazil #VaccIneInjuries

@janiesaysyay - Janiesaysyay

@Karaofthejungle - Kara

My mum got turbo neuroendocrine cancer in her arm from the covid jab. I'm not reporting it to the local police due to their corruption. 👍👍 Don't want them near me. I'm literally allergic.

@janiesaysyay - Janiesaysyay

#TurboCancer Rest in peace Mark.

@tulloch1978 - Hello Dave #excessdeaths

Wales, Mark was diagnosed with an extremely rare form of cancer and died after losing his battle with stage 4 Metastatic Tenosynovial Giant Cell on the 15th of May, 2023. "Getting cancer after covid jabs and booster in the same place." #TurboCancer https://www.dignityfunerals.co.uk/funeral-notices/15-05-2023-mark-stephen-smith/?s=35

Funeral notice for Mr Mark Stephen Smith Mr Mark Stephen Smith sadly passed away on Monday, 15th May 2023. Details of the funeral date and arrangements are available here on their Funeral Notice page. dignityfunerals.co.uk

@janiesaysyay - Janiesaysyay

#MeetMichel #WhiteLines https://t.co/9CuDlTb1uy

@ALEGRA1988 - ALEJANDRA GARZA

Desde Telegram De Liz Fernández. Aprovecho para mandarles el último Pet de mi madre que murió hace 2 años se puso 3 vacunas por más que insistí que no lo hiciera mis hermanos la convencieron, jamás vi algo parecido en un cuerpo humano con tanto dolor fisico, tenía 67 años. 💉☠️ https://t.co/L820ljQhZQ

@janiesaysyay - Janiesaysyay

#MeetMichel > https://t.co/YspRWgCo7J

@janiesaysyay - Janiesaysyay

🚨X deleted my post. SARSCoV2 spike protein, created in a lab, contains gene sequences of HIV. The U.S. DoD, Daszak and now X are desperate to hide this. The HIV genes cause a certain % of Covid patients to progress to Long Covid, a chronic immune deficiency similar to AIDS.

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

@BlackTomThePyr8 - Tom Czerniawski

@JesslovesMJK https://www.biorxiv.org/content/10.1101/2020.01.30.927871v1 THIS!

Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution biorxiv.org

@janiesaysyay - Janiesaysyay

This is the post X just deleted. My reply to @JesslovesMJK showing the Prashant Pradhan "HIV-inserts" paper was forcibly retracted (by Fauci's goon Kristian Andersen) because it caused people to draw parallels between HIV & SARSCoV2, AIDS & Long Covid. They aerosolized AIDS.

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

@JesslovesMJK - Jessica Rose 🤙

The thing that's most crazy about what he said about the HIV inserts being a "conspiracy theory" is that he doesn't even acknowledge why the Pradhan paper was 'disappeared' as a preprint within days of being uploaded. What were they so afraid of? Why was the paper disappeared? We all know that preprints haven't been peer-reviewed so why hide someone's work? https://www.researchgate.net/publication/338957445_Uncanny_similarity_of_unique_inserts_in_the_2019-nCoV_spike_protein_to_HIV-1_gp120_and_Gag

ResearchGate - Temporarily Unavailable researchgate.net

@janiesaysyay - Janiesaysyay

https://t.co/8AlLKTAXYY

@BlackTomThePyr8 - Tom Czerniawski

I NOW REALIZE THAT THIS IS WHAT DASZAK FEARED EMERGING THE MOST - THAT'S WHY HE SO ARDENTLY DISMISSED IT AS A CONSPIRACY THEORY. IT'S ONE OF THE WORST PARTS OF THIS SITUATION, REALLY - SARS-COV-2 IS A BIO-WEAPON PARTLY BASED ON HIV - AND THE HIV ELEMENT USED IS ALSO *A PRION* https://t.co/j4TZxzQFE2

@janiesaysyay - Janiesaysyay

The SarsCov2 spike protein is a chimera. Created in a lab, it contains gene sequence homologs of many lethal organisms, including HIV, SEB, rabies, malaria, animal venoms. That homology is important and drives the pathophysiology and symptoms of Covid. #ItsABi0weap0n

@CharlesRixey - Charles Rixey, MA MBA (c) 🐭

@DeinertDoc @Jikkyleaks @jjcouey @chrismartenson @TyCardon @SweenyFrank @EduEngineer @BretWeinstein @alexandrosM @RMConservative @fynn_fan @quay_dr @gdemaneuf [11] It wasn't ONE thing that made it clear that SARS-CoV-2's origin wasn't natural It was MANY [#1] What did this tell Fauci et al about COVID's origin? [#2] THESE are the things that they KNEW when making their decisions about how to respond to the pandemic it's heartbreaking https://t.co/QKS3k43Oin

@janiesaysyay - Janiesaysyay

https://t.co/ehKIFgRUGj

@KathMLee1 - DrKathrynPhD- typer of typos

One of our key decisions was identifying the target pathogen for our PLANNED 2019 "capabilities demonstration" as part of our DARPA P3 program bioengineeringcommunity.nature.com/posts/modeling… https://t.co/U5vbcSu85D

@janiesaysyay - Janiesaysyay

Grazing in 🐄 the Grass Everything here is so clear you can see it

@JCPEREZCODEX - jean-claude perez

26 CJD Fatal diseases by Biomathematician @JCPEREZCODEX neurologist c. Moret-Chalmin and RIP virologist #lucMontagnier 26 cases of #creutzfeldtJakob fatal disease 11 days after #covid19 JAB DOI:10.13140/RG.2.2.14427.03366

@janiesaysyay - Janiesaysyay

#GrazingInTheGrass #ThoseCowsAreMad #NeedsMoreCowbell #CreuzfeldtJakobDisease #CJD #prions #RIPLucMontagnier #RIPDrBaselga #pandemicplaylist https://www.youtube.com/watch?v=j9XFLCs2FdI

@janiesaysyay - Janiesaysyay

And everything here is so real you can feel it

@NiusMarco - marco nius

Creutzfeld Jacob sur Eudravigilance 62 cas pour Pfizer AZ et Moderna Quelques fiches individuelles plus bas

@janiesaysyay - Janiesaysyay

And it's real #RIPMauricette https://lepointcritique.fr/2022/02/18/maladie-creutzfeldt-jakob-postvaccinale-epidemie-dans-epidemie/

Épidémie de Creutzfeldt-Jakob postvaccinale | Le Point Critique Les cas suspects de maladie de Creutzfeldt-Jakob postvaccinale se multiplient en France. Une dizaine d’études documentent un possible lien avec le vaccin. La précipitation de l’État à écarter cette hypothèse l’expose-t-elle à un scandale sanitaire ? lepointcritique.fr

