reSee.it - Related Post Feed
reSee.it AI Summary
The SarsCov2 spike protein is believed to be a chimera, containing gene sequences similar to various lethal organisms. This homology is important in understanding the pathophysiology and symptoms of Covid. Multiple factors indicated that the origin of SARS-CoV-2 was not natural, which influenced decisions made by Fauci and others in responding to the pandemic. It is disheartening to consider these findings. In a related post, the target pathogen for a planned 2019 capabilities demonstration was identified as part of the DARPA P3 program.
@janiesaysyay - Janiesaysyay
The SarsCov2 spike protein is a chimera. Created in a lab, it contains gene sequence homologs of many lethal organisms, including HIV, SEB, rabies, malaria, animal venoms. That homology is important and drives the pathophysiology and symptoms of Covid. #ItsABi0weap0n
@CharlesRixey - Charles Rixey, MA MBA (c) 🐭
@DeinertDoc @Jikkyleaks @jjcouey @chrismartenson @TyCardon @SweenyFrank @EduEngineer @BretWeinstein @alexandrosM @RMConservative @fynn_fan @quay_dr @gdemaneuf [11] It wasn't ONE thing that made it clear that SARS-CoV-2's origin wasn't natural It was MANY [#1] What did this tell Fauci et al about COVID's origin? [#2] THESE are the things that they KNEW when making their decisions about how to respond to the pandemic it's heartbreaking https://t.co/QKS3k43Oin
@janiesaysyay - Janiesaysyay
@KathMLee1 - DrKathrynPhD- typer of typos
One of our key decisions was identifying the target pathogen for our PLANNED 2019 "capabilities demonstration" as part of our DARPA P3 program bioengineeringcommunity.nature.com/posts/modeling… https://t.co/U5vbcSu85D
reSee.it AI Summary
The Wuhan Institute of Virology, Bat Lady, gain-of-function experiments, and funding from Peter Daszak's EcoHealth Alliance and NIAID are consistently mentioned in posts before 2019. The research involving Bat Lady and Ralph S. Baric in 2015 was funded by USAID's PREDICT program through EcoHealth Alliance. There were corrections made to studies in 2015 and 2020, including the failure to upload the genetic sequence of a man-made gain-of-function SARS-like Corona Chimera. Ralph Baric's 2016 G.O.F. study, funded by NIAID, involved the use of bat CoV sequences to infect "humanized mice." Concerns are raised about the potential of accidental or intentional release of lab-made chimeric viruses causing a pandemic. Dr. Francis A. Boyle, drafter of the 1989 BioWeapon Treaty Act, connected the dots and believes the virus is a super-bioweapon. Moderna's early patent submission for the Covid-19 vaccine in 2019 raises questions, as does the lawsuit filed by the NIH against Moderna. The involvement of Hunter Biden in Ukrainian biowarfare labs is mentioned. The development and testing timeline of the mRNA-1273 vaccine by Moderna is questioned, along with the sponsorship by the Chan/Zuckerberg Initiative. Mark Zuckerberg's alleged censorship of vaccine dangers and natural immunity is also brought up.
@1stacyphillips - Stacy Phillips
Why is it that every time I see anything before 2019 involving the Wuhan Institute of Virology, Bat Lady & gain-of-function experiments w/ Sars-like Corona viruses, Peter Daszak's EcoHealth Alliance & NIAID are named as funding the work? There's this one: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936131/
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1 Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response
Bats harbor severe acute respiratory syndrome (SARS)-like coronaviruses (SL-CoVs) from which the causative agent of the 2002-2003 SARS pandemic is thought to have originated. However, despite the fact that a large number of genetically diverse SL-CoV ...
ncbi.nlm.nih.gov
@1stacyphillips - Stacy Phillips
And this one from 2015 with Ralph S. Baric which was AMENDED in 2015 to show that Wuhan's top Bat Corona-virus researchers, "Bat Lady" Shi Zhenli-Li, was specifically funded for HER work on THAT research by none other than USAID's PREDICT program via EcoHealth Allliance (Daszak).
@1stacyphillips - Stacy Phillips
Oddly enough, that 2015 study at UNC at Chapel Hill (Ralph Baric & Bat Lady) was yet corrected AGAIN in 2020 when they realized they had FAILED to upload the genetic sequence of their man-made gain-of-function SARS-like Corona Chimera to the Genetic Bank. https://ncbi.nlm.nih.gov/nuccore/MT308984
Mutant SARS coronavirus Urbani clone SARS-Urbani-MA_SHC014-spike, comp - Nucleotide - NCBITwitterFacebookLinkedInGitHubNCBI Insights BlogTwitterFacebookYoutube
ncbi.nlm.nih.gov
@1stacyphillips - Stacy Phillips
Ralph Baric's (2016 UNC Chapel Hill) G.O.F. study. Bat Lady not an author but THANKS her for supplying them w/ "WIV1-CoV spike" plasmid & bat CoV sequences to infect "humanized mice" (mice w/ gen-altered lung tissue-more humanlike) with it. NIAID funded. https://pubmed.ncbi.nlm.nih.gov/26976607/
SARS-like WIV1-CoV poised for human emergence - PubMed
Outbreaks from zoonotic sources represent a threat to both human disease as well as the global economy. Despite a wealth of metagenomics studies, methods to leverage these datasets to identify future threats are underdeveloped. In this study, we describe an approach that combines existing metagenomi …
pubmed.ncbi.nlm.nih.gov
@1stacyphillips - Stacy Phillips
2008 Bat Lady inserted human ACE2 binding molecules of SARS-CoV into a SARS-like bat coronavirus using an HIV-based pseudovirus system w/ cell lines expressing human ACE2 receptors-creating a chimera which "gained" ability to infect humans. Lab-induced species jump. Huh. Weird.
@1stacyphillips - Stacy Phillips
They should be REALLY careful doing all this gain-of-function research or, God forbid, they could literally CAUSE a pandemic through an accidental or intentional release of any of these lab-made chimeric sars-like bat corona viruses gen-edited to be super-infectious to humans.
@1stacyphillips - Stacy Phillips
In February 2020 I happened upon interview with Dr. Francis A. Boyle, drafter of the 1989 BioWeapon Treaty Act. He found these studies & connected the dots. The virus is a super-Bioweapon. In Dec 2020 he warned the mRNA vaccines were bioweapons too. https://docs.google.com/document/d/19CmtwRSuFe6GLbv2rwjb5G8_y1aQRr_xiB71v9N8gX0/edit?usp=sharing
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Web word processing, presentations and spreadsheets
docs.google.com
@1stacyphillips - Stacy Phillips
Well gosh it looks like Moderna submitted a patent for approval to start working on the Covid-19 vaccine super-early! Like, Spring of 2019-early. Wait, what? And what's that amendment in Aug 2019, does that say what I think it says? "In case of deliberate release." August 2019?
@1stacyphillips - Stacy Phillips
By November 2021 the NIH had sued Moderna because they left the US government scientists off the vaccine patents. How did Moderna & NIH know the sequence to be able to submit a patent in Spring of 2019 if the virus supposedly came from the wild and was NOT developed in a lab?
@1stacyphillips - Stacy Phillips
WHY? "4 Stages of Ideological Subversion". Watch the first video, you'll see it is describing exactly what is going on right this moment on a global scale. "Demoralization" has occurred. That's why facts don't matter. We are in Destabilization right now. https://bit.ly/TheirUltimateStrategy
Bitly | Page Not Found | 404
bit.ly
@1stacyphillips - Stacy Phillips
I believe many orchestrating "whatever all this is" WANT a globalized centralized technocratic world order either because they are ideologues or because of economic/scientific/academic hubris fueled by greed or ego. Take your pick. Unless humanity wakes up, we're already slaves.
@1stacyphillips - Stacy Phillips
And look who is also involved in Biolabs in Ukraine? Oh yes. Hunter Biden. It's just all corrupt and all connected.
@1stacyphillips - Stacy Phillips
@1stacyphillips - Stacy Phillips
So within 44 days of the specific gene sequence being confirmed, Moderna supposedly flash-developed the mRNA-1273 vaccine, tested it (for 3-7 weeks) on mice, analyzed results & shipped a fully completed & tested clinical product out to begin human trials?
@1stacyphillips - Stacy Phillips
@INFJLOVE CSH Labs (animal/human trials) was shipped the mRNA-1273💉product 25 days after the supposed first gene sequencing (Jan 4 2020). Moderna applied for a patent for💉on March 28th, 2019. BEFORE the pandemic appeared. It means they were developing it ALREADY. +Fauci earns royalties.
@1stacyphillips - Stacy Phillips
Ralph Baric "invented" the SARS-CoV2 MA for testing within that 41 day period too? May want to check the UNC Invention Report reference #18752 to see when he filed it. I'm just curious. Don't tell me they didn't already have the sequence when the Patent was filed in March 2019.
@1stacyphillips - Stacy Phillips
NIAID, NIH, Moderna, Vanderbilt, University of Texas, lots of scientists on here, including Ralph Baric. So it took 25 days to receive the specific sequenced antigen, 15 days to test immunogenicity in mice, that's 40 days right there. But OK. Sure. https://www.biorxiv.org/content/10.1101/2020.06.11.145920v1.full
SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
biorxiv.org
@1stacyphillips - Stacy Phillips
And notice the Chan/Zuckerberg Initiative sponsored the Moderna Vax development. Is this why Mark Zuckerberg censored all content that spoke of the vaccine dangers or natural immunity? Because he was invested in the development of the Moderna vaccine? https://www.biorxiv.org/content/10.1101/2020.06.11.145920v1.full
SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
biorxiv.org
reSee.it AI Summary
US law enforcement agencies are working to bring indictments against Ralph Baric, Anthony Fauci, and Peter Daszak for collaborating to create a bioweapon that caused a global pandemic. They covered up their Gain of Function research and spliced a common cold coronavirus with an HIV gene to make it highly virulent. The Covid vaccines were ready before the discovery of Covid, and the spike proteins they produce have caused deaths worldwide. The mRNA vaccines use CRISPR technology to change DNA and produce a toxic spike protein that cannot be shut off. The lipid nanoparticle packaging is a classified toxin meant to harm humanity. The WHO Charter has been disqualified, and the World Homicide Organization was trying to create another pandemic with the Marburg virus. US District Attorneys and Sheriffs are charging Fauci, Baric, Daszak, and others for premeditated mass murder.
@SpartaJustice - Truth Justice ™
BREAKING NEWS: Three U.S. Law Enforcement Agencies working to bring indictments against Ralph Baric, Anthony Fauci and Peter Daszak who collaborated to bring this global pandemic, genocide and bioweapon against all of humanity. Over 14 million dead from the bioweapon vaccines. This was all done during a time when they were not allowed to do Gain of Function research because there was a moratorium against it. They covered it up and lied and weaponized a common cold coronavirus that's been around for thousands of years. They spliced it with an HIV gene making it very highly virulent, highly toxic and highly damaging. U.S. Patents show they had the Covid vaccines already made and ready to go before they discovered Covid. They weaponized the spike protein and injected this into billions of people. The spike proteins produced by the Covid vaccines have murdered people. People are dropping dead all over the world from heart attacks, strokes, myocarditis and blood clots. They used mRNA CRISPR technology to change the DNA making the body manufacture an out of control toxic spike protein that can't shut off. It's only a matter of time before the vaccinated succumb to damages to the body. European research labs show the lipid nanoparticle packaging of the mRNA vaccines are classified toxins. It was from the very beginning meant to kill and hurt humanity. People in the U.S. and Justin Trudeau are indicted for premeditated mass murder and global terrorism. This is a violation of the Nuremberg code to create a bioweapon and use something that is experimental and force people to take it. They are using these vaccine bioweapons to genocide Americans and people worldwide. It's unfathomable what's happened. Additional Breaking News from a competent source with authority reveals that the WHO Charter has been legally disqualified for some time now. The World Homicide Organization was trying to create another pandemic with the Marburg virus but this will not happen again. We will now stop this madness, this genocide.
Video Transcript AI Summary
In this video, Pascal and Van der Stiel discuss explosive information regarding criminal charges and indictments against Fauci. They claim that Fauci, along with Ralph Barrick and Pete Tirdaszek, collaborated to create a bioweapon and weaponized the spike proteins of the coronavirus. They also mention the harmful effects of the mRNA vaccines and the violation of the Nuremberg Code. Pascal and Van der Stiel express hope that justice will prevail and that the World Health Organization (WHO) charter will be legally qualified. They emphasize the need to stop the genocide and pray for justice to be served.
Full Transcript
Speaker 0: This is a very important video that you, Pascal, did some days ago with an American in Florida.
Speaker 1: Yeah. It was it was 3 o'clock in the morning here and 9 o'clock in Florida in the evening. And I couldn't sleep, and I was watching, my messages and became a message from doctor Martin from the States.
Speaker 0: David Dean Martin?
Speaker 1: Yes. And he informed me that he had launched the criminal charges indictments against Fauci. And I said I called down Van Der Stiehl. I said, let's do a Let's break the news to the people. And she was driving the car, doing the talk with me, me at 3 o'clock here in the suit.
The I think we should share it to the to your audience, to get this very important piece of news, Out of America.
Speaker 0: So just for about 8 minutes, you will see that interview and we will be quiet And afterwards, we will come back to you as you can see us in the interview.
Speaker 1: Yes. Good evening. Good night here from Switzerland or good morning, I should say. Good evening to, Florida, USA, United States of America, great to have you with us, Van der Stiel. How are you doing?
Speaker 2: Pascal, never better. I've been all over South Florida today meeting with people, learning a lot of information, sharing a lot of information, but tonight, it seems as if, there's some explosive information that needs to be shared, and it needs to be shared immediately. Good news, in fact.
Speaker 1: Good. Go ahead.
Speaker 2: So it it looks like our friend David Martin, who has been very busy with now has been working with 3 law enforcement agencies that shall not be named at this time In order to bring indictments against Ralph Barrick from the University of North Carolina in Chapel Hill, one Anthony Fauci, And Pete Tirdaszek with EcoHealth Alliance, 2 of the 3 musketeers that collaborated to bring this global pandemic and genocide and bioweapon against all of humanity, these names have been in our news, not the fake news, but our news for several years now. We've been talking about, the, the actual, the evil that they perpetrated on humanity, the the the the the bioweapons, The weaponization using gain of function research during a time when there was a moratorium on gain of function research. Fauci lied in congress. He lied to Senator Rand Paul when senator Rand Paul asked him if he was funding data function, Fauci lied. And the reason he goes live was because he was running the money Through the non governmental organization called Ego Health Alliance and Peter Daszak, who was funding Ralph Barrick, and, of course, the Wuhan Virology Institute, where the beta function research results are being conducted.
So this was all done during a time when they were not allowed to do it. They covered it up and lied and weaponized a coronavirus, which is a common garden variety cold that has been around for 1000 of years, But they weaponized it, and they spliced in, you know, DNA that includes the HIV gene and other other genetic material That has made this highly virulent, highly toxic, and highly damaging. And it's you know, at this point, with the, Vaccines already ready to go. The patents have been proven that the vaccines were already there before they discovered COVID, that they've made those into bioweapons they've injected The billions of arms and by the estimations we're getting now, has now over 14,000,000 people worldwide are dead.
Speaker 1: This is incredibly Horrible to listen to. It's abhorrent. So they weaponized the spike proteins in Wuhan between the moratorium in the moratorium
Speaker 2: That's right.
Speaker 1: Which was on the USA of America, United States of America, and Canada. Right?
Speaker 2: Exactly. But, I mean, let's put this in the context where people can understand it. That spike protein has done so much atherosclerotic damage, you know, cardiac damage. It is it is murdered people, heart attacks in the middle of soccer matches. In fact, Belgium just lost one of their goalies the other day in the middle of a soccer match.
We've seen athletes in their prime when they should be at their healthiest, dropping dead on fields all over the globe, and this is all because Of the, you know, cardiac arrest, myocarditis, and and just the the cardiovascular damage that people are sustaining From a protein that has spikes on it, bouncing around inside your cell walls of your arteries and doing damage. And so this is what they've Dejected to the people. They've now used the mRNA CRISPR technology to change your DNA, making your body a manufacturer of these spike proteins out of control.
Speaker 1: That's right. Shut off. It can't shut off. That's right.
Speaker 2: So it's only a matter of time once you've had the shot before you you choose to come to this damage. It's Just unbelievable and unfathomable what they've done.
Speaker 1: And it is also now evident, evident in European universities research labs that the packaging of the mRNA, the lipid, the nano lipids Are classified toxic.
Speaker 2: That's right.
Speaker 1: Mixed toxin into a so called, I Called injection. I refused to call the vaccine. No. It was from the beginning meant to kill and hurt people, humanity.
Speaker 2: That's right.
Speaker 1: So that's why people in the US and Trudeau are indicted for premeditated Mass murder and, global terrorism because there was a moratorium to weaponize, the spike proteins, a gain of function.
Speaker 2: This is against Nuremberg Code? Correct. 1000% against the Nuremberg Code, to create a bioweapon and use something that's experimental and force people to take it. That is also another violation of Narvar. You cannot use an experimental Therapy on anybody and and not be considered violating the Nuremberg code.
So in fact, on a side note, this horrific accident in So maybe we've had another 2 more train accidents in Houston and in Michigan in the last several days, but that's turning the eastern United States into a Superfund site With dioxin poisoning, which is what they used in World War one, it's mustard gas.
Speaker 1: Yeah.
Speaker 2: You know, again, this is these public private partnerships, Pascal, we're seeing big government in the corporation, big government, big pharmaceuticals weaponizing, working together, the government having the liability shield, Protection of a corporation that makes you untouchable. And, they're using it to genocide Americans and People worldwide. It's unfathomable what's happened.
Speaker 1: You and I, I mean, the Swiss morning at 3 o'clock here and you driving in Florida at 9 p. M, I think, or something.
Speaker 2: Right. Almost
Speaker 1: We have a great you have a great evening. I have a great morning here to not Celebrate. It's not celebration. But, we we are confident now and we are certain That the wrath of justice starts to have a grip worldwide.
Speaker 2: I believe so. Yeah.
Speaker 1: Especially here in Switzerland, we're progressing, I hope. And in the US and Canada, they are now chasing in the US and Canada, Those people and the prime minister of Canada for mass murder and global terrorism.
Speaker 2: It's about time to go. It's way overdue. It's way overdue.
Speaker 1: We have also something to share with you. So you have a good evening as well. I heard that I'm allowed to share this with you here, Breaking the news in North America and Canada and Switzerland in a few hours when people get up That actually I heard and I know from somebody competent with authority that the WHO charter is actually legally Qualified since quite some time.
Speaker 2: And this is great news because the United States, along with many other countries, I've been scrambling in the past so many months to draft amendments to the International Health Regulations, which would have, subjugated and basically Given about their sovereignty to the United Nations World Health Organization. But as countries were waking up to the genocide being perpetrated by the World Homicide organization. They decided they didn't wanna participate, so the World Homicide Organization shifted from using amendments to the IHR Into now driving people into this international pandemic treaty, which is why we've seen them talk about Marburg virus, a hemorrhagic fever Like Ebola, for which there's only ever been a 160 cases ever reported worldwide. It's extremely rare. But they were gonna turn this into the next Scary pandemic and push it on the on on global humanity to get everybody scared, locked down, and, of course, they had another vaccine, supposedly a vaccine, a shot, an mRNA shot.
No more. They can't do it.
Speaker 1: Happen again And with my dead body and the honor of humanity, we will now stop this madness, this genocide. And I pray to God that we can carry through with justice to do the right thing.
@SpartaJustice - Truth Justice ™
FAUCI'S BIOWEAPONS: Covid-19 and the Covid vaccines are a deliberate bioweapon attack on the United States and around the world. Anthony Fauci deliberately lied to the U.S. Congress. The Covid vaccine Bioweapons produce the Gain of Function Wuhan spike … Show more https://t.co/rEW9dMZ8kq
Video Transcript AI Summary
Dr. Fleming testifies that COVID-19 and the vaccines are a deliberate bioweapon attack on the US. She argues that genetic changes were made to the spike protein in a lab to create COVID-19. She questions the truthfulness of Dr. Fauci's statement that gain of function research was not funded. Dr. Fleming claims that the vaccines have not reduced COVID cases or deaths and considers them bioweapons due to the spike protein. Other speakers express concerns about the toxicity and ineffectiveness of the vaccines, as well as the misinformation from various organizations. They urge people to stop taking vaccines and experimental therapies. The speakers also criticize the experimentation on children and call for legal accountability for the companies involved.
Full Transcript
Speaker 0: Doctor Fleming, we've asked you to come testify about whether COVID nineteen and related vaccines are a deliberate bioweapon attack on the United States. Madam, court reporter, can you please identify yourself for the record?
Speaker 1: My name is Karen Usher, Texas CSR number 5536.
Speaker 0: Thank you. Can you please swear in the witness?
Speaker 1: Doctor Fleming, will you raise your right hand? Do you swear the testimony you give today will be the truth, the whole truth, and nothing but the truth, so help you god?
Speaker 0: I do. Doctor Fleming, do you consent to this testimony being used in any appropriate proceeding? Are you prepared to testify under oath hear today that COVID nineteen is a bioweapon.
Speaker 2: Yes, I am.
Speaker 0: So to be clear, genetic changes were made to the spike protein In a lab to create what is known as the COVID-nineteen, correct?
Speaker 2: That's what all the data shows.
Speaker 0: Doctor Fauci testified under oath to congress, under questioning by senator Rand Paul, that the NIH and NIAID had not funded gain of function research. Was that statement truthful?
Speaker 3: Doctor Fauci, knowing that it is a crime to lie to Congress, Do you wish to retract your statement of May 11th, where you claimed that the NIH never funded gain of function research in Wuhan? Senator Paul, I have never lied before the Congress, and I do not retract that statement. This is your definition that you guys wrote. It says that scientific research that increases the transmissibility among animals is gain of function. They took animal viruses that only occur in animals, and they increased their transmissibility to humans.
How you can say that is not gain of function. It is not. It's a dance, and you're dancing around this because you're trying to obscure responsibility for 4,000,000 People dying around the world from a pandemic.
Speaker 2: Well, as we've shown and as we've talked about, that that was that was a lie. And if you go to the EUA documents for Pfizer, Moderna, Janssen, the 3 that are EUA approved in the US, and you asked that fundamental question, how many people do not get sick For, Pfizer, that using their data, there's no statistically significant reduction in COVID cases For vaccinated people versus unvaccinated. If you look at Moderna, the same thing, no statistical reduction in COVID cases for the vaccinated versus the unvaccinated. Data is very clear, the science is very clear, the vaccines have not done anything to do reduce COVID cases or deaths. Just a fundamental question.
If you understand that This spike protein is a gain of function by a weapon. Why would you then replicate that same genetic sequence and put it in a vaccine.
Speaker 0: Based on all of this, would somebody be totally off base If they believe these vaccines were in and of themselves a bioweapon.
Speaker 2: Well, the fact that the spike protein is a gain of function developed virus which by definition is a bioweapon, replicating that same genetic sequence and and putting it into a vaccine it doesn't matter How you get it into the human body is still a is still a bioweapon.
Speaker 4: I really do believe that the Federal government is captured. And it's captured by corporate interests. Entire US population as well as the world has to understand they can no longer take these COVID vaccines. These are they are toxic and lethal to an end and ineffective That they have completely failed. They can only be viewed as harmful, and they need to be stopped.
Speaker 5: And does it damage the brain? You bet it does. Does it damage the heart? Yes. The liver?
Yes. The bone marrow? Yes. It causes all sorts of harm in the human body. We should have stopped this before it started.
Speaker 6: It's a misinformation from the CDC, the FDA, the American Board of Obstetrics and Gynecology, the American College of OBGYN, the Society of Maternal Field Medicine. It's a misinformation from those organizations that is causing a lot of death and injury in my women of reproductive age, my pregnant women, and my pre born babies. And it's gotta And it's gotta stop now.
Speaker 3: And for the vaccines broadly, we have no idea what's gonna happen Long term now that they're in the body, studies suggest that the vaccines and the spike protein that's produced from them never leaves the human body.
Speaker 6: The the first and most important thing, don't take any more vaccines. Don't take any more boosters. Do not take any more of these dangerous experimental therapies.
Speaker 2: Most alarmingly for the children right now, when you have people at an FDA meeting making a statement that we need to vaccinate the children, But we won't know what happens to them until we vaccinate them.
Speaker 7: But we're never going to learn about how Facebook vaccine is unless we start giving it. Yeah. That's just the way it goes. That's how we found out about rare complications of other vaccines like the Rotomartis vaccine. And I I do think that we are going to I I do think we should vote to approve it.
Speaker 2: That's the experimental phase of a research project. And as of 1947, I thought that we had officially, although it's very clear from The Tuskegee Airmen and other studies that have been done, paid for by the US government, that It it seems that our leaders don't have a problem experimenting on our elderly, on our police officers, on our first responders, on our doctors and nurses, on our general public, and now apparently don't have a problem experimenting on our children. The all the evidence shows there's no statistical benefit to using these vaccines. The mass vaccination has caused pressure selection of these variants. It has produced significant adverse effects in the people it's been given to.
The FDA has admitted during its EUA documents for children that we won't know what it does to our children until we experiment on our children. It's very clear. These vaccines have done nothing to solve the problem. They need to be stopped. The companies need to be held legally accountable.
We need to hold the people accountable that have been responsible for doing this. They have violated the Biological Weapons Convention Treaty. They have violated the Nuremberg Code. They have violated the International Covenant on Civil and Political Rights.
@SpartaJustice - Truth Justice ™
PREMEDITATED MASS MURDER: U.S. District Attorney's and U.S. Sheriffs working together to criminally charge Anthony Fauci, Ralph Baric, Peter Daszak and others for racketeering, collusion, premeditated mass murder by Covid-19, Remdesivir and the vaccines. … Show more https://t.co/1iikpMH7Lp
Video Transcript AI Summary
The speaker discusses the National Vaccine Injury Act and the PrEP Act, stating that felonies were committed in the process of emergency use authorization for vaccines. They argue that corporate liability shields protect pharmaceutical companies and healthcare organizations, but only if no felonies were committed. They claim that felonies have been committed, including racketeering and premeditated and negligent homicide. The speaker also criticizes the vaccination of children in New York City for $100, calling it dangerous. Another speaker testifies that the vaccine is killing people and cites reports of deaths following vaccination. They argue that the risks outweigh the benefits, especially for children. The video includes discussions on vaccine mandates, the safety of vaccines, and allegations of crimes committed by individuals such as Anthony Fauci and Ralph Barrick.
Full Transcript
Speaker 0: There is a single silver bullet inside of the 1986 National Vaccine Injury Act and under the 2005 PrEP Act, Which is that there was a felony committed in the process of promulgating an emergency use authorization. Then the corporate liability shields that protect Companies like Pfizer and Moderna, and and Gilead Sciences, and that protect the hospitals and the consolidated healthcare organization. Those those civil protections against liability exist only if there were no felonies committed in the creation of the Emergency Use Authorization. We know that from racketeering, from lying to congress, and from now, premeditated and negligent and reckless homicide. We know that there are a number of felonies that have been committed.
What we're now doing is actively Pursuing the enforcement of law enforcement around the country to bring those felony cases forward. So that we have a pierce of the liability shield that currently is the reason why the pharmaceutical companies and the healthcare companies and everybody else thinks that they can operate with impunity. Real human beings right now are being murdered by people in lab coats today, right here in Salt Lake.
Speaker 1: I'm gonna be very clear about this and I've recently just testified in the US Senate, December 7, 2022, The vaccine is killing people and is killing large numbers of people. It fulfills all the criteria for the Bradford Hill tenets of causality For, a medicinal product causing death, our CDC, as of December 23, 2022, has over six 1000 Americans that have died within a few days of taking the vaccine. And that's probably a gross under report.
Speaker 0: Right now, we know that in New York, the governor or sorry. The mayor of New York City has said that he's gonna give children. Are you ready for this $100 candy money if they agreed to the injection. Think about that. We were always told when we were kids, don't take money from strangers.
Don't take candy from strangers. Well, guess what? The mayor of New York is saying, take money and candy from strangers and change your genetics, Change your health, change your life in perpetuity for $100.
Speaker 2: New York City is extending the $100 incentive to kids who get vaccinated at city run sites or at their schools. Children Ages 5 to 11 are now eligible to get the Pfizer shot. News 4 talked to 1 mother and daughter who say they're doing their part to beat the pandemic. Well, I'm a little nervous, But I'm also excited. I don't wanna get COVID.
We're down to variant. We were really excited about going forward, to make a small contribution to the health of New York City. Starting on Monday, kids can also get vaccinated at pop up sites at their city schools.
Speaker 1: So as we sit here today, if the topic of discussion is childhood vaccination, it is clear based on publications of Representative data that the risks far outweigh any potential benefits of vaccinating children. And the data are clear. And in the last few weeks now, reports have come in. 1 from Connecticut with oversight from the pathology from the University of Michigan and from the University of Minnesota On 2 teenage boys who died on days 3 4 after the Pfizer vaccine and the parents were horrified to find the children dead at home. Autopsies were performed and the conclusion was crystal clear, the vaccines caused the death With massive heart inflammation and evidence of superimposed catecholamine injury on the heart.
Fatal reports have come in from Choi And from Verma, Choi and Korea. Verma from Washington University in St. Louis. It is clear that a vaccine is being PUSHT is being encouraged in mandating that in fact results in death of children. Results in death of children.
One death is too many. As I've shared with you, in millions of children receiving the The vaccine they don't die of COVID nineteen respiratory illness, but in fact, they die of the vaccine.
Speaker 3: And just a short time ago, I asked doctor Anthony Fauci about the president's Sweeping new requirements.
Speaker 4: There are a number of people for one reason or other, who just do not want to comply And get vaccinated. We've got to get them vaccinated. And hopefully, they will do it willingly. If not, there will have to be things that will essentially put pressure on them, such as you're not gonna work in this particular agency or institution, you're not gonna be able to go to this college or this university, Unless, in fact, you get vaccinated. And I believe that once we start doing that, you will see more and more people willingly Get vaccinated.
Speaker 3: Los Angeles schools are talking about requiring vaccines for children 12 and up. Is that a a model you think would be useful for other schools around the country?
Speaker 4: Lester, I do. I I do believe that that's the case. And this is not anything new. We have requirements for vaccination For a number of other diseases in the school system, so it would not be a unique situation to have requirements of children 12 years old and older to have the vaccination for COVID nineteen.
Speaker 5: Just days after getting their 2nd COVID nineteen vaccine, 2 teenage boys died in their sleep. Medical experts have been investigating what happened and has now released their report. An epidemiologist says it adds to a body of evidence that confirms Pfizer's vaccine can lead to death in children. NTD's Miguel Moreno reports.
Speaker 6: To attend class in some parts of the country, Kids need to be vaccinated against COVID nineteen. The federal government says they're safe, but gives them warning labels of what could lead to death.
Speaker 1: This myocarditis warning that is out on Pfizer, Moderna is very serious.
