TruthArchive.ai - Tweets Saved By @EDJMrSanMan

Saved - November 18, 2023 at 2:56 AM

@AGHuff - Andrew G. Huff, PhD, MS 🇺🇸

Do you have a corrupt local or county government? You can go after their bonds and the government has NO RECOURSE. I will post instructions next week. We are coming for you #Marquette!

Saved - November 18, 2023 at 2:28 AM

@TexasLindsay_ - Te𝕏asLindsay™

The following companies have all lost their minds and suspended X advertising effective immediately: APPLE DISNEY IBM LIONSGATE NBC DISCOVERY PARAMOUNT WARNER BROS These companies do not believe in supporting the most important human right of all—free speech.

Saved - November 17, 2023 at 8:38 PM

@ShawnRyanShow - Shawn Ryan Show

Nick Bryant, the next guest on the show, uncovers the Epstein files. Watch the full trailer now!! https://youtu.be/N2AjsJxGAkY?si=qwtJM2ao-qtKMxSQ

Saved - November 17, 2023 at 7:56 PM
reSee.it AI Summary
A urine test was conducted in Durham, two days after a grid was laid over Newcastle. Initial levels of arsenic may have been higher due to the timing. Symptoms of arsenic poisoning include frequent urination, headache, dehydration, anxiety, breathing difficulties, respiratory irritation, stomach upset, liver issues, gut discomfort, and anger/emotion. The correlation between the grid and positive tests is becoming harder to ignore, especially in non-flight path areas.

@CarolineCoramUK - Caroline Coram

URINE TEST This person took a urine test on 16th October in Durham. This was two days (48hours) after a grid was laid over Newcastle to the north. Approximately 20-70% arsenic is excreted before the 48 hour cutoff so the test was done slightly after that. Therefore initial levels may well have been higher. The person had walked their dog twice, once each day for an hour, 14th and 15th. They used the company Cerascreen for the urine test. https://cerascreen.co.uk It is not necessary to test. Symptom set of arsenic poisoning includes frequent urination and possibly headache, dehydration. Anxiety, breathing difficulties, respiratory irritation and stomach upset can also be present. Later phase usually involves the liver, gut discomfort and anger/emotion. This list is not exhaustive. This is the urine test result and grid. Identity of the tester to remain private. Thank you for sharing this data with us.

Home Health Tests & Nutritional Supplements | cerascreen®️ Large selection of home health test kits to detect deficiencies, allergies or intolerances and high-quality nutritional supplements from the market leader. cerascreen.co.uk

@CarolineCoramUK - Caroline Coram

Please note that whilst the grid and the test occurred between 48-72 hours of each other, it is of course not conclusive proof that the grid caused the arsenic reading. However, given the regularity of the appearance of these grids, and subsequent positive hair tests, simultaneous and post grid reported symptoms and of course Owen Mog (IG) dust test, it is becoming much harder to ignore a possible correlation, particularly in areas that are not normally flight paths.

Saved - November 17, 2023 at 5:44 PM

@FermentiLlc - FERMENTI

What gets me the most censorship online is linking #sauerkraut'' (LacticAcidBacteria) and guidence of miRNA between the cis/trans median of the golgi apparatus. L.A.B.s mediate posttranslational products, hematopoietic cells, and multiple two component regulatory systems.

Saved - November 17, 2023 at 5:35 PM

@FermentiLlc - FERMENTI

Once the mini nuc core heats enough water creating the pocket/foundry we deliver the L.A.B.'s and co2 gas to structure whatever metal or carbon source we choose. Then lift off to the orbital 3d printer to deliver the PolyLA's to grow our next ship. https://t.co/hakK8rUC6B

Saved - November 16, 2023 at 9:47 PM

@elonmusk - Elon Musk

We will do whatever it takes to support your right to free speech!