@janiesaysyay - Janiesaysyay

so real so real so real so real so real

@JesslovesMJK - Jessica Rose 🤙

More oopsies. @waynerohde https://boriquagato.substack.com/p/cg-enrichment-in-covid-vaccine-mrna/comments?s=r

CG enrichment in covid vaccine mRNA why the vaccines may have VERY different systemic effects vs covid virus boriquagato.substack.com

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

🤔 https://pharmaphorum.com/news/shock-as-astrazenecas-charismatic-cancer-rd-chief-jose-baselga-dies/

Shock as AstraZeneca’s charismatic cancer R&D chief José Baselga dies AstraZeneca is mourning the loss of one of its top scientists after eminent cancer researcher José Baselga passed away at the age of just 61.  pharmaphorum.com

@janiesaysyay - Janiesaysyay

@CharlesRixey - Charles Rixey, MA MBA (c) 🐭🇨🇱

@DeinertDoc @Jikkyleaks @AGHuff @BrendanEich @fynn_fan @BitSonicoin @BretWeinstein @joshrogin @alykhansatchu @jjcouey @ichudov @RMConservative @SweenyFrank @TyCardon @quay_dr @RepGallagher @RobertKennedyJr @Doctor_I_am_The @DrKevinWMcCair1 @NIH @WhiteCoatWaste @_whitneywebb @dasher8090 @HansMahncke @garyruskin @emilyakopp I'm just going to set this down right here, on behalf of Dr. Fleming... Which, by the way, is just a bonus when you count the cancer... & the ⬆️furin expression w/hypoxia

@janiesaysyay - Janiesaysyay

"her mother received the first dose of Pfizer on April 5, and her second dose on April 25. On May 6, Cheryl experienced her first episode indicating “something was neurologically wrong,” Gianni explained. “She had extreme brain fog and confusion. She couldn’t remember where>

@janiesaysyay - Janiesaysyay

she was driving, and got really scared...On July 12, a second lumbar puncture came back positive for CJD... Cheryl’s tau protein value was 38,979 pg/ml, while the spectrum for CJD positive patients is 0 – 1,149." https://themadtruther.com/2021/09/01/woman-dies-of-rare-brain-disease-within-3-months-of-second-pfizer-shot-doctor-says-vaccine-could-be-responsible/

Site is undergoing maintenance ∞ From darkness to light ∞ themadtruther.com

@janiesaysyay - Janiesaysyay

@Medic4allHuman - MAMMIE Bocock 🐭

Le peptide de la protéine spike du SARS-CoV-2 forme des amyloïdes En labo l'enzyme des cellules immunitaires clive la protéine spike pour donner un peptide formant des fibrilles amyloïdes Et la spike vaccinale ?!?!? https://cen.acs.org/biological-chemistry/Peptide-SARS-CoV-2-spike/100/web/2022/05?utm_source=Twitter&utm_medium=Social&utm_campaign=CEN Version fr : https://cen.acs.org/biological-chemistry/Peptide-SARS-CoV-2-spike/100/web/2022/05?utm_source=Twitter&utm_medium=Social&utm_campaign=CEN

404 Page Not Found | Chemical & Engineering News cen.acs.org

404 Page Not Found | Chemical & Engineering News cen.acs.org

@janiesaysyay - Janiesaysyay

My relative with vaxx-induced CJD, had strikingly similar symptom presentation as this💉case: "Her current condition progressed rapidly with onset of confusion, forgetfulness, and hallucinations within the next 5 days. Over the next 2 days, the patient developed difficulty>

@janiesaysyay - Janiesaysyay

in walking and echolalia. Although radiological and EEG findings in our patient are suggestive of a prion disease like pathology, we could not perform measurement of 14-3-3 protein in cerebrospinal fluid or post-mortem studies of the brain to confirm the diagnosis>

@janiesaysyay - Janiesaysyay

...recent studies using the aggregation-prediction server- AGGRESCAN and protein-protein docking techniques have indicated that the S1 SUBUNIT OF THE SPIKE-PROTEIN OF SARSCOV2 CAN interact with other aggregation-prone proteins of the brain like amyloid beta, prion protein>

@janiesaysyay - Janiesaysyay

α-synuclein, and tau, presumably through heparin-binding domains, to form homo or hetero-polymers RESEMBLING AMYLOID FIBRILS which may play a pivotal role in the neurodegenerative process of the misfolded protein disorders" aginganddisease.org/EN/10.14336/AD…

@janiesaysyay - Janiesaysyay

The sun beaming down between the leaves https://www.youtube.com/watch?v=T_tffjrItC4

@janiesaysyay - Janiesaysyay

Are spike induced CJD patients dying because they lack sufficient microglia to protect from prion seeding/astrocyte activation or because their microglia are hyperactivated by the spike but cannot protect? https://www.biorxiv.org/content/10.1101/2021.01.05.425436v1.full

@janiesaysyay - Janiesaysyay

And the bir ir irds darting in and out of the trees. "Depending on the type of stimuli and pathological context, as well as the signals from the surrounding microenvironment, MICROGLIA CAN TAKE ON DIFFERENT ACTIVATION STATES AND BECOME EITHER NEUROPROTECTIVE OR NEUROTOXIC.>

@janiesaysyay - Janiesaysyay

Activated microglia can exert detrimental effects by producing proinflammatory mediators, such as TNF-α, IL-1β, IL-6, NO, and ROS...Microglial activation represents one of the hallmarks of many neurodegenerative diseases. However>

@janiesaysyay - Janiesaysyay

prion disease is often associated with DRAMATIC AND CONSPICUOUS MICROGLIAL ACTIVATION...Compared with nonprion controls, immunohistochemical staining with microglial markers revealed MARKEDLY INCREASED MICROGLIA IN CJD... The morphology of the microglia changed to>

@janiesaysyay - Janiesaysyay

an activated state, providing evidence of a microglial response in prion diseases. Hyperactive microglia-associated cytokine storm is prominent in prion pathogenisis.>

@janiesaysyay - Janiesaysyay

A comprehensive study of microglial response in prion disease was performed by whole transcriptome profiling of prion-infected mouse brains. This study revealed that THE GENES UPREGULATED AFTER PRION INFECTION, regardless of the prion strain or mouse genetic background>

@janiesaysyay - Janiesaysyay

ARE EXPRESSED PREDOMINANTLY BY ACTIVATED MICROGLIA, contributing to a growing recognition of the importance of microglia in prion pathogenesis. Analysis of microglia isolated from prion-infected mice demonstrated that, in addition to an upregulation of>

@janiesaysyay - Janiesaysyay

GENES ASSOCIATED WITH METABOLIC AND RESPIRATORY STRESS, a disease-specific, highly proinflammatory profile was observed...At early stages of prion infection, microglia respond to PrPSc deposits and consequently increase their phagocytic capacity to remove PrPSc. However>