Speaker 6: Epidemiologist Peter McCullough Says this in light of a new report. Its authors investigated the cases of 2 teenage boys from different states. Both of them had received 2nd doses of the Pfizer vaccine, only to die a few days later in their sleep. McCullough says that in his view, the study confirms that Pfizer's vaccines led to the deaths of the teenagers.
Speaker 0: Right? These are crimes that are being committed and we need to stop those crimes. But the only way we can do that is to have the corporations that are she administering these agents liable for the damage they're creating. Because I can assure you But the day Moderna or Pfizer or Gilead knows that they will have civil penalties add up to $100,000,000 per count. For every death and every injury they created, I can assure you, they'll stop supplying the injection.
They'll stop supplying Remdesivir. The minute they know that they are on the hook for the liabilities they're actually creating, they'll stop doing this. So what we're doing right now is we're working very aggressively to take felony convictions forward, so that we actually have the ability to hold the perpetrators accountable, and ultimately destroy the very fabric of the system that allows human beings to be sacrificed on the alternative agenda.
Speaker 7: The vaccine is neither safe nor effective. This is very important. And, you asked about motive. What can motivate a stakeholder?
Speaker 2: The stakeholder concept of stakeholder
Speaker 7: Act to want to enact a worldwide mass vaccination program of a vaccine itself, which scientifically medically is neither effective nor safe. That has no proven outcomes and want to vaccinate individuals of which the disease doesn't cause any problems. So there is a goal and stated goal to vaccinate children down to 6 months old. Wait a minute. This isn't a disease for 6 months old.
It's not even a disease for 20 year olds. The bottom line is this is an innocuous disease that has an incredible age dependence to it. So what started out with this idea that maybe a vaccine could be Good. And we'll just vaccinate nursing home workers and seniors and protect people and get through became this, ever, encroaching ever Expanding mass vaccination program that has, now raised all of our concerns because there's a concern that this isn't about Covet at all.
Speaker 2: There were significant obstacles created to suppress access to lifesaving information and lifesaving medications that work incredibly well.
Speaker 7: My estimate is 85% of the deaths could have been avoidable.
Speaker 2: Well, I think this is genocide And a crime against humanity and mass murder.
Speaker 7: Through this vaccine program that We basically have set up exactly what you said, genocide. So can you name any of
Speaker 8: the perpetrators now that would be likely To the,
Speaker 0: trial Absolutely. So at prosecute now dot I o, we have a ton of information including a series of draft indictments. We specifically call out the perpetrators in chief. We know that Anthony Fauci colluded with Ralph Barrett in 2014 to violate the gain of function moratorium and weaponize Coronavirus. We know that happened.
And we know it because we have their documents in their own writing that admit to that. We know that Ralph Barrick and Peter Daszak worked together with the Wuhan Institute of Virology so that in 2016, they could publish a paper that said that the SARS coronavirus was poised for human emergence. And the virus they made reference to was one called WIV1, which stands for Wuhan Institute of Virology Virus 1. See, these are those things that are so self evidently criminal. That in 2016, during the gain of function moratorium, we could have a Chinese weaponized virus ready to be poised for human emergence.
And out of the back of that, we actually have the admission by Peter Daschke, by Ralph Barrick, and by Anthony Fauci, that there is going to be a pandemic that's gonna happen under the presidency of Donald Trump.
Speaker 9: Given as you heard from the introduction that I have been around For a while and have had the opportunity and the privilege and the pleasure of serving in 5 administrations, I thought I would bring that perspective to the topic today is the issue of pandemic, preparedness. And if there's 1 message That I want to leave with you today based on my experience, and you'll see that in a moment, is that there is no question that There will be a challenge to the coming administration in the arena of infectious diseases, both chronic infectious diseases in Sense of already ongoing disease and we have certainly a large burden of that, but also there will be a surprise outbreak. And I hope by the end of my relatively short Presentation, you will understand why history, the history of the last 32 years that I've been the Director of NIAID will tell The next administration that there's no doubt in anyone's mind that they will be faced with the challenges that their predecessors were faced with.
Speaker 0: These are all things that are out in the public. These are admissions of racketeering. They're admissions of collusion. They're admissions of premeditated murder. By the time we get to 2018, and this is the most important piece of all of this crime.
Ralph Barrick, the inventor and the weaponizer of coronavirus also had the hand in developing Remdesivir. The drug that was allegedly used to treat patients with COVID, except for the fact that by 2018, that drug had a kill ratio of 53%. Documented. Published. It was so deadly that the World Health Organization itself pulled the drug from consideration for Ebola treatments.
And ironically, inside of the documents that nobody bothers reading, the death rate occurred regardless of viral load, which means that people were killed who didn't even have Ebola. We murdered people. And by we, I mean, The complacent and ignorant masses that have agreed to let these things go unchecked, murdered people in Africa, The death rate at 53%, and we let that publication of information in 2018 failed to inform our decision in the spring of 2020. When Anthony Fauci, Ralph Baer, Peter Dashick, and others made the decision that we should inject Remdesivir into patients with COVID. We knew we were going to kill people.
That's premeditated murder. We knew we were gonna do it, and we went along with it anyway. And sitting right next to the president, Donald Trump, he signed the death warrant from millions of Americans with the criminals sitting right next to him. Possibly one of the most interesting coups in human history where the perpetrators of the coup were literally sitting in the oval office on a sofa right next to the president. And what he didn't know is that he was signing the death warrant to American citizens.
Speaker 4: Can you do that and present a little bit detail because it's it's it's quite good news. I'd be happy to share You
Speaker 7: wanna talk about it now? Yeah. Please.
Speaker 4: Okay. So, a trial that the National Institute of Allergy and Infectious Diseases, Which is the institute I direct sponsored called the Adaptive Co virus Disease Treatment Trial or ACCT one Was started in February 21st, of this year and it was a randomized placebo controlled trial Comparing the Gilead drug Remdesivir with a placebo.
Speaker 10: The Gilead study confirmed giving Remdesivir for 10 days To 53 COVID nineteen patients early on before May 2020, they found that it caused multiple organ failure, Acute kidney failure, septic shock, and hypotension in 31% of all people they gave it to. And multiple people in that 10 day trial, Their kidneys died and needed emergency kidney transplants. Why did this get my attention? March April of 2020, New York City was reporting as the epicenter of COVID nineteen in America. Every press conference I watched when they were interviewing medical doctors, They all stated the same thing every time.
Every time we start treating these respiratory virus patients with this new novel coronavirus, This respiratory virus moves from the lungs and goes to the kidneys. We have never seen a respiratory virus ever attack kidneys like this before. It causes such severe acute kidney failure. We're not only short on ventilators, we don't have enough dialysis machines to handle the kidney failure. I knew right away from the Gilead study conducted 2 months earlier that the entire kidney failure, multiple organ failure, was a result of remdesivir and had nothing to do with the virus.
And that is absolutely true. I said in May of 2020, went to the media. I said everyone needs to be warned that Anthony Fauci has declared a drug to be the solution to a pandemic for all innocent Americans. He is going to kill Hundreds of thousands if not millions of innocent Americans with this drug.
Speaker 11: Attorneys Dan Watkins and Michael Hamilton announced in a national press conference On 7th of this month, the filing of their landmark lawsuit against these 3 major hospitals on behalf of families who lost their loved ones With the bounties paid to hospitals for using Remdesivir. I like that they're using it the bounty that was paid.
Speaker 10: 43,000 Pennsylvanians have died from COVID. They died from COVID treatment. Peter McCullough just gave us a a statistic of, like, 93% could have been saved. I'm gonna tell you right now, 40,000 of them died from the ill advised hospital protocols in your hospitals.
Speaker 8: So we had, so you can name, Fauci and Barrick.
Speaker 0: Dashie. Yep.
Speaker 8: There's quite a few others.
Speaker 0: Oh, there's a whole host of them. And what's what's being done right now is working together with some very courageous sheriffs, some very courageous DAs. What we're now doing is we're compiling a series of actions where we have now thousands of patients who have died, and we're aggregating those into unified action so that we can actually make a very public statement of what is in fact the felonies that we hope to end the
reSee.it AI Summary
Dr. Vladimir Zelenko's post on Covid origins alleges that in 1999, Anthony Fauci and UNC constructed a coronavirus to infect human cells, securing patent protection for the spike protein chimeric bioweapon in 2002. The CDC patented the SARS coronavirus genome in 2003, while NIAID, UNC, and EcoHealthAlliance violated laws by manipulating the S1 Spike Protein from 2013 to 2016. In 2015, Peter Daszak stated the need for a paninfluenza or pancoronavirus vaccine, and in 2019, a global operation was conducted to force nations into developing and deploying a global vaccine program. Two companies with no vaccine experience were selected to manufacture an untested and unsafe product in 2020.
@DschlopesIsBack - Gain of Fauci
Covid origins: Posted by the late Dr. Vladimir Zelenko @ZelenkoZev on Nov 16th, 2021: How a weapon of eugenics, mass murder, and genocide was made. 1 In 1999, Anthony Fauci (Director of NIAID), in partnership with Ralph Baric and the University of North Carolina Chapel Hill constructed an “infectious, replication defective” recombinant coronavirus to infect human cells. 2 In 2002, NIAID and UNC filed for patent protection securing the rights to the spike protein chimeric bioweapon now modified for use in the gene therapy represented to be a “vaccine” 3 In 2003, the Centers for Disease Control and Prevention patented the genome of the SARS coronavirus securing all commercial use of SARS. 4 In 2013 to 2016, NIAID, UNC Chapel Hill, EcoHealthAlliance (led by Peter Daszak), and the Wuhan Institute of Virology violated 18 USC §175 enabling the construction and chimeric manipulation of a pathogen known to be lethal to humans (the S1 Spike Protein) in repeated and habitual felonious acts. 5 In 2015, Peter Daszak stated to the National Academy of Sciences that, “…until an infectious disease crisis is very real, present, and at an emergency threshold, it is often largely ignored. To sustain the funding base beyond the crisis, he said, we need to increase public understanding of the need for MCMs such as a pan-influenza or pan-coronavirus vaccine. A key driver is the media, and the economics follow the hype. We need to use that hype to our advantage to get to the real issues. Investors will respond if they see profit at the end of process, Daszak stated.” 2016 Feb 12. 6, Developing MCMs for Coronaviruses. Available from (link in comments below): 6 Beginning in September of 2019, NIAID, UNC Chapel Hill, the Bill and Melinda Gates Foundation and the Chinese Centers for Disease Control conspired to conduct a global operation in the release of a respiratory pathogen to force nations into developing and deploying a global vaccine program including having President Trump sign an Executive Order (Executive Order 13887) mandating the production of mRNA vaccines months before any reported SARS outbreak. 7 In 2020, two companies who had never safely produced any vaccine before were selected to manufacture an untested and unsafe product to unleash on the population. Thank You United States Government Vladimir Zev Zelenko MD
reSee.it AI Summary
Covid19 was deliberately released, funded by Anthony Fauci's NIAID. Gain of Function studies continued despite the moratorium. The motive was profit and global control. Numerous individuals and organizations are implicated, including Bill and Melinda Gates, WHO, FDA, CDC, and more. The accused must be arrested.
@SpartaJustice - Truth Justice ™
BREAKING NEWS: Covid-19 was deliberately released on the populations by entities with intent. Anthony Fauci's NIAID was paid 400 million dollars in royalties by Moderna. Covid-19 was engineered in the United States after receiving an infectious clone WIV1-CoV Spike from Wuhan. Not only did Anthony Fauci knowingly and willfully lie in violation of federal law in Congress about not funding Gain of Function, but Anthony Fauci continued these Gain of Function studies and requested additional studies during the moratorium. Ralph S. Baric created SARS-CoV-2 and lied to the world. The fact of the matter is. We the people are currently subject to a criminal conspiracy that is ongoing right now, the evidence is right in our face. This was all done so that the world could be injected with the experimental Covid vaccines creating billions of dollars in profits and shaping the global agenda while killing and injuring millions of people around the world. 2009-2023 Lockstep Vaccination Genocidal Pandemic Criminal Co-conspiracy, including and not limited to individually and collectively: Bill and Melinda Gates individually and the Bill and Melinda Gates Foundation. World Health Organization (WHO) and Officers, Directors, Employees, and Agents Tedros Adhanom Ghebreyesus WHO Director General, U.S. FDA, CDC Executive Directors and Officers. NIH, NIAID Executive Directors and Officers. Anthony Stephen Fauci. Alex Azar HHS, Ralph Baric, Peter Daszak. World Economic Forum, Klaus Schwab and Officers, Directors, Employees, and Agents. Michael Bloomberg, David Rockefeller Jr, Rothschilds, Warren Buffett, George Soros, Ted Turner, Oprah Winfrey, Rockefeller Foundation, Global Business Network (GBN), Peter Schwartz, Chairman GBN. Convicted Vaccination Genocidal Pandemic and Neural Monitoring Governmental Executive Defendants: U.S. Department of Defense Executive Command and DARPA. Xi JinPing, General Secretary of the Chinese Communist Party. Vladimir Vladimirovich Putin, President of the Russian Federation. Donald J. Trump, 45th President of the United States of America. Joseph R. Biden 46th President of the United States of America. Benjamin Netanyahu, Prime Minister of Israel. Boris Johnson, Prime Minister of the UK. Matt Hancock, UK Secretary of State for Health. The Crown Corporation and all of its Subsidiaries including and not limited to Serco. Justin Trudeau, Prime Minister of Canada. Chrystia Freeland DBA Deputy Prime Minister. Dr. Theresa Tam, Canada Chief Health Officer. Dr. Supriya Sharma, Chief medical adviser for Health Canada. OECD - Secretary General - Mathias Cormann. Scott Morrison, Prime Minister of Australia. Jacinda Arden, Prime Minister of New Zealand. King Charles III, Prince William. Governor General Mary Simon. Stefan Löfven Prime Minister of Sweden. Minister of Heath Lena Hallengren. Narendra Modi, Prime Minister of India. Emmanuel Jean-Michel Frédéric Macron, President of France. Edouard Phillipe, Prime Minister of France. Angela Merkel, Chancellor of Germany. António Guterres, Secretary General of the UN. European Union, and President of the Commission, Ursula von der Leyen. President of the Parliament, David Sassoli. President of the European Council, Charles Michel. Michael Ryan, WHO CEO's at GCHQ-UK, NSA-USA and Bilderberg Group, all CEOs, Monarchies, and Members. Convicted Defendant Pandemic Vaccine Programs: Global Alliance Vaccine Initiative (GAVI), CEPI, Pandemic Vaccine Program United States of America, Operation Warp Speed and successor Pandemic Vaccine Program. World Health Organization COVAX, Pandemic Vaccine Program. Pandemic Vaccine Program People's Republic of China, National Institutes for Food and Drug Control. Russian Federation, Rospotrebnadzor. Convicted Genocidal Vaccination Entities: Pfizer, AstraZeneca, Moderna, Johnson and Johnson, The Pirbright Institute. Above named criminal defendants are ordered by the International Tribunal to be immediately arrested and incarcerated.
Video Transcript AI Summary
In this video, the speaker discusses evidence suggesting that the COVID-19 pandemic was not a natural occurrence but rather a deliberate release of a respiratory pathogen. They highlight a publication by the World Health Organization from September 2019 that mentions a world exposure to a respiratory pathogen. The speaker also mentions a report by Moderna, a pharmaceutical company, which reveals a payment of $400 million to the National Institute of Allergy and Infectious Disease (NIAID) for a royalty-bearing license agreement. They argue that this payment indicates a corrupt relationship between NIAID, led by Anthony Fauci, and the perpetrators of the outbreak. The speaker criticizes the lack of action from Congress and governors in addressing these issues. They also discuss a study conducted at the University of North Carolina Chapel Hill, which involved the engineering of a synthetic clone of the virus. The speaker accuses NIAID and other institutions of being part of a criminal conspiracy and calls for the public to share this information widely.
Full Transcript
Speaker 0: You'll see that on September of 2019, and I'll just move enough so you can see the the cover of the World Health Organization publication, you see that if by September of 2019, not only did they know what we were gonna get, we actually have the picture of the coronavirus right there on the cover of the September 2019 issue of A World at Risk published by the World Health Organization. And in the not so fine print in the early pages of that report, we find out that we are going to have a world exposure to an accidental or intentional release of a respiratory pathogen. Now, ladies and gentlemen, there is an operative term that's important to actually highlight in the sentence that is in their document from September of 2019, and the word was release. It's funny how the media continues to insist that there was either a leak or somehow a natural zoonotic transfer, but nobody is bothering to read the actual words written by the perpetrators themselves, which said, release. You know what that means?
Somebody with intent let it out. This is not a Oops, it got away. This is a word that they used and the word that they used was release of a respiratory pathogen. But now we have to sit back and say, Well, Dave, release of a respiratory pathogen, who would have anything to gain from that? And conveniently conveniently, the Moderna report that just came out helped us clarify the what and the why.
And I'm gonna go ahead and add this to the stream with enough screen resolution that hopefully some of you can see it. I will also post the link into the chat on the YouTube channel and on wherever else anybody can share it, because it's helpful to make sure that you see it straight from the horse's mouth. It turns out that if we look at precisely what Moderna said in its recently published report. It said the cost of sales was 1,900,000,000 or 39% of product sales for the Q4 of 2022, including third party royalties of $604,000,000, of which $400,000,000 related to a catch up payment to the National Institute of Allergy Infectious Disease for a new Royalty Bearing License Agreement executed in December. I want you to stop and read what is on this screen right now.
Moderna is paying NIAID Anthony Fauci's organization, which, by the way, executed a royalty bearing license in December. That's before Anthony Fauci went off on his merry way where $400,000,000 was paid to NIAID for a new royalty bearing relationship, and the agreement provides for a low single digit royalty on future COVID COVID Injection Sales. Ladies and gentlemen, this is exactly the racketeering, the pump and dump. This is exactly the racketeering, the entire now Ponzi scheme, that we can add to all the other crimes that I've been talking about since the beginning of this pandemic. And lo and behold, in black and white, we have an unambiguous statement that says that We The People are now paying out of the royalties.
We are paying NIAID, Anthony Fauci's own organization, $400,000,000 for the privilege of having a sole source contract provided by none other than the perpetrators of this particular outbreak. And the news is that no one in Congress, not a single person in Congress, Not Ron Johnson, not Rand Paul, not Ron Paul, not anybody, not any governor, nobody in any party, Republican or Democrat, is taking this particular issue head on. But the criminals are promoting and laughing in our face while we sit there and watch them state explicitly that they are now paying the kickback for the deal that they got. So that's the incentive. But this is where we need to actually Take a Step Back Down Memory Lane and do some really hard examination.
And this show is going to be that hard examination. Now I have made reference to this article more times than I can count. And what's important to realize about this particular article if You're not paying attention, and once again, I will post the link because it's important for me to have all the references. I'll post the link here in the chat. But the article that I'm gonna call your attention to is one that requires me to move myself off the screen so that I can talk you through it as much as I can on the format that we have here.
I encourage you to have a look at this entire document in its full grandeur. But for the time being, let's have a look at what this is. Let's start with the language of the title. The language of the title that says, scars like WIV1 COV poised for human emergence. And then what I'd like you to do is I'd like you to read the very small print that actually lives down here.
That this article was received for review on September 4th 2015 and it was approved for printing on January 6, 2016. So we have a period of roughly 4 plus or minus months, during which time this was under review. And remember, this was under review during the Gain of Function moratorium, that wonderful pause in doing gain of function research that that apparently Ron Paul still has in is entire interactions with Anthony Fauci. No ability to actually hold Fauci accountable for. But during that gain of function moratorium, what happened was there was a selection of pathogens brought over from China and what we found in a preliminary review of those, those particular pathogens, we found out that WIV1, right here you see WIV1, that is Wuhan Institute of Virology Virus 1 COV spike, are poised to emerge in the human population and, due to the efficient replication, in primary human airway epithelial cell cultures.
Now, what's important about that? We said we were gonna have an accident or intentional release of a respiratory pathogen. And it turns out that the spike protein modification that was part of the Wuhan Institute of Virology Virus 1 COV, happened to do a great job of replicating and infecting human airway epithelial cells. But here's where it gets really fun. And we're gonna go ahead and just pop up to the wonderful sentence that we have here, which is, Using the SARS CoV Infectious Clones as a Template.
But stop with that. Using SARS CoV infectious clones this is not a product derived from nature this is a synthetic clone we designed and synthesized a full length infectious clone of WIV1 COV. And you should ask me right now, Dave, who's the we in this conversation? Who's the we that is building an infectious clone of WIV1 COV, including all of the terrible Components that we know make it infectious. And the answer is that it is in fact the University of North Carolina Chapel Hill.
And we also did it by actually adding, check this out, a SARS spike protein that was replaced with the Wuhan Institute of Virology Virus 1 spike protein within the mouse adapted backbone of the model. Let's stop and get this really clear. The thing that killed Americans and continues to kill Americans was engineered from an infectious clone. It was not a naturally occurring phenomenon. It was in fact something that by their own admission was engineered and not in China.
It was engineered in the United States. And why are no members of Congress why are no governors willing to have this conversation? Well, the answer is very simple. You don't get to the internal pat on the back and cash in the pocket deal that we just saw with Moderna and that we've seen for over a decade with UNC Chapel Hill if you actually investigate the real source. Because if you investigated the real source, you'd realize that NIH and NIAID and the National Academy of Sciences and the National Institutes of Health are all part of the criminal conspiracy that gave rise to this problem as evidenced by the $400,000,000 payment I just showed you.
But let's get a little bit further into this. This is really cool. We wanted this to be replicatable in human epithelial cells. We didn't want it in a mouse model, we wanted it in humans. Next, we wanted to determine if the Wuhan Institute of Virology Virus 1 CoV replication potential and models of the human lung.
Previous examination of WAV 1 COV recovered from bat samples demonstrated poor replication. However, replication of epidemic SARS is also poor in this cell type, potentially due to the ACE2 receptor Expression Levels. Therefore, well differentiated primary human airway epithelial cells were infected with the Wuhan Institute of Virology Virus 1 mouse adapted pathogen and WIV1 CoV and SARS CoV Urbani and SARS CoV MA15. And at the time of 24 and 48 hours post infection, both WIV 1 MA fifteen and WIV one COV produced robust infection in human airway epithelial cells. And then we get the smoking gun.
Then we put it in vivo. What does that mean? That means that we actually put a known infectious manufactured clone of a known to be harmful to human lungs Into Living Animals. And we did it where? Not inside of the Wuhan Institute of Virology in Wuhan, China.
We did it at the University of North Carolina, Chapel Hill in violation of all of the statutes prohibiting the work on amplifying biologic agents for the purpose of weaponizing them against humanity. These are criminal admissions of violations of 18 US code and to date not a single member of Congress, not a single attorney general, not a single prosecutor anywhere in this country, not a single governor. No one is willing to have the courage and or fortitude to actually look at the published admissions. Published admissions, that are right here on the page in front of you. Now you can sit back and say, But Dave, did they really know they were doing something wrong.
Well, the answer I hate to break it to you is that they did. Not only did they, they were very specific in saying what they did was actually a problem. But I want you to look very carefully at the fact that the construction of the chimeric SARS like viruses were done and designed using published sequences based on the SARS CoV infectious clone. Why is that important? That's important because this was not drawn from nature.
It was not sampled from nature. It was not derived from nature. This was manufactured in the University of North Carolina Chapel Hill Laboratories. The synthetic, enchimeric, mutant, full length WIV1 was done there and approved by the UNC Institutional Biosafety Committee that's a problem. Let's go on to look at the other problems.
We actually have in vivo infection massive problem. But let's look at the one that I like the most Let's read these 2 beautiful admissions right here Biosafety and Biosecurity. Reported studies were initiated after the University of North Carolina institutional biosafety committee approved the experimental protocol project titled generating infectious clones of bat SARS like COVs, Lab Safety Plan, etcetera, etcetera. These studies were initiated before the US government deliberative process research funding pause on selected gain of function research involving influenza, MERS, and SARS. That, by the way, is the gain of function moratorium.
It's just the whole length of it under the public health description of that moratorium. And the current paper has been reviewed by the funding agency. You know what that means? NIAID. They read it.
They reviewed it. They approved the publication of this and the protocol that was done. And then let's look at what they say next. Continuation of these studies has been requested and approved by NIH. In other words, not only did Anthony Fauci knowingly and willfully lie in violation of federal law in Congress.
But Anthony Fauci continued these studies and requested additional studies and it says it right in black and white. And then we read the last acknowledgement. We thank doctor Zhengli Xi of the Wuhan Institute of Virology for access to the bat COV Sequences and plasma of the WIV 1 CoV spike protein. Research was supported by the National Institute of Allergy and Infectious Disease and the National Institute of Aging of the NIH under the awards blah blah blah to RSB. Who's RSB?
Who is RSB? Who was the one who was the agent who was then selected in January February of 2020 to mislead the world in declaring that SARS CoV 2 was a novel. Never seen it before, never knew about it before, never could have been done before. Who did we ask to make sure that we got the designation that the SARS CoV-two was novel? Oh, that's right, The Very Criminal That Created It.
It's like asking a murderer to be the one who assesses the ballistics study on the gun and on the bullet, and wondering if there's any motivation that that murderer might have to do something, I don't know, untoward with that kind of analysis. Ladies and gentlemen, this isn't a, I wonder how we're gonna get to the bottom of it conversation. And I'm actually embarrassed at the Republican Party in the House right now for the fact that they continue they continue to pretend like they are somehow placating this giant public need to get to the bottom of this story when not a single one of them has the decency and integrity of actually looking at the facts. Not one of them. No one is willing to address this, and it is not just that they're not willing to address that.
They are actively suppressing it by pretending that they're going to do an investigation with the Department of Energy Research that comes up with this pollyannish description of a low confidence interval on anything. We're we've got a problem. We've got a problem. And the problem that is happening right now is that we are being duped into believing there's accountability, and it's worse. It is worse to cover up the crime when you know it's a crime than to actually do so in ignorance.
And that is the reason why I'm calling out the House investigation right now on coronavirus and on SARS CoV 2. They are willfully misleading the public into the illusion of doing anything that is ultimately substantive. And the reason they're doing it is because they can't afford the political cost of calling into question the ultimate criminal racket that has pervaded this country since 1980. The criminal racket of captive agencies, captive federal government authorized agencies, which are captive federal funded agencies who are willing with impunity to get into organized crime rackets with state universities and other universities for the economic benefit of those institutions to criminally conspire to create pathogens known to harm humans. And since the passage of the Bayh Dole Act in 1980, the entirety of this racketeering position has been known, has been promoted, has been has been evidenced time and time again.
And to date, no member of Congress has had the integrity to tell the American people that we need to shut down that criminal racket. That's why they're not willing to talk about it. That's why as much as you can talk about, well, there should be a conversation on Tucker Carlson or on Joe Rogan, neither Tucker Carlson nor Joe Rogan have the Courage to take on this topic. Because this topic strikes at the heart of the criminal racket that is not just behind COVID nineteen. This strikes at the criminal racket of the way in which we administer the captured public agency and public institution funding mechanisms in this country.
And if you'd go after that, you wouldn't get reelected because it turns out that you need to have that money supply flowing back into states if you want to get elected. And there is no question that the reason why no one is willing to have this conversation is because it's too hot to handle, which is the reason why I'm having this conversation. The fact of the matter is We The People are currently subject to a criminal conspiracy that is ongoing right now. The evidence is right in front of our face. There is no ambiguity.
And for every person who took and was injured by a shot, I want you to know this very clearly. Moderna just paid NIAID a $400,000,000 kickback so that they could have the privilege of injecting an experimental gene therapy into you. The fact of the matter is We have the evidence, you now have it, and it is incumbent on each and every one of you to do the right thing. Share this on every platform you can share it. Share it on your YouTubes, on your Twitters, on your LinkedIns, on all of the different platforms you have.
Share it, share it, share it, and see if anybody actually gives a rip. Because I do, but I'm not sure that anybody else does. And it's now time to see if we can actually push this message into a place where it can be heard alongside of the lies that were promoted today by the Republican Party saying they were gonna hold people accountable for a China lab leak story. Well, not one of them not one of them even suggested that maybe the investigations should start close to home.
reSee.it AI Summary
The development of Covid19 as an offensive biological warfare weapon involved the FDA, Pentagon, and CDC, with the Harvard Medical School and Ralph Baric also involved. The CDC has a history of offensive biological weapons, including shipping agents to Saddam Hussein. The end goal of many organizations, including DARPA, is population control and reduction while making billions of dollars. Professor Francis Boyle drafted legislation for the Biological Weapons AntiTerrorism Act of 1989 and advises on human rights, war crimes, and biowarfare. The Chinese Communist Government also helped create Covid19 and the lethal Covid vaccines. All citizens are encouraged to file criminal charges of murder and conspiracy to commit murder.
@SpartaJustice - Truth Justice ™
BREAKING NEWS: The FDA was involved in the development of Covid-19 as an offensive biological warfare weapon at UNCBSL3. The Pentagon bought and paid for the toxic mRNA shots and helped create Covid-19. All are guilty of Nuremberg crimes, murder and conspiracy to commit murder. The CDC Director Rochelle Walensky is also accountable for these murders and Nuremberg crimes. The Harvard Medical School was also involved in the development of Covid-19 at the UNCBSL3 lab with Ralph Baric along with the FDA. The CDC has long been involved in offensive biological weapons dating back to the Reagan Administration. The Reagan Administration authorized the CDC to ship biological warfare agents to Saddam Hussein in Iraq hoping he would use them against Iran. U.S. International Lawyer Professor Francis Boyle states the end goal of DARPA, the Pentagon, the FDA, the CDC, the CIA, Bill Gates, Klaus Schwab, Ralph Baric, Peter Daszak, Anthony Fauci, the Rockefellers, Rothschilds and many others is population control and reduction while making billions of dollars. New reports show worldwide excess deaths of 12 million innocent people. Professor Boyle drafted the U.S. domestic implementing legislation for the Biological Weapons Convention, known as the Biological Weapons Anti-Terrorism Act of 1989, that was approved unanimously by both Houses of the U.S. Congress and signed into law by President George H.W. Bush. Professor Boyle has also advised numerous international bodies in the areas of human rights, war crimes and genocide, nuclear policy, and bio-warfare. From 1991-92, he served as Legal Advisor to the Palestinian Delegation to the Middle East Peace Negotiations. He goes on to say that the population control and reduction objective goes back to the National Security directive by the Henry Kissinger Report written in 1974 which stated that it was in the best interest of National Security for the United States and for Overseas Interests to have a population control and reduction policy. The National Security Study Memorandum NSSM200 Implications of Worldwide Population Growth For U.S. Security and Overseas Interests (THE KISSINGER REPORT) dated December 10, 1974 was Classified and Confidential until it was Declassified on 7/3/89. Read the entire report to understand what they are doing. All citizens of the world are strongly encouraged to go to their local Sheriff's Office, Police Office and District or State Attorney General's Office and file criminal charges of murder and conspiracy to commit murder, demanding that the people responsible be arrested and prosecuted. This must be done, be brave and act now humanity. The Chinese Communist Government also helped the Pentagon and the FDA create Covid-19. They new they were developing a dangerous offensive biological warfare weapon with gain of function properties that had HIV DNA genetically engineered into it and was combined with nanotechnology in order to aerosolize it enabling the bioweapon to travel up to 30 feet in the air. They deliberately created both biological warfare weapons Covid-19 and the lethal Covid vaccines long before the Pandemic and then they created a fraudulent Pandemic in order to release these deadly biological weapons of war on humanity to kill millions of innocent people worldwide.