@xDaily - X News Daily

NEWS: 𝕏's lawyers have come to the defense of an Illinois student being threatened with disciplinary action by his university over posts he made on the platform. This is the first known example so far of X paying legal fees to support users' free speech, as promised in August. https://t.co/yFyK9dOwxS

Saved - November 16, 2023 at 8:14 PM

@FermentiLlc - FERMENTI

Did you know Miyazaki, of "My Neighbor Totoro" fame, also wrote an amazing manifesto against transgenics?? 10 minute video showing this in his masterpiece "Nausicaa of the Vally of the Wind." https://rumble.com/v3w4b5j-hidden-truth-in-scifi-1-miyazaki.html

Hidden Truth in SciFi: #1-Miyazaki Major spoilers ahead!!!!! Miyazaki hid the truth about the post racial cult in his masterpiece of Science Fiction "Nausicaa of the Vally of the Wind." A must read. rumble.com
Saved - November 16, 2023 at 6:44 PM

@KimDotcom - Kim Dotcom

The Guardian deleted 'The letter to America' by Osama Bin Laden to stop people who are witnessing the injustice in Gaza from understanding why Muslims are fighting the US and Israel. I think everyone has a right to read it. Here it is: https://archive.ph/2017.08.05-005631/https://www.theguardian.com/world/2002/nov/24/theobserver

@ggreenwald - Glenn Greenwald

❗️❗️Ever since Oct. 7, we've been urging people to recall the lessons of 9/11: not just US's huge "errors" responding but why it happened. Bin Laden's letter blaming US violence in their region - including US support for Israel - went viral on TikTok, so @guardian deleted it.

Saved - November 16, 2023 at 4:14 PM
reSee.it AI Summary
The vaccine is 95% effective in preventing the virus and reducing disease severity. 99% of those who contract COVID-19 will survive. In response, @benshapiro suggests getting the vaccine.

@benshapiro - Ben Shapiro

The vaccine is 95% effective in preventing you from getting the virus, and also mitigates the severity of the disease. 99% of those who actually get covid-19 will survive. https://t.co/Ep8tMBG311

@benshapiro - Ben Shapiro

In other words, get the vaccine, dopes.

Saved - November 16, 2023 at 4:11 PM
reSee.it AI Summary
The @guardian newspaper removed Osama Bin Laden's 2002 letter to Americans after it gained popularity on TikTok. Some argue that instead of deleting it, we should learn from history to prevent a repeat of the past. Disagreements exist on whether fueling violence in the Middle East will lead to violence in the US or if taking action there is necessary to maintain peace at home.

@simonateba - Simon Ateba

The @guardian newspaper yesterday deleted Osama Bin Laden's letter to the American people published in 2002, a year after the terror attacks of September 11, 2001. The letter was deleted after it went viral on TikTok. NOTE: Some people are pointing out that the world is back to where it was 20 years ago, and that instead of deleting the letter, which can be found anywhere else, we should learn the lessons and work to prevent what happened 20 years ago unless we want history to repeat itself. NOTE: There are disagreements on this. Some people argue that fueling violence in the Middle East will lead to violence here in the United States and that when it happens, people here will not remember the violence they fueled there. Others say the US is the policeman of the world and can only prevent violence here by taking the fight to bad and violent people there.

Saved - November 15, 2023 at 6:10 AM
reSee.it AI Summary
WW3 is underway, hidden behind a web of lies. American patriotism and military intelligence are stronger than you think. The energy is building, the dam is about to burst. We're winning the information war as people share vital knowledge. We're here because it's time, we've trained for this. The plan is to use the public as a weapon. We must unite, defend, and coordinate attacks. MIL-CIV Alliance is crucial. Read, act, save the world. Godspeed.

@BrainStorm_Joe - Joe Rambo

💥WW3 is already here.💥 For those of you that aren't aware that things are happening behind the curtain of lies draped all around us.. I would tell you that I believe you have severely underestimated American patriotism and military intelligence. You can literally feel the energy rising. The tension and anticipation of the dam breaking is palpable. At the rate people are starting to share information in what is absolutely an information war is proof in itself that we are winning. If the bad guys we're in control.. How is it you are reading this post right now? The answer is that it was time... It was time to let us share.. We have literally trained for years for this moment. This has never been attempted. Use of general public to counter the narrative. Every move has been planned and calculated. You and I are not only the plan but the weapon of choice. Need to expend ammunition [muster network to defend and coordinate attacks] to counter. MIL-CIV Alliance. Read it again, act accordingly. We have a world to save. Godspeed.

Saved - November 14, 2023 at 7:43 PM

@drarce - Dr. Mari

Heard that Braggs Apple cider vinegar will now be using Apeel Coated apples. 🤮 No thanks.