@janiesaysyay - Janiesaysyay

this phagocytosis is insufficient, and SUSTAINED PRPSC ACCUMULATION LEADS TO NEURONAL DAMAGE, WHICH COULD IN TURN TRIGGER THE MICROGLIA TO SWITCH TO A PROINFLAMMATORY PHENOTYPE...inflammatory cytokines may also convert astrocytes to a deleterious A1 phenotype.>

@janiesaysyay - Janiesaysyay

Classically activated microglia have been found to induce a putative subtype of reactive astrocytes, termed A1, by secreting IL-1α, TNF-α, and C1q, leading to a loss of neurotrophic functions and neuronal death.>

@janiesaysyay - Janiesaysyay

Thus, microglial activation and astrogliosis may be more closely related than has previously been appreciated." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669569/

Microglia in prion diseases Prion diseases are a group of progressive and fatal neurodegenerative disorders characterized by deposition of scrapie prion protein (PrP[Sc] ) in the CNS. This deposition is accompanied by neuronal loss, spongiform change, astrogliosis, and conspicuous ... ncbi.nlm.nih.gov

@janiesaysyay - Janiesaysyay

And everything here is so near you can feel it.

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

SarsCoV2 Spike S1 subunit acting like a prion:

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

All roads lead to mitochondria

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

Baby can you dig it? Oh la la, this paper from @JCPEREZCODEX "We subsequently recall the usual history of this dreadfull subacute disease, and compare it with this new, extremely acute, prion disease, following closely💉>

@janiesaysyay - Janiesaysyay

In a few weeks, more 50 cases of almost spontaneous emergence of Creutzfeldt-Jakob disease have appeared in France and Europe very soon after the injection of the first or second dose of Pfyzr, M0derna or AstraZneka💉s. >

@janiesaysyay - Janiesaysyay

To summarize, of the 26 cases analyzed, the first symptoms of CJD appeared on average 11.38 days after the injection of the COVID-19 💉." https://www.researchgate.net/publication/358661859_Towards_the_emergence_of_a_new_form_of_the_neurodegenerative_Creutzfeldt-Jakob_disease_Twenty_six_cases_of_CJD_declared_a_few_days_after_a_COVID-19_vaccine_Jab

ResearchGate - Temporarily Unavailable researchgate.net

@janiesaysyay - Janiesaysyay

@JCPEREZCODEX - jean-claude perez

Nota: le 1er février #lucMontagnier me téléphonait encore depuis l'hôpital pour insister sur la fabrication du tableau ci joint...

@janiesaysyay - Janiesaysyay

@JCPEREZCODEX - jean-claude perez

2 articles on: Prions and #creutzfeldtJakob https://www.theepochtimes.com/studies-link-incurable-prion-disease-with-covid-19-vaccine_4511204.html And #monkeypox https://expose-news.com/2022/06/04/two-studies-monkeypox-manipulated-in-biolab/

Studies Link Incurable Prion Disease With COVID-19 Vaccines theepochtimes.com

Two Studies now suggest the circulating Monkeypox Virus has been manipulated in a Biolab Recently we revealed how a study published by Portugal's Institute for Health had found abnormal mutations among the alleged circulating monkeypox virus suggesting it had been manipulated and edited in a biolab. Now a second study has been published adding weight to this theory. Monkeypox illness usually begins with a fever before a rash develops… expose-news.com

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

@justcallme_kari - just call me Kari

Just this week my cousins husband passed away. They told her they suspect CJD but refuse to do an autopsy, they told her it's too dangerous to preform. https://www.theepochtimes.com/studies-link-incurable-prion-disease-with-covid-19-vaccine_4511204.html?utm_campaign=socialshare_twitter&utm_source=twitter.com

Studies Link Incurable Prion Disease With COVID-19 Vaccines theepochtimes.com

@janiesaysyay - Janiesaysyay

Acceleration of CJD after SC2 infection👇 Is the spike protein of the virus/vaxx accelerating existing neurodegeneration? If so, is the post-vaxx CJD really a new form of CJD or is it an enhancement of the disease by spike? #VaxxDependentEnhancement https://www.mdpi.com/2227-9059/9/11/1730/htm

Clinical and Radiological Deterioration in a Case of Creutzfeldt–Jakob Disease following SARS-CoV-2 Infection: Hints to Accelerated Age-Dependent Neurodegeneration Systemic inflammation and the host immune responses associated with certain viral infections may accelerate the rate of neurodegeneration in patients with Creutzfeldt–Jakob disease (CJD), a rare, transmissible neurodegenerative disease. However, the effects of the newly emerged SARS-CoV-2 infection on the pathogenesis of CJD are unknown. In this study, we describe the case of an elderly female patient with sporadic CJD that exhibited clinical deterioration with the emergence of seizures and radiological neurodegenerative progression following an infection with SARS-CoV-2 and severe COVID-19. Despite efforts to control the progression of the disease, a dismal outcome ensued. This report further evidences the age-dependent neurological effects of SARS-CoV-2 infection and proposes a vulnerability to CJD and increased CJD progression following COVID-19. mdpi.com

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

#SpikeDependentEnhancement #Bi0weap0n

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

@AllTheRisks - Jonathan Weissman

@JCPEREZCODEX Thank you for your amazing paper with the late, great Nobel Prize laureate Prof Luc Montagnier. YouTube banned my video prior to the premiere but I'm getting the word out about your research at http://alltherisks.com. #AllTheRisks

Video Transcript AI Summary

Using more c and g in biotechnology translates proteins quicker, evading the immune system. However, altering the folding structure by increasing GC content in Pfizer's and Moderna's drugs poses risks. Computer models show significant differences in folding between the drugs and the natural virus, potentially leading to prion disease concerns. These modifications make the drugs more hazardous than the original virus.

AI Similar Videos

Full Transcript

Speaker 0: If you use more c and g, cytosine and guanine, you translate it quicker. Right? Remember, it's all about biotechnology. More protein, more quickly, avoid the innate immune system. So what's the problem? You change the secondary structure of how this thing folds. At the top right, you can see we've gone from 36% GC content in the natural virus to 53% in Pfizer's drug. I think it's 61% for Moderna. At the bottom right, this is a paper where they used RNA fold, which is a computer model, to understand how different the folding is between Pfizer's drug and the natural virus. Does that look the same to you or does it look like it's folding differently? It's folding differently. We will see in a moment, in the next section, a very serious concern about prion disease related to this modification. The bottom line is these modifications are making things more dangerous even than the natural virus.

alltherisks.com COVID-19 Vaccines: What You Should Have Been Told, 17 September 2022, referenced slides available here alltherisks.com

@janiesaysyay - Janiesaysyay

It sure is mellow grazing in the grass What a trip just watching as the world goes past