Video Transcript AI Summary
The speaker discusses the involvement of various entities in the development and distribution of mRNA vaccines, referring to them as "mRNA Franken shots." They claim that DARPA, the Pentagon, and the FDA are responsible for both creating the COVID-19 virus and the vaccines. They argue that these actions constitute murder and conspiracy to commit murder. The speaker also suggests that the goal of these actions is population control and reduction. They mention threats made to politicians who were initially interested in investigating these matters. The speaker concludes by emphasizing the importance of citizens reporting these issues to law enforcement and seeking accountability for those responsible.
Full Transcript
Speaker 0: I think you're right. I think that, as I've recommended before, Stu, anyone, could go in and file a complaint with a law enforcement, authority, for, murder conspiracy to commit murder, and and demand that people be arrested and prosecuted. And by the way, I did want to draw to the attention of your audience this press release 2013 where these your RNA, frank shots come from. DARPA Awards Moderna Therapeutics a grant for up to $25,000,000 to develop messenger RNA therapeutics. So notice DARPA is the Pentagon.
Let me repeat that. DARPA is the Pentagon. The Pentagon bought, paid for envisioned these mRNA Franken shots. And I should also point out for Dietrich was involved in the development of COVID nineteen, the offensive biological warfare weapon at the University of North Carolina BSL 3. So the Pentagon is both sides of the argument here.
They're developing the the weapon and the, alleged vaccines, which is also a weapon. But but the proof is right here.
Speaker 1: So there's not a law as far as we understand from where we sit In this country, federal level, state level, municipal level, that protects anybody from deploying a weapon of biowarfare. It doesn't give them any kind of liability shield. There's no immunity to liability in a sense. So wouldn't it be true that this Narrative about, congressional liability for Pfizer is kind of a psyop.
Speaker 0: That's correct, to the, liability that deals with civil liability, payment of damages. Here, we are talking about criminal responsibility. And in my book, Resisting Medical Tyranny, I outlined the case for why the, executives involved in the companies, developing these, MRNI, Franken shots are guilty of murder and conspiracy to commit murder. Yes. And you saw that report last week from Portugal that, upwards of 300,000 Americans now had been murdered, as a result of these mRNA, Franken shots.
So, this is quite serious. We cannot, tolerate, more Americans getting murdered, by the Nazis who run these, corporations. And if you look at the, jab resolution, clearly, what we have here is twofold, a violation of the Nuremberg code on medical experimentation, exactly what the United States government prosecuted Nazi doctors for at Nuremberg, and some were executed. Now I'm against the death penalty. So okay.
But that gives you the, idea of how severe the situation is. And then 2nd, as the, jab resolution correctly says, this is a Nuremberg crime against humanity. And Stu, what since this is so important, let me, read for you the definition of a Nuremberg crime against humanity. This was put in to Nuremberg charter by the United States to deal with the Nazi persecution of German Jews. Let me read this here.
Speaker 1: Yeah, please.
Speaker 0: Crimes against humanity, murder, extermination, and other inhumane acts committed against any civilian population. The American people are being treated here like the Nazis treated German Jews, 300,000 are now dead. When are we going to stop this?
Speaker 1: Yeah. What is the threshold for death exactly? That brings me to another point. So you're talking about the executives at the companies that helped to manufacture and then distribute these shots. What about The people inside of our government, they wouldn't be immune from criminal liability either.
They ordered this up in a sense, didn't they?
Speaker 0: That's correct. Would that would depend on, certainly the FDA that has approved these, Franken shots. They violated the Nuremberg code on medical experimentation and have committed a Nuremberg crime against humanity and arguably are responsible for or could be, indicted for murder and conspiracy to commit murder. Again, that requires, mens rea, on their part, and malice of forethought. My book basically dealt with the, chief executive officers and the chief scientific officers, for the mRNA Franken shots.
But, yes, the FDA officials, who approved it have, accountability as well. I should also point out, Stu, that, the FDA itself was involved in the development of COVID nineteen as an offensive biological warfare weapon at the UNC BSL 3. Let me read to you the, contract, and it says who helped develop this thing among others? National Center For Toxicological Research, Food and Drug Administration. So the same people, the FDA, the same agency that is approving these franken shots, these Nazi franken shots, have been involved in the development of COVID nineteen, an offensive biological warfare weapon with gain of function properties that were applied at the University of North Carolina BSL three, Stu.
Speaker 1: With Ralph Barrick's involvement, This is where Ralph Barrett comes in. That's correct. Yep. Okay. So and then what about moving downward downhill to the CDC who recommended these, to is adding them to the childhood vaccination schedule.
What about the media who ran with the safe and effective narrative? Fox is still airing commercials. It's time for your next booster. Go get your next booster. These people clearly the BBC hitting me all the time saying that I'm a conspiracy theorist, a radical conspiracy theorist on these shots.
What about accountability for these people as well?
Speaker 0: I think the CDC she also has accountability. The current, director, Walensky, Biden appointed. She's from the Harvard Medical School. Harvard Medical School is also involved in the development of the COVID nineteen at the UNCBSL three was Ralph Barrick along with the FDA. The CDC has been up to its eyeballs in offensive biological warfare, weapons going back to the Reagan administration.
When the Reagan administration authorized the CDC and American type, culture collection, to ship 40 shipments of weapons they knew were weapon specific biological warfare agents to Saddam Hussein in Iraq in the hope and expectation that he would weaponize them and use them against. And then US troops after goal 41 went in there, blew these biowarfare labs up and contaminated themselves.
Speaker 1: Are there are there politicians are there members of our Federal government, I'm talking about, you know, in the House of Representatives or in the United States Senate that are on committees that had the intel about this gain of function, weapon of biowarfare being, you know, manufactured, concocted, and whipped up at Fort Detrick University in North Carolina Chapel that that the FDA was involved. I mean, ostensibly, it would seem to me that there would be people inside of our government that would know and have a forethought that this was going to happen.
Speaker 0: I think, senator Rand Paul, from what I've seen is the one who has the, best comprehension of what's going on here.
Speaker 1: But did they know beforehand? Did they know that this was going to be developed at the time? I mean, would they have known this? Would they have received intel documents that said, hey. We're going to make a weapon of biowarfare here in the United States.
We're gonna ship it offshore, and then we're going to release it on the world population.
Speaker 0: Well, Stu, I've been saying this for many years. If you, take a look at a, there's a award winning documentary called anthrax wars, 2009 by Cohn and Nadler. You can get it online, dealing with the existential dangers presented by these BSL threes and BSL fours, and they asked me because of my expertise, to consult with them. And at the end of this, documentary, I say in the starkest terms possible. This is a catastrophe waiting to happen, unquote.
Now that was 2009. So, yes, at least my viewpoints on these matters have been out there in the, public record. Indeed, in, 2001. I was the 1st to blow the, whistle on the fact that Amerithrax, came out of a US biological warfare, weapon and, weapons program and laboratory. That was, November 3 at, Harvard Divinity School where the Council For Responsible Genetics was holding its convention, and I was conducting a, workshop against biological warfare weapons.
I said that to Fox TV, November 3. The next day or the the Monday after that. I sent it to Pacific Radio Network, and then I was on the BBC. The whole world heard me. And then, I was censored off of everywhere, after that point an order was given, and no, mainstream news media western mainstream news media has ever interviewed me again.
Speaker 1: So I'm gonna ask you to speculate here, a little bit, and I I know that you like to stick with facts, but what is the What is the game for the people who whipped this up and then released it? What is the game for DARPA, the Pentagon, Ralph Baric, Fauci, EcoHealth Alliance, Peter Daszak, all what what is their what is the end goal here, I guess? What's the end game?
Speaker 0: I think it's population control and reduction, Stu. We if you read the reports now, worldwide, there'd been excess deaths of about 12,000,000 people. So I think that's the, ultimate goal. Remember, that goes back to the, infamous, national security directed by, Henry Kissinger that it is in the national security interest of the United States, for our policy to be population control and reduction. I've never read that that was released.
And then, of course, everyone's making large amounts of money, off of this as well.
Speaker 1: As a lawyer, you represented world governments in the International Court of Justice. Why wouldn't any of our I mean, so you're no hack. Why why wouldn't any of our elected representatives in the senate or congress take you seriously when you're warning about this? Why would they write you off Okay.
Speaker 0: I believe they've been threatened. I I have contacted I've been in touch with members of congress about this matter and so there and after they were threatened. For example, the, one member of Congress, was consulting me on one matter, and I raised, with him the, Ebola, pandemic in, West Africa, Walter Jones. He was a very powerful member of the, house on services committee. He was consulting me on another matter, getting my legal opinion, and since he represented, for Bragg down there where everyone were being deployed, you know, I said congressman, he knew my expertise.
I said, congressman Jones, this, West African Ebola pandemic, came out of the, KENEMA BSL 4. It's extremely dangerous, and, I think you've gotta do something to keep your, troops there from being deployed, by the Obama administration is a is a propaganda stunt. It it's extremely, dangerous. This is a biological warfare, at work. And congressman Jones, said we we discussed the matter, and then he said, I'll get on it right away.
I'll put my, top staffer, in touch with you, and and we'll get on this right away because these were his his constituents. What happened, I was completely cut off. Obviously, someone had threatened congressman Jones. He no longer returned my phone calls, no emails, no messages, no one in his staff either. Now who would be able to threaten an extremely powerful member of the House Armed Services, Committee, to not even act on behalf of his own constituents there.
And what was their threat? I don't know. But it this personally, happened to me. Yes. And even when after congressman Jones died, I said condolences, to his office.
They didn't even acknowledge receipt of, of my condolences.
Speaker 1: I think we probably know why. Certainly not every sheriff has been gotten to. Do you think that that's the course of action here is for citizens to go to their sheriff and report that they've been assaulted with a weapon of biowarfare?
Speaker 0: Yes. And also go to your, district attorney, state's attorney, county attorney. I'm dealing with the county attorney down there, at, Collier County. He he's involved in, drafting their health, freedom declaration. We're we're making progress on And
Speaker 1: then there needs to be an enforcement mechanism in that in that resolution, for how we move forward And what we do with the people who are responsible for this deployment and then what we do with the stockpiles of this deployment, I think it's pretty clear at this point. I mean, it needs to be seized, it needs to be incinerated, And the people responsible for it need to be put on trial and handed down sentences.
Speaker 0: That's not to excuse the Chinese Communist government. They knew full well. They were developing an existentially dangerous offensive biological warfare weapon with gain of function properties with HIV, DNA genetically engineered into there, and that was, subjected to, nanotechnology, to to aerosolize it. This stuff will travel up to 30 feet in the air. So I'm not excusing them at all.
But but they were developing
Speaker 1: it. The the Wuhan Institute of Virology then is, by definition, a bioweapons lab. Pardon me? The Wuhan Institute of Virology then, by definition, is a bioweapons lab.
Speaker 0: Oh, yeah. That's China's Fort Detrick, Stu. What happened was, obviously, president g there, decided that he wanted to play with the big boys, and the big boys had a BSL 4 like we do, r four Dietrich or the British at, Porton Doute, and he was going to have his own, BSL 4 and his offense his own, monopoly of offensive biological warfare weapons just as bad as anything we have. Right.
Speaker 1: Founded by the US taxpayer, and there's no shortage of that going on around the world either as we have reported on this program ad nauseam. Dozens of these bioweapons labs just like the Institute of Virology in Wuhan Located in Ukraine where we're sending 100 of 1,000,000,000 of dollars, and now we're getting reports about the same happening in Taiwan. Interestingly enough, the military industrial complex wants US boots on the ground there. Lindsey Graham, the Pfizer whore, the fossil in the DC beltway there is advocating for US boots on the ground in Taiwan. Seems that they know where all of the bodies are buried, professor Boyle.
Thank you so much for coming here. We
reSee.it AI Summary
The COVID spike protein, believed to be a bioweapon, was engineered in a Cabal biolab. Moderna holds a patent for its genetic sequence, raising questions about its natural origin. The spike protein may contain elements of HIV, causing concerns. Vaccinated individuals showed a higher HIV positivity rate. Renowned scientists suggest COVID contains genetic elements of HIV. Research reveals a HIV-like mutation in the virus, making it more potent. The virus and injections act as delivery vectors. The injection isolates the spike protein, which can cause blood clots and serious health issues. Catching the viral form is considered safer than receiving the injection. President Trump's vaccine push and additional context videos are also discussed.
@TwinTowerCity - Twin Tower City ⭐⭐⭐
THREAD: The Spike Protein is the Bioweapon This thread discusses the COVID-19 spike protein. It was engineered through gain-of-function experiments in a Cabal biolab. There are two delivery vectors for the spike protein bioweapon. The virus. And the more deadly injection.
@TwinTowerCity - Twin Tower City ⭐⭐⭐
A bat coronavirus spike protein was weaponized by the Cabal. It contains a genetic sequence patented by Moderna three years before the plandemic. Researchers say there’s a one in 3 trillion chance the sequence developed naturally. https://www.dailymail.co.uk/news/article-10542309/Fresh-lab-leak-fears-study-finds-genetic-code-Covids-spike-protein-linked-Moderna-patent.html
Scientists find genetic match between Covid and Moderna 2016 patent
The international team of researchers identified a tiny snippet of code that is identical to part of a genetic sequence patented by the US vaccine maker three years before the pandemic.
dailymail.co.uk
@TwinTowerCity - Twin Tower City ⭐⭐⭐
Here’s the CEO of Moderna discussing the COVID genetic sequence patented by his organization three years before the COVID plandemic was unleashed.
Video Transcript AI Summary
Scientists are investigating claims that COVID-19 was manipulated in a lab. They are analyzing data to determine the accuracy of these claims. The possibility of a lab accident cannot be ruled out, as humans make mistakes. It is being examined whether the Wuhan lab in China was conducting virus enhancement or gene modification, leading to an accidental infection. The team is carefully examining a genetic sequence that matches one patented by Moderna for cancer research. This analysis takes time.
Full Transcript
Speaker 0: Let me ask you what the Daily Mail is reporting. It says more evidence COVID was tinkered with in a lab. Now scientists find the virus contains a tiny chunk of DNA that matches sequence patented by Moderna 3 years before the pandemic began. Your reaction, Stefan, what can you tell us?
Speaker 1: So My scientists are looking into those data to see, accurate they are or not. As I've said before, the hypothesis of an escape lab by an accident is possible. You know, human makes mistakes. So, is it possible that the Wuhan lab in China was working On, viruses, enhancement or gene modification. And then there was an accident where somebody was infected in the lab and then infected their families and friends.
It is possible on the claim you just, mentioned, the scientists analyzing to know if it's, real or not.
Speaker 0: Yeah. I mean, I mean, I was struck by the line it matched a genetic sequence patented by Moderna for cancer research purposes, Stefan.
Speaker 1: Yeah. And that's the type of things that the team is looking at very carefully to know, is it is it real or not? Chunk. So it takes a bit of time to analyze all the genetic sequence.
@TwinTowerCity - Twin Tower City ⭐⭐⭐
The spike protein may also include elements of HIV. An Australian vaccine that used the spike protein was abandoned because the vaccine generated HIV antibodies in recipients. https://www.bbc.com/news/world-australia-55269381
Covid: Australian vaccine abandoned over false HIV response
Trials of the Australian vaccine returned false-positive HIV tests, but did not harm participants.
bbc.com
@TwinTowerCity - Twin Tower City ⭐⭐⭐
Research from India found a similarity between HIV and unique inserts in the spike protein. "Amino acid residues in all the 4 inserts have identity or similarity to those in the HIV-1 gp120 or HIV-1 Gag ... unlikely to be fortuitous in nature" https://www.biorxiv.org/content/10.1101/2020.01.30.927871v1.full
Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
biorxiv.org
@TwinTowerCity - Twin Tower City ⭐⭐⭐
A CDC study found vaccinated individuals in Massachusetts had a HIV positivity rate 17X higher than average. "Analysis matching cluster-associated COVID-19 cases with the state HIV case surveillance data identified 6% cases with verified HIV infection.” https://www.civilianintelligencenetwork.ca/2021/08/03/breaking-hiv-confirmed-in-vaccinated/
Breaking: HIV Confirmed in Vaccinated! – Civilian Intelligence Network
civilianintelligencenetwork.ca
@TwinTowerCity - Twin Tower City ⭐⭐⭐
Professor Luc Montagnier, the scientist who discovered HIV, says COVID-19 contains genetic elements of HIV. "French scientist who shared the 2008 Nobel Prize for discovery of HIV insisted its characteristics could not have arisen naturally." https://www.dr-rath-foundation.org/2020/04/nobel-prize-winning-scientist-who-discovered-hiv-says-coronavirus-was-created-in-laboratory/
Nobel Prize-Winning Scientist Who Discovered HIV Says Coronavirus Was Created In Laboratory - Dr. Rath Health Foundation
Dr Rath Foundation
dr-rath-foundation.org
@TwinTowerCity - Twin Tower City ⭐⭐⭐
COVID-19 has a HIV-like mutation according to research by scientists in China and Europe. Nankai University shows the virus has a mutated gene similar to those in HIV that means its ability to bind with human cells could be 1000 times as strong as SARS. https://www.scmp.com/news/china/society/article/3052495/coronavirus-far-more-likely-sars-bond-human-cells-scientists-say
Coronavirus more likely than Sars to bond to human cells, scientists say
Research by team from Nankai University shows new virus has mutated gene similar to those found in HIV and Ebola.
scmp.com
@TwinTowerCity - Twin Tower City ⭐⭐⭐
The virus was the original delivery vector. It has a diameter of ~100nm and can’t pass through blood barriers. Airborne viruses are typically dealt with by the respiratory system (nose/throat/lungs). They rarely enter the bloodstream. So the virus was less deadly than they hoped.
@TwinTowerCity - Twin Tower City ⭐⭐⭐
The COVID virus has 29 proteins. When you catch the virus, your body learns how to defend against all 29 proteins. If you later catch a new strain, where some proteins have mutated, your body still recognizes most of the proteins and knows how to produce the right antibodies.
Video Transcript AI Summary
The delta variant has significantly altered the situation. The level of virus in the nasopharynx of a vaccinated individual with a breakthrough infection is now equivalent to that of an unvaccinated person who is infected. This finding prompted the CDC to revise its guidelines.
Full Transcript
Speaker 0: Data were clear. Now that we have a delta variant, that has changed the entire landscape. Because when you look at the level of virus in the nasopharynx of a vaccinated person who gets a breakthrough infection with delta, It is exactly the same as the level of virus in a unvaccinated person who's infected. That's the problem. So those data were very compelling, and that triggered the change in the CDC guideline.
@TwinTowerCity - Twin Tower City ⭐⭐⭐
The secondary delivery vector is the injection, which isolates the spike protein from the virus. The spike protein has a diameter of ~10nm. It passes through blood barriers, evading the protection of the respiratory system, and attacks the heart, brain, reproductive system etc.
@TwinTowerCity - Twin Tower City ⭐⭐⭐
The injections only teach the body how to defend against that spike protein. Not the other 20+ proteins in the virus. So when you catch a new strain of the virus, with a mutated spike protein, the injection is useless. Injected people still catch, spread and get ill with COVID.
Video Transcript AI Summary
The COVID-19 vaccines have proven to be highly effective in the real world. Both the mRNA vaccine and another vaccine have shown efficacy rates of 94% to 95% for mild to moderate disease. In fact, the real world effectiveness of these vaccines is even more impressive than the results of the clinical trials. It is clear that these vaccines are highly effective in preventing COVID-19.
Full Transcript
Speaker 0: Often when you get into the real world, the effectiveness of vaccines falls short of the original efficacy. That is not at all the case with the vaccines for COVID-nineteen. So now we have 2 vaccines that are really quite effective. The mRNA vaccine highly effective, extraordinarily efficacious 94% to 95% for mild to moderate disease and virtually a 100% efficacious because the real world effectiveness is even more impressive than the results of the clinical trial. Apart efficacy, it has nothing to do with whether or not it's effective.
We know it's highly effective. Highly
@TwinTowerCity - Twin Tower City ⭐⭐⭐
Blood cells normally flow smoothly past each other. But the spike protein, isolated from the rest of the virus, is free to attach to blood cells. This causes cells to stick together, creating clots. Clots that move into the brain or heart can cause strokes or heart attacks.
@TwinTowerCity - Twin Tower City ⭐⭐⭐
If you're going to get the HIV spike protein, it's better to catch the viral form. This allows your respiratory system to deal with it, and your body to build immunity to all 29 proteins, without the toxic spike protein entering your bloodstream and accumulating in your organs.
Video Transcript AI Summary
Vaccines can sometimes have unexpected effects. In some cases, vaccinating someone against a disease can actually make them more susceptible to the infection. This has happened before with vaccines like the respiratory syncytial virus vaccine in children and an HIV vaccine that was tested a few years ago. So, it's important to carefully evaluate the safety of vaccines before administering them.
Full Transcript
Speaker 0: Does the vaccine make you worse? And there are diseases in which you vaccinate someone. They get infected with what you're trying to protect them with, and you actually enhance the infection. This would not be the first time that a vaccine that looked good in initial safety actually made people worse. There was the history of the respiratory syncytial virus vaccine in children, which paradoxically made the children worse.
One of the HIV vaccines that we tested several years ago actually made individuals more likely to get infected.
@TwinTowerCity - Twin Tower City ⭐⭐⭐
Why President Trump Pushed the "Vaccine"
@TwinTowerCity - Twin Tower City ⭐⭐⭐
THREAD: Why President Trump Pushed the "Vaccine" President Trump used Operation Warp Speed to force the Cabal to deploy their bioweapon injections before they were fully prepared. If he hadn't done this, the following would have happened:
@TwinTowerCity - Twin Tower City ⭐⭐⭐
This excellent video by MrTruthBomb provides additional context to the points raised in this thread. It incorporates content from Clif High, X22 Report, AndWeKnow, and Patel Patriot. @clif_high @andweknow @patel_patriot @SacredGeoInt https://www.bitchute.com/video/2PFzMI9bgeqO/
President Trump Vs BIG PHARMA 2 - Clif High/X22 Report/AndWeKnow/Patel Patriot - A MrTruthBomb Film
In this video we look at President Trumps controversial Warp Speed and his public support of the globalist vaccines.
LINK FOR PART 1: https://rumble.com/vqh6tg-president-trump-vs-big-pharma-from-plandemic-scamdemic-2-endgame-a-mrtruthb.html
J…
bitchute.com
@TwinTowerCity - Twin Tower City ⭐⭐⭐
Further to the Spike Protein and HIV connections covered at the beginning of this thread, here's a video that aired on BBC discussing how HIV was added to the COVID "vaccine". https://t.co/QL0xL9iff4
Video Transcript AI Summary
The spike protein on the surface of the coronavirus is crucial for its structure and interaction with our cells. To trigger a strong antibody response, Keith replicates the spike protein in the lab. He uses a small piece of HIV protein as a clamp to lock the spike protein into its original shape. This ensures that the spike protein maintains its structure and effectiveness.
Full Transcript
Speaker 0: It holds it together and allows it to stay 100% in that structure that's present on the surface of the virus.
Speaker 1: The shape of the coronavirus spike protein before the virus meets our cells is what triggers the most protective antibody Response. So Keith must make the spike protein in the lab, locking it into exactly the same shape by adding another protein That acts a bit like a clamp. And that protein is a tiny fragment of HIV.
reSee.it AI Summary
Dr. Luc Montagnier, a Nobel laureate, raised concerns about Covid's artificial creation and modification. He believed it was a meticulous job by molecular biologists, even incorporating an HIV sequence. Some speculate this could be a sophisticated military intelligence operation. #Covid #Vaccine #DeepState #NWO
@bambkb - Kevin - WE THE PEOPLE❤️ - DAD🦁 🐉 🔥
Before he died, Professsor and noble prize winner, Dr. Luc Montagnier expressed concerns that #Covid was artificially created and modified : “This was a professional Job, a meticulous one - They even added an HIV sequence in there! This is not normal!! this was a professional job done by molecular biologists” In my eyes, this whole #Covid and #Vaccine thing looks like a massive MILITARY/intelligence operation!? Who else would be capable of such a thing? #Covid #Vaccine #DeepState #NWO
Video Transcript AI Summary
Professor Luc Montagnier, Nobel Prize winner in medicine and discoverer of HIV, discusses his current work on the virus. He explains that he is not working in the lab but rather on a computer with a colleague, analyzing the measures taken in laboratories on patients. He concludes that there has been manipulation of the virus, with sequences from HIV added to the original bat virus model. However, he does not know who is responsible or the purpose behind it. Montagnier emphasizes that he is only presenting the facts and not accusing anyone.
Full Transcript
Speaker 0: Et nous revenons avec l'actualité du Covid dix-neuf et nous sommes avec le professeur Luc Montagnier bonjour. Bonjour Et merci d'être avec nous. Faut-il le rappeler vous êtes prix Nobel de médecine et c'est vous qui êtes à l'origine de la découverte du VIH.
Speaker 1: C'est une longue histoire mais intéressante aussi pour l'actualité parce qu'on a une expérience Deux deux choses qui se sont passées qui ont été très difficiles à contrôler là-bas à ce moment-là et ce qui a Permis de trouver la vérité c'est comme aujourd'hui.
Speaker 0: Alors ce qui m'intéresse ce matin c'est que vous vous travaillez en ce moment sur le virus. Vous êtes d'accord
Speaker 1: de travail mais pas forcément au labo puisque on travaille sur ordinateur avec Avec un collègue et puis c'est tout. On n'a pas de d'expérience on peut dire, mais l'expérience vient JLM De la maladie elle-même, de toutes les mesures qui sont faites actuellement dans les laboratoires sur les patients.
Speaker 0: Et vous êtes arrivé à certaines conclusions.
Speaker 1: Alors, d'ailleurs, vous arrivez à la conclusion qu'effectivement il y avait eu Une manipulation au sujet de ce virus. C'est-à-dire Et bien qu'une partie, je ne dis pas le total, je ne sais pas, mais il Il y a un modèle qui est évidemment le virus classique et là c'était un modèle surtout venant de la chauve-souris. Mais Ce modèle on a par-dessus ajouté des séquences notamment du VIH, Le virus du du SIDA. Mais quand vous dites on a ajouté, qui a ajouté Ah moi je ne sais pas. Et
Speaker 0: c'est pas naturel, c'est ce que vous voulez dire
Speaker 1: Non, ce n'est pas naturel, c'était un travail de Professionnel, un travail de de biologiste moléculaire. C'est un travail très minutieux, on peut dire de d'horloger, on peut dire Et dans quel bout des séquences.
Speaker 0: Mais dans
Speaker 1: quel but Dans quel but Dans quel but, ce n'est pas n'est pas clair. Moi je je l'expose si vous voulez. Mon mon travail c'est d'exposer les faits, c'est tout. Je ne je n'accuse personne.
reSee.it AI Summary
UNC Chapel Hill played a significant role in the development of Covid-19 and its vaccines. Dr. Fauci and UNC collaborated in creating a coronavirus to infect human cells. Patents were filed, securing rights to the spike protein bioweapon. Violations occurred, enabling the manipulation of a lethal pathogen. The media and profit were emphasized to drive the need for vaccines. A global operation was planned, leading to the release of a respiratory pathogen and the mandate for mRNA vaccines. In 2020, untested products were manufactured for mass distribution.
@DschlopesIsBack - Gain of Fauci
Since UNC is in the news right now, it's a good time to remind you that a bioweapon known as Covid-19 and the even more dangerous "vaccines" for said bioweapon were both largely developed at UNC Chapel Hill. https://t.co/i2jUCa0Q6a
@DschlopesIsBack - Gain of Fauci
Covid origins: Posted by the late Dr. Vladimir Zelenko @ZelenkoProtocol Nov 16th, 2021: How a weapon of eugenics, mass murder, and genocide was made. 1 In 1999, Anthony Fauci (Director of NIAID), in partnership with Ralph Baric and the University of North Carolina Chapel Hill constructed an “infectious, replication defective” recombinant coronavirus to infect human cells. 2 In 2002, NIAID and UNC filed for patent protection securing the rights to the spike protein chimeric bioweapon now modified for use in the gene therapy represented to be a “vaccine” 3 In 2003, the Centers for Disease Control and Prevention patented the genome of the SARS coronavirus securing all commercial use of SARS. 4 In 2013 to 2016, NIAID, UNC Chapel Hill, EcoHealthAlliance (led by Peter Daszak), and the Wuhan Institute of Virology violated 18 USC §175 enabling the construction and chimeric manipulation of a pathogen known to be lethal to humans (the S1 Spike Protein) in repeated and habitual felonious acts. 5 In 2015, Peter Daszak stated to the National Academy of Sciences that, “…until an infectious disease crisis is very real, present, and at an emergency threshold, it is often largely ignored. To sustain the funding base beyond the crisis, he said, we need to increase public understanding of the need for MCMs such as a pan-influenza or pan-coronavirus vaccine. A key driver is the media, and the economics follow the hype. We need to use that hype to our advantage to get to the real issues. Investors will respond if they see profit at the end of process, Daszak stated.” 2016 Feb 12. 6, Developing MCMs for Coronaviruses. Available from: http://ncbi.nlm.nih.gov/books/NBK34904…. 6 Beginning in September of 2019, NIAID, UNC Chapel Hill, the Bill and Melinda Gates Foundation and the Chinese Centers for Disease Control conspired to conduct a global operation in the release of a respiratory pathogen to force nations into developing and deploying a global vaccine program including having President Trump sign an Executive Order (Executive Order 13887) mandating the production of mRNA vaccines months before any reported SARS outbreak. 7 In 2020, two companies who had never safely produced any vaccine before were selected to manufacture an untested and unsafe product to unleash on the population. Thank You United States Government Vladimir Zev Zelenko MD
reSee.it AI Summary
Nobel laureate Luc Montagnier asserts that the Covid virus contains added sequences, including HIV, suggesting a deliberate act by skilled molecular biologists. His expertise makes his viewpoint significant. The implications of such vaccine-related actions are concerning. #VaccineCrimesAgainstHumanity
@bambkb - Kevin - WE THE PEOPLE❤️ - DAD🦁 🐉 🔥
Nobel prize winner in medicine and Professor, Luc Montagnier claims that : “Someone added certain sequences to this #Covid virus, including HIV sequences, it was a meticulous and professional job by molecular biologists!! This #Virus is man-made ” I don’t know many people alive that have better qualifications to speak on this subject than this incredible human being - Please, listen!! #Vaccine #CrimesAgainstHumanity
Video Transcript AI Summary
Professor Luc Montagnier, Nobel Prize winner in Medicine and co-discoverer of HIV, discusses his current work on the virus. He clarifies that he is not working in the lab but rather analyzing data with a colleague. Through their analysis, they have concluded that there was manipulation involved in the virus, specifically the addition of sequences from the HIV virus. However, Montagnier does not know who was responsible for this manipulation or the purpose behind it. He emphasizes that his role is to present the facts and not accuse anyone.