Saved - November 14, 2023 at 5:40 PM
reSee.it AI Summary
Nattokinase, a nutraceutical, can be both a drug and a poison. The formulation is crucial. For the Advanced Recovery mRNA Spike Detox protocol, I recommend NattokinPlus. Find it here: [link]. #health #covid #nutrition #selfcare #FridayFeeling #VeteransDay

@DrJudyAMikovits - Judy A. Mikovits PhD

Nattokinase the nutraceutical is a drug & a poison. I was asked to explain at the Health & Freedom Summit. What matters is the formulation. I recommend NattokinPlus, as part of the Advanced Recovery mRNA Spike Detox protocol: https://shop.therealdrjudy.com/advanced-recovery-mrna-spike-detox.html #truth #health #news #covid #flu #SelfCareMatters #selfcare #nutrition #food #solutions #faith #GodWins #FridayVibes #VeteransDay #FridayFeeling #fridaymorning

Video Transcript AI Summary
Nattokinase is a fermented soybean product that acts as a serine protease, not a kinase. It kills a specific microbe in the body, affecting the microbiome and digestion. However, it is not recommended as it alters the gut biome and is considered toxic. Our bodies naturally break down microorganisms and use them as food. Nattokinase is a drug, and it is concerning that even young children are taking numerous pills without understanding why. Instead of seeking quick fixes, we should address the pollution and environmental destruction that have led to these health issues. It is time to take responsibility and work towards restoring our environment.
Full Transcript
Speaker 0: Nattokinase isn't soy. It it's natto is fermented soybeans, and the the drug with the the nutraceutical theoretically, is is not a kinase that puts a phosphate group on a on a molecule. It's a it's a serine protease. So what they did was they took the natural product, which the fermented nano kills a very specific microbe. So they're like, we'll we'll kill that microbe contributing to the microbiome and the digestion or the metabolism of food in your body when you eat a fermented. That if you ever ate natto, you can only take a little bit of it. It's disgusting. But the way we do it in the fermentation chemistry is to see, we killed a very specific microbe, and then you stabilized it to kill it for eternity and never turn off. And what did you do? You changed the gut microbe of biome, your food no longer vacate food and Nattokinase is a poison. And our body makes, you know, the right microbes breakdown those, microorganisms or it uses them in our own body, as food, to to to nourish and feed our body. So again, there's a reason why it tastes disgusting because you won't eat it. You know, we lost our sense of taste and smell because they took those sensors away from us. You know, how does the stunk hurt somebody? Praise them. You know? But it hurts for a really long time mean, you never forget it. You never go anywhere near that animal. And we've heard all about that all weekend. So again, Nattokinase is a drug. So we're not gonna turn around and do the same thing all over again and just carry around. And we see our 2 year olds as, Heather just said, they're carrying around These pills. You know, just buckets of pills. Why do you choose? Why do I take this? Speaker 1: Why do I take that? Speaker 0: And I got people or patients asking me, what do Speaker 1: I do, Doctor. Judy? Speaker 0: Why do I does that. It's food. Eat it. It's water. Drink it. You're being poisoned. And the kids won't even drink that poison. The autistic kids. Because They know it's poison because they've been poisoned with it through the generations. Stop. You know? Stop looking for the quick answer and go with the tough pollution and ask how we destroy this environment, how god gave us the ability sitting in this room to get it back.
Advanced Recovery MRNA Spike Detox Default Description shop.therealdrjudy.com
Saved - November 13, 2023 at 8:12 PM
reSee.it AI Summary
Melanoma TURBO CANCER is on the rise, but few know about the potential of IP6 (Inositol Hexaphosphate) in curing stage 4 Melanomas. Purified IP6, a compound found in grains and legumes, has shown great effectiveness. High dosage is crucial, with 4 scoops of powder or 30 capsules per day, spread throughout 3-4 doses. IP6 has also shown promise in eradicating lung cancer. Spread the word, as mainstream news may not cover it.

@NaturallyFTW - Natural Immunity FTW

🚩 Melanoma TURBO CANCER is exploding. IP6 (Inositol Hexaphosphate) has cured Multiple people of stage 4 Melanomas. Yet no one knows WTF IP6 even is & doctors would lose their licenses if they gave it to patients. Thanks, FDA! 🫠 (thread 👇) https://t.co/LTyOf1Xbft

@NaturallyFTW - Natural Immunity FTW

IP6 is a naturally occurring, cancer-fighting compound in grains & legumes. 🫘🌱 But purified IP6 is far more effective. NOTE: High Dosage seems is KEY for success! 4 scoops powder, or around 30 capsules per day has worked for people. Spread throughout the day in 3-4 doses. 👌 https://t.co/2YmrkjuXcW