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

@NeBirgitta - Birgitta Neher

⁦@CaudeHenrion⁩ Mitochondrial respiratory chain deficiency correlates with the severity of neuropathology in sporadic Creutzfeldt-Jakob disease https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-020-00915-8

Mitochondrial respiratory chain deficiency correlates with the severity of neuropathology in sporadic Creutzfeldt-Jakob disease - Acta Neuropathologica Communications Mitochondrial dysfunction has been implicated in multiple neurodegenerative diseases but remains largely unexplored in Creutzfeldt-Jakob disease. Here, we characterize the mitochondrial respiratory chain at the individual neuron level in the MM1 and VV2 common molecular subtypes of sporadic Creutzfeldt-Jakob disease. Moreover, we investigate the associations between the mitochondrial respiratory chain and neuropathological markers of the disease. Brain tissue from individuals with sporadic Creutzfeldt-Jakob disease and age-matched controls were obtained from the brain collection of the Austrian Creutzfeldt-Jakob Surveillance. The mitochondrial respiratory chain was studied through a dichotomous approach of immunoreactivities in the temporal cortex and the hippocampal subregions of CA4 and CA3. We show that profound deficiency of all mitochondrial respiratory complexes (I-V) occurs in neurons of the severely affected temporal cortex of patients with Creutzfeldt-Jakob disease. This deficiency correlates strongly with the severity of neuropathological changes, including vacuolation of the neuropil, gliosis and disease associated prion protein load. Respiratory chain deficiency is less pronounced in hippocampal CA4 and CA3 regions compared to the temporal cortex. In both areas respiratory chain deficiency shows a predilection for the MM1 molecular subtype of Creutzfeldt-Jakob disease. Our findings indicate that aberrant mitochondrial respiration could be involved early in the pathogenesis of sporadic Creutzfeldt-Jakob disease and contributes to neuronal death, most likely via ATP depletion. Based on these results, we propose that the restricted MRI diffusion profile seen in the brain of patients with sporadic Creutzfeldt-Jakob disease might reflect cytotoxic changes due to neuronal respiratory chain failure and ATP loss. actaneurocomms.biomedcentral.com

@janiesaysyay - Janiesaysyay

@Biomed_MDPI - Biomedicines MDPI

💡𝗖𝗮𝘀𝗲𝗥𝗲𝗽𝗼𝗿𝘁💡 "Clinical and Radiological Deterioration in a Case of Creutzfeldt–Jakob Disease following SARS-CoV-2 Infection: Hints to Accelerated Age-Dependent Neurodegeneration" 🔗https://www.mdpi.com/2227-9059/9/11/1730

Clinical and Radiological Deterioration in a Case of Creutzfeldt–Jakob Disease following SARS-CoV-2 Infection: Hints to Accelerated Age-Dependent Neurodegeneration Systemic inflammation and the host immune responses associated with certain viral infections may accelerate the rate of neurodegeneration in patients with Creutzfeldt–Jakob disease (CJD), a rare, transmissible neurodegenerative disease. However, the effects of the newly emerged SARS-CoV-2 infection on the pathogenesis of CJD are unknown. In this study, we describe the case of an elderly female patient with sporadic CJD that exhibited clinical deterioration with the emergence of seizures and radiological neurodegenerative progression following an infection with SARS-CoV-2 and severe COVID-19. Despite efforts to control the progression of the disease, a dismal outcome ensued. This report further evidences the age-dependent neurological effects of SARS-CoV-2 infection and proposes a vulnerability to CJD and increased CJD progression following COVID-19. mdpi.com

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

🧵Redo CJD cases with details: "A month ago he was out pacing us on hikes going up Runyon Canyon, and now both physical and cognitive decline have taken place at a shocking speed." GFM created: 5-27-22 "just diagnosed" Death: 6-7-22 #RIPEric #CJD https://gofund.me/a6e48780

Help Our Beloved Eric, organized by Jeff Werner Eric was just diagnosed with a fatal, rapid onset nuerological disorder called Creutzfeldt-Jakob dis… Jeff Werner needs your support for Help Our Beloved Eric gofundme.com

@janiesaysyay - Janiesaysyay

@CharlesRixey - Charles Rixey, MA MBA (c) 🐭🇨🇱

[2] It was read more than 132k times before ResearchGate took it down. It has since been revised and expanded. The evidence is overwhelming @janiesaysyay @jjcouey @Jikkyleaks @akheriaty @JesslovesMJK @EduEngineer @ichudov @TyCardon @EthicalSkeptic https://www.researchgate.net/publication/359855384_The_Myth_of_the_Blind_Watchmaker

ResearchGate - Temporarily Unavailable researchgate.net

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

"He died on August 30, 2021 from complications from Creutzfeldt-Jakob disease, having only discovered in late spring just how incredibly ill he was." https://www.thejc.com/news/uk/top-jewish-sports-journalist-dies-of-creutzfeldt-jakob-disease-1.520042

Top Jewish sports journalist dies of Creutzfeldt-Jakob disease Simon Greenberg also worked with José Mourinho at Chelsea as communications director thejc.com

@janiesaysyay - Janiesaysyay

"The patient passed away two months after the onset of her symptoms." https://www.cureus.com/articles/90302-rapidly-progressive-probable-sporadic-creutzfeldt-jakob-disease

Rapidly Progressive Probable Sporadic Creutzfeldt-Jakob Disease Creutzfeldt-Jakob disease (CJD) is a rare, fatal brain infection caused by a human prion. Because CJD is associated with rapidly progressive neurological degeneration, it requires high suspicion for diagnosis. We report the case of a 79-year-old patient who presented with a rapidly progressive neurological clinical picture. The patient had positive 14-3-3 proteins in cerebrospinal fluid, electroencephalography was significant for periodic discharges, and magnetic resonance imaging of the brain showed both diffusion restriction and increased fluid-attenuated inversion recovery signal in different cortical regions, consistent with probable sporadic CJD infection. The patient was enrolled under hospice and palliative care. The patient passed away two months after the onset of her symptoms. We discuss the probable sporadic CJD diagnostic criteria and possible risk factors that might have led to a faster progressive course. cureus.com

@janiesaysyay - Janiesaysyay

"Richard, 57, died within four weeks of being admitted to hospital." https://www.6pr.com.au/fit-as-a-fiddle-veteran-pe-teacher-dies-after-contracting-extremely-rare-disease/

'Fit as a fiddle' veteran PE teacher dies after contracting extremely rare disease Richard Main spent 37 years working as a PE teacher and was “fit as a fiddle” when he was diagnosed with an extremely rare disease known as Creutzfeldt-Jakob Disease (CJD). CJD is a degenerative brain disorder that progresses at a rapid pace throughout the body and ultimately leads to death. Richard, 57, died within four […] 6pr.com.au