Full Transcript
Speaker 0: Et nous revenons avec l'actualité du Covid dix-neuf et nous sommes avec le professeur Luc Montagnier bonjour. Bonjour Et merci d'être avec nous. Faut-il le rappeler vous êtes prix Nobel de médecine et c'est vous qui êtes à l'origine de la découverte du VIH.
Speaker 1: C'est une longue histoire mais intéressante aussi pour l'actualité parce qu'on a une expérience Deux deux choses qui se sont passées qui ont été très difficiles à contrôler là-bas à ce moment-là et ce qui a Permis de trouver la vérité c'est comme aujourd'hui.
Speaker 0: Alors ce qui m'intéresse ce matin c'est que vous vous travaillez en ce moment sur le virus. Vous êtes d'accord
Speaker 1: de travail mais pas forcément au labo puisque on travaille sur ordinateur avec Avec un collègue et puis c'est tout. On n'a pas de d'expérience on peut dire, mais l'expérience vient JLM De la maladie elle-même, de toutes les mesures qui sont faites actuellement dans les laboratoires sur les patients.
Speaker 0: Et vous êtes arrivé à certaines conclusions.
Speaker 1: Alors, d'ailleurs, vous arrivez à la conclusion qu'effectivement il y avait eu Une manipulation au sujet de ce virus. C'est-à-dire Et bien qu'une partie, je ne dis pas le total, je ne sais pas, mais il Il y a un modèle qui est évidemment le virus classique et là c'était un modèle surtout venant de la chauve-souris. Mais Ce modèle on a par-dessus ajouté des séquences notamment du VIH, Le virus du du SIDA. Mais quand vous dites on a ajouté, qui a ajouté Ah moi je ne sais pas. Et
Speaker 0: c'est pas naturel, c'est ce que vous voulez dire
Speaker 1: Non, ce n'est pas naturel, c'était un travail de Professionnel, un travail de de biologiste moléculaire, c'est un travail très minutieux, on peut dire de d'horloger, on peut dire Et dans quel bout des séquences.
Speaker 0: Mais dans
Speaker 1: quel but Dans quel but Dans quel but, ce n'est pas n'est pas clair. Moi je je l'expose si vous voulez. Mon mon travail c'est d'exposer les faits, c'est tout. Je ne je n'accuse personne.
reSee.it AI Summary
A man claims to possess internal Pfizer documents revealing the reverse engineering process of the Covid vaccine. These documents allegedly expose the manipulation of the vaccine to deliver a toxic substance, Graphene Oxide, into the human body. The vaccines are said to contain 15 billion nanoparticles of Graphene Oxide. The accessed databases supposedly prove that Covid and the vaccine are a bioweapon. The existence of the mysteriously deleted Wuhan databases further supports these claims. If true, this revelation could be a game-changer.
@bambkb - Kevin - WE THE PEOPLE❤️ - DAD🦁 🐉 🔥
This man claims that he is in possession of #Pfizer documents that contain the reverse engineering process of the #Covid #Vaccine : “I hold in my hands an internal document from #Pfizer laboratories, which is given to us by a very special person that we have contact with” “It’s called, ‘reverse engineering the source code of the #Pfizer #BionTech #Vaccine’!! This is very CRITICAL, as it outlines the biological and chemical processes of the #Covid #Vaccine, which was very carefully manipulated to produce an #mRNA that delivers a VERY TOXIC SUBSTANCE into the human body!! Do you know what that TOXIN is? Graphene Oxide!!!” “Each one of these #Vaccines contains 15 BILLION nano-particles of GRAPHENE OXIDE” “The patented databases that we have accessed PROVE that #Covid and the #Vaccine are in FACT a BIOWEAPON!! Do you want to know how we support our claims? BECAUSE WE HAVE A COPY OF THE MYSTERIOUSLY DELETED WUHAN DATABASES!!!!” To be honest, so many facts are out already that this shouldn’t even really matter, BUT, If this is true, it’s 100% GAME OVER!!!!! #Wuhan #ManMade #BioWeapon
Video Transcript AI Summary
I have an internal document from Pfizer Laboratories that reveals the manipulation of chemical and biological processes in the BioNTech Pfizer SARS CoV-2 vaccine. It contains Graphene Oxide, a dangerous toxin, with 15 billion nanoparticles in each 30mg shot. Graphene Oxide causes the spike protein to bind to blood cells, leading to blood clots and heart failure. The patent databases and a copy of the deleted Wuhan databases support the claim that COVID-19 and its vaccines are bioweapons.
Full Transcript
Speaker 0: Hold in my hands an internal document from Pfizer Laboratories which was given to us by a very special person who we have contact with called reverse engineering the source quote of the BioNTech Pfizer SARS CoV-two vaccine. And this is very, very critical because it outlines the chemical and the biological processes which were very, very carefully manipulated in order to be able to produce an mRNA that also contain a very, very dangerous toxin to the human body. You know what that toxin is? That toxin is called Graphene Oxite. And every single one of these vaccines in a 30 milligram shot contains 15,000,000,000 nanoparticles or lipid carrier particles within the MNRA sequence.
15,000,000,000 nano particles. And let me tell you how Graphene Oxide works when it gets into the body Because then the spike protein then binds itself to our blood cells and so on. Graphene oxide then starts to build a structure. And this is why we have people with blood clots, and we have people with heart failure, sudden heart failure, and so on. The patent databases that we have accessed proves that COVID nineteen and COVID nineteen vaccines are in fact a bioweapon.
And how do we support that? Because we have a copy of the mysteriously deleted Wuhan databases that tell us everything. Thank you very much.
reSee.it AI Summary
Film producer Mikki Willis exposes the Covid and Vaccine fraud. Covid is a list of symptoms common to the Flu and Pneumonia. The Spike Protein in the Covid Vaccine activates and expedites these symptoms. The viral model for Covid was created in the US in 2002. In 2005, defense agencies recognized Covid as a bioweapon. In 2015, it was revealed that Covid was poised for human emergence to create a mass demand for vaccines. This information is public. The Covid hoax was caused by a fraudulent PCR test and media hysteria to push the vaccine. Why is the US military doing this?
@bambkb - Kevin - WE THE PEOPLE❤️ - DAD🦁 🐉 🔥
Film producer of the Plandemic series, Mikki Willis exposes the #Covid and #Vaccine fraud : “There is NO such thing as a #Covid virus!! #Covid is essentially a list of symptoms that are common to the #Flu and #Pneumonia” “It’s the SPIKE PROTEIN that’s getting people SICK!! The #Covid #Vaccine contains the #SpikeProtein that activates and expedites the SYMPTOMS that we now know as, #COVID19!!” “In 2002, the viral model that became #Covid19 was created at the University of North Carolina through the process of #GainOfFunction, right here in the United States ” “In 2005, two of our biggest defence agencies, MITRE and DARPA recognized #Covid as a #BIOWEAPON!!! Evidence of this can be found in the career summary of, Dr. Ralph Baric, who was a professor at the University of North Carolina!!” “In 2015, the proceedings of national academies of sciences published that #Covid was POISED for human emergence!! The stated reason for that : to create a MASS DEMAND for #Vaccines!!! All of this was paid for by Fauci’s NIAID/CIA and all the 100s of millions of dollars of cheques were cashed by, Ralph Baric” “This information is in the PUBLIC DOMAIN, anyone can look this up!!!” The #Covid hoax was caused by a FRAUDULENT #PCR test and media hysteria, in order to convince you to take the #Vaccine Why is the USA military doing this to humanity?
Video Transcript AI Summary
There is no such thing as COVID-19 virus. COVID-19 is a list of symptoms similar to the flu and pneumonia. The spike protein in the virus makes people sick. The vaccine, or shot, contains this spike protein, which triggers the symptoms of COVID-19. It is important to understand this because there has been misinformation to confuse us and even doctors. The SARS-CoV-2 virus was created through gain of function research at the University of North Carolina in 2002. In 2005, Coronavirus was identified as a bioweapon. The goal was to create mass demand for vaccines. Anthony Fauci's NIAID funded this research, and the checks were cashed by Dr. Ralph Baric. Blaming China for the virus is dangerous, as it was a collaboration with China and traders within the US.
Full Transcript
Speaker 0: Thing as COVID no such thing as COVID nineteen virus. COVID nineteen is essentially
Speaker 1: a list of symptoms that are common to the flu and pneumonia. Both SARS CoV one and CoV two are what we're speaking about when we talk about the virus itself and they are like an envelope that delivers the message in the form of spike protein. It's that spike protein that makes people sick. The vaccine, which is It's not a vaccine, so let's call it the shot. It contains the spike protein that activates and expedites the development of the symptoms we've come to know as COVID nineteen.
So it's super important that people people understand that because there it there have been a lot of stuff that's been planted to confuse us, to confuse doctors. And so we've Really, you know, take a lot of time to how do we articulate this so we actually understand? Once you understand that, then it becomes clear that In 2002, the viral model that that became SARS CoV-two was created through the process of gain of function at the University of North Carolina at Chapel Hill right here in the US. In 2005, during an event sponsored by 2 of our biggest defense agencies, DARPA and MITRE, Coronavirus was identified as a bioweapon. Evidence of this can be found within the career summary of doctor Ralph Barrick who is a professor at the University of North Carolina at Chapel Hill.
Within his career summary, synthetic coronavirus is listed next to the heading biological warfare enabling technologies. In 2015, the proceedings of National Academy of Sciences published that SARS CoV 2 was poised for human emergence. That the stated reason for that was to create, in their words, at mass demand for vaccines. All of the above was paid for by Anthony Fauci's NIAID and every check totaling 100 of 1,000,000 of dollars was cashed by doctor Ralph Baric of the University of North Carolina at Chapel Hill. There's a that that that's all public domain information that people can look at.
And so when you understand that, this whole idea of the debate about is whether it's It it it's it's it was manipulated in the lab. It's as clear as it can be. In North Carolina? In North Carolina. And so this idea, which be Very dangerous that we're trying to blame it all on China and drive us to some kind of a world war is the very, very dangerous idea when indeed It was in a collaboration with China and all the traders within our own nation who think that somehow they're gonna remain in power should they continue to advance China's power over the US.
It's it's it's kind of silly. No such thing as COVID
reSee.it AI Summary
In 2007, Ralph Baric presented groundbreaking research on creating a more dangerous SARS virus. Yet, the prevailing narrative blames a bat and pangolin at a wet market. Dismissing Baric's expertise seems unwise. UNC Chapel-Hill's renowned researcher deserves attention.
@JoshWalkos - Champagne Joshi
Ralph Baric & His Frankenstein Virus The year is 2007 and Ralph Baric of UNC Chapel-Hill is giving a presentation on the new and exciting science behind synthetically creating the SARS virus and making it more pathogenic. However you are supposed to believe a bat screwed a pangolin that ended up at a wet market. So you should probably completely dismiss this detailed presentation by the world’s most cited coronavirus researcher.
Video Transcript AI Summary
Ralph Barrick from the University of North Carolina discusses synthetic genomics of SARS in this video. He explains the structure and genome organization of the SARS coronavirus and its various proteins. Barrick also discusses the use of synthetic genomics as a platform to control emerging infectious diseases and develop vaccines. He presents the results of experiments involving the synthesis of different SARS virus strains and their ability to infect human airway cells. Barrick also discusses the use of deoptimized codons to attenuate SARS pathogenesis and the rewiring of SARS coronavirus transcription circuits to further attenuate viral pathogenesis. He concludes by highlighting the potential of synthetic genomics and universal attenuation schemes to rapidly produce candidate live virus vaccines for emerging pathogens.
Full Transcript
Speaker 0: We're going to have here from Ralph Barrick, from the University of North Carolina who's going to tell us about synthetic genomics of SARS. So I also would like to thank the organizers for inviting me to talk. It's been a wonderful venue and a real pleasure to be here and capture some new ideas that can be tried out on viruses. So the general themes that I'm going to talk about today are basic, short introduction into, SARS biology, Talk about the synthetic resurrection and reconstruction of a variety of zoonotic SARS viruses and their applications in therapeutics and vaccine design. I'll also touch on codon de optimization as a way to attenuate SARS pathogenesis but I certainly haven't gone to the depth of studies that Eckert's group has done.
And then I'll talk about rewiring SARS coronavirus transcription circuits as a way, universal strategy, to attenuate viral pathogenesis. So this is a schematic diagram of the SARS coronavirus particle. It's about a 100 nanometers in diameter. It contains a Helical nucleocapsid inside. It contains a single stranded plus polarity RNA genome.
This nucleocapsid structure is surrounded by a lipid bilayer It contains several viral glycoprotein spikes. The important ones for today's talk include the M glycoprotein and the E protein, which are shown right here. These proteins are absolutely essential for maturation and release and the production of virus particles, So keep that in mind. The 2nd viral protein of interest for today's talk is the Escalica protein gene, as shown right here, which gives the virus its unique appearance from the electron microscope. It's, the viral attachment protein that binds to the receptor to mediate docking and entry into the cells.
It's involved it regulates tissue tropism, species specificity. It contains a large number of important neutralizing epitopes, and it's the principal component of Now, if you tear this virus particle apart and look at the viral genomic positive stranded RNA, it's about 30,000 base pairs in length. They're the largest plus polarity RNA genomes in nature. The first 20,000 base pairs are so encoded to replicate proteins whose job it is to replicate the genome and express sub genomic messenger RNA that encode these downstream open reading frames. So the genome organization of coronas are quite different than polioviruses, which you've just heard about.
Now, these downstream morphs encode Structural genes like the SEM and nucleocapsid protein that I just mentioned that were present in the Vireon and a variety of accessory or To get these expressed in cells, you find a nested set of sub genomic messenger RNA arranged from the three prime end of the genome so that all the sequences in the smallest message are in the next largest message and so on and so forth. This organization allows different open reading frames to be placed at the 5 prime ends of different messenger RNAs So they can be efficiently translated and expressed themselves. Now the transcription strategy of these viruses are unique And in fact, each messenger RNA contains a leader sequence of about 70 nucleotides shown here as these little blue boxes that is derived from the 5 prime end of the genome. So these are discontinuous stretches of RNA that are joined during transcription And these little red box elements right here are absolutely essential for mediating the joining of these 2 sequences. This will become very important later on in the talk so keep the concept of TRS elements, little red box elements, As being essential for regulation of messenger RNA synthesis.
Now, we'll talk about synthetic genomics in the context Of a platform to control emerging infectious diseases. If you think about emerging viruses, they have tremendous potential to cause high morbidity and mortality And severe economic hardship. Good examples are HIV, the 1918 flu, SARS coronavirus, H5N1, chikungunya virus probably most recently. Now it's clear that zoonotic introductions are increasing and a large number of these viruses have large reservoir pools of animal strains Like SARS and H5 that are maintained as sort of heterogeneous swarms of pools of viruses of which someone may actually emerge in the future to cause endemic disease in humans. This raises a conundrum in terms of how do you protect the public health against a future occurrence that is hard to predict, How do you develop drugs and therapeutics against an unknown from this heterogeneous swarm of variant strains that will actually work against the unknown that will emerge in the future?
How do you target your scarce resources? And so we think platform technologies like synthetic biology, phylogenomic, structure modeling, high throughput sequencing really will provide a platform and our goal is to use SARS coronavirus and its large pool of zoonotic viruses as the model Develop rapid response platforms to protect against this broader heterogeneous pool of variants. We also would like to develop that would attenuate all family members so that you could rapidly develop vaccines for the public, overall public health. Now, a lot of beautiful work in Malik's lab as well as other labs here in China, worked out the basic molecular epidemiology of SARS coronavirus, the virus originated most likely in bats. It probably jumped into civets or humans and in that context, set up a transmission cycle between and raccoon dogs and marketplaces and humans, who frequented those marketplaces.
Over time, it selected for strains that were more efficient at infecting cells in recognizing the human ACE2 receptor for docking and entry leading to the 20,022,003 epidemic Which caused about 8,000 cases and 800 deaths. Now, if you do phylogenetic analysis of the isolates that were sequenced, You find they fall into 2 broad categories. These, this line indicates the strains underneath that line were identified during the epidemic and you have early phase isolates, primarily of January 2003, after a variety of super spreading events. You had middle phase isolates shown here by this group of isolates, and then following an infected physician who came to Hong Kong And resulted in a super spreading event that transmitted the virus to the rest of the world. These were considered late phase isolates.
A vast pool of heterogeneous zoonotic strains, however, reside up here. Most of these, or in fact, none of these, were ever actually successfully cultured. They We exist as sequence signatures in silico. So, one of the immediate goals that we became interested in During the outbreak was to develop a platform of viruses that captured the heterogeneity that exists within the family of viruses. And to do that, we identified sort of representative strains, for example, early phase isolate, or VONI, we had in the lab.
Middle phase isolates were CHKW1, GZ02, those are early phase isolate, animal isolates like from civets, FC16, and HCFC6 One hundred and three, a raccoon dog isolate which is shown down here, a sporadic 2004 human case, GDO3, and a couple of other viruses sequences were identified as good candidates that would capture all the diversity that had been identified within the sequence pool. This shows the sequence that is the sequence variation within the spike glycoprotein. If it's a blue box amino acid, that's an animal associated residue. Early phase changes are shown here in yellow, middle phase changes shown in orange, and late phase changes shown in red. In addition, in 2004, there are a variety of other animal strains as sporadic human cases were identified that had additional variations shown here in white.
It's interesting as much of the variation actually falls within residues or regions that neutralizing epitopes were identified. And in fact, although the number of residues that are changed aren't that great, you can actually reduce neutralization titers by about 20 fold with some of these variants. Now importantly, Farzan's group showed that the 2 key changes during the epidemic were this lysine to asparagine change at and a serine three-nine change at 487 that drove animal adaptation to human strain. And so, keep that in mind. So without access to this pool of strains, we decided to synthesize basically A portfolio of spike glycoprotein genes of about 4 kV each and then use a molecular clone For the urbani epidemic strain that we build in the lab, basically replacing the urbani spike 1 at a time with these various spike like proteins from different phases of the epidemic.
Now, all of these viruses were viable except for the SC 16 variant. This actually can't recognize the human ACE receptor, so it didn't grow, Until we made mouse cells that constitutively expressed the civetase 2 receptor and once we did that, this virus could grow well. Before we had those cells, Since Farzan had identified this 4/79 change as the key residue change, we actually build a recombinant virus with that change and that virus could be cultured. Interestingly enough, 2 of these, the GZ02 and the HCFC 6103 viruses, Actually cause lethal infection in aged animals. They produce an ARDS like disease.
SARS caused ARDS in humans, predominantly in aged populations. That's acute respiratory distress syndrome. It's a clinically devastating end stage lung disease with about a 50% mortality rate. So these are actually some of the first real good animal models for SARS infection. Now, These viruses replicate the human epidemic strains replicate efficiently in human airway epithelial cultures.
These are cultures that are derived from cells lining the trachea of transplant Plantations, you can actually culture them on liquid air interfaces and they take on the architecture of the human airway. SARS, Coronavirus, all the epidemic strains actually like to infect ciliated cells and these epidemic strains replicate very efficiently. The animal strains, however, do not. And this is just some fluorescent microscope images showing the cilia Of the ciliated cells with expression of the SARS nucleocapsid protein from an epidemic strain on the ciliated cells And the zoonotic strains, SC16 and the HCSC 16103, can't replicate. However, If you passage these viruses on human airway cells and culture, you can actually rapidly select out variants that can replicate efficiently in human airways.
Those viruses actually do not contain the mutations that would be had been predicted by Mike Farzan as being, Which were clearly responsible for the 20,022,003 epidemic. Rather, we saw changes At positions 442 and 472 and 479 that mediated the cross species transmission event. So in reality, we've done this a couple of times. There's actually several pathways by which the zoonotic SARS could actually adapt and recognize the human ACE receptor. What's interesting is that the epidemic strains actually efficiently use both the human ACE receptor and the civet ACE receptor.
When we in vitro select for human adaptive strains on human airway culture, they actually lose the ability to recognize the civet receptors. What this data suggests to us actually is that SARS had existed in a transmission cycle between humans and civets actually probably several years prior to the 20,022,003 epidemic, allowing the virus to gain the capacity to recognize both receptors. Okay. So those are the easy ones to do. Oh, the application.
So now that we had a large panel of variant viruses, we could use those for therapeutic testing over vaccines. In this case, I'm going to show you an example of about 30 human monoclonal antibodies that were derived by Antonio Lanza Vecchia. If you take those 30 monoclonals and test their ability to neutralize all the strains that we've made in the laboratory, you find some that only neutralize your body, Some that neutralize all human strains, some that neutralize some civets but not all the animal strains, but you do end up with four antibodies that neutralize all strains that we have in our portfolio including the ones that were in vitro adapted on human airway cultures. Importantly, if you select for escape mutants, these antibodies select for changes in different locations of the receptor binding domain and in fact, 3 of them actually don't overlap. Yes 109, the 230 and the 227 Don't overlap and so these represent good therapeutic cocktails that would capture most of the diversity that exists in SARS and probably work in potential patients that would be infected during future epidemics, and these also actually protect young and aged animals from lethal infection.
Was a paper published by Barry Rock in a couple of papers. Now, the civet and the raccoon dog strains were the easy ones. The true reservoir for SARS is within bat population. So, if you look at a phylogenetic tree, The human strains are shown here in red, the civet strains, raccoon dog strains are shown in purple, but the real variation is within the bat strains. The reservoir, it's thought that these were probably the reservoir for the emergence of the virus.
Now, these are about 80% to 90% identical to SARS. They can't be cultured and they exist as sequence signatures in silico. There's also extensive variation through the replicase and elsewhere in the genome, so when we decided we were going to synthetically resurrect the entire virus. Now, before we start it, it's important to note this is a cryo EM reconstruction of the SARS glycoprotein spike. Notice that there are 3 receptor binding domains shown here in, with bubbles that actually engage the ACE2 receptor.
If look at the sequence, the receptor binding shown here in yellow, there's a large amount of sequence variation, especially Within the contact interface residues that engage the human ACE receptor. And in fact, there's only 4 of 13 contact interface residues that are retained in these fat strains, So we don't actually think it's going to use the human ACE receptor to get into cells. In fact, we think we're going to have a tough time culturing this virus. Now, it's important to note that the SARS RBD that was identified has been proposed by a couple of groups it may have been introduced by recombination processes from unknown strains that haven't yet been identified and that that led to the initial Cross species transmission events. Now, to get back to the issue of in silico sequences, they actually represent hypothetical viruses.
Most synthetic viruses that have been resurrected to this point, actually we knew that the sequence was infectious. In this case, we actually don't know which of the sequences in GenBank were infectious, if any. So, to do that, with an error rate in GenBank ranging About 1 to 500 to 1 to 10000, depending on who did the sequence. We had to do extensive bioinformatics analysis to identify what we thought was the likely consensus sequence. None of the strains that we actually saw we thought were completely correct.
Some of them had deletions in the sequence at the 5 prime end, so we had to Make some educated guess. The basic approach that we build coronaviruses using our molecular clone is shown here, With the SARS clone shown in blue, the clone is broken into 6, 5 kilobytes about 5 kilobytes pieces. Each piece is flanked by bagel 1 restriction endonucleate sites. These are class 2S restriction enzymes that recognize a palindromic sequence But cut and leave asymmetric ends. This allows, since these ends are asymmetric, They actually will not concatemorize like classic sticky ends left by restriction enzymes but rather they become directional.
So, if you end clone A with a bagel site that leaves 1 3 nucleotide overhang and the 5 prime end of the B fragment with the complementary 3 nucleotide overhang, They go together directly. You change different bagel sites at each piece and this allows them to assemble up into 30 kilobytes chromosomes, Like Tinkertoys. Now, the synthetic bat genome that we made using Blue Heron and Bio Basic Basically, it's interchangeable with the urbionic clone. The only real difference was that we broke the F fragment into 2 pieces, so that we could play with the receptor binding domain easily if this thing didn't turn out to be infectious. And in fact, we made this Cloned, we built the full on c DNA, we drove transcripts, electropated that into cells and we can see evidence of replication by the synthesis of sub genomic messenger RNA, But we couldn't culture the virus and we couldn't pass it from cell to cell.
Clearly, there was probably a defect in entry. To solve that problem, We used literature data that has suggested that RBD domains of coronaviruses may be interchangeable between species. So we took the human, Yerboni epidemic receptor binding domain, that's 2 10 amino acids in length, and dropped that into the bat genome backbone, producing a chimera with the receptor binding domain driven from the epidemic strains. Now, when we built that clone, drove transcripts and electroporated that into cells, we got a virus that could replicate quite efficiently. This is just some growth curve data showing, I think, the black box is the Serbani wild type and the white Circles are open.
Open symbols are the bat viruses. You can see they replicate exactly as good as the urbani epidemic strain At low and high multiplicities of infection, they recognize the human ACE2 receptor in DVT cells at low and high multiplicity infections and grow just like the epidemic strains and they also retain the ability to use the cividase two receptor, just like the epidemic strains at low and high multiplicity. They also are capable of infecting human airway epithelial cultures and targeting ciliated cells just like the epidemic strain and they grow to similar titer. Now, if you make anisura just against the bat spike like a protein and use that anti sera to target the SARS wild type virus, it will not neutralize that virus. So clearly, Antisera and vaccines derived against epidemic strains are not going to protect against the bat strain.
If you use that same sera against the RBD chimeric virus, You can neutralize it indicating that there are neutralizing episodes that exist outside the RBDs and if you take the human monoclonals that target the epidemic train RBDs, you can neutralize these viruses quite efficiently. So, in summary, Certainly, synthetic genomics and reverse genetics can be a platform to recover uncultivatable zoonotic precursors, can be used to synthesize this is actually the largest synthetic virus to date. It's going to be a short record, but it is a record. And you can use it now to identify broad spectrum antivirals and vaccines. Clearly, the RBDs are interchangeable.
This is with an 89% amino acid identity within the spike. It's the minimal domain required to host shift coronaviruses. What is the phylogenetic limits to RBD interchange? We actually don't know. Clearly, the human monoclonal and vaccines targeting the SARS RBD would provide protective immunity against natural isolates that emerge by recombinatorial processes in the future or, unfortunately, by deliberate design.
Now, I want to move to the next part of the talk, which is synthetic de optimization schemes to attenuate SARS coronavirus pathogenesis. This is the maturation pathway for how SARS gets out of the cell. The nucleocapsids align underneath an intermediate compartment in the rough ER Golgi Where the M glycoprotein and the E protein are expressed and then these the M and the E protein actually drive the assembly of virions, Which then mature in the Golgi and then are released in the cell and secretory vesicles, which fuse with the plasma membrane. Now, if you knock out E protein expression, this pathway is still viable but you reduce virus yields by about 2 logs And if you knock out the M glycoprotein expression or M and A together, you don't make any virus progeny. So, our approach to deoptimize SARS, coronavirus, The SARS coronavirus genome and to attenuate pathogenesis focused primarily on the E and the M glycoprotein genes, it's about 3 50 amino acids in total.
The strategy we used was to progressively increase the number of de optimized codons. So we started with serine to produce a D SER virus, Serine Leucine Argines to produce the SLR deoptimized strain or a 5 set DSLRVA strain. Basically, the idea is you create a rheostat Well, you're increasing the number of de optimized residues and turning down expression of critical proteins needed for release. This is just a cartoon to show the amino acid sequence and the wild type virus sequence here, so like in the three set At the serine residue, which was optimal in the case of SARS, we just changed it to the most rare codon. If you look at the statistics here, in general, in the wild type E and M gene, there are about 39 Codons that are de optimized.
In the one set, this increased to 52 the 3 set, 94 and the 5 set, 134. We also looked at the CPV values that Eckert just talked about. By these values, these are very minimally on the negative side of the codon pair usage. We also made random controls where we scrambled the codon usage much like Eckert did, retaining the wild type genome organization levelers and we made 3 set and the 5 set. This is, we made these in a mouse adapted background so they'd be pathogenic in mice.
Mouse adapted growth is shown here In black, the blue lines show the serine de optimized viruses which also reach high titers by about 24 hours post infection. If you look at the 3 set mutants, however, you see about a log, log and a half reduction as compared to wild type. The 3 set randomized virus and the 5 set randomized virus in this case, I'm showing 2 different plaques in the 5 set randomized viruses grew just about like wild type. Just like Eckerd had reported, if you randomize the sequence, it really has very little impact on replication, but the optimization does affect Final yield. Now, in contrast to what Eckhard talked about, we actually de optimized in the middle of The downstream, which would potentially affect critical sequences that would affect RNA synthesis.
We're very careful not to knock out any known Sequences, regulatory sequences that make messenger RNA. However, both the serine and the SLR mutant knocked out messenger RNA six expression, which can see right here, these actually were the messages, the genes, the messages that encode the genes that we de optimized And so, we actually found some evidence of long range protein RNA RNA interactions that are regulatory elements that we're trying to decipher. The 5 set de optimized strains showed no CPE in culture. If you develop primers to the 5 prime end of the genome and a leader sequence A primer down here in message 6 that encodes ORF 6. You can actually identify leader containing transcripts, which signatures of the messenger RNAs that are made during infected cells.
In these cultures, you can see evidence of message 7, I'm sorry, message 6, 5, 4, and 3. This is at day 1 post transfection. Even by day 10, you can still see these transcripts infected Cells and they continue at that level with about 5 passages at 5 day intervals. But you actually never can actually see a virus. You can never plaque a virus.
You can never actually show a virus as they're producing CPE. So, 5 set de optimizations really down regulated the production of infectious virions And the ability of these viruses to produce a significant amount of CPE. We can get around this probably by expressing helper cells that make the M gene, but we haven't done that yet. Now, we've looked at the pathogenesis of these isolates in mice. In this case, we're infecting with about 10 LD50.
The mouse adapted Wild type current strain kills the animals in about 4 days from severe Pneumonia? The serine de optimized viruses actually are almost as pathogenic. There's a slight delay in loss of body mass, but all the animals eventually die. The SLR randomized viruses are also pathogenic but again, slightly less pathogenic than the wild type virus. There are some survivors but most animals die.
The 5 set randomized viruses are again slightly less pathogenic, several animals die but there are survivors. But the 3 set de optimized viruses, none of the animals died. There was transient weight loss and the animals recovered. Virus titers within the mice were actually about the same with the wild type, the single de optimized codon, or the 3 set de optimized codon viruses. Okay.
So, our data certainly is in agreement with Eckert's work that suggests that the optimization or strategies to Down regulate translation of viral genes could function as a universal approach to attenuate pathogenesis. In the case of coronas, we can identify novel transcription regulatory sequences that we didn't know exist, we're trying to decipher that, and these are likely very stable. However, in the case of coronaviruses and polioviruses, These are both susceptible to recombination repair and so we needed a strategy to get around that. And so, that is actually the last part of my talk, which should take a couple of minutes, in which we devise strategies to alter the transcription circuits of coronaviruses. Now, remember I said in the case Wild type SARS, these red box elements are absolutely essential to make sub genomic messenger RNAs.