@NaturallyFTW - Natural Immunity FTW

• "Turbo Melanoma" EXPLODING in young people - Thread: https://t.co/1BbOXuVEhX • More info on IP6 getting rid of Several other types of cancer: https://t.co/bztPkEEPlc

@MakisMD - William Makis MD

NEW ARTICLE: TURBO CANCER - MELANOMA - ages 22 to 35 - COVID-19 mRNA Vaccine Turbo Cancer Melanomas are resistant to all new treatments - 20 shocking cases Melanoma is skyrocketing. UK Government Disability data shows a 72% rise in disability due to skin cancer in 2022…

@NaturallyFTW - Natural Immunity FTW

AMAZING - lung cancer ERADICATED by IP6 (Inositol Hexaphosphate)!! After just a few months taking high dose IP6, all her tumors are now just...Gone. 🤯 This will be hitting mainstream news any day now...right? ...right? (LOL nope. Tell your friends!). https://t.co/a7ZtM8d3jg

Saved - November 13, 2023 at 7:39 PM
reSee.it AI Summary
In my relentless pursuit, I aim to obtain complete sequences and annotations for the 99 "hidden" or "newly discovered" genes near telomeres. After analyzing Arthur Stone's breakdown of Kevin McKernan's enigmatic "99 New Genes Behind A Wall," it appears that only around 54 gene numbers have actual sequences. Interestingly, many of these genes are associated with RNA polymerase, a crucial protein for viral replication, such as CoronaVirus. Initial impressions suggest a potential link to a cytokine storm, with Remdesivir and Paxlovid possibly involved in RdRp. This discovery may uncover remnants of an old bioweapons program with Russian and Ukrainian connections.

@RealGeorgeWebb1 - George Webb - Investigative Journalist

Not backing down until I get full sequences and annotations for the 99 “hidden” or “newly discovered” genes near telomeres. https://t.co/lQdMMjZ9UH

Video Transcript AI Summary
George Webb discusses his efforts to obtain information about potential cancer promoters in the Pfizer, Moderna, and J&J vaccines. He mentions the difficulty in accessing the necessary data and the ad hominem attacks he has faced. Webb emphasizes the importance of transparency and the need for answers regarding the vaccine ingredients. He plans to include Kevin McKernan as a witness in his lawsuit to obtain the information. Webb concludes by stating his determination to bring this issue to court and ensure that the truth is revealed.
Full Transcript
Speaker 0: K. Hello, everyone. George Webb, here in Orlando, and, of course, the beautiful George c Young Courthouse. And the place where I've filed lawsuit for the domain information is right over there. So, Kevin and McKernan and I have gone back and for, today about are there s p 40 promoters, which means things that promote cancer. Are those promoters in The shot for Pfizer, Moderna, and J and J, are are they not? So people say they are, and they get a whole bunch of hits on YouTube. And then when you ask them to produce what's Actually, in the what they call the ORI, you don't get anything. When another paper comes out that says there's 99 hidden, they promoted 99 hidden genes that could cause cancer or 99 hidden genes. Right? You press them on it, ask them for the sequences, and then they say, well, you know, it's your fault. You can't read. Well, first First of all, you have to read a very technical paper. Then there's a link at the bottom, supposedly, that has a table which has a listing of e n s numbers. And you have to be smart enough to know to go to what website, the Ensemble website to plug that in. If you don't get it case sensitive right, it doesn't come back. I don't I still don't think the first thing he gave me came back, Kevin McKernan. So it's this incredible Rube Goldberg machine to get a straight answer. All last night, I tried for a straight answer. Send me the sequences Because what can happen is there is a way to disturb the genome to shorten what they call your telomeres. This is sort of like it's really analogous to a, shortening a cat's tail if a cat's tail had 9 lives. If you shorten the tail The telomere on your chromosomes, you live less. You live less. And there are various proteins that can cause the progression of cancer, including the ones that Kevin McKiernan finally sent me the next day after a ton of ad hominem attacks about how I can't read. Again, I think I'm the only reporter ask actually asking for the sequences. And one of the the first one that we can't finally found is ubiquitin peptidase, and it causes cancer. Kevin says I'm trying to create a cancer conspiracy No. I'm just trying to get a straight answer. I'm a reporter who tried 12 times last night trying to get a straight answer. Tell me the went so I can figure out what proteins they make, so I could see what other cancer studies have been done so we can get a straight answer. Because people don't want to have the same thing happened to that happened to me when I was a kid with the polio, had the s v forty, and we all ended up with soft tissue cancers that went through the roof. This is not conspiracy theory. The cancers went through the roof. The advanced industries and states that got Vaccines, the cancers went through the roof. Is it okay I'm on a public sidewalk? Okay I'm on Speaker 1: a public sidewalk? Yeah. Okay. He says it's okay. Speaker 0: I'm gonna focus my wife. So that's the story. Just trying to get a straight answer from Kevin McCarron, but I will bring, in my lawsuit In my lawsuit, I will bring I will add cabinet as witness. I will ask him to be a witness. I will subpoena him to get a straight answer if I have to because every man, woman, and child needs to know what's in these vaccines. And it shouldn't be a constant ad hominem attack on the reporter who's just trying to get a straight answer. And a whole swarm of other deep state trolls that are trying to get an answer that are that are doing ad hominematic texts rather than answering a simple straightforward question. Tell me the sequences so that I can run them down. If you're not gonna run them down, if you're I'm gonna annotate them. Give them to me. Give them to me. So there it is. You'll see thousands and thousands of people attacking me, but still nobody giving me the sequence so they can run down. We ran 1 down, and the first one we ran down, cancer causing. Ubiquitin pepsidase, 3. 1st one, Iran 16. That was the first one on the list. Didn't even come up can't they didn't even come up in an ensemble. It's gotta be easier than this. If people need to be forthright or subpoena. This if this if this is a repeat of what the CIA did in the fifties with Qatar Industries and the polio vaccine, it's gonna be heard in this court, or it's gonna be thrown out in this court. But I'm not backing down. It's gonna be heard in this court.