@janiesaysyay - Janiesaysyay

60 yr old male, California Vaxx: 2021-04-24, 1 dose, M0dern@ Onset: 2021-05-07

@janiesaysyay - Janiesaysyay

62 yr old female, North Carolina Vaxx: 2021-03-08, 1 dose, J@nssen Onset: 2021-03-29

@janiesaysyay - Janiesaysyay

64 yr old female, Florida Vaxx: 2021-04-25, 2, doses, Fizer Onset: 2021-05-06

@janiesaysyay - Janiesaysyay

69 yr old female, Louisiana Vaxx: 2021-03-08, 2 doses, M0dern@ Onset: 2021-04-01

@janiesaysyay - Janiesaysyay

66 yr old male, Texas Vaxx: 2021-01-27, 2 doses, M0dern@ Onset: 2021-06-01 Died: 2021-08-27

@janiesaysyay - Janiesaysyay

67 yr old male, Washington Vaxx: 2021-03-01, 2 doses, Fizer Onset: 2021-05-01

@janiesaysyay - Janiesaysyay

67 yr old male, Washington Vaxx: 2021-02-22, 3 doses, Fizer Onset: 2021-04-01 Died 2021-10-29

@janiesaysyay - Janiesaysyay

58 yr old male, Kansas Vaxx: 2021-10-28, 3 doses, M0dern@ Onset: 2021-11-22

@janiesaysyay - Janiesaysyay

60 yr old female, Missouri Vaxx: 2021-09-21, 2 doses, Fizer Onset: 2021-09-25 Died: 2022-02-01

@janiesaysyay - Janiesaysyay

70 yr old female Vaxx: 2021-02-26, 2021-03-17, 1 dose, M0dern@ Died: 2021-08-02

@janiesaysyay - Janiesaysyay

72 yr old male, Massachusetts Vaxx: 2021-08-06 Died: 2022-03-14

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

"my sister Casey recently became very ill with an extremely rare brain disease and she has declined at a rapid pace." #CJD https://gofund.me/3c74087a

Donate to Loving Casey & her family, organized by Jaime Taylor As many of you may already know, my sister Casey recently became very ill with an extremely rar… Jaime Taylor needs your support for Loving Casey & her family gofundme.com

@janiesaysyay - Janiesaysyay

#CJD

@janiesaysyay - Janiesaysyay

#CJD

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

#RIPCyndi #CJD

@janiesaysyay - Janiesaysyay

Long research 🧵, hit "show replies" to see all

@janiesaysyay - Janiesaysyay

The SARS2 spike protein S1 subunit has a prion-like domain on it, this helps the 🦠 to cause or accelerate neurodegenerative diseases. Montagnier and Perez theorize that the synthetic spike of the 💉 can do the same. https://www.frontiersin.org/articles/10.3389/fnins.2022.1002770/full

Frontiers | SARS-CoV-2, long COVID, prion disease and neurodegeneration frontiersin.org

@janiesaysyay - Janiesaysyay

This paper supports @PlanZip's theory that the SARS2 virus is preferentially targeting the mitochondria in host cells. They surmise it's because of the co-evolution of the two, which predates eukaryotes. #AllRoadsLeadToMitochondria https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047479/

Potential Prion Involvement in Long COVID-19 Neuropathology, Including Behavior Prion’ is a term used to describe a protein infectious particle responsible for several neurodegenerative diseases in mammals, e.g., Creutzfeldt-Jakob disease. The novelty is that it is protein based infectious agent not involving a nucleic acid ... ncbi.nlm.nih.gov

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

#GainOfFunction #Bioweapon

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

@ssayssayssay GFM created 03/11/2023 RIP Sandy

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

@ssayssayssay GFM created 02/05/2023

@janiesaysyay - Janiesaysyay

Diane was a nurse, presumably she received all her inoculations. GFM created: 01/14/2023 Death: 01/23/2023 RIP Diane

@janiesaysyay - Janiesaysyay

Ray got sick with COVID in 12/2021, after the fall booster season. Possible Long Covid. CJD symptoms in 06/2021 GFM created: 12/30/2023 Diagnosis 04/12/2023 Death: 04/21/2023

@janiesaysyay - Janiesaysyay

Looking at this case, it might simply be neurodegeneration from untreated Long Covid (see research of dbdugger) because the time fits that Dx better. RIP Ray thank you for your service ❤️.

@janiesaysyay - Janiesaysyay

GFM created: 12/24/2021 Death: 03/05/2022 RIP Dave #CJD

@janiesaysyay - Janiesaysyay

Facebook and and other social media pages show many more of these accelerated CJD cases. I documented more on @Jaineysez. No informed consent that the COVID 💉 mRNA contained a toxic spike protein with prion-like properties.

@MakisMD - William Makis MD

Portsmouth, RI - 57 year old neonatal nurse Diane Santos died suddenly on January 23, 2023, weeks after diagnosis with fatal Creutzfeldt-Jakob Disease or prion disease There are at least 2 prion sequences in the COVID-19 mRNA vaccine spike protein. #DiedSuddenly #cdnpoli #ableg

@janiesaysyay - Janiesaysyay

#Metoo

@stephanieseneff - Stephanie Seneff

I'm pleased to see somebody else linking the spike protein to prion disease. I hope experts will look into a possibility of antibodies against the YQAGS sequence in the RBD of spike attacking YQRGS in the C-terminal domain of the prion protein. https://wmcresearch.substack.com/p/long-covid-as-prion-disease

Long COVID as Prion Disease The disease has so far remained elusive, perhaps because it is not viral at all. wmcresearch.substack.com

@janiesaysyay - Janiesaysyay

@janiesaysyay - Janiesaysyay

@dbdugger - Daniel Brittain Dugger

Borrowing from a virus that shares the same pathophysiology, it is possible to see sporadic CJD. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997664/

Sporadic Creutzfeldt-Jakob disease in two clinically and virologically controlled Brazilian HIV patients who progressed rapidly to dementia: case reports and literature review Human immunodeficiency virus (HIV)-associated neurocognitive disorders are the main cause of cognitive decline and dementia in people living with HIV (PLHIV). However, extensive workup should be done in patients with rapidly progressive dementia (RPD) ... ncbi.nlm.nih.gov

@janiesaysyay - Janiesaysyay

So real Accelerated CJD clusters in Michigan. https://www.woodtv.com/news/michigan/deadly-clusters-doctors-urge-closer-look-at-rare-always-fatal-brain-disease/

Deadly Clusters: Doctors urge closer look at rare, always fatal brain disease It's a rare but devastating disease: The few who are diagnosed with Creutzfeldt-Jakob disease are handed a death sentence. woodtv.com

@janiesaysyay - Janiesaysyay

So real

@WOODTV - WOOD TV8

After several cases of the "uniformly fatal" Creutzfeldt-Jakob disease in Michigan, doctors are looking for commonalities: https://www.woodtv.com/news/michigan/deadly-clusters-doctors-urge-closer-look-at-rare-always-fatal-brain-disease/

Video Transcript AI Summary

They took him to the ER and admitted him. It was the beginning of the end. Crocodile disease is catastrophic and always fatal. No one has ever survived.