If the leader RNA red box element Can't communicate with these body red box elements, this virus is dead. So, we asked a couple of questions. Can we change the regulatory circuits? Can we redesign them? If we redesign them, will it act as a genetic trap that will cause lethal genome incompatibilities following recombination And what's the impact of the new circuits on pathogenesis?
So we made 2 viruses called here CRG and CNG. In the case of the CRG virus, we took this red box element virus and converted it to a blue box element virus by introducing 3 changes at each of these positions. We also made a green box virus that had a completely different TRS regulatory element each of these locations. Now, these viruses were viable. They grow to 10 to the 7th.
They're small plaquemines but they grow just as well as wild type and they produce all the appropriate sub genomic messenger RNAs and if you're interested, take a look at this paper. So, the answer is yes. Does it affect recombination repair? The answer is yes. That's also in that paper.
I don't have time to go through the data. The idea is if a recombination event occurs, you end up with viruses with Rambled regulatory elements. So the red box elements can't communicate with the blue box elements and the virus dies. So, it's a genetic trap and it's triggered after recombination repair. So, how does this affect pathogenesis?
Now, this is young 10 week old animals infected with the mouse adapted virus or wild type SARS. SARS just replicates in mice, it produces There's no disease in young animals. The mouse adapted strain causes a lethal disease within 4 days. We put the CRG in both backgrounds. In the wild type background, again, we see no weight loss in the animals or death.
In the mouse adapted strain, when you introduce CRG regulatory the new regulatory network, you completely attenuate pathogenesis. You look at virus titers, however, virus titers in young animals are pretty much similar to the parent strain. It actually challenges a current sort of an existing paradigm in virology that to attenuate pathogenesis, you have to knock down replication and that's not the case We also looked in old animals. In the case of old animals, the MA15 virus kills the animals in about 3 days. SARS produces a transient weight loss of about 5% and the animals recover.
In this case, CRG produced no weight loss compared to the SARS parent. In the lethal genetic genome backbone, we saw more extensive weight loss in the older animals. These are 1 year old animals, But all the animals recover. Occasionally, we lose an animal. And again, the virus replicated efficiently in these animals.
So, we think that rewiring the regulatory network of a virus can attenuate pathogenesis because it function as a vaccine. So, we infected young animals and old animals with either the CRG parental virus, A alpha virus encoding the SARS spike or with PBS. We vaccinated them one time, waited 28 days and then challenged them with either a lethal homologous strain or a heterologous strain. You can see that with PBS, all the animals succumb by day 4. In the single vaccinated alpha virus vaccine encoding the SARS spike, you see morbidity, Very little mortality and the animals recover.
There is a lot of virus and a lot of pathology in the lungs. The HCSC 6103 virus is only lethal and only produces disease These in old animals and young animals that just replicated, but not within the CRG. It did replicate some in the VRPS. Now, in the older animals, You can see that the vaccine cocktails via the alpha virus vaccines and PVS, the animals died with homologous and with the heterologous challenge And again, the live attenuated rewired viruses protected advanced both. So, in summary, transcription A circuit redesign can attenuate coronavirus pathogenesis.
We actually think it should function as a universal platform To attenuate current and future emerging coronaviruses of the future. It also protects the ranks from combination repair mechanisms. You can blend this with codon D optimization, to really provide a good strategy to make live attenuated viruses. They protect young and old animals. Since SARS targeted elderly populations, this is currently the only vaccine that works in this population.
Vaccines don't. And, I think the combination of synthetic genomics and family specific universal attenuation scheme Can achieve a goal of rapidly producing candidate live virus vaccines within about 2 weeks of identifying the sequence of the newly emerging pathogens. So the people that did this work included Boyd Yant, Barry Rocks, Damon Deming, Eric Donaldson, Tim Sheehan, And Matt Freeman. So thank you.
@KimDotcom - Kim Dotcom
Listen to Ralph Baric, the creator of Covid-19, about the science behind synthetically created viruses and how to make them more pathogenic. The US Govt funded his illegal bioweapon research at the Wuhan lab. It killed more people than the Nazi holocaust.
Video Transcript AI Summary
Ralph Barrick from the University of North Carolina discusses synthetic genomics of SARS. He explains the structure and genome organization of the SARS coronavirus and its various proteins. Barrick then discusses the use of synthetic genomics as a platform to control emerging infectious diseases, particularly focusing on SARS. He explains the process of synthesizing a portfolio of spike glycoprotein genes to capture the heterogeneity of the virus. Barrick also discusses the use of synthetic deoptimization schemes to attenuate SARS pathogenesis and the rewiring of SARS coronavirus transcription circuits to further attenuate viral pathogenesis. He concludes by highlighting the potential of synthetic genomics and universal attenuation schemes for developing rapid response platforms and vaccines against emerging coronaviruses.
Full Transcript
Speaker 0: We're going to have here from Ralph Barrick, from the University of North Carolina who's going to tell us about synthetic genomics of SARS. So I also would like to thank the organizers for inviting me to talk. It's been a wonderful venue and a real pleasure to be here and capture some new ideas that can be tried out on viruses. So the general themes that I'm going to talk about today are basic, short introduction into, SARS biology, Talk about the synthetic resurrection and reconstruction of a variety of zoonotic SARS viruses and their applications in therapeutics and vaccine design. I'll also touch on codon de optimization as a way to attenuate SARS pathogenesis but I certainly haven't gone to the depth of studies that Eckert's group has done.
And then I'll talk about rewiring SARS coronavirus transcription circuits as a way, universal strategy, to attenuate viral pathogenesis. So this is a schematic diagram of the SARS coronavirus particle. It's about a 100 nanometers in diameter. It contains a Helical nucleocapsid inside. It contains a single stranded plus polarity RNA genome.
This nucleocapsid structure is surrounded by a lipid bilayer It contains several viral glycoprotein spikes. The important ones for today's talk include the M glycoprotein and the E protein, which are shown right here. These proteins are absolutely essential for maturation and release and the production of virus particles, So keep that in mind. The 2nd viral protein of interest for today's talk is the Escalica protein gene, as shown right here, which gives the virus its unique appearance from the electron microscope. It's, the viral attachment protein that binds to the receptor to mediate docking and entry into the cells.
It's involved it regulates tissue tropism, species specificity. It contains a large number of important neutralizing epitopes, and it's the principal component of Now, if you tear this virus particle apart and look at the viral genomic positive stranded RNA, it's about 30,000 base pairs in length. They're the largest plus polarity RNA genomes in nature. The first 20,000 base pairs are so encoded to replicate proteins whose job it is to replicate the genome and express sub genomic messenger RNA that encode these downstream open reading frames. So the genome organization of coronas are quite different than polioviruses, which you've just heard about.
Now, these downstream morphs encode Structural genes like the SEM and nucleocapsid protein that I just mentioned that were present in the Vireon and a variety of accessory or To get these expressed in cells, you find a nested set of sub genomic messenger RNA arranged from the three prime end of the genome so that all the sequences in the smallest message are in the next largest message and so on and so forth. This organization allows different open reading frames to be placed at the 5 prime ends of different messenger RNAs So they can be efficiently translated and expressed themselves. Now the transcription strategy of these viruses are unique And in fact, each messenger RNA contains a leader sequence of about 70 nucleotides shown here as these little blue boxes that is derived from the 5 prime end of the genome. So these are discontinuous stretches of RNA that are joined during transcription And these little red box elements right here are absolutely essential for mediating the joining of these 2 sequences. This will become very important later on in the talk so keep the concept of TRS elements, little red box elements, As being essential for regulation of messenger RNA synthesis.
Now, we'll talk about synthetic genomics in the context Of a platform to control emerging infectious diseases. If you think about emerging viruses, they have tremendous potential to cause high morbidity and mortality And severe economic hardship. Good examples are HIV, the 1918 flu, SARS coronavirus, H5N1, chikungunya virus probably most recently. Now it's clear that zoonotic introductions are increasing and a large number of these viruses have large reservoir pools of animal strains Like SARS and H5 that are maintained as sort of heterogeneous swarms of pools of viruses of which someone may actually emerge in the future to cause endemic disease in humans. This raises a conundrum in terms of how do you protect the public health against a future occurrence that is hard to predict, How do you develop drugs and therapeutics against an unknown from this heterogeneous swarm of variant strains that will actually work against the unknown that will emerge in the future?
How do you target your scarce resources? And so we think platform technologies like synthetic biology, phylogenomic, structure modeling, high throughput sequencing really will provide a platform and our goal is to use SARS coronavirus and its large pool of zoonotic viruses as the model Develop rapid response platforms to protect against this broader heterogeneous pool of variants. We also would like to develop that would attenuate all family members so that you could rapidly develop vaccines for the public, overall public health. Now, a lot of beautiful work in Malik's lab as well as other labs here in China, worked out the basic molecular epidemiology of SARS coronavirus, the virus originated most likely in bats. It probably jumped into civets or humans and in that context, set up a transmission cycle between and raccoon dogs and marketplaces and humans, who frequented those marketplaces.
Over time, it selected for strains that were more efficient at infecting cells in recognizing the human ACE2 receptor for docking and entry leading to the 20,022,003 epidemic Which caused about 8,000 cases and 800 deaths. Now, if you do phylogenetic analysis of the isolates that were sequenced, You find they fall into 2 broad categories. These, this line indicates the strains underneath that line were identified during the epidemic and you have early phase isolates, primarily of January 2003, after a variety of super spreading events. You had middle phase isolates shown here by this group of isolates, and then following an infected physician who came to Hong Kong And resulted in a super spreading event that transmitted the virus to the rest of the world. These were considered late phase isolates.
A vast pool of heterogeneous zoonotic strains, however, reside up here. Most of these, or in fact, none of these, were ever actually successfully cultured. They We exist as sequence signatures in silico. So, one of the immediate goals that we became interested in During the outbreak was to develop a platform of viruses that captured the heterogeneity that exists within the family of viruses. And to do that, we identified sort of representative strains, for example, early phase isolate, or VONI, we had in the lab.
Middle phase isolates were CHKW1, GZ02, those are early phase isolate, animal isolates like from civets, FC16, and HCFC6 One hundred and three, a raccoon dog isolate which is shown down here, a sporadic 2004 human case, GDO3, and a couple of other viruses sequences were identified as good candidates that would capture all the diversity that had been identified within the sequence pool. This shows the sequence that is the sequence variation within the spike glycoprotein. If it's a blue box amino acid, that's an animal associated residue. Early phase changes are shown here in yellow, middle phase changes shown in orange, and late phase changes shown in red. In addition, in 2004, there are a variety of other animal strains as sporadic human cases were identified that had additional variations shown here in white.
It's interesting as much of the variation actually falls within residues or regions that neutralizing epitopes were identified. And in fact, although the number of residues that are changed aren't that great, you can actually reduce neutralization titers by about 20 fold with some of these variants. Now importantly, Farzan's group showed that the 2 key changes during the epidemic were this lysine to asparagine change at and a serine three-nine change at 487 that drove animal adaptation to human strain. And so, keep that in mind. So without access to this pool of strains, we decided to synthesize basically A portfolio of spike glycoprotein genes of about 4 kV each and then use a molecular clone For the urbani epidemic strain that we build in the lab, basically replacing the urbani spike 1 at a time with these various spike like proteins from different phases of the epidemic.
Now, all of these viruses were viable except for the SC 16 variant. This actually can't recognize the human ACE receptor, so it didn't grow, Until we made mouse cells that constitutively expressed the civetase 2 receptor and once we did that, this virus could grow well. Before we had those cells, Since Farzan had identified this 4/79 change as the key residue change, we actually build a recombinant virus with that change and that virus could be cultured. Interestingly enough, 2 of these, the GZ02 and the HCFC 6103 viruses, Actually cause lethal infection in aged animals. They produce an ARDS like disease.
SARS caused ARDS in humans, predominantly in aged populations. That's acute respiratory distress syndrome. It's a clinically devastating end stage lung disease with about a 50% mortality rate. So these are actually some of the first real good animal models for SARS infection. Now, These viruses replicate the human epidemic strains replicate efficiently in human airway epithelial cultures.
These are cultures that are derived from cells lining the trachea of transplant Plantations, you can actually culture them on liquid air interfaces and they take on the architecture of the human airway. SARS, Coronavirus, all the epidemic strains actually like to infect ciliated cells and these epidemic strains replicate very efficiently. The animal strains, however, do not. And this is just some fluorescent microscope images showing the cilia Of the ciliated cells with expression of the SARS nucleocapsid protein from an epidemic strain on the ciliated cells And the zoonotic strains, SC16 and the HCSC 16103, can't replicate. However, If you passage these viruses on human airway cells and culture, you can actually rapidly select out variants that can replicate efficiently in human airways.
Those viruses actually do not contain the mutations that would be had been predicted by Mike Farzan as being, Which were clearly responsible for the 20,022,003 epidemic. Rather, we saw changes At positions 442 and 472 and 479 that mediated the cross species transmission event. So in reality, we've done this a couple of times. There's actually several pathways by which the zoonotic SARS could actually adapt and recognize the human ACE receptor. What's interesting is that the epidemic strains actually efficiently use both the human ACE receptor and the civet ACE receptor.
When we in vitro select for human adaptive strains on human airway culture, they actually lose the ability to recognize the civet receptors. What this data suggests to us actually is that SARS had existed in a transmission cycle between humans and civets actually probably several years prior to the 20,022,003 epidemic, allowing the virus to gain the capacity to recognize both receptors. Okay. So those are the easy ones to do. Oh, the application.
So now that we had a large panel of variant viruses, we could use those for therapeutic testing over vaccines. In this case, I'm going to show you an example of about 30 human monoclonal antibodies that were derived by Antonio Lanza Vecchia. If you take those 30 monoclonals and test their ability to neutralize all the strains that we've made in the laboratory, you find some that only neutralize your body, Some that neutralize all human strains, some that neutralize some civets but not all the animal strains, but you do end up with four antibodies that neutralize all strains that we have in our portfolio including the ones that were in vitro adapted on human airway cultures. Importantly, if you select for escape mutants, these antibodies select for changes in different locations of the receptor binding domain and in fact, 3 of them actually don't overlap. Yes 109, the 230 and the 227 Don't overlap and so these represent good therapeutic cocktails that would capture most of the diversity that exists in SARS and probably work in potential patients that would be infected during future epidemics, and these also actually protect young and aged animals from lethal infection.
Was a paper published by Barry Rock in a couple of papers. Now, the civet and the raccoon dog strains were the easy ones. The true reservoir for SARS is within bat population. So, if you look at a phylogenetic tree, The human strains are shown here in red, the civet strains, raccoon dog strains are shown in purple, but the real variation is within the bat strains. The reservoir, it's thought that these were probably the reservoir for the emergence of the virus.
Now, these are about 80% to 90% identical to SARS. They can't be cultured and they exist as sequence signatures in silico. There's also extensive variation through the replicase and elsewhere in the genome, so when we decided we were going to synthetically resurrect the entire virus. Now, before we start it, it's important to note this is a cryo EM reconstruction of the SARS glycoprotein spike. Notice that there are 3 receptor binding domains shown here in, with bubbles that actually engage the ACE2 receptor.
If look at the sequence, the receptor binding shown here in yellow, there's a large amount of sequence variation, especially Within the contact interface residues that engage the human ACE receptor. And in fact, there's only 4 of 13 contact interface residues that are retained in these fat strains, So we don't actually think it's going to use the human ACE receptor to get into cells. In fact, we think we're going to have a tough time culturing this virus. Now, it's important to note that the SARS RBD that was identified has been proposed by a couple of groups it may have been introduced by recombination processes from unknown strains that haven't yet been identified and that that led to the initial Cross species transmission events. Now, to get back to the issue of in silico sequences, they actually represent hypothetical viruses.
Most synthetic viruses that have been resurrected to this point, actually we knew that the sequence was infectious. In this case, we actually don't know which of the sequences in GenBank were infectious, if any. So, to do that, with an error rate in GenBank ranging About 1 to 500 to 1 to 10000, depending on who did the sequence. We had to do extensive bioinformatics analysis to identify what we thought was the likely consensus sequence. None of the strains that we actually saw we thought were completely correct.
Some of them had deletions in the sequence at the 5 prime end, so we had to Make some educated guess. The basic approach that we build coronaviruses using our molecular clone is shown here, With the SARS clone shown in blue, the clone is broken into 6, 5 kilobytes about 5 kilobytes pieces. Each piece is flanked by bagel 1 restriction endonucleate sites. These are class 2S restriction enzymes that recognize a palindromic sequence But cut and leave asymmetric ends. This allows, since these ends are asymmetric, They actually will not concatemorize like classic sticky ends left by restriction enzymes but rather they become directional.
So, if you end clone A with a bagel site that leaves 1 3 nucleotide overhang and the 5 prime end of the B fragment with the complementary 3 nucleotide overhang, They go together directly. You change different bagel sites at each piece and this allows them to assemble up into 30 kilobytes chromosomes, Like Tinkertoys. Now, the synthetic bat genome that we made using Blue Heron and Bio Basic Basically, it's interchangeable with the urbionic clone. The only real difference was that we broke the F fragment into 2 pieces, so that we could play with the receptor binding domain easily if this thing didn't turn out to be infectious. And in fact, we made this Cloned, we built the full on c DNA, we drove transcripts, electropated that into cells and we can see evidence of replication by the synthesis of sub genomic messenger RNA, But we couldn't culture the virus and we couldn't pass it from cell to cell.
Clearly, there was probably a defect in entry. To solve that problem, We used literature data that has suggested that RBD domains of coronaviruses may be interchangeable between species. So we took the human, Yerboni epidemic receptor binding domain, that's 2 10 amino acids in length, and dropped that into the bat genome backbone, producing a chimera with the receptor binding domain driven from the epidemic strains. Now, when we built that clone, drove transcripts and electroporated that into cells, we got a virus that could replicate quite efficiently. This is just some growth curve data showing, I think, the black box is the Serbani wild type and the white Circles are open.
Open symbols are the bat viruses. You can see they replicate exactly as good as the urbani epidemic strain At low and high multiplicities of infection, they recognize the human ACE2 receptor in DVT cells at low and high multiplicity infections and grow just like the epidemic strains and they also retain the ability to use the cividase two receptor, just like the epidemic strains at low and high multiplicity. They also are capable of infecting human airway epithelial cultures and targeting ciliated cells just like the epidemic strain and they grow to similar titer. Now, if you make anisura just against the bat spike like a protein and use that anti sera to target the SARS wild type virus, it will not neutralize that virus. So clearly, Antisera and vaccines derived against epidemic strains are not going to protect against the bat strain.
If you use that same sera against the RBD chimeric virus, You can neutralize it indicating that there are neutralizing episodes that exist outside the RBDs and if you take the human monoclonals that target the epidemic train RBDs, you can neutralize these viruses quite efficiently. So, in summary, Certainly, synthetic genomics and reverse genetics can be a platform to recover uncultivatable zoonotic precursors, can be used to synthesize this is actually the largest synthetic virus to date. It's going to be a short record, but it is a record. And you can use it now to identify broad spectrum antivirals and vaccines. Clearly, the RBDs are interchangeable.
This is with an 89% amino acid identity within the spike. It's the minimal domain required to host shift coronaviruses. What is the phylogenetic limits to RBD interchange? We actually don't know. Clearly, the human monoclonal and vaccines targeting the SARS RBD would provide protective immunity against natural isolates that emerge by recombinatorial processes in the future or, unfortunately, by deliberate design.
Now, I want to move to the next part of the talk, which is synthetic de optimization schemes to attenuate SARS coronavirus pathogenesis. This is the maturation pathway for how SARS gets out of the cell. The nucleocapsids align underneath an intermediate compartment in the rough ER Golgi Where the M glycoprotein and the E protein are expressed and then these the M and the E protein actually drive the assembly of virions, Which then mature in the Golgi and then are released in the cell and secretory vesicles, which fuse with the plasma membrane. Now, if you knock out E protein expression, this pathway is still viable but you reduce virus yields by about 2 logs And if you knock out the M glycoprotein expression or M and A together, you don't make any virus progeny. So, our approach to deoptimize SARS, coronavirus, The SARS coronavirus genome and to attenuate pathogenesis focused primarily on the E and the M glycoprotein genes, it's about 3 50 amino acids in total.
The strategy we used was to progressively increase the number of de optimized codons. So we started with serine to produce a D SER virus, Serine Leucine Argines to produce the SLR deoptimized strain or a 5 set DSLRVA strain. Basically, the idea is you create a rheostat Well, you're increasing the number of de optimized residues and turning down expression of critical proteins needed for release. This is just a cartoon to show the amino acid sequence and the wild type virus sequence here, so like in the three set At the serine residue, which was optimal in the case of SARS, we just changed it to the most rare codon. If you look at the statistics here, in general, in the wild type E and M gene, there are about 39 Codons that are de optimized.
In the one set, this increased to 52 the 3 set, 94 and the 5 set, 134. We also looked at the CPV values that Eckert just talked about. By these values, these are very minimally on the negative side of the codon pair usage. We also made random controls where we scrambled the codon usage much like Eckert did, retaining the wild type genome organization levelers and we made 3 set and the 5 set. This is, we made these in a mouse adapted background so they'd be pathogenic in mice.
Mouse adapted growth is shown here In black, the blue lines show the serine de optimized viruses which also reach high titers by about 24 hours post infection. If you look at the 3 set mutants, however, you see about a log, log and a half reduction as compared to wild type. The 3 set randomized virus and the 5 set randomized virus in this case, I'm showing 2 different plaques in the 5 set randomized viruses grew just about like wild type. Just like Eckerd had reported, if you randomize the sequence, it really has very little impact on replication, but the optimization does affect Final yield. Now, in contrast to what Eckhard talked about, we actually de optimized in the middle of The downstream, which would potentially affect critical sequences that would affect RNA synthesis.
We're very careful not to knock out any known Sequences, regulatory sequences that make messenger RNA. However, both the serine and the SLR mutant knocked out messenger RNA six expression, which can see right here, these actually were the messages, the genes, the messages that encode the genes that we de optimized And so, we actually found some evidence of long range protein RNA RNA interactions that are regulatory elements that we're trying to decipher. The 5 set de optimized strains showed no CPE in culture. If you develop primers to the 5 prime end of the genome and a leader sequence A primer down here in message 6 that encodes ORF 6. You can actually identify leader containing transcripts, which signatures of the messenger RNAs that are made during infected cells.
In these cultures, you can see evidence of message 7, I'm sorry, message 6, 5, 4, and 3. This is at day 1 post transfection. Even by day 10, you can still see these transcripts infected Cells and they continue at that level with about 5 passages at 5 day intervals. But you actually never can actually see a virus. You can never plaque a virus.
You can never actually show a virus as they're producing CPE. So, 5 set de optimizations really down regulated the production of infectious virions And the ability of these viruses to produce a significant amount of CPE. We can get around this probably by expressing helper cells that make the M gene, but we haven't done that yet. Now, we've looked at the pathogenesis of these isolates in mice. In this case, we're infecting with about 10 LD50.
The mouse adapted Wild type current strain kills the animals in about 4 days from severe Pneumonia? The serine de optimized viruses actually are almost as pathogenic. There's a slight delay in loss of body mass, but all the animals eventually die. The SLR randomized viruses are also pathogenic but again, slightly less pathogenic than the wild type virus. There are some survivors but most animals die.
The 5 set randomized viruses are again slightly less pathogenic, several animals die but there are survivors. But the 3 set de optimized viruses, none of the animals died. There was transient weight loss and the animals recovered. Virus titers within the mice were actually about the same with the wild type, the single de optimized codon, or the 3 set de optimized codon viruses. Okay.
So, our data certainly is in agreement with Eckert's work that suggests that the optimization or strategies to Down regulate translation of viral genes could function as a universal approach to attenuate pathogenesis. In the case of coronas, we can identify novel transcription regulatory sequences that we didn't know exist, we're trying to decipher that, and these are likely very stable. However, in the case of coronaviruses and polioviruses, These are both susceptible to recombination repair and so we needed a strategy to get around that. And so, that is actually the last part of my talk, which should take a couple of minutes, in which we devise strategies to alter the transcription circuits of coronaviruses. Now, remember I said in the case Wild type SARS, these red box elements are absolutely essential to make sub genomic messenger RNAs.
If the leader RNA red box element Can't communicate with these body red box elements, this virus is dead. So, we asked a couple of questions. Can we change the regulatory circuits? Can we redesign them? If we redesign them, will it act as a genetic trap that will cause lethal genome incompatibilities following recombination And what's the impact of the new circuits on pathogenesis?
So we made 2 viruses called here CRG and CNG. In the case of the CRG virus, we took this red box element virus and converted it to a blue box element virus by introducing 3 changes at each of these positions. We also made a green box virus that had a completely different TRS regulatory element each of these locations. Now, these viruses were viable. They grow to 10 to the 7th.
They're small plaquemines but they grow just as well as wild type and they produce all the appropriate sub genomic messenger RNAs and if you're interested, take a look at this paper. So, the answer is yes. Does it affect recombination repair? The answer is yes. That's also in that paper.
I don't have time to go through the data. The idea is if a recombination event occurs, you end up with viruses with Rambled regulatory elements. So the red box elements can't communicate with the blue box elements and the virus dies. So, it's a genetic trap and it's triggered after recombination repair. So, how does this affect pathogenesis?
Now, this is young 10 week old animals infected with the mouse adapted virus or wild type SARS. SARS just replicates in mice, it produces There's no disease in young animals. The mouse adapted strain causes a lethal disease within 4 days. We put the CRG in both backgrounds. In the wild type background, again, we see no weight loss in the animals or death.
In the mouse adapted strain, when you introduce CRG regulatory the new regulatory network, you completely attenuate pathogenesis. You look at virus titers, however, virus titers in young animals are pretty much similar to the parent strain. It actually challenges a current sort of an existing paradigm in virology that to attenuate pathogenesis, you have to knock down replication and that's not the case We also looked in old animals. In the case of old animals, the MA15 virus kills the animals in about 3 days. SARS produces a transient weight loss of about 5% and the animals recover.
In this case, CRG produced no weight loss compared to the SARS parent. In the lethal genetic genome backbone, we saw more extensive weight loss in the older animals. These are 1 year old animals, But all the animals recover. Occasionally, we lose an animal. And again, the virus replicated efficiently in these animals.
So, we think that rewiring the regulatory network of a virus can attenuate pathogenesis because it function as a vaccine. So, we infected young animals and old animals with either the CRG parental virus, A alpha virus encoding the SARS spike or with PBS. We vaccinated them one time, waited 28 days and then challenged them with either a lethal homologous strain or a heterologous strain. You can see that with PBS, all the animals succumb by day 4. In the single vaccinated alpha virus vaccine encoding the SARS spike, you see morbidity, Very little mortality and the animals recover.
There is a lot of virus and a lot of pathology in the lungs. The HCSC 6103 virus is only lethal and only produces disease These in old animals and young animals that just replicated, but not within the CRG. It did replicate some in the VRPS. Now, in the older animals, You can see that the vaccine cocktails via the alpha virus vaccines and PVS, the animals died with homologous and with the heterologous challenge And again, the live attenuated rewired viruses protected advanced both. So, in summary, transcription A circuit redesign can attenuate coronavirus pathogenesis.
We actually think it should function as a universal platform To attenuate current and future emerging coronaviruses of the future. It also protects the ranks from combination repair mechanisms. You can blend this with codon D optimization, to really provide a good strategy to make live attenuated viruses. They protect young and old animals. Since SARS targeted elderly populations, this is currently the only vaccine that works in this population.
Vaccines don't. And, I think the combination of synthetic genomics and family specific universal attenuation scheme Can achieve a goal of rapidly producing candidate live virus vaccines within about 2 weeks of identifying the sequence of the newly emerging pathogens. So the people that did this work included Boyd Yant, Barry Rocks, Damon Deming, Eric Donaldson, Tim Sheehan, And Matt Freeman. So thank you.
@DiedSuddenly_ - DiedSuddenly
Ralph Baric created Covid-19. He talks about the science behind synthetically created viruses and how to make them more pathogenic. The US Govt funded his illegal bio-weapon research at the Wuhan lab.
Video Transcript AI Summary
Ralph Barrick from the University of North Carolina discusses synthetic genomics of SARS in this video. He explains the structure of the SARS coronavirus particle and its important glycoprotein spikes. Barrick also discusses the synthetic resurrection and reconstruction of various zoonotic SARS viruses and their applications in therapeutics and vaccine design. He touches on codon deoptimization as a way to attenuate SARS pathogenesis and rewiring SARS coronavirus transcription circuits as a universal strategy to attenuate viral pathogenesis. Barrick concludes by discussing the potential of synthetic genomics and transcription circuit redesign as a platform to control emerging infectious diseases and develop rapid response platforms for future epidemics.
Full Transcript
Speaker 0: We're going to have here from Ralph Barrick from the University of North Carolina, who's going to tell us about synthetic genomics of SARS. So I also would like to thank the organizers for inviting me to talk. It's been a wonderful venue and a real pleasure to be here and capture some new ideas that can be tried out on viruses. So the general themes that I'm going to talk about today are basic, short introduction into, SARS biology, Talk about the synthetic resurrection and reconstruction of a variety of zoonotic SARS viruses and their applications in therapeutics and vaccine design. I'll also touch on codon de optimization as a way to attenuate SARS pathogenesis but I certainly haven't gone to the depth of studies that Eckert's group has done And then I'll talk about rewiring SARS coronavirus transcription circuits as a way, universal strategy, to attenuate viral pathogenesis.
So this is a schematic diagram of the SARS coronavirus particle. It's about a 100 nanometers in diameter. It contains a Helical nucleocapsid inside. It contains a single stranded plus polarity RNA genome. This nucleocapsid structure is surrounded by a lipid bilayer It contains several viral glycoprotein spikes.
The important ones for today's talk include the M glycoprotein and the E protein, which are shown right here. These proteins are absolutely essential for maturation and release and the production of virus particles, So keep that in mind. The 2nd viral protein of interest for today's talk is the escholica protein gene, as shown right here, which gives the virus its unique appearance in electron microscope. It's, the viral attachment protein that binds to the receptor to mediate docking and entry into the cells. It's involved it regulates tissue tropism, species specificity.
It contains a large number of important neutralizing epitopes and it's the principal component of Now, if you tear this virus particle apart and look at the viral genomic positive stranded RNA, it's about 30,000 base They're the largest plus polarity RNA genomes in nature. The first 20,000 base pairs are so encoded, the replicase proteins The job it is to replicate the genome and express sub genomic messenger RNA that encode these downstream open reading frames. So the genome organization of coronas are quite different than polioviruses, which you've just heard about. Now, these downstream Morse encodes the structural genes like the S, EM, a nucleocapsid protein that I just mentioned that were present in the virion and a variety of accessory Orfs. To get these expressed in cells, you find A nested set of sub genomic messenger RNA arranged from the three prime end of the genome so that all the sequences in the smallest message are in the next largest message and so on and so forth.