@RealGeorgeWebb1 - George Webb - Investigative Journalist

After completing a preliminary analysis of Arthur Stone’s @ArthurSton74344 lookup and breakdown of Kevin McKernan’s cryptic “99 New Genes Behind A Wall”, it looks like only 54 or so of the gene numbers led to an actual sequence. Of those listed genes, there appear to be a lot if genes involved with RNA polymerase, a protein needed for some viruses to replicate like CoronaVirus. My initial reaction to reading Arthur’s annotations is “Cytokine Storm”. Remdesivir and Paxlovid also are involved potentially with RdRp. I could be completely wrong, but those are my initial impressions. I also think this has the Alachua Alchem Russian Ukrainian fingerprints of an old bioweapons program now finally “revealed”.

Saved - November 13, 2023 at 6:51 PM
reSee.it AI Summary
Gene editing technology like CRISPR has made it technically feasible to manipulate human DNA and virus genomes. Major nuclear powers, including Israel, are believed to be using gene editing for creating gene-targeted bio-weapons. The potential dangers of this technology have been warned about for over a decade, with concerns that AI could easily wipe out humanity by creating deadly viruses. Genetic sequencing and virus construction have been discussed as potential threats since 2012.

@KimDotcom - Kim Dotcom

Sorry Elon, it’s technically feasible. Human DNA is code Virus genome is code CRISPR is the editor Was the Wired story from 1998 premature? Totally Do all major nuclear powers (incl. Israel) use gene editing to create gene targeted bio-weapons? Totally Imagine what AI will do https://t.co/YevoD2kj4A

@elonmusk - Elon Musk

@KimDotcom This is not true, nor is it technically even feasible @CommunityNotes

@KimDotcom - Kim Dotcom

I have been warning about this for over a decade. This is a tweet I made before Covid-19: https://x.com/KimDotcom/status/1067725821924728833?s=20

@KimDotcom - Kim Dotcom

Billions of people may die because genetic programming technology can now be used to turn a common influenza virus into a mass killing super virus. It’s going to be as easy to create a biological killer virus as it is to write a computer virus. AI could wipe out humanity easily.

@KimDotcom - Kim Dotcom

This is from 2012: https://x.com/KimDotcom/status/246803438577528832?s=20

@KimDotcom - Kim Dotcom

“@davelab6: @KimDotcom hard to speak out to someone pointing a nuclear gun at you” Read about genetic sequencing and virus construction.

Saved - November 13, 2023 at 5:16 PM
reSee.it AI Summary
Israeli TV channels reveal high death rates among vaccinated individuals, suggesting an immune system decline. This acknowledgment highlights the pandemic's impact on the vaccinated population.