AI Similar Videos

Full Transcript

Speaker 0: Into the ER and they admitted him, and, that was the beginning of the of the end, really. Crocodile, yeah, cold disease is really, catastrophic when it happens. Unfortunately, it's uniformly fatal. No one's ever survived.

Deadly Clusters: Doctors urge closer look at rare, always fatal brain disease It's a rare but devastating disease: The few who are diagnosed with Creutzfeldt-Jakob disease are handed a death sentence. woodtv.com

@janiesaysyay - Janiesaysyay

https://gofund.me/ac42c7a6 #RIPRaffaelle

Creutzfeldt-Jakob Disease: Raffaele Dioguardi, organisiert von Biagio Pepe Hello, my name is Biagio Pepe, I am fundraising in hopes to raise… Biagio Pepe braucht deine Unterstützung für Creutzfeldt-Jakob Disease: Raffaele Dioguardi gofundme.com

@janiesaysyay - Janiesaysyay

https://gofund.me/f284fa4e #RIPRon

Ron Smarr's Journey with CJD, organized by Colleen Smarr In March 2023, Ron's journey began as he experienced a significant decline in mental & cogn… Colleen Smarr needs your support for Ron Smarr's Journey with CJD gofundme.com

@janiesaysyay - Janiesaysyay

Well done @veryvirology! The EU admitted we might see CJD cases arising from prion contamination in the 💉 because of the use of bovine fats in the LNPs. https://veryvirology.substack.com/p/prions-one-of-these-things-is-not

Prions: One Of These Things Is Not Like The Others A surprising development constitutes some unexpectedly good news. veryvirology.substack.com

@janiesaysyay - Janiesaysyay

Remember Jay, he was the MI attorney Dx with an aggressive Heidenhain variant of CJD who died very quickly. Then MI Doctors found a cluster of CJD cases. > https://t.co/I9jSou7XcE

@janiesaysyay - Janiesaysyay

CJD is easy to miss because it is often misdiagnosed as Parkinson's or dementia. So doctors went back and looked at patient records. > https://t.co/LHZZcSEEHJ

@janiesaysyay - Janiesaysyay

Joe College Stage IV cancer #NoCollegeMandates https://www.gofundme.com/f/support-aidan-fertig-as-he-battles-stage-4-cancer

Support Aidan Fertig as he battles stage 4 cancer, organized by Michelle Larson We are are family that firmly believes in asking only for what we n… Michelle Larson needs your support for Support Aidan Fertig as he battles stage 4 cancer gofundme.com

@janiesaysyay - Janiesaysyay

Stage IV cancer #NoCollegeMandates https://www.gofundme.com/f/help-jada-ease-her-mind

Help Jada beat cancer, organized by Sarath Som Hello, my name is Sarath and I’m the godmother of a bright and beautiful teenager named Jadalynn Ngu… Sarath Som needs your support for Help Jada beat cancer gofundme.com

@janiesaysyay - Janiesaysyay

Recurring T cell Acute Lymphoblastic Leukemia https://www.gofundme.com/f/dylans-leukaemia-treatment

Please Help Dylan Beat Leukaemia, organized by Kelly Payne Please use #helpdylan when posting on social media Dylan’s story. On the evenin… Kelly Payne needs your support for Please Help Dylan Beat Leukaemia gofundme.com

@janiesaysyay - Janiesaysyay

Agressive Lymphoma https://gofund.me/ff6b97d6

Help Jorge Andres get his bone marrow transplant, organized by Carlos A. Briceño Our family is asking for your help so my nephew can get the bone m… Carlos A. Briceño needs your support for Help Jorge Andres get his bone marrow transplant gofundme.com

@janiesaysyay - Janiesaysyay

Stage III recurring Lymphoma https://gofund.me/378e85cd

Dillons “warrior” fund, organized by Courtney Gibbs My little brother Dillon was diagnosed with stage 3 Hodgkin’s Lymphoma July of 2021. Dillon is … Courtney Gibbs needs your support for Dillons “warrior” fund gofundme.com

@janiesaysyay - Janiesaysyay

Stage II Lymphoma https://t.co/gu2X8ZIZpq

@janiesaysyay - Janiesaysyay

#NoCollegeMandates #Lymphoma #Cancer https://t.co/Tu171VfplH

@janiesaysyay - Janiesaysyay

Advanced lymphoma #NoCollegeMandates #Lymphoma #Cancer https://t.co/dA39frEhm8

@janiesaysyay - Janiesaysyay

#NoCollegeMandates #Lymphoma #Cancer https://t.co/FZOuST50fS

@janiesaysyay - Janiesaysyay

#NoCollegeMandate #Lymphoma #Cancer https://t.co/8z0koIqu5H

@janiesaysyay - Janiesaysyay

https://t.co/bWzkGSTQBA

@janiesaysyay - Janiesaysyay

Stage III lymphoma, large tumor in chest. https://t.co/judFD5YgeW

@janiesaysyay - Janiesaysyay

Stage IV Glioma #NoCollegeMandates https://t.co/z4pFKSHAm7

@janiesaysyay - Janiesaysyay

Stage IV Glioma #NoCollegeMandates https://t.co/DmeNkxjCy4

@janiesaysyay - Janiesaysyay

https://t.co/Fmwcx2oHc9

@janiesaysyay - Janiesaysyay

College student with Stage IV colon cancer metastasized into lung. #NoCollegeMandates #SeeUInCourtGene https://t.co/uALQAr7L2I

@janiesaysyay - Janiesaysyay

https://t.co/GkifnTaAY4

@janiesaysyay - Janiesaysyay

Stage IV cancer https://t.co/j28Nb93zGM

@janiesaysyay - Janiesaysyay

Stage IIIb Hodgkin's lymphoma with large mass in chest. https://t.co/eBekwydywK

@janiesaysyay - Janiesaysyay

Recent graduate in occupational therapy with stage IV gastric cancer. https://t.co/k0yqMljqFF

@janiesaysyay - Janiesaysyay

https://t.co/VUwQsuBuCu https://t.co/jNdH7pxBDX

@janiesaysyay - Janiesaysyay

#NoCollegeMandates #GeneImComing4U #SeeUInCourt https://t.co/03gCX0Eck6

@janiesaysyay - Janiesaysyay

#NoCollegeMandates #Lymphoma #HodgkinsLymphoma #Cancer #WarpSpeed https://t.co/5cKCKbHHqb