This organization allows different open reading frames to be placed at the 5 prime ends of different messenger RNAs So they can be efficiently translated and expressed themselves. Now, the transcription strategy of these viruses are unique And in fact, each messenger RNA contains a leader sequence of about 70 nucleotides shown here as these little blue boxes that is derived from the 5 prime end of the genome. So these are discontinuous stretches of RNA that are joined during transcription And these little red box elements right here are absolutely essential for mediating the joining of these 2 sequences. This will become very important later on in the talk, so keep the concept of TRS elements, the little red box elements, As being essential for regulation of messenger RNA synthesis. Now, we'll talk about synthetic genomics in the context Of a platform to control emerging infectious diseases.
If you think about emerging viruses, they have tremendous potential to cause high morbidity and mortality And severe economic hardship. Good examples are HIV, the 1918 flu, SARS coronavirus H5N1, chikungunya virus probably most recently. Now it's clear that zoonotic introductions are increasing and a large number of these viruses have large reservoir pools of animal strains Like SARS and H5 that are maintained as sort of heterogeneous swarms of pools of viruses of which someone may actually emerge in the future to cause endemic disease in humans. This raises a conundrum in terms of how do you protect the public health against a future occurrence that is hard to predict? How do you develop drugs and therapeutics against an unknown from this heterogeneous swarm of variant strains that will actually work against the unknown that will emerge in the future?
How do you target your scarce resources? And so we think platform technologies like synthetic biology, phylogenomics, structure modeling, high throughput sequencing really will provide a platform and our goal is to use SARS coronavirus and its large pool of zoonotic viruses as the model To develop rapid response platforms to protect against this broader heterogeneous pool of variants. We also would like to develop strategies that would attenuate all family members so that you could rapidly develop vaccines for the public, overall public health. Now, A lot of beautiful work in Malik's lab as well as other labs here in China. Worked out the basic molecular epidemiology of SARS coronavirus, the virus originated most likely in bats.
It probably jumped into civets or humans and in that context, set up a transmission cycle between and raccoon dogs and marketplaces and humans, who frequent into those marketplaces, over time, had selected for strains that were more infecting human cells and recognizing the human ACE2 receptor for docking and entry leading to the 2000 to 2003 epidemic, Which caused about 8,000 cases and 800 deaths. Now, if you do phylogenetic analysis of the isolates that were sequenced, You find, they fall into 2 broad categories. These are, this line indicates the strains underneath that line were Identified during the epidemic and you have early phase isolates, primarily of January 2003, after a variety of super spreading events. You had middle phase isolates shown here by this group of isolates. And then following an infected physician who came to Hong Kong And resulted in a super spreading event that transmitted the virus to the rest of the world.
These were considered late phase isolates. A vast pool of heterogeneous zoonotic strains, however, reside up here. Most of these were, in fact, none of these were ever actually Cultured, they actually exist as sequence signatures in silico. So, one of the immediate goals that we became interested in During the outbreak was to develop a platform of viruses that captured the heterogeneity that exists within the family of viruses. And to do that, we identified sort of representative strains, for example, middle phase, early phase isolate, or Vonni, we had in the lab.
Middle phase isolates were CHKW1, GZ02, those are early phase isolate, animal isolates like from civets, SE16 and HCSC6 one hundred and three, a raccoon dog isolate which is shown down here, the sporadic 2004 human case, GDO3, and a couple of other viruses sequences were identified as good candidates that would capture all the diversity that had been identified within the sequence pool. This shows the sequence variation within the spike glycoprotein. If it's a blue box amino acid, that's an animal associated residue. Early phase changes are shown here in yellow, middle phase changes shown in orange, and late phase changes shown in red. In addition, in 2004, there are a variety of other animal strains, as sporadic human cases were identified, that had additional variations shown here in white.
[Dr. It's interesting as much of the variation actually falls within residues or regions that neutralizing epitopes were identified. And in fact, although the number of residues that are changed aren't that great, you can actually reduce neutralization titers by about 20 fold, with some of these variants. Now importantly, Farzan's group showed that the 2 key changes during the epidemic were this lysine to asparagine change at four 79 and a serine three-nine change at 487 that drove animal adaptation to human strain. And so, keep that in mind.
So without access to this pool of strains, we decided to synthesize basically A portfolio of spiked glycoprotein genes of about 4 kV each and then use a molecular clone For the Erbani epidemic strain that we've built in the lab, basically replacing the Erbani spike 1 at a time with these various spike glycoproteins from different phases of the epidemic. Now all of these viruses were viable except for the SC 16 variant. This actually can't recognize the human ACE receptor, so it didn't grow Until we made mouse cells that constitutively express the cividase 2 receptor and once we did that, this virus could grow well. Before we had those cells, Since, Farzan had identified this 4/79 change as the key residue change, we actually build a recombinant virus with that change and that virus could be cultured. Interestingly enough, 2 of these, the GZ02 and the HCFC 6103 viruses, actually cause lethal infection in aged animals.
Produce an ARDS like disease, SARS caused ARDS in humans, predominantly in aged populations. That's acute respiratory distress syndrome, it's a Clinically devastating end stage lung disease with about a 50% mortality rate. So these are actually some of the first real good animal models for SARS infection. Now, these viruses replicate, the human epidemic strains replicate efficiently in human airway epithelial cultures. These are cultures that are derived from cells lining the trachea of transplant patients.
You can actually culture them on liquid air interfaces and they take on the architecture Of the human airway. SARS, coronavirus, all the epidemic strains actually like to infect ciliated cells And these epidemic strains replicate very efficiently. The animal strains, however, do not. And this is just some fluorescent microscope images showing the cilia of the ciliated cells with an expression of the SARS nucleocapsid protein from an epidemic strain on the ciliated cells And the zoonotic strains, SE16 and the HCSC 16103 can replicate. However, If you passage these viruses on human airway cells and culture, you can actually rapidly select out variants that can replicate efficiently in human airways.
Those viruses actually do not contain the mutations that would be had been predicted by Mike Farzan as being, Which were clearly responsible for the 20,022,003 epidemic. Rather, we saw changes At positions 442 and 472 and 479 that mediated the cross species transmission event. So, in reality, we've done this a couple of times. There's actually Several pathways by which the zoonotic SARS could actually adapt and recognize the human ACE receptor. What's interesting is that the epidemic strains Actually efficiently use both the human ACE receptor and the civet ACE receptor.
When we in vitro select for human adapted strains on human airway culture, they actually lose the ability to recognize specific receptors. What this data suggests to us actually is that SARS had existed in a transmission cycle between humans and civets actually probably for several years prior to the thousand two, 2003 epidemic, allowing the virus to gain the capacity to recognize both receptors. Okay. So those are the easy ones to do. Oh, the application.
So now that we had a large panel of variant viruses, we could use those for therapeutic testing over vaccines. In this case, I'm going to show you an example of about 30 human monoclonal antibodies that were derived by Antonio Lancevicchia. If you take those 30 monoclonals and test their ability to neutralize all the strains that we've made in the laboratory, you find some that only neutralize your body, Some that neutralize all human strains, some that neutralize some civets but not all the animal strains but you do end up with four antibodies that neutralize all strains that we have in our portfolio, including the ones that were in vitro adapted on human airway cultures. Importantly, if you select for escape mutants, these antibodies select for changes in different locations of the Scepter binding domain and in fact, 3 of them actually don't overlap. Yes, 109, the 230 and the 227 don't overlap and so these represent good therapeutic cocktails that would capture most of the diversity that exists in SARS And probably work in potential patients that would be infected during future epidemics and these also actually protect young and aged animals from lethal infection.
That was a paper published by Barry Rock in a couple of papers. Now, the civet and the raccoon dog strains were the easy ones. The true reservoir for SARS is within bat population. So, if you look at a phylogenetic tree, The human strains are shown here in red, the civet strains, raccoon dog strains are shown in purple, but the real variation is within the bat strain. The reservoir, it's thought that these were probably the reservoir for the emergence of the virus.
Now, these are about 80% to 90% identical to SARS. They can't be cultured and they exist as sequence signatures in silico. There's also extensive variation through the replicase and elsewhere in the genome, so when we decided we were going to synthetically resurrect the entire virus. Now, before we start it, it's important to note this is a cryo EM reconstruction of the SARS glycoprotein spike. Notice that there are 3 receptor binding domains shown here in, with bubbles that actually engage the ACE2 receptor.
If look at the sequence, the receptor binding shown here in yellow, there's a large amount of sequence variation, especially Within the contact interface residues that engage the human ACE receptor. And, in fact, there's only 4 of 13 contact interface residues that are retained in these fat strains So we don't actually think it's going to use the human ACE receptor to get into cells. In fact, we think we're going to have a tough time culturing this virus. Now, it's important to note that the SARS RBD that was identified, has been proposed by a couple of groups that it may have been introduced by recombination processes from unknown strains that haven't yet been identified and that that led to the initial, cross species transmission events. Now to get back to the issue of in silico sequences, they actually represent hypothetical viruses.
Most synthetic viruses that have been resurrected to this point, Actually, we knew that the sequence was infectious. In this case, we actually don't know which of the sequences in GenBank were infectious, if any. So to do that, with an error rate in GenBank ranging from about 1 to 500 to 1 to 10000, depending on who did the sequence, We had to do extensive bioinformatics analysis to identify what we thought was the likely consensus sequence. None of the strains that we actually saw we thought were completely correct. Some of them had deletions in the sequence of the 5 prime end, so we had to make some educated guess.
The basic approach that we build coronaviruses using our molecular clone is shown here, with the SARS clone shown in blue. The clone is broken into 6, 5 kilobytes about 5 kilobytes pieces. Each piece is flanked by bagel One restriction endonucleate sites. These are class 2S restriction enzymes that recognize a palindromic sequence but cut and leave asymmetric ends. This allows, since these ends are asymmetric, they actually will not concatemorize like classic sticky ends left by restriction enzymes, Enzymes, but rather they become directional.
So, if you end clone A with a bagel site that leaves 13 nucleotide overhang And the 5 prime end of the B fragment with the complementary 3 nucleotide overhang, they go together directly. You change different vagal sites at each piece And this allows them to assemble up into 30 kilobytes chromosomes, like tinker toys. Now, the synthetic bat genome that we made using Blue Heron and Bio Basic, basically is interchangeable with the urbani clone. The only real difference was that we broke the F fragment into 2 pieces, so that we could play with the receptor binding domain easily If this thing didn't turn out to be infectious. And in fact, we made this clone, we built the full on cDNA, we drove transcripts, electropated that in the cells And we can see evidence of replication by the synthesis of sub genomic messenger RNA but we couldn't culture the virus and we couldn't pass it from cell to cell.
Clearly, there was probably a defect in entry. To solve that problem, we Use literature data that has suggested that RBD domains of coronaviruses may be interchangeable between species. So, we took the human, the urbani Epidemic receptor binding domain, that's 2 10 amino acids in blood, and drop that into the bat genome backbone, Producing a chimera with the receptor binding domain driven from the epidemic strains. Now, when we built that clone, drove transcripts and electroporated that cells, we got a virus that could replicate quite efficiently. This is just some growth curve data showing, I think, the black box is the Yarbani wild type and the white circles are open open symbols are the bat viruses.
You can see they Replicate exactly as good as the Urbana epidemic strain at low and high multiplicities of infection. They recognize the human ACE2 receptor in DVT cells At low and high multiplicity infections and grow just like the epidemic strains and they also retain the ability to use the cividase two receptor just like the epidemic strains at low and high multiplicity. They also are capable of infecting human airway epithelial cultures And targeting ciliated cells, just like the epidemic strain, and they grow to similar titer. Now, if you make anti sera just against the bat spike like a protein and use that anti sera to target the SARS wild type virus, it will not neutralize that virus. So clearly, antisera and vaccines derived against epidemic strains are not going to protect against The bat strain.
If you use that same sera against the RBD chimeric virus, you can neutralize it indicating that there are neutralizing episodes that resist that exist outside the RBDs and if you take the human monoclonals that target the epidemic strain RBDs, you can neutralize these viruses quite efficiently. So in summary, certainly synthetic genomics and reverse genetics can be a platform to recover uncultivatable zoonotic precursors, Can be used to synthesize this is actually the largest synthetic virus to date. This is going to be a short record, but it is a record. And you can use it now to identify a broad spectrum antivirals and vaccines. Clearly, the RBDs are interchangeable.
This is with an 89% amino acid identity within the spike. It's the minimal domain required to host shift coronaviruses. What is the phylogenetic limits to RBD interchange? We actually don't know. Clearly, the human monoclonal and vaccines targeting the SARS RBD would provide immunity against natural isolates that emerge by recombinatorial processes in the future or unfortunately by deliberate design.
So now I want to move to the next part of the talk, which is synthetic de optimization schemes to attenuate SARS coronavirus pathogenesis. This is the maturation pathway for how SARS gets out of the cell. The nucleic capsids align underneath an intermediate compartment in the rough ER Golgi Where the M glycoprotein and the E protein are expressed. And then these the M and the E protein actually drive the assembly of virions, Which then mature in the Golgi and then are released in the cell and secretory vesicles, which fuse with the plasma membrane. Now, if you knock out E protein expression, this pathway is still viable, but you reduce virus yields by about 2 logs and if you knock out the M glycoprotein expression or M and A together, you don't make any virus progeny.
So, our approach to deoptimize SARS, coronavirus, The SARS coronavirus genome and to attenuate pathogenesis focused primarily on the E and the M glycoprotein genes, so it's about 3 50 amino acids in total. The strategy we used was to progressively increase the number of deoptimized codons. So we started with serine to produce a D SER virus, Serine Leucine Argines to produce the SLR deoptimized strain or a 5 set DSLR VA strain. Basically, the idea is you create a rheostat Where you're increasing the number of de optimized residues and turning down expression of critical proteins needed for release. This is just a cartoon to show the amino acid sequence and the wild type virus sequence here, so like in the three set At the serine residue, which was optimal in the case of SARS, we just changed it to the most rare codon.
If you look at the statistics here, in general, in the wild type E and M gene, there are about 39 Codons that are de optimized. In the one set, this increased to 52 the 3 set, 94 and the 5 set, 134. We also looked at the CPV values that Eckert just talked about. By these values, these are very minimally on the negative side of the codon pair usage. We also made random controls where we scrambled the codon usage much like Eker did, retaining the wild type genome organization levelers and we made 3 set in the 5 set.
This is, we made these in a mouse adapted background so they'd be pathogenic in mice. Mouse adapted growth is shown here In black, the blue lines show the serine de optimized viruses which also reach high titers by about 24 hours post infection. If you look at the 3 set mutants, however, you see about a log, log and a half reduction as compared to wild type. The 3 set randomized virus the 5 set randomized virus in this case, I'm showing 2 different plaques in the 5 set randomized viruses grew just about like wild type. So just like Eckerd had reported, if you randomize the sequence, it really has very little impact on replication, but the optimization does affect Final yield.
Now, in contrast to what Eckhard talked about, we actually de optimized in the middle of the Downstream, which would potentially affect critical sequences that would affect RNA synthesis. We're very careful not to knock out any known Sequences, regulatory sequences that make messenger RNA. However, both the serine and the SLR mutant knocked out messenger RNA 6 expression, which you can see right here. These actually were the messages, the genes, the messages that encode the genes that we de optimized and so we actually found some evidence of long range Protein RNA RNA interactions that are regulatory elements that we're trying to decipher. The 5 set de optimized strains showed no CPE in culture.
If you develop primers to the 5 prime end of the genome in a leader sequence and a primer down here in In message 6 that encodes ORF 6, you can actually identify leader containing transcripts, which are signatures of the messenger RNAs that are made during infected In these cultures, you can see evidence of message 6, 5, 4, and 3. This is at day 1 post transfection. Even by day 10, you can still see these transcripts infected cells and they continue At that level with about 5 passages at 5 day intervals. But you actually never can actually see a virus. You can never plaque a virus.
You can never actually show a virus as they're producing CPE. So, 5 set de optimizations really down regulated the production of infectious virions And the ability of these viruses to produce a significant amount of CPE. We can get around this probably by expressing helper cells that make the M gene, but we haven't done that yet. Now, we've looked at the pathogenesis of these isolates in mice. In this case, we're infecting with about 10 LD50.
A mouse adapted Strain, wild type, current strain kills the animals in about 4 days from severe pneumonia. The serine de optimized viruses actually are almost as pathogenic. There's a slight delay in loss of body mass, but all the animals eventually die. The SLR randomized viruses are also pathogenic but again slightly less pathogenic than the wild type virus. There are some survivors but most animals die.
The 5 set randomized viruses are again slightly less pathogenic, several animals die but there are survivors. But the 3 set de optimized viruses, none of the animals died, there was transient weight loss and the animals recovered. Virus titers within the mice were actually about the same with wild type, the single de optimized codon or the 3 set de optimized codon viruses. Okay. So, our data certainly is in agreement with Eckert's work that suggests that the optimization or strategies Down regulate translation of viral genes could function as the universal approach to attenuate pathogenesis.
In the case of coronas, we can identify novel transcription regulatory sequences that we didn't know exist, we're trying to decipher that, and these are likely very stable. However, in the case of coronaviruses and polioviruses. These are both susceptible to recombination repair and so we needed a strategy to get around that. And so that is actually the last part of my talk, which should take a couple of minutes, in which we devise strategies to alter the transcription circuits of coronaviruses. Now, remember I said in the case Wild type SARS, these red box elements are absolutely essential to make sub genomic messenger RNAs.
If the leader RNA red box element can't communicate with these body Red box elements, this virus is dead. So we asked a couple questions. Can we change the regulatory circuits? Can we redesign them? If we redesign them, will it act as a genetic trap that will cause lethal genome incompatibilities following recombination and what's the impact of the new circuits on Pathogenesis.
So we made 2 viruses called here CRG and CNG. In the case of the CRG virus, we took this red box element virus We converted it to a blue box element virus by introducing 3 changes at each of these positions. We also made a green box virus that had a completely different TRS regulatory element at each of these locations. Now, these viruses were viable. They grow to 10 to the 7th.
They're small plaquedians but they grow just as well as wild type and they produce all the appropriate genomic messenger RNAs and if you're interested, take a look at this paper. So the answer is yes. Does it affect recombination repair? The answer is yes. That's also in that paper.
I don't have time to go through the data. The idea is if a recombination event occurs, you end up with viruses with Scrambled regulatory elements, so the red box elements can't communicate with the blue box elements and the virus dies. So, it's a genetic trap and it's triggered after recombination repair. So, how does this affect pathogenesis? Now, this is young 10 week old animals infected with the mouse adapted virus or wild type SARS.
SARS just replicates in mice, it produces no disease in young animals. The mouse adapted strain causes a lethal disease within 4 days. We put the CRG in both backgrounds. In the wild type background, again, we see no weight loss in the animals or death. In the mouse adapted strain, when you introduce CRG regulatory the new regulatory network you completely attenuate pathogenesis.
Look at virus titers, however, virus titers in young animals are pretty much similar to the parent strains. It's actually challenges a current sort of an existing paradigm in virology that to attenuate pathogenesis, you have to knock down replication and that's not case with these viruses. We also looked in old animals. In the case of old animals, the MA15 virus kills the animals in about 3 days. SARS produces a transient weight loss of about 5% and the animals recover.
In this case, CRG produced no weight loss compared to the SARS parent. In the lethal genetic genome backbone, we saw more extensive weight loss in the older animals. These are 1 year old animals, But all the animals recovered. Occasionally, we lose an animal. And again, the virus replicated efficiently in these animals.
So, we think that rewiring the regulatory network of a virus can attenuate pathogenesis, could it function as a vaccine. So, we infected young animals and old animals with either the CRG parental virus, A alphavirus encoding the SARS spike or with PBS. We vaccinated them one time, waited 28 days and then challenged them with either a lethal homologous strain or a heterologous strain. You can see that with PBS, all the animals succumb by day 4. In the single vaccinated alpha virus vaccine encoding the SARS spike, you see morbidity, very little mortality, The animals recover.
There is a lot of virus and a lot of pathology in the lungs. The HCSC 6,103 virus is only lethal and only produces disease in old animals, The young ions that just replicated but not within the CRT. It did replicate some in the VRPS. Now, in the older animals, You can see that the vaccine cocktails via the alphavirus vaccines in PBS, the animals died with homologous and with the heterologous challenge And again, the live attenuated rewired viruses protected advanced both. So, in summary, transcription Circuit redesign can attenuate coronavirus pathogenesis.
We actually think it should function as a universal platform To attenuate current and future emerging coronaviruses of the future. It also protects the range through combination repair mechanisms. You can blend this with codam de optimization, to really provide a good strategy to make live attenuated viruses. They protect young and old animals. Since SARS targeted elderly populations, this is currently the only vaccine that works in this population.
Still, vaccines don't. And, I think the combination of synthetic genomics and family specific universal attenuation scheme Can achieve a goal of rapidly producing candidate live virus vaccines within about 2 weeks of identifying the sequence of the newly emerging pathogens. So, The people that did this work included Boyd Yant, Barry Rocks, Damon Deming, Eric Donaldson, Tim Sheehan, And Matt Freeman. So thank you.
reSee.it AI Summary
Professor Luc Montagnier, a Nobel Prize winner, expressed concerns before his death that Covid-19 was artificially created and modified. He believed it was a professional job done by molecular biologists, even containing an HIV sequence. Some speculate that this whole Covid and Vaccine situation resembles a military or intelligence operation. There are claims that DARPA and the DoD were involved in creating Covid and the Vaccine.
@bambkb - Kevin - WE THE PEOPLE❤️ - DAD🦁 🐉 🔥
🚨🚨🚨Before he died, Professsor and noble prize winner, Dr. Luc Montagnier expressed concerns that #Covid was artificially created and modified 😳 : “This was a professional Job, a meticulous one - They even added an HIV sequence in there! This is not normal!! this was a professional job done by molecular biologists!! This virus is MAN MADE!!”😳😳 In my eyes, this whole #Covid and #Vaccine thing looks like a massive MILITARY/intelligence operation!? Who else would be capable of such a thing? Do you know that DARPA and the DoD created #Covid and the #Vaccine? This is a FACT!!!! #Covid #Vaccine #DeepState #NWO #Illuminati
Video Transcript AI Summary
Professor Luc Montagnier, a Nobel Prize winner in medicine and the discoverer of HIV, discusses his current work on the virus. He explains that he is working with a colleague on a computer rather than in a lab. Their work is based on the disease itself and the measures being taken in laboratories on patients. Professor Montagnier concludes that there has been manipulation of the virus, specifically the addition of sequences from HIV. He clarifies that this is not a natural occurrence but the result of meticulous work by a molecular biologist. However, the purpose behind this manipulation is unclear, and Professor Montagnier emphasizes that he is only presenting the facts and not accusing anyone.
Full Transcript
Speaker 0: Et nous revenons avec l'actualité du Covid dix-neuf et nous sommes avec le professeur Luc Montagnier bonjour. Bonjour Et merci d'être avec nous. Faut-il le rappeler vous êtes prix Nobel de médecine et c'est vous qui êtes à l'origine de la découverte du VIH.
Speaker 1: C'est une longue histoire mais intéressante aussi pour l'actualité parce qu'on a une expérience Deux deux choses qui se sont passées qui ont été très difficiles à contrôler là-bas à ce moment-là et ce qui a Permis de trouver la vérité c'est comme aujourd'hui.
Speaker 0: Alors ce qui m'intéresse ce matin c'est que vous vous travaillez en ce moment sur le virus.
Speaker 1: Nous sommes d'accord de travail mais pas forcément au labo puisque on travaille sur ordinateur Avec un collègue et puis c'est tout. On n'a pas de d'expérience on peut dire, mais l'expérience vient JLM De la maladie elle-même, de toutes les mesures qui sont faites actuellement dans les laboratoires sur les patients.
Speaker 0: Et vous êtes arrivé à certaines conclusions.
Speaker 1: Alors d'ailleurs vous arrivez à la conclusion qu'effectivement il y avait eu Une manipulation au sujet de ce virus. C'est-à-dire Et bien qu'une partie, je ne dis pas le total, ce n'est pas, mais il Il y a un modèle qui est évidemment le virus classique et là c'était un modèle surtout venant de la chauve-souris. Mais Ce modèle on a par-dessus ajouté des séquences notamment du VIH, Le virus du du SIDA. Mais quand vous dites on a ajouté, qui a ajouté Ah moi je ne sais pas.
Speaker 0: Et c'est pas naturel, c'est ce que vous voulez dire
Speaker 1: Non, ce n'est pas naturel, c'était un travail de Professionnel, un travail de de biologiste moléculaire. C'est un travail très minutieux, on peut dire de d'horloger, on peut dire Et dans quel bout des séquences.
Speaker 0: Mais dans
Speaker 1: quel but Dans quel but Dans quel but, ce n'est pas n'est pas clair. Moi je je l'expose si vous voulez. Mon mon travail c'est d'exposer les faits, c'est tout. Je ne je n'accuse personne.
@JackStr42679640 - Jack Straw
#BREAKING NEWS: DARPA Unclassified documents confirm SARS-CoV-2 was created by EcoHealth Alliance at the Wuhan Institute of Virology coordinated by Peter Daszak. It was designed to be deliberately virulent and humanized resulting in 6.5 million deaths. Anthony Fauci was involved. L.Aboli
Video Transcript AI Summary
The speaker expresses outrage over the global death toll of 6,500,000 due to the COVID-19 pandemic. They accuse Anthony Fauci and Peter Daszak of being involved in the pandemic's origins and call for criminal charges and investigations. The speaker questions why Fauci can lie to Congress without consequences while others face contempt charges. They believe that the responsibility lies with individuals within the US government and the Chinese Communist Party. The speaker calls for accountability and suggests that the pandemic was a result of negligence and criminal actions. They mention Peter Daszak's involvement in investigating the lab leak, despite his connection to the lab in Wuhan.
Full Transcript
Speaker 0: We The People are dying in massive numbers. 6,500,000. 6,500,000 globally. That's criminal charges. Did Anthony Don't you lie about gain of function, gain of function work?
Absolutely, in my opinion, he did. And how about criminal charges? We're gonna we're gonna after Bannon for contempt because he didn't bother to show up to a farce hearing, but we're gonna let Fauci lie to congress about something that is sequential enough to result in 6,000,000 deaths? Can anyone explain this to me? We, the people of the United states should be outraged.
Instead of hap pitting a war against people who are Christians, people who believe in the United States, people who want on our country to succeed. Maybe we should look at the people who are responsible for the one of the greatest pandemics in human history, and who have result that's resulted in millions of deaths worldwide. I pray that every country in the world, every country, send it to the US, Ask us, when are we gonna investigate the crooks? The US government didn't do this, but there were people in the US government who did. There are criminals involved who I believe were responsible for this, who were negligent in their work.
They did it. The Chinese I mean, his party was involved in this. Anthony Fauci appears to be involved in this. Peter Dasik appears to be involved in this. Let's hold them accountable.
It's time for criminal charges, criminal investigations. Jail, here we go.
Speaker 1: Is this the same, Peter Gasick They said to investigate the ground leak.
Speaker 0: Yes. This is Peter Daszak who, was was out there. We sent him to China to decide whether or not this was a lab leak or natural origin. Peter Daszak, whose company built this in the lab with the Chinese Communist party in Wuhan, China was sent to China to investigate himself.
reSee.it AI Summary
Dr. Luc Montagnier, a Nobel laureate, believed that Covid-19 was artificially created and modified, stating that it contained an HIV sequence. He described it as a professional job done by molecular biologists. The author speculates that the Covid and vaccine situation may be part of a military or intelligence operation. #DeepState #NWO
@bambkb - Kevin - WE THE PEOPLE❤️ - DAD🦁 🐉 🔥
🚨🚨🚨Before he died, Professsor and Nobel prize winner, Dr. Luc Montagnier expressed concerns that #Covid was artificially created and modified : “This was a professional Job, a meticulous one - They even added an HIV sequence in there! This is not normal!! this was a professional job done by molecular biologists”😳😳 In my eyes, this whole #Covid and #Vaccine thing looks like a massive MILITARY/intelligence operation!? Who else would be capable of such a thing? #Covid #Vaccine #DeepState #NWO
Video Transcript AI Summary
Professor Luc Montagnier, Nobel Prize winner in Medicine and co-discoverer of HIV, discusses his current work on the virus. He mentions that he is not conducting experiments in the lab but rather working on a computer with a colleague. They have concluded that there has been manipulation of the virus, specifically the addition of sequences from the HIV virus. However, Montagnier does not know who is responsible for this manipulation or the purpose behind it. He emphasizes that his role is to present the facts and not accuse anyone.
Full Transcript
Speaker 0: Et nous revenons avec l'actualité du Covid dix-neuf et nous sommes avec le professeur Luc Montagnier bonjour. Bonjour. Et merci d'être avec nous. Faut-il le rappeler vous êtes prix Nobel de médecine et c'est vous qui êtes à l'origine de la découverte du VIH. C'est une longue histoire mais intéressante aussi pour l'actualité parce
Speaker 1: qu'on a une expérience Deux deux choses qui se sont passées qui ont été très difficiles à contrôler là-bas à ce moment-là et ce qui a permis de trouver la vérité c'est comme aujourd'hui alors ce
Speaker 0: qui m'intéresse ce matin c'est que vous vous travaillez en ce moment sur le virus. JJB Nous n'avons pas le travail mais
Speaker 1: pas forcément au labo puisque on travaille sur ordinateur avec un collègue Et puis c'est tout, on n'a pas de d'expérience on peut dire, mais on se l'expérience vient du De la maladie elle-même, de toutes les mesures qui sont faites actuellement dans les laboratoires sur les patients.
Speaker 0: Et vous êtes arrivé à certaines conclusions JLM Alors d'ailleurs, nous
Speaker 1: sommes arrivés à la conclusion qu'effectivement il y avait eu Une manipulation au sujet de ce virus. C'est-à-dire Et bien qu'une partie, je ne dis pas le total, n'est-ce pas, mais il Il y a un modèle qui est évidemment le virus classique et là c'était un modèle surtout venant de la chauve-souris. Mais ce modèle on a par dessus ajouté des séquences notamment du Du VIH, le virus du SIDA. Mais quand vous dites on a ajouté, qui a ajouté Ah moi je ne sais pas.
Speaker 0: Et c'est pas naturel, c'est ce que vous voulez
Speaker 1: Non, ce n'est pas naturel, c'était un travail de professionnel, un travail de de biologiste spoliculaire. C'est un travail très minutieux, On peut dire d'horloger, on peut dire Et dans quel bout des séquences Et dans quel but Dans quel but, ce n'est pas clair. Moi je ne je ne l'expose si vous voulez. Mon mon travail c'est d'exposer les faits, c'est tout. Je ne je n'accuse personne.
@KimDotcom - Kim Dotcom
American scientist Ralph Baric developed the spike protein that was inserted into Covid-19 and he worked with the Wuhan lab where the virus was created. Covid-19 was made in America and funded by the US Govt. Where’s the media? Where’s the outrage? Where’s the criminal tribunal? https://t.co/RwDAM9lDUH
reSee.it AI Summary
Newly released email implicates DARPA funding in the development of the COVID-19 virus, overseen by Peter Daszak and Ralph Baric. Join @CovidVaccineAdverseReactions for more updates.