@stkirsch - Steve Kirsch

In Israel, they are finally admitting that this is a PANDEMIC OF THE VACCINATED! Translation: Israeli television channels have now told the truth about the C19 vaccines, claiming that they cause extremely high death rates compared to the unvaccinated, due to a complex "erosion of the immune system".

@CrazyBytezz - GEWOON ⚓️ MEREL 

De Israëlische televisiezenders hebben nu de waarheid verteld over de C19-vaccins, waarbij ze beweren dat deze extreem hoge sterftecijfers veroorzaken in vergelijking met ongevaccineerden, door een complexe "erosie van het immuunsysteem". @markrutte nu jij nog held !!! https://t.co/fsYWGb4tjf

Saved - November 13, 2023 at 3:27 AM

@FermentiLlc - FERMENTI

This will be used to exploit the non terminal peptides intrinsic membrane Metalloproteinase 1 subunit formation. https://en.m.wikipedia.org/wiki/Metalloproteinase

Metalloproteinase - Wikipedia en.m.wikipedia.org

@FermentiLlc - FERMENTI

@EDJMrSanMan @KimDotcom Or add genes.. for "sustainable development goals"... but it's G.R.A.S. so it's not GOF.. 2023: "Saccharomyces cerevisiae: Multifaceted Applications in One Health and the Achievement of Sustainable Development Goals" https://www.mdpi.com/2673-8392/3/2/43

Saccharomyces cerevisiae: Multifaceted Applications in One Health and the Achievement of Sustainable Development Goals Saccharomyces cerevisiae (SC), a yeast with an extensive history in food and beverage fermentations, is increasingly acknowledged for its multifaceted application in promoting and benefiting all aspects of a ‘One Health’ approach, including the prevention and control of zoonoses. For instance, SC contributes to environmentally sustainable agricultural practices through the reduced use of toxic agents, thus minimizing air and soil pollution while enhancing crop quality. Additionally, this versatile yeast can improve the health of domestic and farm animals, leading to more efficient and sustainable food production, while fostering synergistic impacts across environmental, animal, and human health spheres. Moreover, SC directly applies benefits to human health by promoting improved nutrition, improving gut health through probiotics, as an alternative to antibiotics, and treating gastric disorders. By aligning with several Sustainable Development Goals (SDGs), SC is vital in advancing global health and well-being, environmental sustainability, and responsible consumption and production. This entry illustrates the numerous benefits of SC and highlights its significant impact on a global ‘One Health’ scale, promoting the achievement of SDGs through its unique characteristics and deeper understanding of its contribution to the One Health concept. mdpi.com
Saved - November 13, 2023 at 2:42 AM
reSee.it AI Summary
The microbiome's response to heat stress in dairy cows involves the activation of enzyme and ATPase regulators, protein folding, and upregulation of protein processing in the ER, TGF-beta signaling, and cholesterol metabolism pathways. Conversely, the inner mitochondrial membrane protein complex and electron transfer activity are downregulated, along with the oxidative phosphorylation pathway. This study sheds light on how the microbiome coordinates metabolic changes under heat stress. (442 characters)

@FermentiLlc - FERMENTI

Amazing discription how the #microbiome uses the" two component regulatory system" under heat stress to recoordinate metabolism in dairy cows. Not what the article is about but a perfect and recent example "Our results showed that enzyme regulator activity, ATPase regulator activity, and protein folding were upregulated, while inner mitochondrial membrane protein complex and electron transfer activity were downregulated under HS. Correspondingly, protein processing in ER, TGF-beta signaling, and cholesterol metabolism pathways were upregulated, while the oxidative phosphorylation pathway was downregulated in the heat-stressed cows." https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-023-09484-1

