@CartlandDavid - Dr David Cartland

Dear covid cultists and purveyors of safe and effective: (please send this mega thread to all those who call you a conspiracy theorist and spreader of covid misinformation)……please share this library of hard hitting published articles demonstrating unsafe and defective FAR and WIDE to every doctor and nurse that you know…..Kind Regards Dr @CartlandDavid

@CartlandDavid - Dr David Cartland

https://www.cureus.com/articles/209584-sars-cov-2-vaccination-and-the-multi-hit-hypothesis-of-oncogenesis#!/ https://pubs.rsna.org/doi/full/10.1148/radiol.230743 https://academic.oup.com/cid/article/75/1/e545/6563799 https://academic.oup.com/ofid/article/10/6/ofad209/7131292 https://www.medrxiv.org/content/10.1101/2023.12.13.23299926v1.full.pdf https://www.sciencedirect.com/science/article/abs/pii/S0264410X23015062 https://www.sciencedirect.com/science/article/abs/pii/S0264410X23015165

SARS-CoV-2 Vaccination and the Multi-Hit Hypothesis of Oncogenesis Cancer is a complex and dynamic disease. The “hallmarks of cancer” were proposed by Hanahan and Weinberg (2000) as a group of biological competencies that human cells attain as they progress from normalcy to neoplastic transformation. These competencies include self-sufficiency in proliferative signaling, insensitivity to growth-suppressive signals and immune surveillance, the ability to evade cell death, enabling replicative immortality, reprogramming energy metabolism, inducing angiogenesis, and activating tissue invasion and metastasis. Underlying these competencies are genome instability, which expedites their acquisition, and inflammation, which fosters their function(s). Additionally, cancer exhibits another dimension of complexity: a heterogeneous repertoire of infiltrating and resident host cells, secreted factors, and extracellular matrix, known as the tumor microenvironment, that through a dynamic and reciprocal relationship with cancer cells supports immortality, local invasion, and metastatic dissemination. This staggering intricacy calls for caution when advising all people with cancer (or a previous history of cancer) to receive the COVID-19 primary vaccine series plus additional booster doses. Moreover, because these patients were not included in the pivotal clinical trials, considerable uncertainty remains regarding vaccine efficacy, safety, and the risk of interactions with anticancer therapies, which could reduce the value and innocuity of either medical treatment. After reviewing the available literature, we are particularly concerned that certain COVID-19 vaccines may generate a pro-tumorigenic milieu (i.e., a specific environment that could lead to neoplastic transformation) that predisposes some (stable) oncologic patients and survivors to cancer progression, recurrence, and/or metastasis. This hypothesis is based on biological plausibility and fulfillment of the multi-hit hypothesis of oncogenesis (i.e., induction of lymphopenia and inflammation, downregulation of angiotensin-converting enzyme 2 (ACE2) expression, activation of oncogenic cascades, sequestration of tumor suppressor proteins, dysregulation of the RNA-G quadruplex-protein binding system, alteration of type I interferon responses, unsilencing of retrotransposable elements, etc.) together with growing evidence and safety reports filed to Vaccine Adverse Effects Report System (VAERS) suggesting that some cancer patients experienced disease exacerbation or recurrence following COVID-19 vaccination. In light of the above and because some of these concerns (i.e., alteration of oncogenic pathways, promotion of inflammatory cascades, and dysregulation of the renin-angiotensin system) also apply to cancer patients infected with SARS-CoV-2, we encourage the scientific and medical community to urgently evaluate the impact of both COVID-19 and COVID-19 vaccination on cancer biology and tumor registries, adjusting public health recommendations accordingly. cureus.com

Do vaccines increase or decrease susceptibility to diseases other than those they protect against? Contrary to the long-held belief that the effects of vaccines are specific for the disease they were created; compelling evidence has demonstrated tha… sciencedirect.com

Long term follow up and outcomes of Covid-19 vaccine associated myocarditis in Victoria, Australia: A clinical surveillance study Myocarditis and myopericarditis are well described adverse events of special interest (AESI) following COVID-19 vaccinations. Although reports are rea… sciencedirect.com

@CartlandDavid - Dr David Cartland

https://www.cureus.com/articles/199892-analysis-of-the-association-between-bnt162b2-mrna-covid-19-vaccination-and-deaths-within-10-days-after-vaccination-using-the-sex-ratio-in-japan#!/ https://zenodo.org/record/8120771 medrxiv.org/content/10.110… https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4125239 https://mdpi-res.com/d_attachment/vaccines/vaccines-10-01651/article_deploy/vaccines-10-01651.pdf?version=1664615143 https://www.ncbi.nlm.nih.gov/pubmed/20193633 Vaccines and Autoimmune diseases of the adult https://www.bmj.com/content/354/bmj.i4626/rr https://www.ncbi.nlm.nih.gov/m/pubmed/10648110/ https://www.bmj.com/rapid-response/2011/10/28/repairing-damage-whether-vaccine-induced-or-not https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139748/ eyedrugregistry.com/submit-an-inqu… pubmed.ncbi.nlm.nih.gov/37243095/ sciencedaily.com/releases/2007/… ncbi.nlm.nih.gov/pmc/articles/P… bmj.com/content/381/bm… frontiersin.org/articles/10.33… bmj.com/content/380/bm… nejm.org/doi/full/10.10…