@CartlandDavid - Dr David Cartland
Nuremberg 2: New Inculpatory Evidence Reveals Darpa Funded Fauci's Team's Development of the Covid-19 Virus BREAKING — Newly released email reveals that the COVID-19 virus was developed as part of a DARPA grant overseen by Peter Daszak & Ralph Baric. Patrick Webb on X🔗 Join us👇 @CovidVaccineAdverseReactions
reSee.it AI Summary
I discovered that emails obtained through freedom of information requests show the Gates Foundation, NIH, and BioNTech were planning COVID vaccines before the WHO officially recognized COVID-19 as a concern or declared it a pandemic. Check out the full episode for more details.
@OdessaOrlewicz - Odessa Orlewicz
Breaking: Freedom of information emails reveal Gates Foundation, NIH, and BioNTech had been organizing covid "vaccines" well before the WHO had even declared "Covid 19" as an official "concern" let alone a "Pandemic." These are just short clips from the full episode... https://t.co/wO97x909dR
Video Transcript AI Summary
Welcome to Liberty Talk Canada. Bill Gates has been linked to COVID-19 vaccine preparations before the pandemic was officially declared. Through a Freedom of Information request, it was revealed that the Gates Foundation was in discussions with BioNTech about a vaccine as early as February 2020, despite the WHO not declaring a pandemic until March. The Gates Foundation had also invested in BioNTech in September 2019, suggesting prior knowledge of the outbreak. Emails indicate that NIH officials were more concerned about market sentiment regarding vaccines than public health. This behavior reflects a profit-driven approach, with key figures in the NIH potentially benefiting financially from vaccine developments, similar to Graham's involvement with Moderna.
Full Transcript
Speaker 0: Welcome to Liberty Talk Canada. I'm Odessa Orlowitz. Smoking gun, Bill Gates, through freedom of information request by ICANN, has been proven that he was teeing up COVID 19 vaccines well before the pandemic was even declared. At this point, they put Martha Stewart in jail for far less than what Bill Gates is slowly getting caught for. Back in 2020, ICANN sued NIH to get access to his emails during the pandemic and won.
The latest batch contains a very interesting email in which Bill and Melinda Gates Foundation official introduces Graham at NIH to Ugar Sahin, CEO of BioNTech. Now isn't that interesting? They were already working on COVID vaccines when it wasn't even declared till January 30th that it was an outbreak of concern. Nothing more than outbreak of concern. And the pandemic wasn't called a pandemic by the WHO till March 11th.
Why is it that prior to the WHO announcing that it's a concern on the 30th January 2019, these guys say they've already been working on a vaccine in their February 2nd conversation. In other words, they knew this was a pandemic, and they had been starting to prepare well before it. It's a smoking gun. These emails are a smoking gun. Even though the rest of it is redacted, this is enough.
So we know that the Gates Foundation bought shares in BioNTech back in September 2019. So one person had a cold that they labeled SARS CoV-two and they'd already been setting all this up. And that it is ready to discuss a corresponding license agreement. In another email on March 13, 2020, a market research company reached out to Graham saying that stock markets were plunging and asking him to answer some questions to help them understand market sentiment of the vaccines industry towards COVID 19 vaccines. So they weren't worried about saving lives.
They were worried about money. Graham forwarded the email to the VRC director and said, FYI, quote, I never answer inquiries like this, but do you think it might be appropriate for people like us to speak to the investor world and try to calm things down? In other words, saying, come on, guys. This is it. We're making these vaccines.
You're gonna make a ton of money. They they had this all teed up. Both these incidences show how the NIH acts just like a for profit corporation. This is Fauci. You know, he's the science.
Corporation with a vested interest in forming partnerships and worrying about financial markets, perhaps because the agency and many of its employees stand to profit from the success of the vaccines they develop, just like Graham did from the Moderna vaccine.
@OdessaOrlewicz - Odessa Orlewicz
Here's the full episode: https://t.co/e7JtFgzpx0
reSee.it AI Summary
I shared a thread discussing the idea that Covid was a premeditated hoax, highlighting various events leading up to the pandemic. I pointed out the Rockefeller Foundation's 2010 predictions, the foreshadowing in the film "Contagion," and statements from figures like Bill Gates and Fauci that seemed to anticipate a pandemic. I noted the increase in WHO funding and a 2019 simulation by the Gates Foundation. I concluded that Covid was not a surprise but rather a planned event, suggesting that virology itself is a flawed concept.
@DrWojakMD - Dr. Wojak, M.D.
(1/19) ⚠️🧵 Covid Was a Premeditated Hoax: A Thread With the next fake pandemic looming, let’s revisit how the last one was premeditated. Here’s a chronological breakdown of the most glaring signs of foreknowledge. Even the most informed will find new info here.👇
@DrWojakMD - Dr. Wojak, M.D.
(2/19) 2010: 10 years before Covid, The Rockefeller Foundation’s ‘Scenarios for the Future of Technology’ outlines ‘Lock Step,’ where a pandemic leads to: - total government control - authoritarian leadership - lasting restrictions More blueprint than “hypothetical scenario.”
@DrWojakMD - Dr. Wojak, M.D.
(3/19) 2011 film Contagion foreshadows Covid: - virus from bats in Asia, spread via wet markets - viral videos alert the West - CDC & WHO lead, locals sidelined - independent media dismissed - social distancing, vax passports Classic predictive programming. More examples later.
Video Transcript AI Summary
Many have noted the similarities between the 2011 film Contagion and the current pandemic. In Contagion, the virus is a coronavirus originating from bats in Asia and spreading through wet markets, much like we were initially told about COVID-19.
The West becomes aware through viral videos from Asia spread via alternative media. The CDC, WHO, and other centralized authorities manage the response, sidelining local authorities. Independent media is dismissed as conspiracy theorists. The film references the CDC's overreaction to H1N1, justifying it as erring on the side of caution. A miracle cure, like forsythia or hydroxychloroquine, is promoted prematurely.
Social distancing, a term now common, is emphasized. When an independent journalist points out the financial ties between those handling the pandemic and vaccine manufacturers, they're portrayed negatively. Ultimately, a vaccine developed collaboratively heals the world, and vaccination passports allow people to return to public life.
Full Transcript
Speaker 0: People have been pointing out a lot of the similarities between the 02/2011 film Contagion and the current pandemic that we're all being told about, spreading across the world and keeping many of us captives in our own homes. The similarities are striking. The virus in Contagion is a coronavirus. And as we were first told about COVID nineteen, the fictional virus in Contagion comes from bats in Asia. It's also spread in wet markets.
The West First becomes aware of the spread through viral videos coming out of Asia that are spread throughout the alternative media. The response to the virus is handled by the CDC and the WHO and other centralized authorities that supersede all the local authorities who are depicted as idiots that can't possibly understand the seriousness of the situation. Independent media is derided as not real journalism, but as crackpot conspiracy theorists. The film mentions the CDC's overreaction to h one n one and explains it away as better safe than sorry, and people suggesting otherwise are just being shortsighted and probably want your grandma to die. There's also a mysterious miracle cure that's being touted and promoted before any research has been conducted.
This is forsythia. Hydroxychloroquine. They talk about social distancing, a term that no one had heard in 02/2011 and a term that everyone is painfully familiar with today. Right now, our best defense has been social distancing.
Speaker 1: We start tonight with the coronavirus pandemic. The White House task force warns people not to violate social distancing guidelines because if they do, it could spark a second wave of sickness.
Speaker 0: When the independent media journalist points out that the same people handling the pandemic are the same people that stand again financially from a vaccine. On your blog, you also wrote that the World Health Organization is somehow in bed with pharmaceutical companies. Because they are. That's who stands to gain from this. They're working hand in glove.
He's depicted as a lunatic. In the end, of course, the world is healed by the vaccine developed by the Jewish doctor with the help of his black friend at the CDC and the selfless white woman who tests the vaccine on herself. And once the vaccine is administered, people are given a vaccination passport that allows them to go out into public. These are striking similarities.
@DrWojakMD - Dr. Wojak, M.D.
(4/19) 2015: 5 years before Covid, Peter Daszak, head of EcoHealth Alliance, which funneled NIAID funds to Wuhan, says, “We need to increase public understanding of medical countermeasures like a pan-coronavirus vaccine… Investors will follow the profit.” @DrDMartinWorld great work exposing the origins of these "vaccines" deserves its own thread.
@DrWojakMD - Dr. Wojak, M.D.
(5/19) 2017: 3 years before Covid, Bill Gates predicts a highly infectious virus will kill over 10 million people. Funny how he accurately “predicted” the Covid death toll, despite the entire thing being a hoax, with excess deaths mostly due to vaccines and pandemic protocols.
Video Transcript AI Summary
Growing up, nuclear war was the big fear. Now, a global catastrophe is more likely to be a highly infectious virus. An epidemic, whether natural or intentional, is the most probable cause of over ten million deaths in the coming decades.
The lack of preparedness is alarming. We should be running simulations, like germ games instead of war games, to identify vulnerabilities. Starting now allows us to be ready for the next epidemic.
Full Transcript
Speaker 0: When I was a kid, the disaster we worried about most was a nuclear war. Today, the greatest risk of global catastrophe doesn't look like this. Instead, it looks like this. If anything kills over ten million people in the next few decades, it's most likely to be a highly infectious virus rather than a war. I think, an epidemic, either naturally caused or intentionally caused, is the most likely thing to cause, say, ten million excess deaths.
We're not ready for the next epidemic. We need to do simulations, germ games, not war games, so that we see where the holes are. We need to do simulations, germ games, not war games, so that we see where the holes are. If we start now, we can be ready for the next epidemic. Thank you.
I think an epidemic, either naturally caused or intentionally caused, is the most likely thing to cause, say, ten million excess deaths, and that it's pretty surprising how little preparedness there is for it.
@DrWojakMD - Dr. Wojak, M.D.
(6/19) 2017: 3 years before Covid, Fauci asserts there will be a “surprise” pandemic under the new Trump administration. Seems less like a “surprise” when he sounds so certain, doesn’t it? Fauci’s central role in the AIDS hoax of the 80s made him the ideal front man for Covid.
Video Transcript AI Summary
Based on my experience, I want to emphasize that the next administration will definitely face challenges related to infectious diseases. This includes managing existing chronic infectious diseases, which already pose a significant burden. However, more importantly, be prepared for a surprise outbreak. It's not a matter of if, but when, so pandemic preparedness is crucial.
Full Transcript
Speaker 0: There will be a surprise outbreak. It's the issue of pandemic, preparedness. And if there's one message that I want to leave with you today based on my experience, and you'll see that in a moment, is that there is no question that there will be a challenge to the coming administration in the arena of infectious diseases, both chronic infectious diseases in the sense of already ongoing disease, and we have certainly a large burden of that, but also there will be a surprise outbreak.
@DrWojakMD - Dr. Wojak, M.D.
(7/19) 2017: 3 years before Covid, SPARS Pandemic scenario is created by Johns Hopkins & the Gates Foundation to prepare for a future pandemic. These are the same people who hosted a coronavirus pandemic simulation (Event 201) just a couple months before Covid.
@DrWojakMD - Dr. Wojak, M.D.
(8/19) 2018-19: 1 year before Covid, the WHO’s budget conveniently saw a significant increase for “outbreak and crisis response”.
@DrWojakMD - Dr. Wojak, M.D.
(9/19) Jan 2019: 11 months before Covid, a virologist at Chatham House trains leaders on using fear and inflated death numbers to control the public and promote vaccines during a pandemic.
Video Transcript AI Summary
As the flu commissioner for Belgium, appointed in 2006, my role was an unpaid endeavor that became critical during the 2009 pandemic. On day one, transparency and a unified message are key. Being a non-politician helped avoid political attacks and allowed me to navigate challenges more effectively.
We branded the virus as the "Mexican flu," which, while controversial, improved public recognition. Media relationships were crucial, enabling comprehensive coverage and leveraging free airtime through collaborative efforts with TV anchors.
Predicting future scenarios was important for managing public anxiety and shaping appropriate media coverage. Our calm, cool, and collected approach was designed to reassure the public while preparing for the worst. Maintaining public trust meant addressing questions promptly, even attending funerals to show empathy.
Full Transcript
Speaker 0: Thank you very much, Harp. Thanks for the invitation. And I was asked to to tell you about my experiences being the crisis manager, the flu commissioner for Belgium and highlighting the communication aspects there. These are some of my conflicts of interest over the past twenty years, I guess. It all started for me at that time, well, actually in 02/2006 when I was appointed.
This is an unpaid hobby, so it's not a profession or a function, whatever. It's it's really a hobby that that flu commissioner thing. On 04/24/2009, that was when WHO said, okay, there will be a pandemic and that's when the the thing started. And then you have one opportunity to do it right. I mean, one is so important.
In day one, you start your communication with the press, with the people and you have to do it right. I mean, you have to go for one voice, one message. In Belgium, they chose to appoint a non politician to do that. I mean, I have no party affiliations and that makes things a little bit, at that time at least, a little bit easier because you're not you're not attacked politically, majority minority, that doesn't come into play and that was a huge advantage. The second advantage is that you can play in Brussels the complete naive guy and get a lot more done than you would otherwise be be able to do.
So one voice, one message, that's the tone that you set on day one, and you have to be you have to be very transparent in that. My name is the Intermissary Commissary for Pandemic Influenza Preparedness Planning. That, of course, is too long. That became the flu commissary, and that was and that was a lot a lot easier. You have to be omnipresent that first day or the first days.
So that you attract the media attention, you you make an agreement with them that you will tell them all, and if they call, you will pick up the phone. When you do that, then you can profit from these early days to get complete corporate coverage of the field, and they're not going to search for alternative voices there. And if you do that, that makes things a lot easier. And then you convey the message, and you can do that if you do it that way, that our country is ready for a pandemic. That is a gross overestimation for sure, but it is crucial to, well, to go into that pandemic.
First of all, what's in the name if you talk about the pandemic? It's quite important. People are talking about the swine flu, the pandemic h one and one zero nine virus, novel influenza, two thousand and nine, a h one and one flu. At some point, was called the North American influenza, the novel flu virus. That was way too difficult.
So we called it the Mexican flu. Yeah. That got me into huge trouble with the with the ambassador of Mexico at that time, and she was she was furious. Afterwards, we became good friends. I still get invited to their to their New Year's reception every year.
But people were making fun of it, and and okay, that's that's probably unavoidable. But the fact to have a a clear and recognizable name, was easy for the lay public to understand and use was was actually quite important. It also worked. This is the word of the year of 02/2009. Defriending on Facebook became number one.
To my big disappointment, Mexican flu was second and flu commissary was was number six. So the term works, and that makes things a lot a lot easier. These first weeks, that's easy street. When you have no opposition and and everybody needs news and they can come to you for news, you can bring quite a lot of neutral information and it is picked up and it is well, the news is brought the way you bring it and that is you can only do that in the first couple of weeks or months. One of the problems that we have or that we had is that we did not have a media budget.
That was really €0 that we could spend. That means that you have to use every opportunity you can get to, well, not Britannia rules the waves, but rule the airwaves to to bring out your your message. And that's what that's something that you can do for free on radio, on TV. If you have good preexisting relationships with the media, we you can try something else. We tried the the following thing.
We asked all of the anchors of the different TV stations, are you willing for free to participate in a sort of infomercial that you would pay for all of you? And they said, yes. We'll we'll we'll do that. And and that was hugely influential and and, well, we would never be able nobody would ever be able to pay for something like this. But if you have pretty good pre existing relationships with them, then then you can you can ask for return favor and they will or they might do that.
One of the things that we tried, but it's ten years ago, was using Facebook and and Twitter, but well, there were not enough people on Facebook and Twitter at that time to really have an impact. If we would do that now, that would be a prime channel to communicate. However, that works both ways. I mean, also the fake news would be transmitted much more readily through Facebook, through Twitter than than it did ten ten years ago. Answering the question of the day, no matter what the the journalist's question is, is quite important.
So we had a call center which was gradually becoming more and more populated. And every almost hour to hour, and later day to day, you have to get an idea what are the questions that the people are asking. And and every day, these questions were delivered multiple times so that I could work them in into the interviews no matter what the question was. The first questions, that was the first peak, and that peak was about 900 calls per day at the the moment, at the per week at the the first peak. The first questions were travel related.
Can I still go to Mexico? I have planned a vacation. Can I get my money back? If you solve that problem by declaring an emergency, you help quite a lot of people and that first peak goes goes away. And then you have to predict the future.
That's hard because the future has not happened yet. Predicting the past is a lot easier, but you have to predict the future in order to to prepare the public and not have an over and over exaggeration or an exaggeration of the the information in the press. So I said, Belgium, small country, we will also have h one and one cases. When you bring that, it is front page news. When then, a couple of days later, the first h one one one case arrives in the country, is the second time that they have to bring that news.
So they bring it in a more muted and I think appropriate way. You can only do that when you prepare the scene for that. That was the second wave of questions people were asking more questions about what do I do when I get sick and so on, and that gives you the opportunity to work with them. And then you have to say, okay, well, we will have H one and one deaths. Of course, that would be unavoidable.
I used there, sir Donaldson's quote where he said that in UK, by the peak of the epidemic, forty people would die per day at the end of the summer. So sixty two at that time million people in UK, Forty deaths a day. I worked it out for Belgium. That would be seven deaths a day at the peak of the epidemic. I used that in the media.
Seven Belgian flu deaths per per day at the peak of the epidemic would be realistic. That is true in every year, even in per pandemicly. That that is very, very conservative. However, talking about fatalities is important because when you say that, people say, wow. What do you mean?
People die because of influenza? And that was a necessary step to take. And then of course, a couple of days later, you had the first h one and one death in the country and the scene was set and it was already talked about. That was the third peak of of questions where that were well, the first that it had an impact and you have to have to deal with that. I went to the first couple of funerals.
You have to be very quiet, sit in the back, but but it it it shows that you care and and I think that was at that time quite important. So all in all, at that time, the overall feeling in the population in the press was the Belgian approach is is reasonable. In fact, we wanted to be calm, cool and collected and our mantra was, and that was from day one at this moment, it is comparable more or less to seasonal influenza in terms of outcome, but we have to prepare for severe scenarios. Like in 1918, the first wave was rather mild and you could not predict that the second wave would have a would carry high mortality. We focus on low cost basic hygiene measures.
We did not do any school closures. We used antivirals for high risk groups. Actually, we used antivirals in the beginning for people who were ill. I had pre positioned cars in the different provinces and they would drive antivirals to patients when they would be diagnosed by influenza in order to delay the onset of the epidemic and that worked until the the end of the of the school year. We only purchased one dose of vaccine per person and the the vaccination plan would be to vaccinate more or less the same high risk groups as for seasonal influenza.
And then the vacation came. And that is communication wise a very dangerous period. It's a dangerous period because the more untrained journalists are at the helm, yeah, and you get the weirdest questions. They're understaffed, so more articles from other countries will come in and contaminate your message, and and that that was a weird period. That was pictures that my father took from the holiday with the grand children and I was not I was not the most social guy, I I must admit.
And and my son was born two weeks before the pandemic struck, so that was not good timing. And then comes the time, inevitably, that they they they're going to talk about you. The flu commissioner is a really a great guy. And then you then you get the feel good articles about, yeah, what does he like, what music does he like, Pictures from my first laboratory when I was 13 years old. And it's all feel good, but when they do that, they also sharpen the axis at the at the same time.
And then then your your personal life your your personal life becomes a little bit compromised, and and so then they come to your home and you have to really limit that because if you do not limit that, then then you have no life. And then comes then everything is set about the pandemic, about you, and then the the search for controversy. A certain point in time, had a controversy about the the payment of the physicians for the mass vaccination that would happen in in a couple of months or a couple of weeks later. And then the the quote that I gave them in terms of how much money they would receive, that was far too low and I had to be fired. You can solve that quite easily.
I said, okay, you want me to be fired. I would like to win the lottery. The odds of both of these things are happening are are fairly slim and that and that passed. And then you come to the the the phase where they're going to be much more critical. And the first one was the government does not do enough.
The h one and one vaccine will arrive too late and there will not be enough vaccine. Get it while you can. That was the that was the first the first really atmosphere that was created. So not enough vaccine, get it while you can. So at that point, I had to say, okay, I will be the last one to be vaccinated.
I mean, you can all go in before me. I'll I'll be I'll be the last one and and that later on I regretted that that message. That vaccination campaign got a huge number of questions. That was actually the the crux of the of the campaign was the the vaccination campaign and many people had had questions there. So you had to show them that you had I mean, if if the the stockpiles, you had to walk there and walk in the in the rooms where the where you could show them that we have the vaccines and they are they are already in the country.
A lot of a lot of reassurance was necessary there. And then you had to pick who is going to be vaccinated first. And then, well, women and children first, whatever. I mean, risk groups, they were important. And then I misused the fact that the top top football soccer clubs in Belgium inappropriately and against all agreements vaccinated their they made their soccer players priority people.
So I said, I can use that. Because if the the population really believes that this this vaccine is so desirable that even the soccer players would be dishonest to get their vaccine, I I said, okay, I can I can play with that? So I made a big fuzz about this. This is Van Rance. He's he's raving mad.
But but it worked. And and actually, these vaccination campaigns by the GPs went really, really well in a number of weeks everybody could be could be vaccinated. That's still a fairly relevant portion of the panel. Well, it it worked fine in Flanders. So you know Belgium, it's a complicated country.
And and this is the the vaccination coverage. And you could see Flanders did really well. I did as many interviews in French than than in Dutch. However, in in the Flemish part of the country, we listen to the Flemish media. In the French speaking part of the country, they equally often listen to the or watch the French television where all kind of other messages were were coming across and that was really polluting the the vaccination campaign in.
And then, of course, people say, okay, the vaccine is unsafe and then you get the swine flu hoax and the vaccine could kill you, say no to the vaccine that atmosphere starts. And then after the crisis, everybody becomes smart. Yeah. And you you have to accept that from the from the get go. And then the overall statement was, no, well, the government did too much, of course, because the number of deaths were disappointing to some people.
And then all the books are written and everybody uses all the data and forgets that you had to take the decisions based on a fragment of the data that were available or that would be available later on. And then it was turned into a scam. People were really making money out of it. And and I think the the the Council of Europe played a a very bad role in this. This is Wolfgang Wodark, and I want to shame him actually because he, in the Council of Europe, had a motion for a recommendation, fake pandemics, a threat for health.
They basically said that all these all these virologists, vaccinologists, they all have money in their pockets. They're they're dishonest people. That's easy to say. This is when you Google for h one and one. Of course, there was a peak in October and November.
You didn't hear Wodark at that time. When you Google Wodark, you see that it starts nicely after the end of the pandemic. People become very brave at the end of the pandemic. I think that's not good. Then as time goes by, I still have one minute and fifty one seconds, I would like to actually issue a warning.
This all started in, well, April 2009. Many years have passed. In fact, three thousand five hundred and sixty days today, five zero eight weeks and almost ten years have passed. And that has an impact because people are forgetting about the pandemics a little bit. This is when you look for influenza and pandemic in PubMed.
Until 02/2003, '2 thousand and '4, there wasn't much. Then H5N1 came and some interest was raised. Then the the two thousand and nine pandemic arrived, then there was a lot of interest, and that is what happened since. So the interest is scientifically is is going down. Also, the leadership is changing, and this was a good exercise for a big pandemic.
I agree. But when we're moving farther away from 02/2009, that experience is being lost. At that time, Margaret Chen, the TWH show, Tom Frieden CDC, Susan Jacob, the e CDC. Well, we're now one or two directors further and that experience from 02/2009, of course, been other experiences, but that one is not there anymore. The same for the leadership, the political leadership.
At that time, Obama, Brown, Sarkozy in Belgium, Von Rampoye were there, and well, we're two or three political leaders further down the road, and and a lot of what was learned in 02/1999 has been sort of unlearned and and would have to be invented all. Well, there is still Angela Merkel and Apostrophe. They're the they're the mainstays. We can always count on them. So are we ready for the next pandemic?
I don't think we are. But I would say that pandemics are like a box of chocolates. And then I would like to invoke the words of the philosopher, Forrest Gump, you never know what you're going to get. Yes. Thank you.
Speaker 1: Okay, Mark. Thank you very much. Any comments or questions? Yes.
Speaker 2: Hi. Thank you very much. Kieran Boltsherman. I'm clinical director at the British Medical Journal. I suppose what's changed since 02/2009?
We live in an era of fake news and social media. How will we get the messages across today?
Speaker 0: It is scary. And I I I'm I'm really afraid of that because that was not around in 02/2009. People would still respect authority that you got by by learning something or by professional experience. That is gone. Everybody has graduated from the University of Google, and respect for for knowledge is is gone because why would you need knowledge when you can create knowledge by typing a couple of keywords in Google and getting it yourself.
That is extremely dangerous. Also, the the level of politicians that we have. I mean I mean, when I show these pictures, except for maybe some exceptions, you might want them back. It it is different. When I look at The US and also Italy, the anti vaccination sentiments there, they're growing and they're growing also at the political level that is very unsettling.
Yeah.
Speaker 1: Okay. Any other questions? Yes. Shout. Already have
Speaker 3: my permission at SHOW. So what about engaging the social that the influences of of this day, like the entertainment industry?
Speaker 0: That has been tried to a certain extent also in 02/2009. I mean, you saw Barack Obama being vaccinated. We do that every year in the hospital. In the hospital, the director and the vice director in their underwear are vaccinated. That that has a huge impact.
So influencers are are important. But you you well, you need to ride influencers. I mean the
Speaker 3: The wrong ones like the Kardashians.
Speaker 0: I I Well, if if they do the right things, they might not be the wrong ones. But but I I think they become unpredictable. They come they become unpredictable, I think.
Speaker 3: How fast is the Emmy's? With? The Emmy's.
Speaker 0: The Emmy Awards.
Speaker 3: We gave a flu shot.
Speaker 0: That was not necessary. I think they meant well. I don't think the Emmy Awards ceremony necessarily is the setting to do vaccinations, but I think they meant well. I saw the footage.
Speaker 1: Other questions?
Speaker 4: Yes. Caroline Brown, WHO Regional Office for Europe. Mark, I really like your presentation and I've seen it before and it's still entertaining.
Speaker 1: It's probably entertaining the first time. Okay. No,
Speaker 4: it's still. So Belgium called it the Mexican flu, as did many countries. It's it's a good name, but certainly from WHO perspective, we we try to avoid implicating the countries. And I think that's part of preparedness. Let's be prepared for the next pandemic.
What are we gonna call it that we could all call it?
Speaker 0: Well, we talk we still talk about the Spanish flu, the Hong Kong flu, the Asian flu, and I've never felt that that was extremely discriminating against, for example, the Spanish people. I I agree and I understand it, but the the different names that were used were they're okay to use in scientific journals, that is fine. But to use that in communication with the public, it was over their head. When you talk about age one and one, then you lose 90% of the audience.
Speaker 4: I understand, but I can assure you that our Spanish colleagues are still sensitive about nineteen eighteen.
Speaker 1: It's not the WHO that determines the name.
Speaker 0: True. But I I I do understand the sensitivities.
Speaker 2: But do
Speaker 3: you think people understand h one n one now?
Speaker 0: Well, a lot more people do than than a couple of years ago, but never overestimate that really. I mean, it is over their heads.
Speaker 1: But h one zero one is seasonal today, so the Spanish flu is not seasonal, so Yeah.
Speaker 0: To a certain extent.
Speaker 5: So you have mentioned your experience with Belgium. Do you believe similar experiences have been in other European or even non European countries?
Speaker 0: I think it might be well, in Belgium this was possible, not because it's a great country, but it's a small country. If you want to do this, one voice, one message in a a huge country, it is very difficult to achieve, I think. I think it's more important or what what worked more was the fact that that was apolitical. I I think that had more of an influence. If you do if you have a career politician do that, from day one, he gets attacked by the opposition whose duty it is to oppose.
But that it makes life very hard I think for them.
Speaker 1: Perhaps if you compare it to The Netherlands, which is quite similar, we had about 20 spokespeople. Yeah. And so that made it very difficult. Yeah. So I'm coming
Speaker 5: from Italy. Don't remember what happened in Italy. Honestly, it was ten years ago.
Speaker 1: Okay. Thank you very much, Mark.
@DrWojakMD - Dr. Wojak, M.D.
(10/19) Aug 2019: 6 months before Covid, the Australian Government publishes a 230-page influenza pandemic plan.
@DrWojakMD - Dr. Wojak, M.D.
(11/19) 5 Sep 2019: 4 months before Covid, a 4chan anon blows the whistle and reveals EXACTLY what would unfold, matching Bill Gates’s earlier prediction of 9-10 million deaths. “Do not accept any vaccines for a deadly virus in winter 2020.”
@DrWojakMD - Dr. Wojak, M.D.
(12/19) Sep 2019: 4 months before Covid, the Global Vaccination Summit calls for “strong surveillance systems” to ensure global injections. 6 days later, the WHO warns of a “rapidly spreading pandemic due to a lethal respiratory pathogen.”
@DrWojakMD - Dr. Wojak, M.D.
(13/19) 24 Sep 2019: 3 months before Covid, Trump’s Executive Order 13887 pushes for expanding rapid vaccine production.
@DrWojakMD - Dr. Wojak, M.D.
(14/19) 18 Oct 2019: 2 months before Covid, Bill Gates Foundation hosts a coronavirus pandemic simulation: Event 201. Deep state criminals love to do “simulations” of their psyops before the real thing.
Video Transcript AI Summary
We're here to simulate a multi-stakeholder Pandemic Emergency Board meeting as a severe pandemic emerges. Global collaboration between business and governments is critical.
There are conspiracy theories circulating, so we need to address bad actors spreading fake news and bring them to justice. This new coronavirus causes respiratory illness, and demand for protective equipment is rising, overwhelming healthcare. Despite concerns, 65% are eager for a vaccine, though its timely arrival is uncertain.
Penalties, including arrest, are in place for spreading falsehoods, and controlling information access might be necessary. We must balance saving lives with avoiding an economic collapse.
The pandemic has led to protests, riots, violent crackdowns, martial law, and a loss of public trust. The economic and societal impacts, including distrust of news and breakdown of social cohesion, could last for years.
Full Transcript
Speaker 0: On behalf of our center and our partners, the World Economic Forum and the Bill and Melinda Gates Foundation, I'd like to extend a very warm welcome to our audience here in New York, as well as our larger virtual audience participating online today. The event two zero one scenario is fictional. Today's scenario is going to simulate meetings of a multi stakeholder group called the Pandemic Emergency Board.
Speaker 1: We're at the start of what's looking like it will be a severe pandemic, and there are problems emerging that can only be solved by global business and governments working together.
Speaker 0: There has been some conspiracy theories that are around about the potential that pharmaceutical companies or the UN have released this for their own benefit.