@janiesaysyay - Janiesaysyay

#NoCollegeMandates https://t.co/bFxtk1as5x

@janiesaysyay - Janiesaysyay

Senior at UNH with recent lymphoma Dx, 22 yrs old. https://t.co/E9tGe5xCda

@janiesaysyay - Janiesaysyay

Senior with recent Hodgkins lymphoma Dx, 21 yrs old. > #NoCollegeMandates #lymphoma #cancer #WarpSpeed https://t.co/ZcKpLDk3xl

@janiesaysyay - Janiesaysyay

New college graduate with aggressive Non-Hodgkin's lymphoma, 22 yrs old. > #NoCollegeMandates #lymphoma #cancer #MedTwitter https://t.co/1wh0AK9Wbh

@janiesaysyay - Janiesaysyay

Nursing student with #lymphoma. #NoCollegeMandates #JoeCollege #cancer #WarpSpeed #CorrelationNotCausation https://t.co/Vo6JTpNnGc

@janiesaysyay - Janiesaysyay

2022, college student with Stage IV #lymphoma, 22 yrs old. #NoCollegeMandates #WarpSpeed #cancer #CorrelationNotCausation https://t.co/YMJnK0cczx

@janiesaysyay - Janiesaysyay

2022, Stage II Hodgkins #lymphoma, 21 yr old pre-med student. #NoCollegeMandates #SeeUInCourtGene #JoeCollege #WarpSpeed #CorrelationNoCausation https://t.co/LJH7HLGYcU

@janiesaysyay - Janiesaysyay

Hodgkins #lymphoma, 21 yr old in vocational school. > #NoCollegMandates #WarpSpeed #CorrelationNotCausation https://t.co/rfziOEXnuJ

@janiesaysyay - Janiesaysyay

2022 Stage III Hodgkin's lymphoma, now refractory, 22 yr old philosophy student. > https://t.co/EIzcpD9Msa

@janiesaysyay - Janiesaysyay

Hodgkin's #Lymphoma #cancer #NoCollegeMandates #CorrelationNotCausation > https://t.co/xFwqGXQfOl

@janiesaysyay - Janiesaysyay

Stage II Hodgkin's #Lymphoma My guess is a lot of people in the salon business got vaxxed to continue their careers. > #WarpSpeed #CorrelationNotCausation https://t.co/DbJ4a8lDCW

@janiesaysyay - Janiesaysyay

Stage IV Hodgkin's #Lymphoma. One of April's symptoms was that she passed out. https://t.co/4AGsTWxzSG

@janiesaysyay - Janiesaysyay

2022, college senior with Non-Hodgkin' Lymphoma > #NoCollegeMandates #cancer #WarpSpeed #CorrelationNotCausation https://t.co/XmtgfU9P0h

@janiesaysyay - Janiesaysyay

Stage II Hodgkin's lymphoma, gymnastics coach and college freshman. > #NoCollegeMandates #cancer #WarpSpeed #CorrelationNotCausation https://t.co/ovAX0JL7QV

@janiesaysyay - Janiesaysyay

Hodgkin's Lymphoma, 21 yrs old. > https://t.co/yhSG63Fygl

@janiesaysyay - Janiesaysyay

2022, Non-Hodgkin's Lymphoma. > https://t.co/03HDzqWELL

@janiesaysyay - Janiesaysyay

Hodgkin's Lymphoma, 25 and 20 yr old. > #NoCollegeMandates #WarpSpeed #CorrelationNotCausation https://t.co/qQdBwa1Ow0

@janiesaysyay - Janiesaysyay

Grad student in Public Health, 23 yrs old with lymphoma. > #NoCollegeMandates #WarpSpeed #CorrelationNotCausation https://t.co/05KvFgGBjb

@janiesaysyay - Janiesaysyay

Many students were diagnosed late 2022, or spring 2023 with lymphoma. Dajohnna is Stage 3b Hodgkin's. > https://t.co/4fSXMjOo1m

@janiesaysyay - Janiesaysyay

Large Cell Lymphoma, and 20 yr old with Stage IV Hodgkin's. > #NoCollegeMandates #CorrelationNotCausation https://t.co/GFQGUVqxGP

@janiesaysyay - Janiesaysyay

Grad student in social work, Non-Hodgkin's Lymphoma, 22 yrs. old. > https://t.co/32pjCDkdCs

@janiesaysyay - Janiesaysyay

Late 2021, graduate and flight attendant, Stage III Hodgkin's Lymphoma, 21 yrs old. > https://t.co/radFIZbZoc

@janiesaysyay - Janiesaysyay

06/23 College freshman with "out of nowhere" stage IV sarcoma, 19 yrs old. > https://t.co/wTUP2mlNLw

@janiesaysyay - Janiesaysyay

07/23 22 yr old recent graduate with Hodgkin's Lymphoma > #NoCollegeMandates #cancer #CorrelationNotCausation https://t.co/4mneBEkCoc

@janiesaysyay - Janiesaysyay

Another day, another GFM account for a 💉'd college student with #BloodCancer whose career and life are threatened because he had no #InformedConsent. #XCensors #CensorshipKILLS https://t.co/oNznnNj26f

@janiesaysyay - Janiesaysyay

01/22 Stage III Thymoma > https://t.co/0F4R81OagB

@janiesaysyay - Janiesaysyay

07/22 20 yr old with recurring Metastatic Testicular Cancer > https://t.co/uhdJPCrKNa

@janiesaysyay - Janiesaysyay

03/23 22 yr old nursing student with Mucinous Cancer > https://t.co/Wzsn6TjBdz

@janiesaysyay - Janiesaysyay

https://t.co/gOQNQdyma3

@janiesaysyay - Janiesaysyay

Including #DiedSuddenly college students on this thread 08/23 19 yr old nursing student 💔> https://t.co/fbep9j4fkA

@janiesaysyay - Janiesaysyay

https://t.co/QGuMVSylAX

@janiesaysyay - Janiesaysyay

04/23 19 yr old 08/23 24 yr old #DiedSuddenly #CorrelationNotCausation https://t.co/nHZ8Faat92

@janiesaysyay - Janiesaysyay

05/23 18 yr old 08/23 21 yr old with #PMBCL. It is no longer "rare." > https://t.co/ZsxDeT6zgn

@janiesaysyay - Janiesaysyay

05/23 19 yr old, Non Hodgkin's lymphoma derails his college basketball hopes. > https://t.co/hWMNeeGRul

@janiesaysyay - Janiesaysyay

05/23 Nursing student with Stage III brain tumor. > #NoCollegeMandates https://t.co/ikIsfRejX2

@janiesaysyay - Janiesaysyay

07/23 18 yr old Hodgkin's 08/23 19 yr old Non Hodgkin's https://t.co/WgHtGijs8M

@janiesaysyay - Janiesaysyay

01/23 22 yr old with #GrayZoneLymphoma > #NoCollegeMandates #CorrelationNotCausation https://t.co/CEKzd5qfe7