Analysis of the Association Between BNT162b2 mRNA COVID-19 Vaccination and Deaths Within 10 Days After Vaccination Using the Sex Ratio in Japan Introduction: The association between coronavirus disease 2019 (COVID-19) vaccinations and deaths after vaccination has been investigated primarily through cohort and self-controlled case series studies. In the present study, the sex ratios of reported deaths were compared by period. Methods: Descriptive analysis was conducted using data on deaths reported after vaccination with the BNT162b2 mRNA vaccine. The data used were published by the Ministry of Health, Labour and Welfare in Japan. The risk period was defined as within 10 days of vaccination, and the control period was defined as 11 to 180 days after vaccination. Sex ratios were calculated for all-cause deaths and each outcome by dividing the number of males by that of females and multiplying by 100. Fisher's exact test was performed to analyze the results. Graphs were created to show the number of days from vaccination to death and that of reported deaths. Results: For all-cause deaths among individuals aged ≥65 years, the sex ratio during the risk period was 92, significantly lower than that during the control period (130) (p=0.0050). Conversely, for all-cause deaths among those aged ≤64 years, the sex ratio during the risk period was 204, significantly higher than that during the control period (111) (p=0.044). Reported deaths were concentrated during the risk period in both groups. Sex ratios by period for each outcome were also examined. However, the differences were not significant across any of the outcomes. Conclusion: The results indicate that the BNT162b2 mRNA vaccination may influence the occurrence of death during the risk period. In a cohort study in Japan, there was no significant increase in all-cause mortality owing to vaccination. This does not contradict the results of the present study. The results of a cohort study provide support for vaccine safety. However, this does not indicate that vaccine-related deaths are nonexistent; it only indicates that their number is not large enough to make a significant difference. Japan has relief services for adverse health effects that provide financial support to patients. On this occasion, it is difficult to determine whether a postvaccination death is incidental or vaccine-related. A self-controlled risk interval design and a comparison of sex ratios by period may be useful in examining the association between vaccination and deaths after vaccination when a cohort study does not detect a significant difference due to a low mortality rate. The latter approach may be particularly useful for analyzing data with reporting bias. The author believes that this approach may not provide conclusive evidence, but it can offer valuable insights into assessing vaccine safety. cureus.com

A SYSTEMATIC REVIEW OF AUTOPSY FINDINGS IN DEATHS AFTER COVID-19 VACCINATION ABSTRACT Background: The rapid development and widespread deployment of COVID-19 vaccines, combined with a high number of adverse event reports, have led to concerns over possible mechanisms of injury including systemic lipid nanoparticle (LNP) and mRNA distribution, spike protein-associated tissue damage, thrombogenicity, immune system dysfunction, and carcinogenicity. The aim of this systematic review is to investigate possible causal links between COVID-19 vaccine administration and death using autopsies and post-mortem analysis.   Methods: We searched for all published autopsy and necropsy reports relating to COVID-19 vaccination up until May 18th, 2023. We initially identified 678 studies and, after screening for our inclusion criteria, included 44 papers that contained 325 autopsy cases and one necropsy case. Three physicians independently reviewed all deaths and determined whether COVID-19 vaccination was the direct cause or contributed significantly to death.   Findings: The most implicated organ system in COVID-19 vaccine-associated death was the cardiovascular system (53%), followed by the hematological system (17%), the respiratory system (8%), and multiple organ systems (7%). Three or more organ systems were affected in 21 cases. The mean time from vaccination to death was 14.3 days. Most deaths occurred within a week from last vaccine administration. A total of 240 deaths (73.9%) were independently adjudicated as directly due to or significantly contributed to by COVID-19 vaccination.   Interpretation: The consistency seen among cases in this review with known COVID-19 vaccine adverse events, their mechanisms, and related excess death, coupled with autopsy confirmation and physician-led death adjudication, suggests there is a high likelihood of a causal link between COVID-19 vaccines and death in most cases. Further urgent investigation is required for the purpose of clarifying our findings.  zenodo.org

Serious Adverse Events of Special Interest Following mRNA Vaccination in Randomized Trials Introduction: In 2020, prior to COVID-19 vaccine rollout, the Coalition for Epidemic Preparedness Innovations and Brighton Collaboration created a priority list papers.ssrn.com

Vaccines and autoimmune diseases of the adult - PubMed Infectious agents contribute to the environmental factors involved in the development of autoimmune diseases possibly through molecular mimicry mechanisms. Hence, it is feasible that vaccinations may also contribute to the mosaic of autoimmunity. Evidence for the association of vaccinations and the … pubmed.ncbi.nlm.nih.gov

Autoimmune Disease bmj.com

Vaccination and autoimmunity-'vaccinosis': a dangerous liaison? - PubMed The question of a connection between vaccination and autoimmune illness (or phenomena) is surrounded by controversy. A heated debate is going on regarding the causality between vaccines, such as measles and anti-hepatitis B virus (HBV), and multiple sclerosis (MS). Brain antibodies as well as clinic … pubmed.ncbi.nlm.nih.gov

Repairing the damage whether vaccine-induced or not. bmj.com

Vaccine-Associated Uveitis All of the widely administered vaccines have been reported to cause uveitis. The ocular inflammation is usually temporary and resolves with topical ocular steroids. During a 26-year period, a total of 289 cases of vaccine-associated uveitis were reported ... ncbi.nlm.nih.gov