Transcriptomic regulations of heat stress response in the liver of lactating dairy cows - BMC Genomics The global dairy industry is currently facing the challenge of heat stress (HS). Despite the implementation of various measures to mitigate the negative impact of HS on milk production, the cellular response of dairy cows to HS is still not well understood. Our study aims to analyze transcriptomic dynamics and functional changes in the liver of cows subjected to heat stress (HS). To achieve this, a total of 9 Holstein dairy cows were randomly selected from three environmental conditions - heat stress (HS), pair-fed (PF), and thermoneutral (TN) groups - and liver biopsies were obtained for transcriptome analysis. Both the dry matter intake (DMI) and milk yield of cows in the HS group exhibited significant reduction compared to the TN group. Through liver transcriptomic analysis, 483 differentially expressed genes (DEGs) were identified among three experimental groups. Especially, we found all the protein coding genes in mitochondria were significantly downregulated under HS and 6 heat shock proteins were significant upregulated after HS exposure, indicating HS may affect mitochondria integrity and jeopardize the metabolic homeostasis in liver. Furthermore, Gene ontology (GO) enrichment of DEGs revealed that the protein folding pathway was upregulated while oxidative phosphorylation was downregulated in the HS group, corresponding to impaired energy production caused by mitochondria dysfunction. The liver transcriptome analysis generated a comprehensive gene expression regulation network upon HS in lactating dairy cows. Overall, this study provides novel insights into molecular and metabolic changes of cows conditioned under HS. The key genes and pathways identified in this study provided further understanding of transcriptome regulation of HS response and could serve as vital references to mitigate the HS effects on dairy cow health and productivity. bmcgenomics.biomedcentral.com
Saved - November 13, 2023 at 2:06 AM

@StealthMedical1 - Stealth Medical

https://t.co/CKfEhrAJdP

Saved - November 13, 2023 at 1:57 AM

@EDJMrSanMan - Eric D. Jarman

Colonel Tom Bearden said it best. 10% of scientist are evil, 10% are angels and the rest are captured in a system designed to make them work only on approved projects https://youtu.be/eNU3MLqyzPk

@FermentiLlc - FERMENTI

@EDJMrSanMan It's prerequisite for scientists to have low empathy. Nobody calls a baby a fetal tissue sample. Nobody calls gain of function post translational products...they dont understand suffering the way normal ppl do... because they are transhumanists and mutations are money.

Saved - November 13, 2023 at 1:45 AM

@EDJMrSanMan - Eric D. Jarman

Fellow mere mortals like myself have you ever wondered when humanized mice came to be or what the technology used is called? Why even care? Ever heard the question are you a mouse or a man before? Feeling like a mouse the last almost four years? https://www.jax.org/news-and-insights/jax-blog/2011/September/cre-lox-breeding https://t.co/UQFtTsPq4M

Saved - November 12, 2023 at 11:51 PM

@EDJMrSanMan - Eric D. Jarman

H/T ⁦@SunLabTB⁩ I hid table is from a paper he coauthored with a study intern. Look at the pathways to ruining the pkr signaling leads to serious disease. Notice gene deletion? Still don’t think the AI tech to knockout genes doesn’t exist? https://www.frontiersin.org/articles/10.3389/fimmu.2021.702142

Protein Kinase R in Bacterial Infections: Friend or Foe? The global antimicrobial resistance crisis poses a significant threat to humankind in the coming decades. Challenges associated with the development of novel antibiotics underscore the urgent need to develop alternative treatment strategies to combat bacterial infections. Host-directed therapy is a promising new therapeutic strategy that aims to boost the host immune response to bacteria rather than targeting the pathogen itself, thereby circumventing the development of antibiotic resistance. However, host-directed therapy depends on the identification of druggable host targets or proteins with key functions in antibacterial defense. Protein Kinase R (PKR) is a well-characterized human kinase with established roles in cancer, metabolic disorders, neurodegeneration, and antiviral defense. However, its role in antibacterial defense has been surprisingly underappreciated. Although the canonical role of PKR is to inhibit protein translation during viral infection, this kinase senses and responds to multiple types of cellular stress by regulating cell-signaling pathways involved in inflammation, cell death, and autophagy – mechanisms that are all critical for a protective host response against bacterial pathogens. Indeed, there is accumulating evidence to demonstrate that PKR contributes significantly to the immune response to a variety of bacterial pathogens. Importantly, there are existing pharmacological modulators of PKR that are well-tolerated in animals, indicating that PKR is a feasible target for host-directed therapy. In this review, we provide an overview of immune cell functions regulated by PKR and summarize the current knowledge on the role and functions of PKR in bacterial infections. We also review the non-canonical activators of PKR and speculate on the potential mechanisms that trigger activation of PKR during bacterial infection. Finally, we provide an overview of existing pharmacological modulators of PKR that could be explored as novel treatment strategies for bacterial infections. frontiersin.org
Saved - November 12, 2023 at 10:18 PM
reSee.it AI Summary
I am offering a free legal complaint template to challenge COVID-19 mandates. Lawyers can use it to seek a Declaratory Judgment and injunctive relief. The template is backed by 2,000 hours of work and is legally sound. It can also be repurposed for lawsuits seeking monetary damages. It is illegal to require vaccination under the PREP ACT. I will fundraise to file the complaint in federal courts nationwide. Join me at https://www.givesendgo.com/Covidpenalty.