@janiesaysyay - Janiesaysyay

09/22 22 yr old star college athlete with Ewing sarcoma, her 16 yr old brother had Burkitt lymphoma in 2021. #NoCollegeMandates > https://t.co/EuEsCIdjAl

@janiesaysyay - Janiesaysyay

03/22 Recent college grad and HCW 10/22 22 yr old Master's student Both with recurring Non Hodgkin's lymphoma > https://t.co/Z3WrB9vVND

@janiesaysyay - Janiesaysyay

01/23 - 03/23 College freshmen diagnosed with Hodgkin's lymphoma 01/23 - 04 /23 College freshman and senior with Non Hodgkin's lymphoma > #NoCollegeMandates https://t.co/b6vy8b7xs4

@janiesaysyay - Janiesaysyay

06/22 20 yr old college student with recurring Stage II Hodgkin's with large mass in chest and blood clots. > https://t.co/ywsIPgxtZo

@janiesaysyay - Janiesaysyay

02/22 18 yr old freshman with recurring Hodgkin's 12/22 18 yr old freshman with Hodgkin's 01/23 19 yr old sophomore with NHL 02/23 recent college grad and local news reporter with aggressive NHL > #NoCollegeMandates https://t.co/tkMYIt61mt

@janiesaysyay - Janiesaysyay

https://t.co/aFEHxKKts1

@janiesaysyay - Janiesaysyay

https://t.co/njY4Iu0JSQ

@janiesaysyay - Janiesaysyay

https://t.co/GrQku7nBks

@janiesaysyay - Janiesaysyay

#CauseUnknown #CorrelationNotCausation > https://t.co/vMnHxrJOhs

@janiesaysyay - Janiesaysyay

Long 🧵👆👇, keep showing replies to see all > https://t.co/wn80QbdPZl

@janiesaysyay - Janiesaysyay

> https://t.co/r5SDI2wGbV

@janiesaysyay - Janiesaysyay

?https://t.co/jqwAKYu0li

@janiesaysyay - Janiesaysyay

> https://t.co/64nQiAbxvn

@janiesaysyay - Janiesaysyay

🙏 https://t.co/5Hd98i1EEl

@janiesaysyay - Janiesaysyay

I am shadowbanned click on blue link to see full tweet > https://x.com/MakisMD/status/1705538518897107347?s=20 > https://t.co/6NiIgI14Dr

@janiesaysyay - Janiesaysyay

Lol doc, it has been reported by me for some time now. > https://t.co/72RZ83xPFA

@janiesaysyay - Janiesaysyay

https://x.com/DoorlessCarp/status/1705613482752696674?s=20 https://t.co/LaJXuLBU3V

@janiesaysyay - Janiesaysyay

> https://x.com/CaelorumAngelus/status/1704578692339388769?s=20 https://t.co/vOHSjcFcp6

@janiesaysyay - Janiesaysyay

08/23 24 yr old, Stage 4 Melanoma, passed. 22yr old Stage 3b Melanoma > https://t.co/14jjX6KKqz

@janiesaysyay - Janiesaysyay

02/23 21yr old, Stage IV Hodgkin's > #CorrelationNotCausation https://t.co/1oLfBNfVZY

@janiesaysyay - Janiesaysyay

08/23 23yrd old AML > #CorrelationNotCausation https://t.co/IBixITiKpx

@janiesaysyay - Janiesaysyay

05/23 21yr old Stage III Rhabdomyosarcoma > https://t.co/gZ8omypVGO

@janiesaysyay - Janiesaysyay

06/23 21 yr old, Stage IV Glioblastoma > #CorrelationNotCausation https://t.co/aWIIxUIVtu

@janiesaysyay - Janiesaysyay

07/23 22yr old college student suffers cardiac arrest and coma. > https://t.co/o3jJkpfx2R

@janiesaysyay - Janiesaysyay

05/23 College student with metastatic melanoma in parotid gland. Dr Arne Burkhardt found invading lymphocytes in the parotid glands during autopsies of 💉 patients. > #CorrelationNotCausation https://t.co/zIrKt97keV

@janiesaysyay - Janiesaysyay

09/23 22yr old, Hodgkin's > https://t.co/L0hGIfAi4h

@janiesaysyay - Janiesaysyay

07/23 22yr old college senior, Acute Undifferentiated Leukemia. > #CorrelationNotCausation https://t.co/GohgtAMhd6

@janiesaysyay - Janiesaysyay

02/23 College senior and athlete, Hodgkin's > https://t.co/ns3nQQTMrn

@janiesaysyay - Janiesaysyay

07/23 19yr old architectural student with Grade II Clear Cell Ependymoma, hydrocephalus, hydroheprosis of the kidney, mass behind uterus. Brain tumor came back after surgery. > https://t.co/x4byX3y5vm

@janiesaysyay - Janiesaysyay

05/23 19yr old, Stage IV Glioblastoma > https://t.co/06hIF9z5Aa

@janiesaysyay - Janiesaysyay

https://x.com/LastOutlaw1993/status/1706955505195975006?s=20

@janiesaysyay - Janiesaysyay

https://x.com/Fynnderella1/status/1708868750072811821?s=20

@janiesaysyay - Janiesaysyay

02/23 19yr old sudden strokes, hole in heart 06/23 19yr old collapses suddenly at home, massive blood cl0t on brain, Basiler Artery Stroke, hole in heart. https://t.co/HBtEFx6ZxX

@janiesaysyay - Janiesaysyay

08/23 20+ old, mini strokes, hole in heart 09/23 19yr old scholarship student, mini strokes, hole in heart. > https://t.co/O2FD1KhABX

@janiesaysyay - Janiesaysyay

09/23 20+ large blood cl0t, stroke, paralysis, holes in heart. > https://t.co/NmQdj3Kcn0

@janiesaysyay - Janiesaysyay

03/23 15yr old hole in the heart. 09/23 17yr old mini strokes, hole in the heart. > https://t.co/4ix3yOcjDR

@janiesaysyay - Janiesaysyay

11/22 20yr old collapses at home, stroke, heart attack, death. 09/23 23yr old dies suddenly of heart failure. > https://t.co/Ed4iJl13jr

@janiesaysyay - Janiesaysyay

01/24 18yr old collapses, cardiac arrest. > https://t.co/9hltFGp2fu

@janiesaysyay - Janiesaysyay

09/23 20yr old has recurring #Rhabdomyosarcoma and repeated amput*tions. "The loss-of-function of tumor suppressor p53 is associated with many cancers including rhabdomyosarcoma... 50% of RMS cases have been shown to carry some form of mutation to the P53 gene." > https://t.co/Efcn3lnDx2

@janiesaysyay - Janiesaysyay

04/23 Rhabdomyosarcoma, Stage IV https://t.co/em9yMsD4zg