Speaker 2: And maybe this is a time for us to showcase some cases where we are able to bring forward some bad actors and leave it before the courts to decide whether they have actually spread some fake news.
Speaker 3: A new coronavirus. Infected
Speaker 0: people got a respiratory illness with symptoms ranging from mild flu like signs to severe pneumonia. In related news, a significant demand for personal protective equipment like N95 masks and gloves are on the rise. Patients are overwhelming healthcare facilities. People are avoiding public spaces out of fear of infection and in compliance with public health recommendations. Our US affiliate has just released polling results on public expectations for a vaccine, and sixty five percent of those polled are eager to take the vaccine, even if it's experimental.
Speaker 4: I'm not optimistic about having the vaccine in time to be relevant during this pandemic.
Speaker 0: With enough money and political will, anything is possible.
Speaker 3: Penalties have been put in place for spreading harmful falsehoods, including arrest.
Speaker 5: If the solution means controlling and reducing access to information, I think it's the right choice.
Speaker 6: What exactly are the risks and benefits of staying home from work? Absolutely, we need to save lives, but we literally cannot afford a heavy handed response that suffocates our economy.
Speaker 3: The world saw large scale protests and in some places riots. This led to violent crackdowns in some countries and even martial law. The public lost trust in their respective administration. Economists say the economic turmoil caused by such a pandemic will last for years. The societal impacts, the loss of faith in government, the distrust of news, and the breakdown of social cohesion could last even longer.
Video Transcript AI Summary
Event 201 was a simulation exercise that occurred right before the COVID-19 lockdowns. It was hosted by the Johns Hopkins Center for Health Security, the same group that accurately predicted the 2001 anthrax attacks with a similar simulation beforehand.
Event 201 involved actors who greatly benefited from COVID-19 policies. Avril Haines, a long-time consultant for Palantir and former CIA Deputy Director under Obama, was directly involved in the simulation. Haines, who is now the Director of National Intelligence, essentially the CIA's boss in the Biden administration, attempted to remove her connection to Palantir from her online biographies when she joined the Biden campaign.
Full Transcript
Speaker 0: If people don't know what event two zero one was, they did a mock they pretended they were doing a mock. Hey. What would happen if a if a a a virus got out, and how do we handle it? They did that, like, five seconds before we had to go into lockdowns for coronavirus. And who who's they that did that?
Tell people who the they is.
Speaker 1: Right. So event two zero one was hosted by the Johns Hopkins Center, for Health Security, which previously the people that ran that and the which included one of the moderators for event two zero one or the people that did the simulation before the two thousand one anthrax attacks that directly predicted what would happen just several months later when the anthrax attacks did happen. And, obviously, the anthrax attacks were intended to go much farther until but a lot of their plans for utilizing the aftermath of the anthrax attacks sort of things didn't go according to plan, basically, when it got traced back to the US military,
Speaker 0: that the
Speaker 1: anthrax was from the US military. Right?
Speaker 0: Yeah.
Speaker 1: So event two zero one was a simulation very much like that involving a lot of actors that benefited hugely from COVID nineteen policies. And one of the it's not a Peter Thiel connection, but it is a Palantir connection. So one of the longest running consultants for Palantir is a woman named Avril Haines, who was a CIA deputy director under Obama serving under John Brennan. And Afrohaines was one of, you know, these people involved directly in the event two zero one simulation.
Speaker 0: And she's a
Speaker 1: palace. Biden is the top intelligence official in his administration, so the director of national intelligence. So, basically, the CIA's boss is her.
Speaker 0: And so who and how what's her connection to Palantir?
Speaker 1: She's a longtime consultant for them. But as soon as she joined the Biden campaign, she tried to delete it from her biographies online.
@DrWojakMD - Dr. Wojak, M.D.
(15/19) 29 Oct 2019: 2 months before Covid, Fauci & HHS officials discuss the need for a “global event” to “disrupt the system” and make the public more willing to accept an experimental mRNA shot. C’mon guys don’t make it too obvious.
Video Transcript AI Summary
We can't just shut down our current vaccine system and immediately switch everyone to a new, untested vaccine. To move beyond traditional egg-based vaccine production, which has served us well, we need a demonstrably superior alternative. This requires extensive clinical trials, potentially taking a decade even under ideal circumstances.
Perhaps we need a disruptive entity, free from bureaucratic constraints. It’s difficult to alter perceptions of influenza unless we address the problem disruptively and iteratively from within.
Imagine if a novel avian virus emerged in China, we could obtain its RNA sequence and transmit it to regional or even local centers, possibly even directly to homes, to print vaccines on patches for self-administration.
Full Transcript
Speaker 0: Why don't we blow the system up? I mean, obviously, we can't just turn off the spigot on the system we have and then say, hey. Everyone in the world should get this new vaccine. We haven't given to anyone yet. But there must be some way that we grow vaccines mostly in eggs the way we did in 1947.
Speaker 1: In order to make the transition from getting out of the tried and true egg growing, which we know gives us results that can be beneficial, we've done well with that, to something that has to be much better. You have to prove that this works, and then you've gotta go through all of the clinical trials, phase ones, phase twos, phase three, and then show that this particular product is gonna be good over a period of years. That alone, if it works perfectly, is gonna take a decade.
Speaker 2: There might be a need or even an urgent call for an entity Right. Of excitement out there that's completely disruptive, that's not beholden to bureaucratic strings and processes.
Speaker 1: So we really do have a problem of how the world perceives influenza, and it's going to be very difficult to change that unless you do it from within and say, I don't care what your perception is, we're going to address the problem in a disruptive way and in an iterative way because you do need both.
Speaker 2: But it is not too crazy to think that an outbreak of a novel avian virus could occur in in China somewhere. We could get the RNA sequence from that, beam it to a number of regional centers, if not local, if not even in your home at some point, and print those vaccines on a patch and self administer.
@DrWojakMD - Dr. Wojak, M.D.
(16/19) Google Trends: A notable spike in “anti-vax” and “anti-vaxxer” mentions right before Covid. Coincidence, or were we being primed by the media?
@DrWojakMD - Dr. Wojak, M.D.
(17/19) Covid wasn’t a surprise—it was a premeditated hoax. Virology's a sham. Viruses don’t exist. The particles virologists point to are just cell debris—not disease-causing. PCR tests are nonsense. Contagion is a myth. 2025 will be a big year for people waking up to this.
@DrWojakMD - Dr. Wojak, M.D.
(18/19) Other notable examples of predictive programming: - 2012 London Olympics opening - 2016 X-Files episode - 2017 Nature article on Wuhan lab Let me know what I’ve missed.👇 Follow for more threads like this.
Video Transcript AI Summary
There are claims that everyone has a piece of foreign DNA in their genome, which begs the question of who put it there. This tampering can shut down our immune systems. It's a widespread failure through gene tampering, a virus within a virus from the smallpox vaccine called the Spartan virus, which removes the adenosine deaminase gene using CRISPR Cas9.
This is a weapon to depopulate the planet. Our own government lies as a matter of policy, hoarding technology, driven by corporate greed and a darker objective: the takeover of America and the world. They use weather wars, aerial contaminants, and electromagnetic waves to distract and enslave citizens. The government collects your data, preparing to use it against you, and the final takeover will begin with banks going offline, followed by EMP bombs, seemingly an attack by terrorists or Russia, but it's really an invasion of the US.
Full Transcript
Speaker 0: Tad O'Malley has been making claims.
Speaker 1: Claims about what?
Speaker 0: You and everyone you know has a piece of DNA in your genome, put there without your knowing it. But by whom? Well, that's the question of the day. This is an Internet lunatic. You're not saying you believe him.
Speaker 1: Hold on, agent Einstein. You're talking to a scientist.
Speaker 0: Forgive me, assistant director. It may sound insensitive, but the suggestion is pure science fiction. What I'm saying, agent Einstein, is that the facts as I understand them cannot be discounted out of hand. No one has the right or the ability to tamper with your DNA. Unless we gave them that ability.
When you say they're tampering with our DNA, that they're able to shut down our immune systems by the addition of something to our DNA. Yes. But I don't know how exactly. Or how it's being triggered. I don't know that either.
Or why it's happening now. What can we possibly do? We need to act quickly. You were right about that.
Speaker 1: Well,
Speaker 0: I was wrong about the science. I was wrong about what's causing it. Dead wrong, in fact. But it's clearly a widespread failure of our immune systems. Through gene tampering.
A virus within a virus that was put there through the smallpox vaccine is what these men are calling the Spartan virus. We have to figure this out. What's wrong with the science? Okay. The Spartan virus removes the adenosine deaminase gene from your DNA.
It removes the ADA gene, and your immune system will simply vanish. Yeah. But I'm not getting sick. It's only a matter of time. Okay?
So how does it work? How does the virus remove the ADA gene? A process called CRISPR Cas nine. RNA and a protein cutting genes at exact locations. Exactly.
But in this instance, used as a weapon. The ultimate weapon, the ability to depopulate the planet, to kill everyone but the chosen by tampering with their DNA.
Speaker 1: Through gene editing.
Speaker 0: Why do such a thing and lie about it? Own government.
Speaker 1: Your own government lies a matter of course, a matter of policy. The Tuskegee experiments on black men in the thirties, Henrietta Lacks.
Speaker 0: What are they trying to do?
Speaker 2: That's the missing piece. But it's not hard to imagine. A government hiding, hoarding technology for seventy years at the expense of human life and the future of the planet. Driven not only by corporate greed, but a darker objective. The takeover of America.
And then the world itself by any means necessary, however violent or cruel or efficient by severe drought brought on by weather wars conducted secretly using aerial contaminants and high altitude electromagnetic waves in a state of perpetual war to create problem reaction solution scenarios to distract, enrage, and enslave American citizens at home with tools like the Patriot Act and the National Defense Authorization Authorization Act, which abridge the constitution in the name of national security. The militarization of police forces in cities across The US, the building of prison camps by the Federal Emergency Management Agency with no stated purpose, the corporate takeover of food and agriculture, important a important The
Speaker 0: your phone, collects your data, and monitors your whereabouts with impunity.
Speaker 2: A government preparing to use that data against you when it strikes, and the final takeover begins. By a well oiled and well armed multinational group of elites that will cull, kill, and subjugate.
Speaker 0: Happening as we sit here.
Speaker 2: It's happening all around us.
Speaker 1: The other shoe waiting to drop.
Speaker 2: It'll probably start on a Friday. The banks will announce a security action necessitating their computers to go offline all weekend. Digital money will disappear.
Speaker 0: They can just steal your money?
Speaker 1: Followed by the detonation of strategic electromagnetic pulse bombs to knock out major grids.
Speaker 2: What will seem like an attack on America by terrorists or Russia.
Speaker 0: An invasion of The US.
Speaker 1: The Russians tried it in '47.
@DrWojakMD - Dr. Wojak, M.D.
(19/19) Links to sources: - 2/19: https://www.nommeraadio.ee/meedia/pdf/RRS/Rockefeller%20Foundation.pdf - 4/19: https://www.unz.com/proberts/how-the-covid-pandemic-was-orchestrated/ - 5/19: https://www.youtube.com/watch?v=jDxb21qIilM - 6/19: https://www.youtube.com/watch?v=DNXGAxGJgQI - 7/19: https://forbiddenknowledgetv.net/wp-content/uploads/2021/04/spars-pandemic-scenario-copy.pdf - 8/19: https://www.who.int/about/accountability/results/2018-2019 - 9/19: https://vimeo.com/320913130 - 10/19: https://stopworldcontrol.com/downloads/australia-pandemic-plan.PDF - 11/19: https://archive.4plebs.org/pol/thread/225497848/#225498529 - 12/19: https://health.ec.europa.eu/system/files/2019-11/ev_20190912_mi_en_0.pdf - 12/19: https://www.gpmb.org/reports/m/item/2019-a-world-at-risk - 13/19: https://www.presidency.ucsb.edu/documents/executive-order-13887-modernizing-influenza-vaccines-the-united-states-promote-national - 14/19: https://centerforhealthsecurity.org/our-work/tabletop-exercises/event-201-pandemic-tabletop-exercise - 15/19: https://www.c-span.org/program/public-affairs-event/universal-flu-vaccine/535344 - 18/19: https://www.nature.com/articles/nature.2017.21487
How the Covid “Pandemic” Was Orchestrated
Everything you should know about Covid
unz.com
WHO Results Report 2018-2019 - Driving impact in every country
WHO Results Report 2018-2019. 18 May 2020. This report lays out the vital work that we do, and shows how, even as we are responding to one public health event or crisis, we are also working to support countries in meeting the health needs of their populations, strengthening their systems, and planning for the unexpected. This report demonstrates that accountability is at the heart of all that we do.
who.int
Communication and public engagement - MARC VAN RANST - 9
Lecture by Marc Van Ranst, Belgian Flu Commissioner, at the ESWI/Chatham House Influenza Pandemic Preparedness Stakeholders Conference on 22 January 2019
vimeo.com
Page not found - Stop World Control
stopworldcontrol.com
A World at Risk
GPMB 2019 Annual Report
gpmb.org
Executive Order 13887—Modernizing Influenza Vaccines in the United States To Promote National Security and Public Health | The American Presidency Project
presidency.ucsb.edu
Event 201 | Johns Hopkins Center for Health Security
The Johns Hopkins Center for Health Security in partnership with the World Economic Forum and the Bill and Melinda Gates Foundation hosted Event 201, a high-level pandemic exercise on October 18, 2019, in New York, NY.
centerforhealthsecurity.org
Inside the Chinese lab poised to study world's most dangerous pathogens - Nature
Maximum-security biolab is part of plan to build network of BSL-4 facilities across China.
nature.com
@DrWojakMD - Dr. Wojak, M.D.
⚠️For anyone raising an eyebrow at the claim of virology being a sham, see the thread linked below. 🦠 https://t.co/iEqIDqO7gx
@DrWojakMD - Dr. Wojak, M.D.
(1/28) 🚨⚠️ Virology is a Sham — Explained for Every Attention Span I’ve tailored this thread to all attention spans—from 10-word memes for goldfish brains to 25,000-word papers for chads—and everything in between. Pick length that suits you and see why virology’s a scam. 🧵👇
@I_Am_JohnCullen - John Cullen 🐓
What if the vaccines weren't really for COVID, but were for a weaponized version of bird flu, that Dr Fauci did Gain of Function on, back in 2014? What would that mean? https://t.co/due63havvH
reSee.it AI Summary
I report that a Dutch lawsuit against the Architects of the Great Reset quotes Dr. Francis Boyle as saying the COVID-19 mRNA injection is a bioweapon conceived by the Pentagon and funded by DARPA. The clip features Joseph Sansone and other experts arguing the injections rely on illegal gain‑of‑function research, a nanolipid delivery system, and a long‑running nanotechnology program.
@SenseReceptor - Sense Receptor
🚨NEW: For the first time ever, the Covid jabs are called "bioweapons" in court! 💥 Dutch lawyer suing the Architects of the Great Reset quotes Dr. Francis Boyle, who died right after agreeing to testify: "The COVID mRNA injection is a bioweapon... conceived by the Pentagon." "The core of Professor Boyle's argument is that the COVID-19 mRNA injections contain derivatives of illegal military gene-function research. As a result, the COVID-19 injections qualify by definition as a military biological weapon system. A, bioweapon, in other words." "This technology is, as Boyle declared, paid for, developed, financed and conceived by the Pentagon and its research institute DARPA. This technology platform, nanotechnology platform, was not an afterthought." This clip of Peter Stassen, the lawyer suing the "Architects of the Great Reset" in Dutch court on behalf of plaintiffs harmed by the Covid injections, is taken from a video posted by Dr. Joseph Sansone to Rumble on March 14, 2026. Sansone is one of five expert witnesses involved in the case, along with retired pharma R&D executive Sasha Latypova (@sasha_latypova), former Assistant Secretary of HUD Catherine Austin Fitts (@solari_the), et al. Note that Dr. Francis Boyle, an eminent professor of international law who helped to draft the implementing legislation for the Biological Weapons Anti-Terrorism Act of 1989, died mysteriously soon after he agreed to take part in this lawsuit.... ----------------Partial transcription of clip--------------- "I will start with the statement of Joseph Sansone. It is based on the sworn statement of the late Professor Dr. Francis Boyle, who has determined and concluded Professor Boyle is the greatest authority in the field of bioweapons legislation. He is the author of it, so he knows what is legally meant by it. "He knew, like no other, that the COVID-19 mRNA injection is a bioweapon. He has also made that loud and clear to the world known, after which, despite being in good health, he passed away shortly after he had declared himself willing to give testimony under oath about this in court. "The core of Professor Boyle's argument is that the COVID-19 mRNA injections contain derivatives of illegal military gene-function research. As a result, the COVID-19 injections qualify by definition as a military biological weapon system. A, bioweapon, in other words. "This bioweapon consists of two integrated components, the pathogenic load and the delivery mechanism. It is beyond doubt that the pathogenic load is the product of illegal gene or function research. Boyle refers to this, to an article in the scientific journal Nature Medicine, of which I have included the link in this plea note. "If you open that link, you will immediately read the warning that true scientists believe that an animal is the most likely source of the coronavirus. You will also immediately know that what is called the new normal, true scientists are, not scientists, but faith fanatics. These are the scientists behind whom the respondents hide. "The article in Nature Medicine that Boyle reports on was published in 2015, and the title reads, translated, A Cluster of Circulating Coronaviruses in Bats, Similar to SARS Shows Potential for Human Infection. I present to you what the summary of this research included in the article reveals. It states, based on these findings, we have synthetically created an infectious fully SHC014 recombinant virus, developed and demonstrated robust viral replication both in vitro and in vivo. "So it states, we researchers have created a SARS-like coronavirus with a spike protein optimized for human infection. I cannot provide a better example of illegal gain-of-function research. And who wrote that article from 2015? Among others, researchers affiliated with UNC Chapel Hill and the Wuhan Institute of Virology. Wuhan? Yes, Wuhan. You know, where, according to the official narrative, people suddenly dropped dead on the street when COVID-19 broke out because there was a bat mutated the spike protein. The pathogenic payload of the bioweapon is the result of this research. "So it's not about a natural spike protein, but an illegally developed synthetically made pathogen that has been optimized for human infection. The spike protein mRNA with the instructions to human cells to produce this very pathogenic spike protein is one of the two crucial building blocks of the COVID-19 bioweapon. "Now, the delivery system, the NLPs, you know, the nanolipid particles that encapsulate the mRNA payload and deliver it into the interior of the cells. The propaganda term for this is fat globules, as if we're talking about something as harmless as a stick of butter. What did Boyle declare about it? Boyle declared that it is actually about a nanotechnology enhanced delivery platform. "This technology is, as Boyle declared, paid for, developed, financed and conceived by the Pentagon and its Research Institute DARPA. This technology platform, nanotechnology platform was not an afterthought. "Dr. Boyle points out that the virus itself was aerosolized and engineered with nanotechnology from the very beginning. This indicates a long-term program aimed at the application of advanced delivery systems and this technology has been used in the COVID-19 injections. "Boyle determined that the NLP delivery system in the injections is the result of a specific teacher-sponsored program for nanotechnological biological weapons. In the presentation by Sansone, you can read further about the legal implications of this. It is also argued that Gates and Bourla qualify as suspects of crimes against humanity as defined in the Rome Statute concerning the International Criminal Court."
Video Transcript AI Summary
Speaker 0 presents the statement of Joseph Sanson, based on the sworn statement of the late professor doctor Francis Boyle, described as the greatest authority in bioweapons legislation and the author of it. Boyle is asserted to have concluded that the COVID-19 mRNA injection is a bioweapon, and that he knew this “like no other” before his death, which occurred shortly after he declared willingness to testify under oath in court.
The core of Boyle’s argument, as presented, is that the COVID-19 mRNA injections contain derivatives of illegal military gene function research, and therefore qualify by definition as a military biological weapon system—a bioweapon. This bioweapon is said to consist of two integrated components: a pathogenic load and a delivery mechanism. It is asserted that the pathogenic load results from illegal gene or function research.
Boyle is described as referring to an article in Nature Medicine, with a link included in the plea note. If opened, the article is claimed to warn that true scientists believe an animal is the most likely source of the coronavirus, and that what is called the “new normal” are not scientists but faith fanatics. The 2015 Nature Medicine article is summarized as reporting that, based on findings, researchers synthetically created an infectious fully SHC014 recombinant virus with robust viral replication in vitro and in vivo, a SARS-like coronavirus with a spike protein optimized for human infection. The article is attributed to researchers including those affiliated with UNC Chapel Hill and the Wuhan Institute of Virology, implying that the spike protein and pathogenic payload were the result of illegal gain-of-function research.
The spike protein mRNA is described as providing instructions to human cells to produce this pathogenic spike protein, emphasized as not being a natural spike protein but an illegally developed, synthetically made pathogen optimized for human infection. The delivery system is identified as nanolipid particles (NLPs) that encapsulate the mRNA payload and deliver it into cells. The rhetoric labels these as fat globules, and Boyle is said to declare that this is actually a nanotechnology-enhanced delivery platform. This technology is described as being paid for, developed, financed, and conceived by the Pentagon and its research institute DARPA, with the claim that the virus was aerosolized and engineered with nanotechnology from the beginning, indicating a long-term program for advanced delivery systems.
The claim is made that this technology has been used in the COVID-19 injections, with the NLP delivery system described as the result of a specific teacher-sponsored program for nanotechnological biological weapons. The presentation by Samsung is cited for further legal implications, and it is argued that Gates and Borla qualify as suspects of crimes against humanity under the Rome Statute of the International Criminal Court.
Full Transcript
Speaker 0: I will start with the statement of Joseph Sanson. It is based on the sworn statement of the late professor doctor Francis Boyle, who has determined and concluded. Professor Boyle is the greatest authority in the field of bioweapons legislation. He is the author of it. So he knows what is legally meant by it.
He knew. Like no other that the COVID nineteen mRNA injection is a bioweapon. He has also made that loud and clear to the world known. After which despite being in good health, he passed away shortly after he had declared himself willing. To give testimony under oath about this in court.
The core of Professor Boyle's argument is that the COVID-nineteen mRNA injections contain derivatives of illegal military gene function research. As a result, the COVID-nineteen injections qualify by definition as a military biological weapon system, a bioweapon in other words. This bioweapon consists of two integrated components. The pathogenic load and the delivery mechanism. It is beyond doubt that the pathogenic load is the product of illegal gene or function research.
Boyle refers to this to an article in the scientific journal Nature Medicine, of which I have included the link in this plea note. If you open that link, you will immediately read the warning that true scientists believe that an animal is the most likely source of the coronavirus. You will also immediately know that what is called the new normal, true scientists, are not scientists but faith fanatics. These are the scientists behind whom the respondents hide. The article in nature medicine that Boyle reports on was published in 2015.
And the title reads translated, a cluster of circulating coronaviruses in bats similar to SARS shows potential for human infection. I present to you. What the summary of this research included in the article reveals. It states based on these findings we have synthetically created an infectious fully SHC zero fourteen recombinant virus developed. And demonstrated robust viral replication.
Both in vitro and in vivo. So it states, we researchers have created a SARS like coronavirus with a spike protein optimized for human infection. I cannot provide a better example of illegal gain of function research. And who wrote that article from 2015? Among others, researchers affiliated with UNC Chapel Hill and the Wuhan Institute of Virology.
Wuhan. Yes, Wuhan. You know, where according to the official narrative, people suddenly dropped dead on the street when COVID nineteen broke out because there was a bat mutated. The spike protein, the pathogenic payload of the bioweapon is the result of this research. So it's not about a natural spike protein, but an illegally developed synthetically made pathogen that has been optimized for human infection.
The spike protein mRNA with the instructions to human cells to produce this very pathogenic spike protein is one of the two crucial building blocks of the COVID nineteen bioweapon. Now the delivery system, the NLPs, you know, the nanolipid particles that encapsulate the mRNA payload and deliver it into the interior of the cells. The propaganda term for this is fat globules as if we're talking about something as harmless as a stick of butter. What did Boyle declare about it? Boyle declared that it is actually about A nanotechnology enhanced delivery platform.
This technology is as Boyle declared. Paid for developed financed and conceived by the Pentagon and its research institute DARPA. This technology platform, nanotechnology platform was not an afterthought. Doctor Boyle points out that the virus itself was aerosolized and engineered with nanotechnology from the very beginning. This indicates a long term program aimed at the application of advanced delivery systems.
And this technology has been used in the COVID nineteen injections. Boyle determined that the NLP delivery system in the injections is the result of a specific teacher sponsored program for nanotechnological biological weapons. In the presentation by Samsung you can read further about the legal implications of this. It is also argued that gates and Borla qualify as suspects of crimes against humanity as defined in the Rome statute concerning the international criminal court.
reSee.it AI Summary
I read that a Dutch court heard arguments claiming Covid was planned by Bill Gates, the WEF, and WHO, and that the Covid vaccine is a biological weapon; the mRNA injection is described as a military-grade bioweapon.
@liz_churchill10 - Liz Churchill
On ‘Long Covid Awareness Day’ it is important to know that a court in the Netherlands heard arguments that ‘Covid’ was planned in advance by Bill Gates, WEF and WHO…and that the ‘Covid Vaccine’ is a Biological Weapon “The Covid mRNA injection is a military-grade Bioweapon…” https://t.co/6QWD28cyAg
reSee.it AI Summary
The COVID spike protein, believed to be a bioweapon, was engineered in a Cabal biolab. Moderna holds a patent for its genetic sequence. Elements of HIV are found in the spike protein, which can cause HIV antibodies and blood clots. Vaccinated individuals had a higher HIV positivity rate. The virus and injections are delivery vectors, but injections only protect against the spike protein. Catching the viral form allows the respiratory system to build immunity to all 29 proteins. It's crucial to avoid the toxic spike protein accumulating in organs.
@TwinTowerCity - Twin Tower City ⭐⭐⭐
THREAD: The Spike Protein is the Bioweapon This thread discusses the COVID-19 spike protein. It was engineered through gain-of-function experiments in a Cabal biolab. There are two delivery vectors for the spike protein bioweapon. The virus. And the more deadly injection.
@TwinTowerCity - Twin Tower City ⭐⭐⭐
A bat coronavirus spike protein was weaponized by the Cabal. It contains a genetic sequence patented by Moderna three years before the plandemic. Researchers say there’s a one in 3 trillion chance the sequence developed naturally. https://www.dailymail.co.uk/news/article-10542309/Fresh-lab-leak-fears-study-finds-genetic-code-Covids-spike-protein-linked-Moderna-patent.html
Scientists find genetic match between Covid and Moderna 2016 patent
The international team of researchers identified a tiny snippet of code that is identical to part of a genetic sequence patented by the US vaccine maker three years before the pandemic.
dailymail.co.uk
@TwinTowerCity - Twin Tower City ⭐⭐⭐
Here’s the CEO of Moderna discussing the COVID genetic sequence patented by his organization three years before the COVID plandemic was unleashed.
@TwinTowerCity - Twin Tower City ⭐⭐⭐
The spike protein may also include elements of HIV. An Australian vaccine that used the spike protein was abandoned because the vaccine generated HIV antibodies in recipients. https://www.bbc.com/news/world-australia-55269381
Covid: Australian vaccine abandoned over false HIV response
Trials of the Australian vaccine returned false-positive HIV tests, but did not harm participants.
bbc.com
@TwinTowerCity - Twin Tower City ⭐⭐⭐
Research from India found a similarity between HIV and unique inserts in the spike protein. "Amino acid residues in all the 4 inserts have identity or similarity to those in the HIV-1 gp120 or HIV-1 Gag ... unlikely to be fortuitous in nature" https://www.biorxiv.org/content/10.1101/2020.01.30.927871v1.full
Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
biorxiv.org
@TwinTowerCity - Twin Tower City ⭐⭐⭐
A CDC study found vaccinated individuals in Massachusetts had a HIV positivity rate 17X higher than average. "Analysis matching cluster-associated COVID-19 cases with the state HIV case surveillance data identified 6% cases with verified HIV infection.” https://www.civilianintelligencenetwork.ca/2021/08/03/breaking-hiv-confirmed-in-vaccinated/
Breaking: HIV Confirmed in Vaccinated! – Civilian Intelligence Network
civilianintelligencenetwork.ca
@TwinTowerCity - Twin Tower City ⭐⭐⭐
Professor Luc Montagnier, the scientist who discovered HIV, says COVID-19 contains genetic elements of HIV. "French scientist who shared the 2008 Nobel Prize for discovery of HIV insisted its characteristics could not have arisen naturally." https://www.dr-rath-foundation.org/2020/04/nobel-prize-winning-scientist-who-discovered-hiv-says-coronavirus-was-created-in-laboratory/
Nobel Prize-Winning Scientist Who Discovered HIV Says Coronavirus Was Created In Laboratory - Dr. Rath Health Foundation
Dr Rath Foundation
dr-rath-foundation.org
@TwinTowerCity - Twin Tower City ⭐⭐⭐
COVID-19 has a HIV-like mutation according to research by scientists in China and Europe. Nankai University shows the virus has a mutated gene similar to those in HIV that means its ability to bind with human cells could be 1000 times as strong as SARS. https://www.scmp.com/news/china/society/article/3052495/coronavirus-far-more-likely-sars-bond-human-cells-scientists-say
Coronavirus more likely than Sars to bond to human cells, scientists say
Research by team from Nankai University shows new virus has mutated gene similar to those found in HIV and Ebola.
scmp.com
@TwinTowerCity - Twin Tower City ⭐⭐⭐
The virus was the original delivery vector. It has a diameter of ~100nm and can’t pass through blood barriers. Airborne viruses are typically dealt with by the respiratory system (nose/throat/lungs). They rarely enter the bloodstream. So the virus was less deadly than they hoped.
@TwinTowerCity - Twin Tower City ⭐⭐⭐
The COVID virus has 29 proteins. When you catch the virus, your body learns how to defend against all 29 proteins. If you later catch a new strain, where some proteins have mutated, your body still recognizes most of the proteins and knows how to produce the right antibodies.
@TwinTowerCity - Twin Tower City ⭐⭐⭐
The secondary delivery vector is the injection, which isolates the spike protein from the virus. The spike protein has a diameter of ~10nm. It passes through blood barriers, evading the protection of the respiratory system, and attacks the heart, brain, reproductive system etc.
@TwinTowerCity - Twin Tower City ⭐⭐⭐
The injections only teach the body how to defend against that spike protein. Not the other 20+ proteins in the virus. So when you catch a new strain of the virus, with a mutated spike protein, the injection is useless. Injected people still catch, spread and get ill with COVID.
@TwinTowerCity - Twin Tower City ⭐⭐⭐
Blood cells normally flow smoothly past each other. But the spike protein, isolated from the rest of the virus, is free to attach to blood cells. This causes cells to stick together, creating clots. Clots that move into the brain or heart can cause strokes or heart attacks.
@TwinTowerCity - Twin Tower City ⭐⭐⭐
If you're going to get the HIV spike protein, it's better to catch the viral form. This allows your respiratory system to deal with it, and your body to build immunity to all 29 proteins, without the toxic spike protein entering your bloodstream and accumulating in your organs.