@GodsRiddles - Brian Ward

Within days, I am providing a "free" legal complaint (template form) to anyone still under a COVID-19, influenza, testing, or masking mandate. Any lawyer could take this legal complaint, understand it within an hour, and effectively challenge the mandate's legality by seeking a Declaratory Judgment and injunctive relief action on behalf of their client. The template truly represents 2,000 hours of my life and is irrefutable by the Constitution, statute, regulation, or any other law. A lawyer could also take the contents and repurpose it for a successful lawsuit, seeking monetary damages under appropriate conditions. It was and still is illegal to require any person to inject an unlicensed drug or a licensed drug under the PREP ACT into their body as a condition for ANYTHING. Participation is your autonomous choice 100% of the time! I will start my official fundraising this week to see the complaint filed in fed courts across the nation to establish court precedent. You can join in on the "soft opening" should you desire :) - https://www.givesendgo.com/Covidpenalty

EndTheMandate I am consulting on 17 major lawsuits against governors, hospitals, and state health agencies that issued a vaccine mandate relying exclusively on investigati... givesendgo.com
Saved - November 13, 2023 at 1:57 AM

@EDJMrSanMan - Eric D. Jarman

Colonel Tom Bearden said it best. 10% of scientist are evil, 10% are angels and the rest are captured in a system designed to make them work only on approved projects https://youtu.be/eNU3MLqyzPk

@FermentiLlc - FERMENTI

@EDJMrSanMan It's prerequisite for scientists to have low empathy. Nobody calls a baby a fetal tissue sample. Nobody calls gain of function post translational products...they dont understand suffering the way normal ppl do... because they are transhumanists and mutations are money.

Saved - November 13, 2023 at 1:45 AM

@EDJMrSanMan - Eric D. Jarman

Fellow mere mortals like myself have you ever wondered when humanized mice came to be or what the technology used is called? Why even care? Ever heard the question are you a mouse or a man before? Feeling like a mouse the last almost four years? https://www.jax.org/news-and-insights/jax-blog/2011/September/cre-lox-breeding https://t.co/UQFtTsPq4M

Saved - November 12, 2023 at 11:51 PM

@EDJMrSanMan - Eric D. Jarman

H/T ⁦@SunLabTB⁩ I hid table is from a paper he coauthored with a study intern. Look at the pathways to ruining the pkr signaling leads to serious disease. Notice gene deletion? Still don’t think the AI tech to knockout genes doesn’t exist? https://www.frontiersin.org/articles/10.3389/fimmu.2021.702142

Protein Kinase R in Bacterial Infections: Friend or Foe? The global antimicrobial resistance crisis poses a significant threat to humankind in the coming decades. Challenges associated with the development of novel antibiotics underscore the urgent need to develop alternative treatment strategies to combat bacterial infections. Host-directed therapy is a promising new therapeutic strategy that aims to boost the host immune response to bacteria rather than targeting the pathogen itself, thereby circumventing the development of antibiotic resistance. However, host-directed therapy depends on the identification of druggable host targets or proteins with key functions in antibacterial defense. Protein Kinase R (PKR) is a well-characterized human kinase with established roles in cancer, metabolic disorders, neurodegeneration, and antiviral defense. However, its role in antibacterial defense has been surprisingly underappreciated. Although the canonical role of PKR is to inhibit protein translation during viral infection, this kinase senses and responds to multiple types of cellular stress by regulating cell-signaling pathways involved in inflammation, cell death, and autophagy – mechanisms that are all critical for a protective host response against bacterial pathogens. Indeed, there is accumulating evidence to demonstrate that PKR contributes significantly to the immune response to a variety of bacterial pathogens. Importantly, there are existing pharmacological modulators of PKR that are well-tolerated in animals, indicating that PKR is a feasible target for host-directed therapy. In this review, we provide an overview of immune cell functions regulated by PKR and summarize the current knowledge on the role and functions of PKR in bacterial infections. We also review the non-canonical activators of PKR and speculate on the potential mechanisms that trigger activation of PKR during bacterial infection. Finally, we provide an overview of existing pharmacological modulators of PKR that could be explored as novel treatment strategies for bacterial infections. frontiersin.org
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